Details of the Target

General Information of Target

Target ID LDTP10882
Target Name Eyes absent homolog 3 (EYA3)
Gene Name EYA3
Gene ID 2140
Synonyms
Eyes absent homolog 3; EC 3.1.3.48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEMQDLTSPHSRLSGSSESPSGPKLGNSHINSNSMTPNGTEVKTEPMSSSETASTTADGS
LNNFSGSAIGSSSFSPRPTHQFSPPQIYPSNRPYPHILPTPSSQTMAAYGQTQFTTGMQQ
ATAYATYPQPGQPYGISSYGALWAGIKTEGGLSQSQSPGQTGFLSYGTSFSTPQPGQAPY
SYQMQGSSFTTSSGIYTGNNSLTNSSGFNSSQQDYPSYPSFGQGQYAQYYNSSPYPAHYM
TSSNTSPTTPSTNATYQLQEPPSGITSQAVTDPTAEYSTIHSPSTPIKDSDSDRLRRGSD
GKSRGRGRRNNNPSPPPDSDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGL
RMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSANLCL
ATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLT
LALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFER
IIQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRISSHSDLMALHHALELEYL
Target Bioclass
Enzyme
Family
HAD-like hydrolase superfamily, EYA family
Subcellular location
Cytoplasm
Function
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye.
Uniprot ID
Q99504
Ensemble ID
ENST00000373863.3
HGNC ID
HGNC:3521
ChEMBL ID
CHEMBL4296245

