Details of the Target

General Information of Target

Target ID LDTP10782
Target Name Erbin (ERBIN)
Gene Name ERBIN
Gene ID 55914
Synonyms
ERBB2IP; KIAA1225; LAP2; Erbin; Densin-180-like protein; Erbb2-interacting protein; Protein LAP2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVAANCSLRVKRPLLDPRFEGYKLSLEPLPCYQLELDAAVAEVKLRDDQYTLEHMHAFG
MYNYLHCDSWYQDSVYYIDTLGRIMNLTVMLDTALGKPREVFRLPTDLTACDNRLCASIH
FSSSTWVTLSDGTGRLYVIGTGERGNSASEKWEIMFNEELGDPFIIIHSISLLNAEEHSI
ATLLLRIEKEELDMKGSGFYVSLEWVTISKKNQDNKKYEIIKRDILRGKSVPHYAAIEPD
GNGLMIVSYKSLTFVQAGQDLEENMDEDISEKIKEPLYYWQQTEDDLTVTIRLPEDSTKE
DIQIQFLPDHINIVLKDHQFLEGKLYSSIDHESSTWIIKESNSLEISLIKKNEGLTWPEL
VIGDKQGELIRDSAQCAAIAERLMHLTSEELNPNPDKEKPPCNAQELEECDIFFEESSSL
CRFDGNTLKTTHVVNLGSNQYLFSVIVDPKEMPCFCLRHDVDALLWQPHSSKQDDMWEHI
ATFNALGYVQASKRDKKFFACAPNYSYAALCECLRRVFIYRQPAPMSTVLYNRKEGRQVG
QVAKQQVASLETNDPILGFQATNERLFVLTTKNLFLIKVNTEN
Target Bioclass
Other
Family
LAP (LRR and PDZ) protein family
Subcellular location
Cell junction, hemidesmosome
Function
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion.
Uniprot ID
Q96RT1
Ensemble ID
ENST00000284037.10
HGNC ID
HGNC:15842

