Details of the Target

General Information of Target

Target ID LDTP10842
Target Name Histone-lysine N-methyltransferase SETDB2 (SETDB2)
Gene Name SETDB2
Gene ID 83852
Synonyms
C13orf4; CLLD8; KMT1F; Histone-lysine N-methyltransferase SETDB2; EC 2.1.1.366; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAA
SHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKAL
FSTPAAVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESP
ILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLYTKGSTWK
GKSTQSTEGKTS
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily
Subcellular location
Nucleus
Function
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Uniprot ID
Q96T68
Ensemble ID
ENST00000317257.12
HGNC ID
HGNC:20263

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C655(6.39)  LDD1703  [1]
DBIA
 Probe Info  		C707(1.16); C709(1.16)  LDD0531  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C707(1.16); C709(1.16)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C103(1.76); C111(1.76)  LDD1094  [2]
 LDCM0216  AC100 PaTu 8988t C103(1.01); C111(1.01)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C103(1.03); C111(1.03)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C103(0.96); C111(0.96)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C103(1.06); C111(1.06)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C103(0.82); C111(0.82)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C103(0.98); C111(0.98)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C103(1.12); C111(1.12)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C103(0.88); C111(0.88)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C103(1.07); C111(1.07)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C103(1.48); C111(1.48)  LDD1104  [2]
 LDCM0226  AC11 PaTu 8988t C103(1.44); C111(1.44)  LDD1105  [2]
 LDCM0227  AC110 PaTu 8988t C103(1.36); C111(1.36)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C103(1.03); C111(1.03)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C103(1.15); C111(1.15)  LDD1108  [2]
 LDCM0230  AC113 HCT 116 C707(1.06); C709(1.06)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C707(0.96); C709(1.40)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C707(0.87); C709(1.20)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C707(1.12); C709(1.11)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C707(0.95); C709(1.08)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C707(1.00); C709(1.10)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C707(1.00); C709(1.17)  LDD0553  [2]
 LDCM0237  AC12 PaTu 8988t C103(1.39); C111(1.39)  LDD1116  [2]
 LDCM0238  AC120 HCT 116 C707(1.09); C709(1.25)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C707(1.14); C709(0.93)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C707(0.93); C709(1.23)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C707(1.00); C709(1.06)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C707(0.85); C709(1.24)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C707(0.92); C709(1.35)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C707(1.11); C709(1.31)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C707(1.06); C709(1.20)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C707(0.97); C709(0.97)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C707(1.07); C709(1.07)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C707(1.31); C709(1.31)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C707(1.05); C709(1.05)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C707(1.44); C709(1.44)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C707(1.45); C709(1.45)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C707(1.35); C709(1.35)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C707(1.36); C709(1.36)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C707(1.16); C709(1.16)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C707(1.41); C709(1.41)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C707(1.24); C709(1.24)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C707(1.52); C709(1.52)  LDD0575  [2]
 LDCM0259  AC14 PaTu 8988t C103(1.56); C111(1.56)  LDD1138  [2]
 LDCM0260  AC140 HCT 116 C707(1.72); C709(1.72)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C707(1.35); C709(1.35)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C707(1.37); C709(1.37)  LDD0579  [2]
 LDCM0270  AC15 PaTu 8988t C103(1.52); C111(1.52)  LDD1149  [2]
 LDCM0279  AC2 HCT 116 C707(1.06); C709(1.06)  LDD0596  [2]
 LDCM0285  AC25 HEK-293T C707(0.71); C709(0.71)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C707(0.75); C709(0.75)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C707(0.64); C709(0.64)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C707(0.64); C709(0.64)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C707(0.68); C709(0.68)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C707(1.12); C709(1.12)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C707(0.64); C709(0.64)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C707(0.70); C709(0.70)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C707(0.80); C709(0.80)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C707(0.71); C709(0.71)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C707(0.75); C709(0.75)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C707(0.99); C709(0.99)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C707(1.12); C709(1.12)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C707(0.86); C709(0.86)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C707(1.01); C709(1.01)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C707(1.08); C709(1.08)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C707(1.20); C709(1.20)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C707(0.88); C709(0.88)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C707(1.10); C709(1.10)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C707(1.21); C709(1.21)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C707(1.28); C709(1.28)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C707(0.84); C709(0.84)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C707(0.73); C709(0.73)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C707(0.95); C709(0.95)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C707(1.15); C709(1.15)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C707(0.95); C709(0.95)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C707(1.16); C709(1.16)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C707(1.14); C709(1.14)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C707(1.09); C709(1.09)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C707(1.00); C709(1.00)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C707(1.09); C709(1.09)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C707(1.12); C709(1.12)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C707(1.12); C709(1.12)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C707(1.17); C709(1.17)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C707(0.98); C709(0.98)  LDD0917  [2]
 LDCM0323  AC6 PaTu 8988t C103(1.61); C111(1.61)  LDD1202  [2]
