Details of the Target

General Information of Target

Target ID LDTP10094
Target Name Ribulose-phosphate 3-epimerase (RPE)
Gene Name RPE
Gene ID 6120
Synonyms
Ribulose-phosphate 3-epimerase; EC 5.1.3.1; Ribulose-5-phosphate-3-epimerase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDCGSVGGQRTQRLPGRQRLLFLPVGLSGRPGGSETSARRCLSALSDGLGALRPRAPAAR
GGVSRASPLLLLLLVPSPRLAAAAPRRQLGDWERSRLGYAAPPAGRSSAWRCSPGVAAAA
GALPQYHGPAPALVSCRRELSLSAGSLQLERKRRDFTSSGSRKLYFDTHALVCLLEDNGF
ATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFS
ALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNEKKLLELRTEI
VALHAQQDRALTQTDRKIETEVAGLKTMLESHKLDNIKYLAGSIFTCLTVALGFYRLWI
Target Bioclass
Enzyme
Family
Ribulose-phosphate 3-epimerase family
Function Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Uniprot ID
Q96AT9
Ensemble ID
ENST00000354506.10
HGNC ID
HGNC:10293

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.G102W .
HEC1B SNV: p.G102W .
SW756 SNV: p.V115I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C23(0.92)  LDD3379  [2]
BTD
 Probe Info  		C217(1.92)  LDD1700  [3]
HHS-475
 Probe Info  		Y127(1.63)  LDD0267  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C23(0.00); C217(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
JW-RF-010
 Probe Info  		C23(0.00); C217(0.00)  LDD0026  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
Acrolein
 Probe Info  		C23(0.00); C217(0.00)  LDD0217  [9]
W1
 Probe Info  		N.A.  LDD0236  [1]
NAIA_5
 Probe Info  		C23(0.00); C217(0.00); C5(0.00)  LDD2223  [10]
HHS-465
 Probe Info  		Y127(0.00); K120(0.00)  LDD2240  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C217(0.55)  LDD2142  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C217(1.02)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C217(1.00); C23(0.89); C186(1.19)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C217(1.07); C23(1.05)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C217(0.97); C23(1.18); C186(1.00)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C217(1.18); C23(1.09); C186(1.42)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C217(1.16); C23(0.99)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C217(1.16); C23(1.11); C186(1.17)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C217(1.06); C23(0.99); C186(1.20)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C217(1.04); C23(1.04)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C217(1.03); C23(1.03); C186(1.32)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C217(1.09); C23(1.11)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C217(1.28); C23(1.07); C186(1.54)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C217(1.19); C23(1.09); C186(1.08)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C217(1.17); C23(1.05)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C217(1.21); C23(1.11); C186(1.16)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C217(1.18); C23(1.03); C186(1.00)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C217(1.02); C23(0.93); C186(1.36)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C217(1.05); C23(0.99)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C217(1.03); C23(1.05); C186(1.04)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C217(1.10); C23(1.10); C186(1.17)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C217(1.08); C23(1.27); C186(1.24)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C217(0.93); C23(1.18); C186(0.82)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C217(1.07); C23(1.02)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C217(1.15); C23(1.03); C186(1.06)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C217(1.10); C23(1.04); C186(1.20)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C217(1.08); C23(0.98); C186(1.20)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C217(1.03); C23(1.00)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C217(1.09); C23(1.05); C186(1.06)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C217(1.26); C23(0.96); C186(0.99)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C217(1.23); C23(1.29); C186(1.46)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C217(1.20); C23(1.08)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C217(1.29); C23(1.12); C186(1.27)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C217(1.01); C23(0.87); C186(1.37)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C217(1.08); C23(1.10); C186(1.11)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C217(1.14); C23(0.96); C186(1.17)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C217(0.99); C23(1.03)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C217(1.10); C23(1.04); C186(0.97)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C217(1.26); C23(1.01); C186(1.36)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C217(1.11); C23(1.20); C186(1.12)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C217(1.16); C23(1.11)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C217(1.18); C23(1.00); C186(1.03)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C217(1.25); C23(1.08); C186(1.05)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C217(1.12); C23(0.97); C186(1.32)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C217(1.08); C23(1.10); C186(1.00)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C217(1.00); C23(1.06)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C217(0.98); C23(1.06); C186(1.10)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C217(1.20); C23(1.23); C186(1.74)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C217(1.25); C23(1.06); C186(1.25)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C217(1.18); C23(1.24)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C217(1.29); C23(0.95); C186(1.03)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C217(1.22); C23(1.11); C186(1.20)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C217(1.01); C23(1.08); C186(1.39)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C217(1.03); C23(0.97)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C217(1.09); C23(1.16); C186(1.08)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C217(0.98); C23(1.00)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C217(1.15); C23(0.93); C186(1.19)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C217(1.17); C23(1.28); C186(1.34)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C217(1.15); C23(1.10)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C217(1.19); C23(1.00); C186(1.10)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C217(1.19); C23(0.98); C186(1.24)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C217(1.11); C23(1.73); C186(1.05)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C217(1.01); C23(1.02); C186(1.27)  LDD1569  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C217(0.61)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C217(1.13); C23(1.09); C186(1.12)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C217(1.02); C23(0.84); C186(1.21)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C217(1.09); C23(1.06); C186(0.98)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa