Details of the Target

General Information of Target

Target ID LDTP10256
Target Name Nucleoporin SEH1 (SEH1L)
Gene Name SEH1L
Gene ID 81929
Synonyms
SEC13L; SEH1; Nucleoporin SEH1; GATOR2 complex protein SEH1; Nup107-160 subcomplex subunit SEH1; SEC13-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK
RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
Target Bioclass
Transporter and channel
Family
WD repeat SEC13 family
Subcellular location
Chromosome, centromere, kinetochore
Function
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.; As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex.
Uniprot ID
Q96EE3
Ensemble ID
ENST00000262124.15
HGNC ID
HGNC:30379

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.A8S DBIA    Probe Info 
HCT15 SNV: p.R62H DBIA    Probe Info 
HS936T SNV: p.S295F DBIA    Probe Info 
HT115 SNV: p.Q280R DBIA    Probe Info 
JURKAT SNV: p.S151N .
KYSE180 SNV: p.D224N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K12(7.14)  LDD0274  [2]
STPyne
 Probe Info  		K251(7.27); K306(10.00); K314(5.24)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
DBIA
 Probe Info  		C315(2.59); C77(1.36)  LDD3311  [4]
BTD
 Probe Info  		C30(1.31)  LDD2099  [5]
5E-2FA
 Probe Info  		H16(0.00); H48(0.00)  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C133(0.00); C161(0.00); C49(0.00); C77(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C133(0.00); C161(0.00); C49(0.00); C77(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
Phosphinate-6
 Probe Info  		C315(0.00); C301(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		C30(0.00); C165(0.00)  LDD0219  [11]
Methacrolein
 Probe Info  		C165(0.00); C30(0.00); C167(0.00)  LDD0218  [11]
AOyne
 Probe Info  		13.90  LDD0443  [12]
NAIA_5
 Probe Info  		C133(0.00); C30(0.00); C77(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C30(1.10)  LDD2117  [5]
 LDCM0025  4SU-RNA HEK-293T C315(2.80)  LDD0371  [15]
 LDCM0214  AC1 HEK-293T C77(1.00); C301(0.75); C30(0.96); C133(0.85)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C77(1.05); C301(1.03); C30(0.96)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C77(0.90); C301(0.86); C133(0.95)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C77(1.01); C301(0.98); C30(0.98)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C77(1.00); C301(1.09); C30(1.05); C49(1.05)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C77(1.07); C301(0.82); C30(1.05); C133(0.78)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C77(0.92); C301(0.80); C30(0.94); C133(1.07)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C77(1.03); C301(0.96); C30(1.04)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C77(0.73); C301(0.78); C133(0.80)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C77(0.99); C301(0.96); C30(0.99)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C77(1.02); C301(1.02); C30(0.97)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C77(1.02); C301(1.01); C49(0.85)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C77(1.08); C301(1.00); C30(1.03); C49(1.03)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C77(0.94); C301(0.95); C30(1.01); C133(0.79)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C77(1.15); C301(1.13); C30(0.99); C133(0.95)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C77(1.03); C301(0.91); C30(0.94); C133(0.99)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C77(1.08); C301(0.92); C30(0.96)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C77(1.11); C301(0.96); C133(0.94)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C77(0.96); C301(0.84); C30(0.96)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C77(1.05); C301(0.84); C49(0.97)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C77(1.12); C301(0.86); C133(0.86)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C77(0.98); C301(1.22); C30(1.05); C49(0.99)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C77(1.04); C301(1.18); C30(1.04); C133(0.87)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C77(0.94); C301(0.85); C30(0.99); C133(1.15)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C77(0.91); C301(0.99); C30(0.96); C133(1.09)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C77(1.12); C301(1.14); C30(1.01)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C77(1.21); C301(1.21); C133(0.96)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C77(1.07); C301(1.02); C30(0.96)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C77(1.05); C301(0.97); C49(0.77)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C77(0.90); C301(1.15); C30(1.11); C49(1.14)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C77(0.89); C301(0.82); C30(0.99); C133(1.07)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C77(1.08); C301(1.00); C30(0.98)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C77(0.90); C301(0.84); C30(0.99); C133(1.37)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C77(1.17); C301(0.97); C30(0.91); C133(0.80)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C77(0.86); C301(0.94); C30(0.97)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C77(1.03); C301(1.15); C133(0.96)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C77(1.02); C301(1.18); C30(0.92)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C77(1.10); C301(0.87); C49(0.83)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C77(0.98); C301(1.14); C30(1.03); C49(1.01)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C77(1.10); C301(0.79); C30(1.08); C133(1.01)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C77(0