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.N113IfsTer5
SNV: p.V748A		 .
COLO678 SNV: p.M1251I .
L428 SNV: p.A1003G .
MCC13 SNV: p.T141I; p.G891E .
MEWO SNV: p.P108L DBIA    Probe Info 
NCIH446 SNV: p.Y977F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K162(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		K1319(5.00)  LDD0275  [2]
Probe 1
 Probe Info  		Y733(16.03); Y1021(19.12)  LDD3495  [3]
DBIA
 Probe Info  		C1316(2.25)  LDD3314  [4]
BTD
 Probe Info  		C68(1.08)  LDD2099  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		C464(0.00); C1309(0.00)  LDD2224  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		C1309(0.00); C464(0.00)  LDD0147  [8]
Phosphinate-6
 Probe Info  		C14(0.00); C464(0.00); C1309(0.00)  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		43.71  LDD1884  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C464(1.15)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1309(1.18); C464(0.95)  LDD2117  [5]
 LDCM0215  AC10 HEK-293T C464(1.08)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C464(1.17); C68(1.24)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C464(1.11)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C464(1.11)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C464(1.05)  LDD1513  [13]
 LDCM0277  AC18 HEK-293T C464(1.01)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C464(1.28); C68(1.04)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C464(0.99)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C464(1.03)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C1309(1.05)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C464(1.13)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C464(1.06)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C1309(0.85)  LDD1523  [13]
 LDCM0286  AC26 HEK-293T C464(0.94)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C464(1.02); C68(1.04)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C464(0.95)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C1309(0.91)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C464(0.99); C68(1.16)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C464(1.10)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C464(1.10)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C1309(0.97)  LDD1532  [13]
 LDCM0295  AC34 HEK-293T C464(1.25)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C464(1.13); C68(1.13)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C464(1.12)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C1309(1.11)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C464(1.15)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C464(0.94)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C464(1.12)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C1309(1.02)  LDD1541  [13]
 LDCM0304  AC42 HEK-293T C464(1.11)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C464(1.15); C68(1.16)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C464(1.23)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C1309(1.07)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C464(1.14)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C464(1.09)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C1309(1.12)  LDD1549  [13]
 LDCM0312  AC5 HEK-293T C1309(1.08)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C464(1.15)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C464(0.98); C68(1.10)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C464(1.23)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C1309(1.08)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C464(1.13)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C464(1.01)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C1309(1.04)  LDD1558  [13]
 LDCM0321  AC58 HEK-293T C464(1.07)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C464(1.05); C68(1.12)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C464(1.03)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C464(1.09)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C1309(1.12)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C464(1.05)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C464(1.06)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C1309(0.93)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C464(1.07)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C1309(1.08)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C1309(1.16)  LDD1511  [13]
 LDCM0275  AKOS034007705 HEK-293T C1309(1.06)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 13.28  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C1309(20.00)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C1309(1.00); C464(1.05)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C464(0.95)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C464(0.99)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C1309(1.07); C464(0.82)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C464(1.02)  LDD1575  [13]
 LDCM0373  CL104 HEK-293T C464(1.01)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C1309(0.93); C464(1.00)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C464(1.13)  LDD1579  [13]
 LDCM0377  CL108 HEK-293T C464(1.09)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C1309(1.01); C464(0.76)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C464(0.85)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C464(1.00)  LDD1584  [13]
 LDCM0382  CL112 HEK-293T C464(0.97)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C1309(0.89); C464(0.94)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C464(1.09)  LDD1588  [13]
 LDCM0386  CL116 HEK-293T C464(1.02)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C1309(1.05); C464(0.95)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C464(1.24)  LDD1592  [13]
 LDCM0390  CL12 HEK-293T C1309(0.81)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C464(1.01)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C1309(0.90); C464(0.96)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C464(1.16)  LDD1597  [13]
 LDCM0395  CL124 HEK-293T C464(1.10)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C1309(1.16); C464(0.86)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C464(1.17)  LDD1601  [13]
 LDCM0399  CL128 HEK-293T C464(0.96)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C1309(0.99); C464(0.82)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C464(1.30)  LDD1605  [13]
 LDCM0403  CL16 HEK-293T C464(1.05)  LDD1607  [13]
 LDCM0405  CL18 HEK-293T C464(1.09)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C464(1.07); C68(1.12)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C464(1.16)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C464(1.00)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C1309(0.99)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C464(1.12)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C464(0.95)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C1309(0.81)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C1309(1.05); C464(0.80)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C464(1.12)  LDD1618  [13]
 LDCM0416  CL28 HEK-293T C464(1.04)  LDD1620  [13]
 LDCM0419  CL30 HEK-293T C464(1.00)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C464(1.05); C68(1.00)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C464(1.15)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C1309(0.90)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C464(1.10)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C464(0.88)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C1309(0.92)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C1309(1.08); C464(1.00)  LDD1630  [13]
 LDCM0429  CL4 HEK-293T C464(1.04)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C464(0.98)  LDD1634  [13]
 LDCM0432  CL42 HEK-293T C464(0.87)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C464(1.00); C68(1.09)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C464(1.08)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C1309(0.90)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C464(1.01)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C464(0.89)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C1309(0.97)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C1309(1.04); C464(1.08)  LDD1643  [13]
 LDCM0441  CL50 HEK-293T C464(1.18)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C464(1.17)  LDD1646  [13]
 LDCM0445  CL54 HEK-293T C464(1.11)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C464(1.09); C68(1.20)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C464(1.13)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C1309(0.96)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C464(1.12)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C464(0.91)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C464(1.07)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C1309(0.92)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C1309(1.14); C464(0.93)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C464(1.06)  LDD1657  [13]
 LDCM0456  CL64 HEK-293T C464(1.01)  LDD1659  [13]
 LDCM0458  CL66 HEK-293T C464(1.10)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C464(1.08); C68(1.07)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C464(1.09)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C1309(1.00)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C464(1.01); C68(1.03)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C464(1.10)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C464(0.98)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C1309(0.88)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C1309(1.05); C464(0.95)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C464(1.15)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C464(1.04)  LDD1672  [13]
 LDCM0471  CL78 HEK-293T C464(1.08)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C464(1.06); C68(1.01)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C464(0.76)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C464(1.07)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C1309(0.85)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C464(1.11)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C464(0.99)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C1309(0.89)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C1309(1.00); C464(0.96)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C464(1.21)  LDD1683  [13]
 LDCM0482  CL88 HEK-293T C464(0.92)  LDD1685  [13]
 LDCM0484  CL9 HEK-293T C1309(0.94)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C464(0.90)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C464(1.02); C68(1.06)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C464(1.07)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C1309(0.93)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C464(1.10)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C464(0.89)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C1309(0.94)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C1309(1.01); C464(0.89)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C464(1.08)  LDD1696  [13]
 LDCM0427  Fragment51 HEK-293T C464(1.09)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C464(1.02)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C464(1.01)  LDD1497  [13]
 LDCM0024  KB05 IGR37 C1316(2.25)  LDD3314  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C68(1.08)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1309(0.72)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1309(0.81)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1309(0.84)  LDD2111  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C68(1.91)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1309(1.15); C464(1.01)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C464(1.26)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1309(0.87); C464(0.79)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1309(1.18)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1309(1.00)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C464(1.50)  LDD2136  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1309(0.72)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1309(1.21)  LDD2146  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Plakophilin-4 (PKP4) Beta-catenin family Q99569
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) . Q9HC29

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402