Details of the Target

General Information of Target

Target ID LDTP10996
Target Name HAUS augmin-like complex subunit 7 (HAUS7)
Gene Name HAUS7
Gene ID 55559
Synonyms
UCHL5IP; UIP1; HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAPDEDREPESARMQRAQMA
ALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASD
EDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPP
QAFRGDGVPRVLGGQERPGPGPAHPGGAAHVAPQLQPPDHGDWTYEEQFKQLYELDGDPK
RKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKG
LNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFA
YSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGH
PVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESAEPPEKKMALVADEQQRLMQRALQQ
NFLAMAAQLPMSIRINSQASESRQDSAVNLTGTNGSNSISMSVEINGIMYTGVLFAQPPA
PTPTSAPNKGGGGGGGSSSNAGGRGGNTGTSGGQAGPAGLSTPSTSTSNNSLP
Target Bioclass
Other
Family
HAUS7 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Uniprot ID
Q99871
Ensemble ID
ENST00000370211.10
HGNC ID
HGNC:32979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HKGZCC SNV: p.Q4L .
MOLT4 SNV: p.S197N IA-alkyne    Probe Info 
OE33 SNV: p.V314L .
RH30 SNV: p.A319S .
SNU1 SNV: p.P293Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.49  LDD0402  [1]
Probe 1
 Probe Info  		Y15(6.22)  LDD3495  [2]
BTD
 Probe Info  		C132(1.34)  LDD2107  [3]
DBIA
 Probe Info  		C119(4.67)  LDD0209  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C40(0.00); C73(0.00); C109(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C73(0.00); C109(0.00); C40(0.00); C59(0.00)  LDD0165  [6]
Lodoacetamide azide
 Probe Info  		C73(0.00); C59(0.00); C40(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C132(1.57); C130(1.40)  LDD2117  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C192(2.42)  LDD0372  [11]
 LDCM0214  AC1 HEK-293T C69(1.06); C119(1.05); C50(1.06); C348(1.11)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C69(1.59); C119(0.99); C50(1.06); C348(1.07)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C119(1.02); C50(1.01); C348(0.99); C83(0.94)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C69(1.31); C119(1.04); C50(1.06); C348(1.16)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C119(0.88); C348(1.03); C83(0.92)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C69(1.23); C119(0.98); C50(1.12); C348(1.05)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C69(0.97); C119(1.03); C50(1.09); C348(0.98)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C69(1.02); C119(0.93); C50(1.01); C348(1.17)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C119(1.01); C50(1.03); C348(1.16); C83(0.97)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C69(1.27); C119(0.99); C50(1.08); C348(1.07)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C69(1.38); C119(0.99); C50(1.15); C348(1.13)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C69(0.85); C119(1.03); C50(1.04); C348(0.95)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C119(0.90); C348(1.30); C83(1.07)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C69(1.00); C119(0.88); C50(1.04); C348(1.27)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C69(1.12); C119(1.10); C50(1.01); C348(1.02)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C69(0.92); C119(1.12); C50(1.10); C348(1.03)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C69(1.01); C119(1.08); C50(1.17); C348(0.99)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C119(0.97); C50(1.06); C348(1.23); C83(0.93)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C69(1.25); C119(1.09); C50(1.16); C348(1.06)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C69(0.95); C119(0.95); C50(1.01); C348(0.98)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C119(0.95); C50(1.02); C348(1.11); C83(1.04)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C119(0.84); C348(1.16); C83(1.00)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C69(0.86); C119(1.02); C50(0.99); C348(1.12)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C69(1.06); C119(1.00); C50(1.05); C348(1.01)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C69(1.16); C119(1.14); C50(1.09); C348(1.09)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C69(1.10); C119(1.10); C50(1.06); C348(1.04)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C119(1.02); C50(1.12); C348(1.21); C83(1.08)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C69(1.31); C119(1.06); C50(1.08); C348(1.10)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C69(1.15); C119(0.99); C50(1.07); C348(0.99)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C119(0.87); C348(1.04); C83(1.14)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C69(1.58); C119(1.08); C50(0.99); C348(1.17)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C69(1.29); C119(0.99); C50(1.01); C348(0.97)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C69(1.16); C119(1.06); C50(1.06); C348(1.09)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C69(0.94); C119(1.04); C50(1.12); C348(1.16)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C69(1.20); C119(1.03); C50(1.12); C348(1.13)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C119(1.14); C50(1.12); C348(1.10); C83(1.01)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C69(1.20); C119(1.04); C50(1.11); C348(1.12)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C69(1.06); C119(1.15); C50(1.05); C348(1.01)