C23(0.00); C217(0.00)  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C23(1.84); C217(0.21)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C217(1.05); C23(0.95)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C217(0.90); C23(0.86)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C217(0.99); C23(1.03); C186(0.87)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C217(1.04); C23(1.05)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C217(1.05); C23(0.95); C186(1.20)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C217(1.18); C23(1.18); C186(1.08)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C217(0.84); C23(0.90); C186(0.88)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C217(1.00); C23(0.96)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C217(1.13); C23(1.04); C186(0.98)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C217(1.20); C23(1.22); C186(1.08)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C217(0.96); C23(0.92); C186(0.85)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C217(1.09); C23(1.01)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C217(0.97); C23(0.94); C186(0.93)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C217(1.03); C23(0.99); C186(1.23)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C217(1.09); C23(0.91); C186(1.03)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C217(0.83); C23(0.95); C186(0.71)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C217(1.20); C23(1.15)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C217(1.05); C23(1.00); C186(1.07)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C217(1.09); C23(0.89); C186(1.10)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C217(0.91); C23(1.12); C186(0.88)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C217(1.11); C23(0.99)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C217(1.15); C23(1.03); C186(1.28)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C217(1.22); C23(1.11); C186(1.11)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C217(0.89); C23(1.10); C186(0.84)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C217(1.12); C23(1.12); C186(0.96)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C217(1.05); C23(1.02)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C217(1.11); C23(1.06); C186(1.39)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C217(1.07); C23(0.95); C186(1.15)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C217(0.97); C23(0.99); C186(0.92)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C217(1.09); C23(1.03)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C217(1.06); C23(1.25); C186(1.14)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C217(1.10); C23(1.07); C186(0.98)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C217(1.15); C23(1.11); C186(0.99)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C217(0.91); C23(0.97)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C217(0.97); C23(1.01); C186(1.22)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C217(0.86); C23(0.90); C186(1.09)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C217(0.86); C23(1.07); C186(0.74)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C217(0.90); C23(1.19); C186(0.96)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C217(0.92); C23(1.10)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C217(1.12); C23(1.04); C186(1.01)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C217(0.94); C23(1.11); C186(1.13)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C217(1.10); C23(1.03); C186(1.04)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C217(0.91); C23(1.10); C186(1.11)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C217(1.13); C23(0.93)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C217(1.22); C23(1.10); C186(0.95)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C217(1.09); C23(1.27); C186(1.25)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C217(1.07); C23(0.78)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C217(1.04); C23(0.96); C186(1.25)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C217(1.10); C23(0.91); C186(1.09)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C217(0.99); C23(0.90); C186(0.89)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C217(1.14); C23(0.89); C186(1.61)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C217(0.98); C23(1.12); C186(0.96)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C217(1.05); C23(1.09)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C217(0.96); C23(1.11); C186(0.99)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C217(1.15); C23(1.09); C186(1.20)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C217(1.18); C23(0.90); C186(1.10)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C217(1.13); C23(0.96)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C217(1.20); C23(1.00); C186(0.99)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C217(1.11); C23(1.22); C186(0.85)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C217(1.01); C23(1.12)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C217(1.08); C23(1.02); C186(0.92)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C217(0.86); C23(1.04); C186(0.76)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C217(1.07); C23(1.15); C186(0.80)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C217(1.07); C23(0.90); C186(1.19)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C217(1.06); C23(1.10)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C217(1.05); C23(1.08); C186(1.36)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C217(1.15); C23(1.20); C186(1.01)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C217(1.08); C23(0.87); C186(1.20)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C217(1.20); C23(0.98)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C217(1.20); C23(1.01); C186(1.00)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C217(1.15); C23(1.25); C186(1.05)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C217(1.14); C23(1.10)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C217(1.01); C23(1.41); C186(1.14)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C217(0.97); C23(1.07); C186(1.14)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C217(0.83); C23(0.98); C186(0.94)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C217(0.94); C23(0.82); C186(1.11)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C217(0.96); C23(0.98)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C217(0.88); C23(1.06); C186(0.94)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C217(1.17); C23(1.20); C186(1.18)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C217(1.01); C23(1.04); C186(1.27)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C217(1.19); C23(1.09)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