Details of the Target

General Information of Target

Target ID LDTP11071
Target Name 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2)
Gene Name DPH2
Gene ID 1802
Synonyms
DPH2L2; 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
Target Bioclass
Other
Family
DPH1/DPH2 family, DPH2 subfamily
Function
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.
Uniprot ID
Q9BQC3
Ensemble ID
ENST00000255108.8
HGNC ID
HGNC:3004

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.Q101R .
CORL23 SNV: p.G244V .
MCC13 SNV: p.P183S .
MFE319 SNV: p.L230F; p.E332G .
MOLT4 SNV: p.A109V IA-alkyne    Probe Info 
OCUG1 SNV: p.V149M .
RH30 SNV: p.T435I .
SW837 SNV: p.F355S .
YSCCC SNV: p.E10Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0224  [1]
DBIA
 Probe Info  		C251(2.56)  LDD0080  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C157(0.91); C134(0.96); C251(1.16)  LDD1507  [8]
 LDCM0215  AC10 PaTu 8988t C250(0.95); C251(0.70)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C250(1.04); C251(1.10)  LDD1105  [2]
 LDCM0237  AC12 PaTu 8988t C250(0.96); C251(0.92)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C250(1.02); C251(1.05)  LDD1138  [2]
 LDCM0270  AC15 PaTu 8988t C250(0.92); C251(0.89)  LDD1149  [2]
 LDCM0276  AC17 PaTu 8988t C250(0.64); C251(0.64)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C250(0.55); C251(0.55)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C250(0.69); C251(0.69)  LDD1157  [2]
 LDCM0279  AC2 HEK-293T C157(0.94); C134(0.98)  LDD1518  [8]
 LDCM0280  AC20 PaTu 8988t C250(0.55); C251(0.55)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C250(0.60); C251(0.60)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C250(0.62); C251(0.62)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C250(0.61); C251(0.61)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C250(0.49); C251(0.49)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C250(0.57); C251(0.57)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C250(0.81); C251(0.81)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C250(0.56); C251(0.56)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C250(0.72); C251(0.72)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C250(0.73); C251(0.73)  LDD1168  [2]
 LDCM0290  AC3 HEK-293T C157(0.87); C134(0.94); C251(1.41)  LDD1529  [8]
 LDCM0291  AC30 PaTu 8988t C250(0.57); C251(0.57)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C250(0.49); C251(0.49)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C250(0.98); C251(0.98)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C250(0.70); C251(0.70)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C250(0.58); C251(0.58)  LDD1174  [2]
 LDCM0296  AC35 HEK-293T C157(0.79); C134(0.99); C251(1.30)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C157(1.03); C134(0.95); C251(1.04)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C157(0.91); C134(1.02); C251(1.11)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C157(1.07); C134(1.00); C251(1.10)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C157(0.95); C134(0.98)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C157(1.01); C134(0.98); C251(1.00)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C157(1.04); C134(1.07); C251(0.71)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C157(0.82); C134(0.94); C251(1.31)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C157(1.09); C134(0.98)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C157(0.94); C134(0.98); C251(1.30)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C157(0.94); C134(0.94); C251(0.97)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C157(1.02); C134(1.04); C251(1.02)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C157(1.14); C134(0.99); C251(0.94)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C157(1.14); C134(0.93)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C157(1.32); C134(1.02); C251(0.96)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C157(0.95); C134(0.98); C251(0.96)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C157(0.99); C134(1.07); C251(0.94)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C157(0.99); C134(0.98)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C157(0.84); C134(0.99); C251(1.10)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C157(0.92); C134(0.90); C251(1.05)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C157(1.01); C134(1.04); C251(1.04)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C157(1.15); C134(0.97); C251(0.96)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C157(0.96); C134(0.94)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C157(1.07); C134(1.04); C251(1.06)  LDD1558  [8]
 LDCM0320  AC57 HCT 116 C250(0.46); C251(0.46)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C250(0.49); C251(0.49)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C250(0.59); C251(0.59)  LDD0639  [2]
 LDCM0323  AC6 PaTu 8988t C250(0.88); C251(0.92)  LDD1202  [2]