.85); C301(0.99); C30(0.99); C133(1.21)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C77(0.86); C301(0.83); C30(0.97); C133(0.88)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C77(1.07); C301(0.96); C49(0.72)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C77(1.14); C301(0.99); C30(1.02)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C77(0.87); C301(0.99); C133(1.07)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C77(0.90); C301(0.91); C30(0.98)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C77(1.19); C301(0.88); C49(0.70)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C77(0.98); C301(1.18); C30(1.04); C49(1.03)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C77(1.03); C301(0.81); C30(1.01); C133(0.84)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C77(0.97); C301(1.05); C30(1.02); C133(1.09)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C77(0.82); C301(0.84); C30(0.90); C133(0.81)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C77(0.91); C301(0.86); C30(0.97)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C77(0.91); C301(0.80); C133(0.99)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C77(0.84); C301(1.16); C30(0.95); C49(0.79)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C77(1.01); C301(0.97); C30(0.96)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C77(0.97); C301(0.93); C49(0.60)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C77(0.76); C301(1.12); C30(1.00); C49(0.79)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C77(0.90); C301(0.80); C30(1.02); C133(0.95)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C77(0.98); C301(0.99); C30(0.98); C133(1.01)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C77(1.19); C301(0.86); C30(1.01); C133(0.88)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C77(1.04); C301(0.84); C30(0.94); C133(1.11)  LDD1569  [16]
 LDCM0248  AKOS034007472 HEK-293T C77(1.15); C301(1.13); C49(0.68)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C77(0.99); C301(0.98); C30(0.85); C133(0.91)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C77(0.92); C301(0.78); C30(1.01); C133(1.22)  LDD1514  [16]
 LDCM0156  Aniline NCI-H1299 11.29  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C30(0.00); C133(0.00); H23(0.00); C77(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C30(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C77(1.27); C301(1.01); C30(0.84)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C77(1.11); C301(0.99); C30(1.12); C49(1.45)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C77(1.09); C301(1.17); C30(0.99)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C77(0.82); C301(1.04); C30(0.96)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C77(0.97); C301(0.88); C30(0.95); C49(0.63)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C77(0.87); C301(1.20); C30(0.94)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C77(1.10); C301(1.01); C30(0.98)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C77(0.99); C301(1.02); C30(1.00)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C77(0.89); C301(1.11); C30(0.94); C49(0.65)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C77(0.89); C301(1.16); C30(0.99)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C77(0.88); C301(1.04); C30(1.05)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C77(1.13); C301(0.94); C30(0.91)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C77(1.15); C301(1.02); C30(1.16); C133(0.84)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C77(1.03); C301(0.84); C30(0.86); C49(0.80)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C77(0.82); C301(1.11); C30(0.96)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C77(0.87); C301(1.01); C30(0.92)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C77(1.03); C301(1.54); C30(0.93)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C77(0.89); C301(0.87); C30(0.95); C49(0.64)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C77(0.70); C301(1.03); C30(0.97)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C77(0.91); C301(0.95); C30(0.99)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C77(0.80); C301(1.02); C30(0.88)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C77(0.99); C301(0.98); C30(0.96); C49(0.56)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C77(0.77); C301(0.88); C30(1.03)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C77(1.00); C301(1.07); C30(1.07); C133(1.37)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C77(1.14); C301(1.04); C30(0.98)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C77(0.94); C301(1.07); C30(1.03)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C77(1.09); C301(0.99); C30(0.93); C49(0.54)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C77(1.11); C301(1.09); C30(0.93)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C77(0.82); C301(0.99); C30(0.96)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C77(0.76); C301(1.09); C30(0.94)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C77(1.05); C301(0.96); C30(0.93); C49(0.58)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C77(0.88); C301(1.02); C30(0.92)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C77(0.87); C301(1.09); C30(1.01)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C77(0.73); C301(0.91); C30(0.87)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C77(0.93); C301(1.07); C30(1.02); C49(0.49)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C77(0.71); C301(1.09); C30(0.88)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