Details of the Target

General Information of Target

Target ID LDTP10541
Target Name Intraflagellar transport protein 74 homolog (IFT74)
Gene Name IFT74
Gene ID 80173
Synonyms
CCDC2; CMG1; Intraflagellar transport protein 74 homolog; Capillary morphogenesis gene 1 protein; CMG-1; Coiled-coil domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNA
FSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTER
CLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFIT
VAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFL
WIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASE
VDEGGGQLPEEILELSGSRLEQ
Target Bioclass
Transporter and channel
Family
IFT74 family
Subcellular location
Cell projection, cilium
Function
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. Essential for flagellogenesis during spermatogenesis.
Uniprot ID
Q96LB3
Ensemble ID
ENST00000380062.10
HGNC ID
HGNC:21424

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.L458I .
HT115 SNV: p.L545W .
JURKAT SNV: p.K516Ter .
KMCH1 SNV: p.R15T .
MOLT4 SNV: p.T378A; p.S435L IA-alkyne    Probe Info 
NCIH1666 Deletion: p.Q147_G148delinsR .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
DBIA
 Probe Info  		C53(3.14)  LDD3493  [2]
AHL-Pu-1
 Probe Info  		C53(5.11)  LDD0168  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
ENE
 Probe Info  		N.A.  LDD0006  [7]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C53(5.11)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C53(2.02)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C53(1.09)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C53(1.13)  LDD0813  [11]
 LDCM0216  AC100 HEK-293T C53(0.79)  LDD0814  [11]
 LDCM0217  AC101 HEK-293T C53(0.81)  LDD0815  [11]
 LDCM0218  AC102 HEK-293T C53(0.86)  LDD0816  [11]
 LDCM0219  AC103 HEK-293T C53(0.83)  LDD0817  [11]
 LDCM0220  AC104 HEK-293T C53(0.70)  LDD0818  [11]
 LDCM0221  AC105 HEK-293T C53(0.95)  LDD0819  [11]
 LDCM0222  AC106 HEK-293T C53(1.10)  LDD0820  [11]
 LDCM0223  AC107 HEK-293T C53(0.86)  LDD0821  [11]
 LDCM0224  AC108 HEK-293T C53(0.89)  LDD0822  [11]
 LDCM0225  AC109 HEK-293T C53(0.87)  LDD0823  [11]
 LDCM0226  AC11 HEK-293T C53(0.97)  LDD0824  [11]
 LDCM0227  AC110 HEK-293T C53(0.76)  LDD0825  [11]
 LDCM0228  AC111 HEK-293T C53(0.56)  LDD0826  [11]
 LDCM0229  AC112 HEK-293T C53(0.67)  LDD0827  [11]
 LDCM0237  AC12 HEK-293T C53(1.06)  LDD0835  [11]
 LDCM0259  AC14 HEK-293T C53(1.24)  LDD0857  [11]
 LDCM0270  AC15 HEK-293T C53(0.92)  LDD0868  [11]
 LDCM0276  AC17 HEK-293T C53(0.89)  LDD0874  [11]
 LDCM0277  AC18 HEK-293T C53(1.11)  LDD0875  [11]
 LDCM0278  AC19 HEK-293T C53(1.13)  LDD0876  [11]
 LDCM0279  AC2 HEK-293T C53(1.03)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C53(0.90)  LDD0878  [11]
 LDCM0281  AC21 HEK-293T C53(1.12)  LDD0879  [11]
 LDCM0282  AC22 HEK-293T C53(0.89)  LDD0880  [11]
 LDCM0283  AC23 HEK-293T C53(0.90)  LDD0881  [11]
 LDCM0284  AC24 HEK-293T C53(1.08)  LDD0882  [11]
 LDCM0285  AC25 HEK-293T C53(0.90)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C53(0.92)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C53(0.99)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C53(0.97)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C53(0.92)  LDD0887  [11]
 LDCM0290  AC3 HEK-293T C53(0.99)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C53(0.99)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C53(0.86)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C53(1.04)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C53(0.88)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C53(1.06)  LDD0893  [11]
 LDCM0296  AC35 HEK-293T C53(1.04)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C53(0.95)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C53(0.97)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C53(0.96)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C53(1.01)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C53(1.06)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C53(1.09)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C53(1.11)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C53(1.01)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C53(1.04)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C53(1.02)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C53(1.04)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C53(1.00)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C53(1.05)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C53(1.06)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C53(1.10)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C53(1.05)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C53(0.93)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C53(0.96)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C53(1.06)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C53(0.99)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C53(0.96)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C53(1.03)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C53(1.04)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C53(1.19)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C53(0.97)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C53(0.96)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C53(0.99)  LDD0921  [11]
