Details of the Target

General Information of Target

Target ID LDTP10307
Target Name AMSH-like protease (STAMBPL1)
Gene Name STAMBPL1
Gene ID 57559
Synonyms
AMSHLP; KIAA1373; AMSH-like protease; AMSH-LP; EC 3.4.19.-; STAM-binding protein-like 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASARGKELRLIL
SPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRFYTAPPGPRLALCFVDIRRF
GRWDLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFNGIGNYLRA
EILYRLKIPPFEKARSVLEALQQHRPSPELTLSQKIRTKLQNPDLLELCHSVPKEVVQLG
GKGYGSESGEEDFAAFRAWLRCYGMPGMSSLQDRHGRTIWFQGDPGPLAPKGRKSRKKKS
KATQLSPEDRVEDALPPSKAPSRTRRAKRDLPKRTATQRPEGTSLQQDPEAPTVPKKGRR
KGRQAASGHCRPRKVKADIPSLEPEGTSAS
Target Bioclass
Enzyme
Family
Peptidase M67C family
Function
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains.
Uniprot ID
Q96FJ0
Ensemble ID
ENST00000371924.5
HGNC ID
HGNC:24105
ChEMBL ID
CHEMBL4630848

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.K405RfsTer21 .
LNCaP clone FGC Deletion: p.K405RfsTer21 .
LOXIMVI SNV: p.K142T DBIA    Probe Info 
LS180 Deletion: p.K405RfsTer21 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.16  LDD0402  [1]
STPyne
 Probe Info  		K111(4.44); K149(10.00); K150(6.59)  LDD0277  [2]
BTD
 Probe Info  		C420(0.78)  LDD2109  [3]
AHL-Pu-1
 Probe Info  		C213(4.03)  LDD0169  [4]
DBIA
 Probe Info  		C98(6.78)  LDD0209  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C402(0.00); C98(0.00); C38(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C98(0.00); C402(0.00); C38(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C420(1.52)  LDD2117  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C213(4.03)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C98(0.96); C213(1.46); C276(0.98)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C98(1.04)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C98(0.87); C38(1.03); C276(0.92)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C98(0.91); C213(1.06)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C98(1.04); C276(0.98)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C98(0.98); C213(0.93); C276(0.92)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C98(1.07); C213(1.03); C276(1.09)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C98(1.00)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C98(0.74); C38(0.96); C276(0.69)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C98(1.01)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C98(0.96); C213(0.97)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C98(1.00); C213(1.11)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C98(0.86); C276(0.96)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C98(0.97); C213(1.31); C276(0.92)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C98(0.85); C276(0.97)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C98(0.95); C213(0.99); C276(0.97)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C98(0.94)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C98(0.92); C38(0.98); C276(0.89)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C98(0.96); C213(0.84)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C98(1.08); C213(0.88)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C98(1.05); C38(1.06); C276(1.10)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C98(1.10); C276(0.98)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C98(0.92); C213(1.19); C276(1.04)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C98(0.80); C276(0.87)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C98(0.76); C213(1.30); C276(0.82)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C98(1.01)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C98(0.98); C38(1.10); C276(0.92)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C98(0.73); C213(1.11)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C98(0.99); C213(0.86)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C98(1.02); C276(1.02)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C98(0.99); C213(0.74); C276(0.96)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C98(0.91); C213(0.91)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C98(0.92); C276(0.96)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C98(0.89); C213(1.49); C276(0.77)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C98(1.08)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C98(0.96); C38(1.06); C276(1.07)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C98(0.96); C213(0.84)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C98(0.97); C213(0.95)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C98(1.02); C276(1.03)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C98(1.01); C213(1.04); C276(0.99)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C98(0.67); C276(0.97)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C98(0.93); C213(1.07); C276(0.97)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C98(0.94); C213(0.84)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C98(0.97)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C98(0.99); C38(1.03); C276(0.99)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C98(0.88); C213(1.02)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C98(0.90); C213(0.98)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C98(0.96); C276(0.99)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C98(0.94); C213(0.95); C276(1.01)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C98(0.94); C276(1.03)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C98(0.84); C213(1.16); C276(0.80)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C98(0.94)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C98(0.93); C38(0.98); C276(0.90)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C98(0.91); C276(0.95)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C98(0.90); C213(1.14)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C98(0.94); C213(0.70)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C98(0.94); C276(1.06)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C98(1.07); C213(0.94); C276(1.04)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C98(0.88); C276(0.98)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C98(0.99); C213(0.87); C276(1.06)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C98(0.78); C276(1.03)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C98(0.95); C213(0.82)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C98(0.90); C213(1.22); C276(0.94)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C98(0.77); C276(0.94)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 11.48  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C38(2.97)  LDD2214  [11]