C77(1.12); C301(1.36); C30(1.02)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C77(0.82); C301(0.88); C30(0.88); C133(0.75)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C77(1.16); C301(1.20); C30(1.14)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C77(1.02); C301(0.99); C133(1.03)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C77(1.06); C301(1.00); C30(1.00); C49(0.63)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C77(1.23); C301(1.29); C30(1.08)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C77(0.96); C301(0.98); C49(1.60)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C77(1.26); C301(1.34); C30(1.12); C49(1.58)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C77(1.16); C301(0.83); C30(1.18); C133(0.91)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C77(1.24); C301(0.74); C30(1.11); C133(1.08)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C77(1.18); C301(1.03); C30(1.03)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C77(0.92); C301(0.90); C30(1.01); C49(0.65)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C77(0.83); C301(1.17); C30(1.04)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C77(1.13); C301(1.08); C30(0.98)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C77(1.01); C301(0.86); C30(1.07); C133(0.91)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C77(0.90); C301(1.05); C30(0.95)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C77(0.94); C301(1.04); C30(1.10)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C77(0.93); C301(1.17); C133(0.87)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C77(1.08); C301(0.92); C30(1.10)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C77(1.20); C301(0.80); C49(1.17)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C77(1.30); C301(1.22); C30(1.12); C49(1.38)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C77(1.10); C301(0.84); C30(1.16); C133(0.89)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C77(0.97); C301(0.74); C30(1.03); C133(1.41)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C77(1.22); C301(1.33); C30(1.00)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C77(0.79); C301(1.00); C30(0.97)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C77(0.91); C301(1.28); C30(1.01)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C77(1.20); C301(1.19); C30(0.99)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C77(0.90); C301(0.95); C30(0.92); C133(1.24)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C77(1.15); C301(1.15); C30(1.09)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C77(1.21); C301(1.12); C133(1.04)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C77(1.08); C301(1.02); C30(1.06)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C77(0.98); C301(0.74); C49(1.29)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C77(0.97); C301(1.07); C30(1.08); C49(1.51)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C77(1.34); C301(0.94); C30(1.15); C133(0.81)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C77(1.20); C301(1.08); C30(1.06); C133(1.25)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C77(0.78); C301(1.23); C30(0.95)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C77(0.91); C301(1.12); C30(0.99); C133(0.97)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C77(0.98); C301(0.89); C30(0.94); C49(0.57)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C77(1.08); C301(1.18); C30(1.07)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C77(0.71); C301(0.94); C30(0.93); C133(1.05)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C77(1.33); C301(0.90); C30(0.96)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C77(1.02); C301(0.95); C133(1.03)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C77(1.09); C301(0.85); C30(1.00)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C77(1.10); C301(0.92); C49(1.44)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C77(1.02); C301(1.21); C30(1.15); C49(1.52)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C77(1.04); C301(0.90); C30(1.19); C133(1.10)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C77(0.96); C301(1.02); C30(1.02)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C77(1.00); C301(1.04); C30(1.11); C133(1.31)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C77(0.87); C301(1.21); C30(0.94)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C77(1.05); C301(0.96); C30(0.99); C49(0.50)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C77(0.81); C301(1.16); C30(1.00)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C77(0.96); C301(0.81); C30(0.87)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C77(0.99); C301(0.88); C30(0.99); C133(0.92)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C77(0.98); C301(1.13); C30(1.05)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C77(0.96); C301(0.98); C133(1.22)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C77(1.10); C301(0.96); C30(1.04)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C77(1.24); C301(1.16); C49(1.36)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C77(0.98); C301(1.01); C133(1.03)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C77(1.04); C301(1.01); C30(1.12); C49(1.46)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C77(1.08); C301(0.80); C30(1.13); C133(0.82)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C77(1.02); C301(0.64); C30(1.10); C133(1.13)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C77(0.94); C301(1.24); C30(0.97)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