C217(1.22); C23(1.04); C186(1.16)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C217(0.77); C23(0.62)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C217(1.16); C23(1.19); C186(1.29)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C217(1.09); C23(1.14)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C217(1.08); C23(1.10); C186(1.26)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C217(1.17); C23(1.07); C186(1.20)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C217(0.94); C23(0.96); C186(0.75)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C217(1.20); C23(1.29); C186(1.16)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C217(1.04); C23(1.08)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C217(1.01); C23(1.16); C186(0.97)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C217(1.24); C23(1.11); C186(1.18)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C217(1.23); C23(1.18); C186(1.33)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C217(0.93); C23(1.09); C186(0.86)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C217(1.19); C23(0.94)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C217(1.19); C23(0.86); C186(0.80)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C217(1.17); C23(1.09); C186(0.86)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C217(1.06); C23(0.91)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C217(1.03); C23(1.06); C186(1.30)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C217(1.06); C23(1.02); C186(0.86)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C217(0.92); C23(1.18); C186(1.11)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C217(1.05); C23(1.06)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C217(1.03); C23(1.09); C186(1.14)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C217(0.84); C23(0.80); C186(0.93)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C217(1.13); C23(1.02); C186(1.18)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C217(1.03); C23(0.97); C186(1.08)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C217(1.19); C23(1.09)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C217(1.10); C23(0.95); C186(0.94)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C217(1.08); C23(1.03); C186(0.80)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C217(1.07); C23(0.98)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C217(0.99); C23(1.08); C186(1.08)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C217(1.06); C23(0.97); C186(1.20)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C217(0.81); C23(1.02); C186(0.93)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C217(1.07); C23(1.33); C186(1.25)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C217(0.87); C23(0.89); C186(1.04)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C217(0.95); C23(0.81)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C217(1.08); C23(1.11); C186(1.23)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C217(1.11); C23(0.87); C186(1.08)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C217(1.27); C23(1.06); C186(1.40)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C217(1.13); C23(1.15)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C217(1.03); C23(0.81); C186(1.08)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C217(1.10); C23(1.09); C186(0.96)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C217(1.02); C23(0.85)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C217(1.00); C23(0.83); C186(1.02)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C217(1.04); C23(1.07); C186(1.19)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C217(1.03); C23(1.16); C186(1.05)  LDD1698  [12]
 LDCM0625  F8 Ramos C217(0.86); C23(0.40)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C217(0.63); C23(0.74)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C217(0.13); C23(6.66)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C217(0.75); C23(0.43)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C217(0.97); C23(0.87)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C217(0.71); C23(0.52)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C217(0.69); C23(0.15)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C217(0.82); C23(0.90)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C217(0.47); C23(0.21)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C217(0.86); C23(0.49)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C217(0.62); C23(0.18)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C217(1.08); C23(0.99)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C217(1.12); C23(0.98)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C217(0.71); C23(0.57)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C217(1.08); C23(0.97); C186(0.94)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C217(0.90); C23(0.65)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C217(0.84); C23(0.72)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C217(1.05); C23(1.34); C186(1.16)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C217(1.17); C23(0.40)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C217(1.52); C23(0.55)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C217(0.75); C23(0.50)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C217(0.71); C23(0.65)  LDD2188  [13]
 LDCM0119  HHS-0401 DM93 Y127(1.63)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y127(1.20)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C217(0.89)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C217(1.05)  LDD1497  [12]
 LDCM0024  KB05 OV56 C23(0.92)  LDD3379  [2]
 LDCM0109  NEM HeLa N.A.  LDD0224  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C217(0.91)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C217(1.03)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C217(0.64)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C217(0.78)  LDD2107  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C217(0.93)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C217(0.35)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C217(1.89)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C217(0.71)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C217(0.91)  LDD2125  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C217(0.75)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C217(0.47)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C217(1.16)  LDD2134  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C217(0.97)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C217(1.92)  LDD1700  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C217(0.76)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C217(0.35)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribulose-phosphate 3-epimerase (RPE) Ribulose-phosphate 3-epimerase family Q96AT9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ergocalciferol Small molecular drug DB00153

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578