 LDCM0367  CL1 HEK-293T C98(0.93); C213(1.11)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C98(0.82); C276(0.68)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C98(1.00); C38(1.02); C276(0.93)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C98(1.01); C213(0.96)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C98(0.91); C213(1.01)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C98(1.03); C276(0.98)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C98(0.91); C38(1.11); C276(0.84)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C98(0.90); C213(1.01)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C98(1.01); C213(0.94)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C98(1.05); C276(1.05)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C98(0.90); C38(1.03); C276(0.91)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C98(0.73); C213(0.98)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C98(1.05); C213(1.06); C276(0.89)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C98(0.94); C213(1.04)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C98(1.02); C276(0.94)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C98(0.98); C38(1.11); C276(0.98)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C98(0.71); C213(1.13)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C98(0.96); C213(1.41)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C98(1.14); C276(0.93)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C98(1.07); C38(0.98); C276(0.96)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C98(0.85); C213(0.89)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C98(1.16); C213(0.97)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C98(1.10); C276(0.89)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C98(0.78); C276(0.78)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C98(0.94); C38(1.06); C276(0.92)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C98(0.87); C213(1.05)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C98(1.11); C213(1.18)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C98(1.05); C276(0.89)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C98(0.89); C38(1.01); C276(0.94)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C98(0.93); C213(0.83)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C98(1.08); C213(0.99)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C98(1.05); C276(0.95)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C98(0.96); C38(0.99); C276(0.95)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C98(0.82); C213(0.97)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C98(1.12); C213(0.96)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C98(1.07); C276(0.78)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C98(1.07); C38(1.09); C276(0.98)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C98(0.98); C213(1.56); C276(0.81)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C98(1.00)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C98(0.89); C38(1.07); C276(0.85)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C98(0.85); C213(0.96)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C98(0.88); C213(0.95)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C98(1.08); C213(0.66)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C98(0.98); C276(0.84)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C98(1.03); C213(1.00); C276(0.98)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C98(1.00); C276(0.81)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C98(0.85); C213(0.89)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C98(1.04); C213(1.14)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C98(1.11); C276(0.98)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C98(1.17); C38(1.02); C276(0.93)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C98(0.90); C213(1.21); C276(0.92)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C98(1.25); C276(0.94)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C98(1.04)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C98(0.97); C38(1.02); C276(0.90)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C98(1.06); C213(0.98)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C98(1.07); C213(0.67)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C98(0.95); C276(0.87)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C98(1.00); C213(0.73); C276(0.99)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C98(1.09); C276(0.75)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C98(1.12); C213(0.86)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C98(1.18); C276(1.00)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C98(1.04); C38(1.07); C276(0.94)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C98(0.93); C38(1.00); C276(0.96)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C98(0.78); C213(1.49); C276(0.74)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C98(1.03)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C98(0.98); C38(0.99); C276(1.00)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C98(0.95); C213(1.04)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C98(1.04); C213(0.98)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C98(1.14); C276(0.82)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C98(1.09); C213(0.83); C276(0.93)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C98(1.02); C276(0.80)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C98(0.67); C213(0.88)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C98(0.91); C213(1.13); C276(0.86)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C98(0.84); C213(1.37)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C98(0.95); C38(1.11); C276(1.05)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C98(0.90); C213(1.36); C276