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C119(0.77); C348(1.18); C83(1.06)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C69(1.15); C119(0.92); C50(1.32); C348(1.04)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C69(1.04); C119(0.96); C50(1.01); C348(1.05)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C69(1.01); C119(1.08); C50(1.08); C348(1.14)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C69(1.05); C119(1.02); C50(1.02); C348(1.04)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C69(0.95); C119(1.03); C50(1.05); C348(1.08)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C119(1.09); C50(1.07); C348(1.04); C83(1.04)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C69(1.13); C119(0.96); C50(1.11); C348(1.07)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C69(0.98); C119(1.01); C50(1.03); C348(1.10)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C119(0.92); C348(1.22); C83(0.92)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C69(1.12); C119(0.90); C50(1.02); C348(1.15)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C69(1.15); C119(1.22); C50(1.04); C348(1.09)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C69(0.97); C119(1.07); C50(1.12); C348(1.10)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C69(1.13); C119(1.04); C50(1.10); C348(1.35)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C119(1.09); C50(1.15); C348(1.08); C83(1.04)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C119(0.69); C348(1.12); C83(0.95)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C69(1.28); C119(1.00); C50(1.11); C348(1.12)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C69(1.09); C119(0.99); C50(1.09); C348(1.15)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C119(0.90); C348(1.25); C83(0.99)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C69(1.46); C119(0.96); C50(1.05); C348(1.15)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C69(0.87); C119(1.12); C50(1.12); C348(1.06)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C69(0.96); C119(0.95); C50(1.00); C348(1.10)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C69(0.94); C119(1.01); C50(0.96); C348(0.94)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C69(0.82); C119(0.98); C50(1.06); C348(1.09)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C69(1.08); C119(1.12); C50(1.05); C348(1.15)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C69(1.09); C119(1.03); C50(1.04); C348(1.07)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 11.76  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C8(20.00)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C69(1.07); C119(0.96); C50(1.15); C348(1.30)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C119(0.60); C348(1.27); C83(0.83)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C69(0.93); C119(1.09); C50(1.46); C348(1.02)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C69(0.93); C119(0.99); C50(1.26); C348(1.16)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C119(1.04); C50(1.56); C348(1.08); C83(0.59)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C69(0.98); C119(1.02); C50(1.05); C348(1.15)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C69(0.99); C119(0.97); C50(1.14); C348(1.02)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C69(1.06); C119(1.05); C50(1.50); C348(1.16)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C119(1.00); C50(1.55); C348(1.15); C83(0.89)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C69(1.00); C119(1.03); C50(1.03); C348(1.11)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C69(0.94); C119(0.94); C50(1.14); C348(1.08)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C69(0.86); C119(0.94); C50(1.74); C348(1.27)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C69(0.90); C119(1.04); C50(1.04); C348(1.04)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C119(0.97); C50(1.75); C348(1.09); C83(0.85)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C69(0.91); C119(0.90); C50(1.41); C348(1.22)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C69(0.96); C119(0.96); C50(1.09); C348(1.11)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C69(1.03); C119(1.06); C50(1.16); C348(1.21)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C119(1.11); C50(1.50); C348(1.25); C83(0.73)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C69(0.90); C119(0.93); C50(1.08); C348(1.17)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C69(0.97); C119(0.95); C50(1.07); C348(1.12)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C69(1.11); C119(1.01); C50(1.13); C348(1.18)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C119(1.04); C50(0.98); C348(1.11); C83(0.88)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C69(0.94); C119(1.03); C50(1.00); C348(1.13)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C69(1.14); C119(1.26); C50(1.29); C348(1.06)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C69(0.92); C119(0.94); C50(1.14); C348(1.08)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C69(1.07); C119(1.06); C50(1.37); C348(1.33)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C119(1.09); C50(1.19); C348(0.98); C83(0.87)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C69(0.92); C119(0.69); C50(0.59); C348(1.19)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C69(0.95); C119(1.00); C50