 LDCM0332  AC68 HCT 116 C707(0.83); C709(0.83)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C707(0.98); C709(0.98)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C103(0.91); C111(0.91)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C707(1.65); C709(1.65)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C707(0.81); C709(0.81)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C707(0.94); C709(0.94)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C707(1.14); C709(1.14)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C707(1.18); C709(1.18)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C707(1.12); C709(1.12)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C707(0.98); C709(0.98)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C707(1.03); C709(1.03)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C707(0.89); C709(0.89)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C707(0.96); C709(0.96)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C103(1.11); C111(1.11)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C707(1.02); C709(1.02)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C707(0.96); C709(0.96)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C707(1.39); C709(1.39)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C707(1.98); C709(1.98)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C707(1.47); C709(1.47)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C707(1.93); C709(1.93)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C707(2.23); C709(2.23)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C707(1.56); C709(1.56)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C707(1.86); C709(1.86)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C707(2.26); C709(2.26)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C707(2.85); C709(2.85)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C707(1.71); C709(1.71)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C707(2.16); C709(2.16)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C707(1.12); C709(1.12)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C707(1.05); C709(1.05)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C707(1.76); C709(1.76)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C707(1.16); C709(1.16)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C707(2.38); C709(2.38)  LDD0681  [2]
 LDCM0365  AC98 PaTu 8988t C103(1.18); C111(1.18)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C103(0.89); C111(0.89)  LDD1245  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C103(1.45); C111(1.45)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C103(1.37); C111(1.37)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C103(1.43); C111(1.43)  LDD1154  [2]
 LDCM0369  CL100 HCT 116 C707(1.21); C709(1.21)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C103(1.22); C111(1.22)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C103(1.30); C111(1.30)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C103(1.84); C111(1.84)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C103(1.46); C111(1.46)  LDD1252  [2]
 LDCM0382  CL112 HEK-293T C707(0.85); C709(0.85)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C707(0.74); C709(0.74)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C707(0.80); C709(0.80)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C707(0.71); C709(0.71)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C707(0.69); C709(0.69)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C707(1.07); C709(1.07)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C707(1.09); C709(1.09)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C707(1.06); C709(1.06)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C707(1.09); C709(1.09)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C707(0.95); C709(0.95)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C707(0.97); C709(0.97)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C707(1.14); C709(1.14)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C707(1.06); C709(1.06)  LDD0993  [2]
 LDCM0436  CL46 HCT 116 C707(0.87); C709(0.87)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C707(0.88); C709(0.88)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C707(0.80); C709(0.80)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C707(0.86); C709(0.86)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C707(0.90); C709(0.90)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C707(0.79); C709(0.79)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C707(0.86); C709(0.86)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C707(0.83); C709(0.83)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C707(0.72); C709(0.72)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C707(0.73); C709(0.73)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C707(0.79); C709(0.79)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C707(0.78); C709(0.78)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C707(0.83); C709(0.83)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C707(0.94); C709(0.94)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C707(0.83); C709(0.83)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C707(0.96); C709(0.96)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C707(0.88); C709(0.88)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C707(1.03); C709(1.03)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C707(1.15); C709(1.15)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C707(1.02); C709(1.02)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C707(1.28); C709(1.28)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C707(1.23); C709(1.23)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C707(1.05); C709(1.05)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C707(0.92); C709(0.92)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C707(1.00); C709(1.00)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C707(1.14); C709(1.14)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C707(1.06); C709(1.06)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C707(1.09); C709(1.09)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C707(1.08); C709(1.08)  LDD0784  [2]
 LDCM0486  CL91 HCT 116 C707(0.96); C709(0.96)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C707(1.01); C709(1.01)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C707(1.12); C709(1.12)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C707(0.93); C709(0.93)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C707(0.99); C709(0.99)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C707(1.03); C709(1.03)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C707(1.43); C709(1.43)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C707(1.13); C709(1.13)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C707(1.01); C709(1.01)  LDD0811  [2]
 LDCM0625  F8 Ramos C574(2.45)  LDD2187  [4]
 LDCM0573  Fragment11 Ramos C574(20.00)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C574(0.51)  LDD2191  [4]
 LDCM0576  Fragment14 Ramos C574(1.29)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C574(0.63)  LDD2194  [4]
 LDCM0582  Fragment23 Ramos C574(0.51)  LDD2196  [4]
 LDCM0586  Fragment28 Ramos C574(1.22)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C574(0.79)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C574(0.59)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C574(0.81)  LDD2201  [4]
 LDCM0468  Fragment33 HCT 116 C707(1.07); C709(1.07)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C574(0.92)  LDD2203  [4]
 LDCM0610  Fragment52 Ramos C574(1.71)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C574(0.66)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C574(3.28)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C574(0.60)  LDD2188  [4]
 LDCM0022  KB02 T cell C655(6.39)  LDD1703  [1]
 LDCM0023  KB03 Ramos C574(2.15)  LDD2183  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ARL14 effector protein (ARL14EP) . Q8N8R7

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578