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.S41Ter .
BXPC3 SNV: p.V454I .
HT115 SNV: p.D299Y .
KPL1 SNV: p.V366L .
MCF7 SNV: p.V366L .
MOLT4 SNV: p.R253K .
NCIH2172 SNV: p.S20Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C476(1.09)  LDD0593  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
AOyne
 Probe Info  		14.60  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C476(0.95)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C476(0.63)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C476(0.63)  LDD0824  [2]
 LDCM0237  AC12 HEK-293T C476(0.71)  LDD0835  [2]
 LDCM0246  AC128 HEK-293T C476(1.01)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C476(1.28)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C476(1.04)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C476(0.94)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C476(1.01)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C476(1.35)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C476(1.09)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C476(1.11)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C476(1.37)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C476(1.51)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C476(1.69)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C476(1.44)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C476(0.84)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C476(1.23)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C476(1.63)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C476(1.38)  LDD0860  [2]
 LDCM0270  AC15 HEK-293T C476(0.71)  LDD0868  [2]
 LDCM0276  AC17 HCT 116 C476(1.09)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C476(0.66)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C476(1.19)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C476(0.99)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C476(0.89)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C476(0.72)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C476(0.97)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C476(0.86)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C476(1.30)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C476(0.79)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C476(0.82)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C476(0.92)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C476(0.75)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C476(0.81)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C476(0.97)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C476(0.85)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C476(0.79)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C476(0.85)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C476(0.83)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C476(0.80)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C476(0.77)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C476(0.63)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C476(0.74)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C476(0.87)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C476(0.66)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C476(0.99)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C476(0.71)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C476(0.64)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C476(0.88)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C476(0.73)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C476(0.77)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C476(0.91)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C476(1.20)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C476(1.17)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C476(0.98)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C476(1.34)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C476(1.03)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C476(1.29)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C476(1.08)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C476(1.00)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C476(1.34)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C476(1.13)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C476(1.48)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C476(1.78)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C56(0.88); C476(0.91)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C476(1.12)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C476(1.08)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C476(0.76)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C56(1.04); C476(1.03)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C476(0.98)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C56(0.78); C476(1.03)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C476(1.11)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C476(0.95)  LDD1567  [6]
 LDCM0332  AC68 HEK-293T C476(0.98)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C476(0.88)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C476(0.68)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C476(0.87)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C476(1.02)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C476(1.09)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C476(0.98)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C476(0.99)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C476(1.03)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C476(0.93)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C476(0.90)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C476(0.99)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C476(0.99)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C476(0.67)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C476(0.95)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C476(0.87)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C476(1.04)  LDD0946  [2]
 LDCM0248  AKOS034007472 HEK-293T C476(0.72)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C476(0.96)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C476(0.74)  LDD0873  [2]
 LDCM0156  Aniline NCI-H1299 12.22  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C476(1.14)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C476(1.34)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C476(1.01)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C476(0.84)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C476(0.78)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C476(0.82)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C476(0.75)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C476(0.76)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C476(0.74)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C476(0.78)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C476(0.94)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C476(0.83)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C476(1.46)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C476(0.65)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C476(0.85)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C476(0.79)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C476(0.86)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C476(0.83)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C476(0.79)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C476(0.87)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C476(1.28)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C476(0.73)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C476(0.84)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C476(1.55)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C476(0.81)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C476(1.11)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C476(1.07)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C476(1.53)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C476(1.46)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C56(0.97); C476(1.03)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C476(1.00)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C476(1.12)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C476(0.98)  LDD1603  [6]
 LDCM0400  CL13 HCT 116 C476(1.27)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C476(1.14)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C476(1.36)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C476(1.22)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C56(0.92); C476(1.06)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C476(1.21)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C476(1.06)  LDD1610  [6]
 LDCM0407  CL2 HCT 116 C476(1.21)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C56(1.23); C476(1.18)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C476(1.05)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C56(1.48); C476(1.19)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C476(1.14)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C476(1.23)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C56(1.15); C476(1.23)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C476(1.17)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C476(1.19)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C476(1.14)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C56(0.97); C476(1.11)  LDD1621  [6]
 LDCM0418  CL3 HCT 116 C476(1.06)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C476(1.16)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C476(1.04)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C476(1.03)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C476(0.76)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C476(0.96)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C476(1.01)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C476(0.82)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C476(0.79)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C476(1.05)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C476(1.12)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C476(1.00)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C476(0.81)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C476(1.04)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C476(1.06)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C476(0.92)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C476(0.95)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C476(1.04)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C476(0.95)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C476(1.20)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C476(0.97)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C476(1.18)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C476(1.22)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C476(0.96)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C476(1.08)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C476(1.09)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C476(1.04)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C476(0.99)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C476(1.15)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C476(0.94)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C476(1.00)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C476(1.21)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C476(1.15)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C476(1.13)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C476(0.68)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C476(0.86)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C476(0.91)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C476(0.84)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C476(0.90)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C476(0.88)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C476(0.85)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C476(0.81)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C476(0.86)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C476(1.29)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C476(0.82)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C476(0.77)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C476(0.86)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C476(0.80)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C476(1.09)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C476(1.11)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C56(0.90); C476(1.07)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C476(1.15)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C476(1.11)  LDD1675  [6]
 LDCM0473  CL8 HCT 116 C476(1.15)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C56(0.96); C476(1.25)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C476(1.15)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C56(1.34); C476(1.06)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C476(1.12)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C476(1.20)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C56(1.10); C476(1.23)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C476(1.20)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C476(1.21)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C476(1.08)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C56(0.97); C476(1.08)  LDD1686  [6]
 LDCM0484  CL9 HCT 116 C476(1.23)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C476(0.97)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C476(1.06)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C476(1.03)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C476(0.96)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C476(0.99)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C476(1.15)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C476(1.12)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C476(0.91)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C476(0.88)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C476(1.00)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C476(1.26)  LDD1698  [6]
 LDCM0625  F8 Ramos C518(0.70)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C518(0.81)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C518(0.28); C476(0.21)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C518(0.77)  LDD2191  [7]
 LDCM0575  Fragment13 Ramos C518(0.90)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C518(0.95); C476(0.80)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C518(1.49)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C518(0.81)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C518(0.67)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C518(0.85)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C518(0.63); C476(2.94)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C518(0.88)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C518(0.90)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C518(0.75)  LDD2201  [7]
 LDCM0468  Fragment33 HEK-293T C476(1.00)  LDD1066  [2]
 LDCM0596  Fragment38 Ramos C518(1.05)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C518(0.72)  LDD2184  [7]
 LDCM0427  Fragment51 HEK-293T C476(0.91)  LDD1025  [2]
 LDCM0610  Fragment52 Ramos C518(0.80)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C518(1.00)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C518(0.62)  LDD2186  [7]
 LDCM0571  Fragment9 Ramos C518(2.40)  LDD2188  [7]
 LDCM0022  KB02 HEK-293T C476(1.04)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C476(0.93)  LDD1497  [6]
 LDCM0024  KB05 NALM-6 C476(2.01)  LDD3339  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) Cation transport ATPase (P-type) (TC 3.A.3) family P13637
60 kDa heat shock protein, mitochondrial (HSPD1) Chaperonin (HSP60) family P10809
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Methyl-CpG-binding protein 2 (MECP2) . P51608
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840