(1.35); C348(1.01)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C69(1.15); C119(1.09); C50(1.16); C348(1.37)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C119(1.04); C50(1.08); C348(1.20); C83(0.81)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C69(1.17); C119(1.05); C50(1.06); C348(1.25)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C69(1.03); C119(0.98); C50(1.18); C348(1.11)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C69(1.08); C119(0.97); C50(1.01); C348(1.25)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C119(1.06); C50(1.05); C348(1.20); C83(1.11)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C69(1.02); C119(0.86); C50(1.39); C348(1.26)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C69(1.03); C119(1.01); C50(1.18); C348(1.15)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C69(0.91); C119(0.94); C50(1.48); C348(1.24)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C69(1.18); C119(1.04); C50(1.08); C348(1.17)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C119(0.93); C50(1.14); C348(1.15); C83(0.87)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C119(0.96); C50(0.97); C348(1.05); C83(1.02)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C69(1.35); C119(1.02); C50(1.06); C348(1.19)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C69(1.03); C119(0.84); C50(1.39); C348(1.27)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C119(0.96); C348(1.08); C83(1.07)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C69(1.24); C119(0.97); C50(1.02); C348(1.13)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C69(1.63); C119(1.03); C50(1.01); C348(1.03)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C69(1.01); C119(1.02); C50(1.40); C348(1.27)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C119(1.05); C50(1.03); C348(1.01); C83(0.75)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C69(0.90); C119(1.05); C50(1.01); C348(0.99)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C69(1.18); C119(0.89); C50(1.08); C348(1.01)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C69(1.04); C119(1.06); C50(1.11); C348(1.14)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C69(0.98); C119(0.87); C50(1.17); C348(1.08)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C69(1.31); C119(0.96); C50(1.00); C348(1.10)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C119(0.98); C50(1.07); C348(0.99); C83(0.89)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C69(1.16); C119(0.96); C50(1.14); C348(1.08)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C69(0.77); C119(0.67); C50(1.15); C348(1.20)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C119(0.82); C348(1.06); C83(0.95)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C69(1.19); C119(1.26); C50(0.90); C348(1.11)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C69(1.28); C119(1.05); C50(1.20); C348(1.18)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C69(0.93); C119(1.11); C50(1.56); C348(1.30)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C69(0.82); C119(0.81); C50(1.16); C348(1.07)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C69(0.95); C119(0.97); C50(1.15); C348(1.07)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C69(0.85); C119(1.03); C50(1.21); C348(1.09)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C69(1.09); C119(1.02); C50(1.73); C348(1.14)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C69(1.11); C119(1.09); C50(1.11); C348(1.15)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C119(1.28); C50(1.11); C348(1.13); C83(0.88)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C69(1.21); C119(1.03); C50(1.11); C348(1.12)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C69(0.91); C119(0.79); C50(1.29); C348(1.22)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C119(1.10); C348(1.14); C83(1.19)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C69(1.00); C119(1.07); C50(1.03); C348(1.19)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C69(0.94); C119(1.08); C50(1.14); C348(1.13)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C69(1.06); C119(1.12); C50(1.18); C348(1.16)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C69(1.07); C119(1.08); C50(1.07); C348(1.15)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C119(1.07); C50(1.48); C348(1.09); C83(0.96)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C69(0.98); C119(0.98); C50(1.01); C348(1.01)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C69(0.91); C119(1.09); C50(1.72); C348(1.29)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C69(0.75); C119(0.91); C50(1.65); C348(1.08)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C119(1.10); C50(1.04); C348(1.17); C83(0.93)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C69(1.51); C119(0.99); C50(1.07); C348(1.03)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C69(0.96); C119(0.86); C50(1.48); C348(1.13)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C119(1.05); C348(1.15); C83(1.08)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C69(1.28); C119(0.81); C50(0.98); C348(1.14)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C69(0.97); C119(0.91); C50(1.66); C348(1.21)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C69(1.38); C119(1.07); C50(1.20); C348(1.11)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C69(1.18); C119