 LDCM0324  AC60 HEK-293T C53(1.06)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C53(0.98)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C53(0.94)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C53(1.05)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C53(0.99)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C53(0.95)  LDD0932  [11]
 LDCM0345  AC8 HEK-293T C53(0.99)  LDD0943  [11]
 LDCM0349  AC83 HEK-293T C53(1.13)  LDD0947  [11]
 LDCM0350  AC84 HEK-293T C53(0.81)  LDD0948  [11]
 LDCM0351  AC85 HEK-293T C53(0.83)  LDD0949  [11]
 LDCM0352  AC86 HEK-293T C53(0.89)  LDD0950  [11]
 LDCM0353  AC87 HEK-293T C53(0.85)  LDD0951  [11]
 LDCM0354  AC88 HEK-293T C53(0.83)  LDD0952  [11]
 LDCM0355  AC89 HEK-293T C53(0.88)  LDD0953  [11]
 LDCM0357  AC90 HEK-293T C53(0.84)  LDD0955  [11]
 LDCM0358  AC91 HEK-293T C53(0.95)  LDD0956  [11]
 LDCM0359  AC92 HEK-293T C53(0.86)  LDD0957  [11]
 LDCM0360  AC93 HEK-293T C53(0.72)  LDD0958  [11]
 LDCM0361  AC94 HEK-293T C53(0.76)  LDD0959  [11]
 LDCM0362  AC95 HEK-293T C53(0.84)  LDD0960  [11]
 LDCM0363  AC96 HEK-293T C53(0.60)  LDD0961  [11]
 LDCM0364  AC97 HEK-293T C53(0.60)  LDD0962  [11]
 LDCM0365  AC98 HEK-293T C53(0.96)  LDD0963  [11]
 LDCM0366  AC99 HEK-293T C53(1.11)  LDD0964  [11]
 LDCM0248  AKOS034007472 HEK-293T C53(1.05)  LDD0846  [11]
 LDCM0356  AKOS034007680 HEK-293T C53(1.18)  LDD0954  [11]
 LDCM0275  AKOS034007705 HEK-293T C53(1.19)  LDD0873  [11]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C53(1.06)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C53(1.19)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C53(0.92)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C53(0.99)  LDD0968  [11]
 LDCM0371  CL102 HEK-293T C53(0.98)  LDD0969  [11]
 LDCM0372  CL103 HEK-293T C53(1.01)  LDD0970  [11]
 LDCM0373  CL104 HEK-293T C53(1.07)  LDD0971  [11]
 LDCM0374  CL105 HEK-293T C53(1.00)  LDD0972  [11]
 LDCM0375  CL106 HEK-293T C53(1.14)  LDD0973  [11]
 LDCM0376  CL107 HEK-293T C53(1.23)  LDD0974  [11]
 LDCM0377  CL108 HEK-293T C53(1.11)  LDD0975  [11]
 LDCM0378  CL109 HEK-293T C53(1.14)  LDD0976  [11]
 LDCM0379  CL11 HEK-293T C53(1.24)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C53(1.04)  LDD0978  [11]
 LDCM0381  CL111 HEK-293T C53(1.06)  LDD0979  [11]
 LDCM0382  CL112 HEK-293T C53(1.04)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C53(0.96)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C53(0.97)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C53(1.11)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C53(1.03)  LDD0984  [11]
 LDCM0387  CL117 HEK-293T C53(0.99)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C53(1.01)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C53(1.05)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C53(1.12)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C53(0.96)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C53(1.01)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C53(0.95)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C53(0.97)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C53(0.93)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C53(0.98)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C53(0.99)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C53(1.02)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C53(0.93)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C53(1.06)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C53(1.10)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C53(1.17)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C53(1.53)  LDD1001  [11]
 LDCM0404  CL17 HEK-293T C53(0.97)  LDD1002  [11]
 LDCM0405  CL18 HEK-293T C53(0.80)  LDD1003  [11]
 LDCM0406  CL19 HEK-293T C53(1.01)  LDD1004  [11]
 LDCM0407  CL2 HEK-293T C53(1.15)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C53(0.87)  LDD1006  [11]
 LDCM0409  CL21 HEK-293T C53(0.77)  LDD1007  [11]
 LDCM0410  CL22 HEK-293T C53(0.79)  LDD1008  [11]
 LDCM0411  CL23 HEK-293T C53(0.97)  LDD1009  [11]
 LDCM0412  CL24 HEK-293T C53(0.98)  LDD1010  [11]
 LDCM0413  CL25 HEK-293T C53(0.77)  LDD1011  [11]
 LDCM0414  CL26 HEK-293T C53(0.96)  LDD1012  [11]
 LDCM0415  CL27 HEK-293T C53(0.86)  LDD1013  [11]
 LDCM0416  CL28 HEK-293T C53(1.02)  LDD1014  [11]
 LDCM0417  CL29 HEK-293T C53(1.05)  LDD1015  [11]