C77(0.98); C301(1.01); C30(1.05); C49(0.44)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C77(0.92); C301(1.32); C30(1.09)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C77(0.92); C301(0.83); C30(0.89); C133(0.94)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C77(1.18); C301(0.96); C30(1.02)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C77(1.11); C301(1.05); C133(1.40)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C77(0.79); C301(0.73); C30(0.83)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C77(1.22); C301(1.32); C30(1.05)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C77(1.50); C301(0.98); C49(1.34)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C77(1.18); C301(1.05); C30(1.11); C49(1.33)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C77(0.99); C301(0.83); C30(1.16); C133(0.86)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C77(1.04); C301(0.79); C30(1.00); C133(1.20)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C77(0.96); C301(1.12); C30(0.95)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C77(1.01); C301(0.96); C30(1.01); C49(0.33)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C77(0.82); C301(0.97); C30(0.95)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C77(0.92); C301(0.97); C30(1.09)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C77(1.08); C301(0.89); C30(1.02); C133(0.99)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C77(1.38); C301(0.89); C49(1.70)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C77(0.88); C301(0.71); C30(0.87)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C77(1.07); C301(1.12); C133(1.02)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C77(0.93); C301(1.24); C30(0.93)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C77(1.13); C301(0.85); C49(1.34)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C77(1.05); C301(1.00); C30(0.98); C49(1.47)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C77(0.91); C301(1.09); C30(0.97); C133(0.71)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C77(0.91); C301(0.86); C30(0.95); C133(1.00)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C77(0.78); C301(0.93); C30(0.90)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C77(1.02); C301(0.91); C30(0.93); C49(0.62)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C77(0.78); C301(0.98); C30(0.96)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C77(0.85); C301(1.36); C30(0.99)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C315(1.14)  LDD1702  [5]
 LDCM0625  F8 Ramos C30(1.17); C77(0.99); C161(0.78)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C30(0.53); C77(0.58)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C30(3.77); C161(9.17)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C30(0.65); C77(0.46)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C30(1.18); C77(0.63)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C30(0.59); C77(0.66)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C30(0.43); C77(0.39)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C30(0.86); C77(0.74)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C30(0.57); C77(0.57)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C30(1.16); C77(1.44)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C30(0.50)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C30(1.77); C77(0.62)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C30(1.47); C77(0.90)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C30(0.75); C77(0.51)  LDD2201  [17]
 LDCM0468  Fragment33 HEK-293T C77(0.83); C301(0.91); C30(1.07)  LDD1671  [16]
 LDCM0596  Fragment38 Ramos C30(1.28); C77(0.96)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C30(0.50); C77(0.43); C161(0.38)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C77(0.96); C301(0.95); C30(1.04); C49(0.47)  LDD1631  [16]
 LDCM0610  Fragment52 Ramos C30(2.25); C77(0.72)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C30(2.89); C77(0.47)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C30(0.42); C77(0.50); C161(0.46)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C30(0.38); C77(0.35)  LDD2188  [17]
 LDCM0107  IAA HeLa C30(0.00); C165(0.00); C49(0.00); C167(0.00)  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C30(1.01); C133(0.93); C77(1.00); C49(1.05)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C30(0.97); C133(1.05); C77(1.35); C49(0.92)  LDD1497  [16]
 LDCM0024  KB05 G361 C315(2.59); C77(1.36)  LDD3311  [4]
 LDCM0109  NEM HeLa H23(0.00); H236(0.00); H223(0.00)  LDD0223  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C30(1.31)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C30(1.13)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C30(0.53)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C30(0.93)  LDD2111  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C30(0.88)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C30(0.81)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C30(0.99)  LDD2127  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C30(1.27)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C30(0.96)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C30(0.84)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C30(2.00)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C30(0.96)  LDD2146  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore complex protein Nup85 (NUP85) Nucleoporin Nup85 family Q9BW27
Protein SEC13 homolog (SEC13) WD repeat SEC13 family P55735

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578