 LDCM0324  AC60 HCT 116 C250(0.43); C251(0.43)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C250(0.45); C251(0.45)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C250(0.51); C251(0.51)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C250(0.44); C251(0.44)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C250(0.45); C251(0.45)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C250(0.54); C251(0.54)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C250(0.55); C251(0.55)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C250(0.42); C251(0.42)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C250(0.80); C251(0.80)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C250(0.68); C251(0.68)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C250(1.00); C251(1.21)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C250(0.96); C251(0.96)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C250(0.92); C251(0.92)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C250(0.81); C251(0.81)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C250(0.74); C251(0.74)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C250(0.65); C251(0.65)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C250(0.91); C251(0.91)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C250(0.82); C251(0.82)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C250(0.72); C251(0.72)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C250(0.72); C251(0.72)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C250(0.98); C251(0.98)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C250(0.83); C251(0.95)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C250(0.91); C251(0.91)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C250(0.97); C251(0.97)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C250(0.90); C251(0.90)  LDD0665  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C250(1.05); C251(1.05)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C250(0.76); C251(0.77)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C250(0.93); C251(0.94)  LDD1154  [2]
 LDCM0367  CL1 HCT 116 C250(1.33); C251(1.33)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C250(1.07); C251(1.07)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C157(0.67); C134(1.00); C251(0.99)  LDD1573  [8]
 LDCM0370  CL101 PaTu 8988t C250(1.34); C251(1.50)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C250(0.98); C251(1.06)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C250(0.83); C251(1.06)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C250(1.00); C251(0.93)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C250(0.86); C251(0.86)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C250(0.71); C251(0.71)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C250(0.75); C251(0.75)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C250(0.71); C251(0.71)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C250(0.79); C251(0.79)  LDD1257  [2]
 LDCM0379  CL11 HCT 116 C250(0.88); C251(0.88)  LDD0696  [2]
 LDCM0380  CL110 PaTu 8988t C250(0.62); C251(0.62)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C250(0.60); C251(0.60)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C250(0.50); C251(0.50)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C250(0.89); C251(0.89)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C250(0.90); C251(0.90)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C250(1.10); C251(1.10)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C250(0.57); C251(0.57)  LDD1265  [2]
 LDCM0387  CL117 HEK-293T C157(1.06); C134(1.13); C251(1.01)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C157(1.04); C134(0.97)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C157(1.16); C134(1.07); C251(0.87)  LDD1593  [8]
 LDCM0390  CL12 HCT 116 C250(0.90); C251(0.90)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C157(0.87); C134(1.05); C251(0.95)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C157(1.03); C134(1.22); C251(1.13)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C157(0.95); C134(1.01)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C157(1.21); C134(0.98); C251(0.71)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C157(0.77); C134(1.04); C251(1.02)  LDD1599  [8]
 LDCM0396  CL125 HCT 116 C250(0.65); C251(0.65)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C250(0.79); C251(0.79)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C250(0.69); C251(0.69)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C250(0.61); C251(0.61)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C250(0.69); C251(0.69)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C250(1.15); C251(1.15)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C250(0.81); C251(0.81)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C251(1.22)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C251(1.22)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C251(1.66)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C251(1.71)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C250(1.13); C251(1.13)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C251(1.89)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C251(1.84)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C251(2.15)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C251(1.65)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C251(2.35)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C251(1.30)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C251(1.23)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C251(2.18)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C251(1.35)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C251(1.34)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C250(1.00); C251(1.00)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C251(2.00)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C157(0.80); C134(1.04); C251(1.18)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C157(0.85); C134(1.05); C251(1.04)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C157(1.10); C134(1.13); C251(0.81)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C157(0.99); C134(1.05); C251(1.00)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C157(0.85); C134(1.04)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C157(0.96); C134(1.14); C251(0.91)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C157(1.01); C134(1.03); C251(1.06)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C157(1.07); C134(1.00); C251(0.68)  LDD1632  [8]