(0.85)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C98(0.97)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C98(1.13); C38(1.13); C276(0.84)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C98(0.94); C213(0.85)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C98(0.88); C213(0.88)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C98(0.85); C276(0.83)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C98(1.12); C213(0.96); C276(0.98)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C98(0.99)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C98(0.88); C276(0.75)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C98(0.83); C213(0.94)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C98(1.12); C213(1.41)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C98(1.10); C276(0.95)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C98(1.22); C38(1.13); C276(0.92)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C98(0.97); C213(1.18); C276(1.34)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C98(1.00)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C98(0.97); C38(1.13); C276(1.35)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C98(0.98); C213(0.98)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C98(0.94); C213(0.57)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C98(1.08); C38(1.01); C276(0.98)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C98(0.86); C276(0.95)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C98(1.03); C213(0.80); C276(0.88)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C98(0.83); C276(0.74)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C98(0.85); C213(1.09)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C98(1.13); C213(0.99)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C98(1.00); C38(0.99); C276(0.98)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C98(1.00); C213(1.12); C276(0.93)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C98(1.05)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C98(0.96); C38(1.02); C276(1.07)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C98(0.79); C213(0.77)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C98(0.95); C213(0.80)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C98(1.11); C213(0.85)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C98(1.00); C276(0.94)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C98(0.93); C213(0.74); C276(0.92)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C98(0.87); C276(0.82)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C98(0.82); C213(0.73)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C98(1.14); C213(0.80)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C98(1.14); C276(0.92)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C98(1.12); C38(1.01); C276(1.00)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C98(0.93); C213(1.03); C276(0.83)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C98(0.96); C213(0.83)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C98(1.08)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C98(0.93); C38(1.00); C276(1.00)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C98(0.95); C213(0.79)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C98(0.95); C213(0.90)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C98(0.96); C276(0.94)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C98(0.67); C213(0.90); C276(0.84)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C98(0.95); C276(1.05)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C98(0.71); C213(0.77)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C98(1.03); C213(1.31)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C98(1.12); C276(0.93)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C98(1.18); C276(1.02)  LDD1698  [10]
 LDCM0625  F8 Ramos C38(0.90)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C38(1.02)  LDD2189  [12]
 LDCM0575  Fragment13 Ramos C38(1.00)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C38(1.00)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C38(1.00)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C38(2.37)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C38(1.05)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C38(1.06)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C38(0.44)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C38(0.78)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C38(0.64)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C38(1.07)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C98(1.06); C276(1.02)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C38(0.45)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C38(0.77)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C98(1.07); C213(0.93)  LDD1631  [10]
 LDCM0610  Fragment52 Ramos C38(0.77)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C38(0.81)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C38(0.58)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C38(1.49)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C98(1.13); C38(0.91); C276(1.05)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C98(6.78)  LDD0209  [5]
 LDCM0024  KB05 HMCB C38(1.62)  LDD3312  [13]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C420(0.78)  LDD2109  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C420(1.41)  LDD2136  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Ras-related protein Rab-2A (RAB2A) Rab family P61019
Ras-related protein Rab-2B (RAB2B) Rab family Q8WUD1
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) Stealth family Q3T906
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein INCA1 (INCA1) INCA family Q0VD86
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Splicing factor 3B subunit 5 (SF3B5) SF3B5 family Q9BWJ5
Germinal center-associated signaling and motility-like protein (GCSAML) . Q5JQS6
Lymphocyte transmembrane adapter 1 (LAX1) . Q8IWV1
Melanoma-associated antigen 3 (MAGEA3) . P43357
Melanoma-associated antigen 6 (MAGEA6) . P43360
MORN repeat-containing protein 5 (MORN5) . Q5VZ52
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
RING finger protein 32 (RNF32) . Q9H0A6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840