 LDCM0418  CL3 HEK-293T C53(1.18)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C53(0.81)  LDD1017  [11]
 LDCM0420  CL31 HEK-293T C53(0.87)  LDD1018  [11]
 LDCM0421  CL32 HEK-293T C53(0.86)  LDD1019  [11]
 LDCM0422  CL33 HEK-293T C53(0.77)  LDD1020  [11]
 LDCM0423  CL34 HEK-293T C53(0.91)  LDD1021  [11]
 LDCM0424  CL35 HEK-293T C53(0.85)  LDD1022  [11]
 LDCM0425  CL36 HEK-293T C53(0.78)  LDD1023  [11]
 LDCM0426  CL37 HEK-293T C53(0.78)  LDD1024  [11]
 LDCM0428  CL39 HEK-293T C53(0.55)  LDD1026  [11]
 LDCM0429  CL4 HEK-293T C53(1.02)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C53(0.85)  LDD1028  [11]
 LDCM0431  CL41 HEK-293T C53(0.63)  LDD1029  [11]
 LDCM0432  CL42 HEK-293T C53(0.60)  LDD1030  [11]
 LDCM0433  CL43 HEK-293T C53(0.66)  LDD1031  [11]
 LDCM0434  CL44 HEK-293T C53(0.81)  LDD1032  [11]
 LDCM0435  CL45 HEK-293T C53(0.59)  LDD1033  [11]
 LDCM0436  CL46 HEK-293T C53(0.78)  LDD1034  [11]
 LDCM0437  CL47 HEK-293T C53(0.87)  LDD1035  [11]
 LDCM0438  CL48 HEK-293T C53(0.88)  LDD1036  [11]
 LDCM0439  CL49 HEK-293T C53(0.89)  LDD1037  [11]
 LDCM0440  CL5 HEK-293T C53(1.13)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C53(0.79)  LDD1039  [11]
 LDCM0442  CL51 HEK-293T C53(0.91)  LDD1040  [11]
 LDCM0443  CL52 HEK-293T C53(1.27)  LDD1041  [11]
 LDCM0444  CL53 HEK-293T C53(1.27)  LDD1042  [11]
 LDCM0445  CL54 HEK-293T C53(0.86)  LDD1043  [11]
 LDCM0446  CL55 HEK-293T C53(0.91)  LDD1044  [11]
 LDCM0447  CL56 HEK-293T C53(0.97)  LDD1045  [11]
 LDCM0448  CL57 HEK-293T C53(1.01)  LDD1046  [11]
 LDCM0449  CL58 HEK-293T C53(1.09)  LDD1047  [11]
 LDCM0450  CL59 HEK-293T C53(0.84)  LDD1048  [11]
 LDCM0451  CL6 HEK-293T C53(1.11)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C53(0.82)  LDD1050  [11]
 LDCM0453  CL61 HEK-293T C53(0.96)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C53(1.02)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C53(1.06)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C53(1.02)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C53(1.12)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C53(1.07)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C53(1.04)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C53(1.05)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C53(1.10)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C53(1.14)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C53(1.09)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C53(1.17)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C53(1.14)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C53(0.99)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C53(0.94)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C53(0.91)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C53(1.25)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C53(0.96)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C53(0.97)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C53(1.38)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C53(0.99)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C53(1.11)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C53(1.04)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C53(1.06)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C53(1.07)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C53(1.00)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C53(0.94)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C53(1.03)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C53(0.94)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C53(1.08)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C53(1.13)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C53(1.17)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C53(1.07)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C53(1.12)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C53(1.01)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C53(1.19)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C53(1.36)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C53(1.05)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C53(1.05)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C53(1.03)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C53(1.12)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C53(1.25)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C53(1.79)  LDD1702  [12]
 LDCM0468  Fragment33 HEK-293T C53(1.03)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C53(0.89)  LDD1025  [11]
 LDCM0022  KB02 HEK-293T C53(1.18)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C53(1.05)  LDD1497  [10]
 LDCM0024  KB05 ZR-75-1 C53(3.14)  LDD3493  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Protein hinderin (KIAA1328) . Q86T90

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761