 LDCM0429  CL4 HCT 116 C250(1.00); C251(1.00)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C157(0.95); C134(1.05); C251(0.93)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C157(0.78); C134(0.95); C251(1.08)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C157(0.99); C134(1.03)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C157(0.81); C134(1.20); C251(0.95)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C157(0.78); C134(0.98); C251(1.04)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C157(1.11); C134(1.12); C251(0.95)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C157(1.04); C134(1.08); C251(0.92)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C157(0.87); C134(1.04)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C157(0.96); C134(1.08); C251(1.02)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C157(0.93); C134(1.11); C251(1.00)  LDD1643  [8]
 LDCM0440  CL5 HCT 116 C250(0.94); C251(0.94)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C157(0.97); C134(1.08)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C157(0.88); C134(1.15); C251(0.98)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C157(0.95); C134(0.93); C251(0.83)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C157(0.89); C134(0.83)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C157(0.82); C134(1.09); C251(1.23)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C157(0.95); C134(1.05); C251(1.00)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C157(1.11); C134(0.97); C251(0.87)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C157(1.04); C134(1.13); C251(0.88)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C157(0.81); C134(1.10)  LDD1653  [8]
 LDCM0451  CL6 HCT 116 C250(0.78); C251(0.78)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C157(0.92); C134(1.17); C251(0.87)  LDD1655  [8]
 LDCM0453  CL61 PaTu 8988t C250(0.64); C251(0.64)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C250(1.30); C251(1.30)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C250(1.21); C251(1.21)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C250(1.96); C251(1.96)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C250(1.08); C251(1.08)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C250(1.00); C251(1.00)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C250(0.81); C251(0.81)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C250(0.66); C251(0.66)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C250(0.63); C251(0.63)  LDD1340  [2]
 LDCM0462  CL7 HCT 116 C250(0.82); C251(0.82)  LDD0779  [2]
 LDCM0463  CL70 PaTu 8988t C250(0.71); C251(0.71)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C250(1.10); C251(1.10)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C250(1.87); C251(1.87)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C250(0.76); C251(0.76)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C250(0.76); C251(0.76)  LDD1346  [2]
 LDCM0469  CL76 HCT 116 C250(0.78); C251(0.78)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C250(1.43); C251(1.43)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C250(0.75); C251(0.75)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C250(0.84); C251(0.84)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C250(1.22); C251(1.22)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C250(0.78); C251(0.78)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C250(0.79); C251(0.79)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C250(0.80); C251(0.80)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C250(0.72); C251(0.72)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C250(0.85); C251(0.85)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C250(0.73); C251(0.73)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C250(1.11); C251(1.11)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C250(1.02); C251(1.02)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C250(0.69); C251(0.69)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C250(0.62); C251(0.62)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C250(0.93); C251(0.93)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C250(1.16); C251(1.16)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C157(0.96); C134(1.10); C251(1.11)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C157(1.09); C134(0.95); C251(1.11)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C157(1.00); C134(1.07); C251(0.93)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C157(1.13); C134(1.11); C251(1.05)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C157(0.81); C134(0.86)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C157(1.11); C134(1.00); C251(0.85)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C157(0.99); C134(0.98); C251(1.05)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C157(0.99); C134(1.01)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C157(1.24); C134(1.01); C251(1.54)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C157(1.14); C134(1.14); C251(1.20)  LDD1698  [8]
 LDCM0468  Fragment33 PaTu 8988t C250(0.99); C251(0.99)  LDD1347  [2]
 LDCM0427  Fragment51 HEK-293T C157(1.13); C134(0.91)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C251(2.56)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C251(2.51)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C251(1.46)  LDD0082  [2]
 LDCM0109  NEM HeLa N.A.  LDD0224  [1]
 LDCM0628  OTUB2-COV-1 HEK-293T C251(0.47)  LDD2207  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein mago nashi homolog (MAGOH) Mago nashi family P61326
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-17A (IL17A) IL-17 family Q16552
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.