(0.94); C50(1.20); C348(1.26)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C119(1.04); C50(1.03); C348(1.04); C83(0.82)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C69(1.05); C119(0.90); C50(1.03); C348(1.10)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C69(1.01); C119(0.91); C50(1.52); C348(1.14)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C69(1.09); C119(1.00); C50(1.04); C348(1.13)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C69(0.93); C119(1.00); C50(1.23); C348(1.07)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C119(0.97); C50(1.23); C348(1.11); C83(0.94)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C69(1.20); C119(1.04); C50(1.15); C348(1.11)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C69(0.87); C119(0.91); C50(1.42); C348(1.20)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C119(1.06); C50(1.21); C348(1.14); C83(0.88)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C119(0.92); C348(1.14); C83(1.05)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C69(1.13); C119(1.08); C50(1.10); C348(1.14)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C69(1.16); C119(1.11); C50(1.08); C348(1.07)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C69(1.01); C119(1.00); C50(1.47); C348(1.33)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C119(1.07); C50(1.01); C348(1.07); C83(0.94)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C69(0.89); C119(1.09); C50(1.02); C348(1.09)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C69(0.87); C119(1.02); C50(1.58); C348(1.25)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C69(1.05); C119(1.03); C50(1.04); C348(1.05)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C119(1.11); C50(1.05); C348(1.04); C83(0.91)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C69(0.98); C119(0.71); C50(2.01); C348(1.40)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C69(1.23); C119(1.01); C50(0.96); C348(0.99)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C69(1.04); C119(0.98); C50(1.14); C348(0.99)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C119(0.71); C348(1.07); C83(1.01)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C69(1.12); C119(0.88); C50(1.05); C348(1.06)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C69(0.93); C119(0.97); C50(1.60); C348(1.02)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C69(1.01); C119(1.23); C50(1.15); C348(1.17)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C119(1.09); C50(1.07); C348(1.19); C83(0.87)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C69(0.95); C119(0.93); C50(1.06); C348(1.23)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C69(1.01); C119(1.13); C50(1.08); C348(1.12)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C69(0.99); C119(1.06); C50(1.06); C348(1.05)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C69(1.19); C119(1.02); C50(1.10); C348(0.99)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C69(0.73); C119(0.65); C50(1.40); C348(1.76)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C119(1.23); C50(1.04); C348(1.05); C83(0.94)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C69(1.11); C119(0.85); C50(1.30); C348(1.15)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C69(0.90); C119(0.92); C50(1.68); C348(1.13)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C119(0.97); C348(1.11); C83(1.06)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C69(0.96); C119(0.76); C50(1.25); C348(1.20)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C69(1.04); C119(0.79); C50(1.67); C348(1.21)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C69(0.99); C119(0.92); C50(2.13); C348(1.16)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C119(1.10); C50(1.18); C348(1.01); C83(0.78)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C69(0.94); C119(0.97); C50(1.05); C348(1.10)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C69(0.95); C119(0.90); C50(1.21); C348(1.12)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C130(0.08)  LDD1702  [3]
 LDCM0576  Fragment14 Ramos C40(0.86)  LDD2193  [13]
 LDCM0580  Fragment21 Ramos C40(0.35)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C40(0.52)  LDD2196  [13]
 LDCM0586  Fragment28 Ramos C40(0.41)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C40(0.77)  LDD2199  [13]
 LDCM0468  Fragment33 HEK-293T C69(1.05); C119(1.02); C50(1.11); C348(1.18)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C40(0.74)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C40(1.33)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C119(1.12); C50(1.08); C348(1.04); C83(0.81)  LDD1631  [12]
 LDCM0022  KB02 T cell C130(7.53); C132(0.00)  LDD1703  [14]
 LDCM0023  KB03 Jurkat C119(4.67)  LDD0209  [4]
 LDCM0024  KB05 NALM-6 C50(1.30)  LDD3339  [15]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C132(1.34)  LDD2107  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C130(0.86)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C132(1.46); C130(1.70)  LDD2127  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C338(1.59)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
HAUS augmin-like complex subunit 6 (HAUS6) HAUS6 family Q7Z4H7
Peripherin (PRPH) Intermediate filament family P41219
Developmental pluripotency-associated protein 3 (DPPA3) . Q6W0C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.