Details of the Target

General Information of Target

Target ID LDTP10008
Target Name E3 ubiquitin-protein ligase RNF34 (RNF34)
Gene Name RNF34
Gene ID 80196
Synonyms
E3 ubiquitin-protein ligase RNF34; EC 2.3.2.27; Caspase regulator CARP1; Caspases-8 and -10-associated RING finger protein 1; CARP-1; FYVE-RING finger protein Momo; Human RING finger homologous to inhibitor of apoptosis protein; hRFI; RING finger protein 34; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVY
FVQYKIMFSCSMKSSHQKPSGCWQHISCNFPGCRTLAKYGQRQWKNKEDCWGTQELSCDL
TSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHA
PNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSSYCVV
AEIYQPMLDRRSQRSEERCVEIP
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Cell membrane
Function
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation. {|Ref.13}.
TTD ID
T68265
Uniprot ID
Q969K3
DrugMap ID
TTEWDK1
Ensemble ID
ENST00000361234.10
HGNC ID
HGNC:17297

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT1197 Deletion: p.T203HfsTer49 .
LNCaP clone FGC SNV: p.C86R DBIA    Probe Info 
MFE319 SNV: p.S323N DBIA    Probe Info 
NCIH2052 SNV: p.R352H DBIA    Probe Info 
RKO Deletion: p.S181QfsTer71 DBIA    Probe Info 
SKES1 SNV: p.E339Ter DBIA    Probe Info 
TOV21G SNV: p.A331S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C137(8.82)  LDD0170  [1]
DBIA
 Probe Info  		C65(49.02)  LDD0209  [2]
IA-alkyne
 Probe Info  		C65(0.00); C137(0.00)  LDD0162  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C137(8.82)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C137(2.16)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C65(0.80); C137(0.95); C149(1.08)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C65(0.84); C137(1.19); C149(1.16); C287(1.20)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C65(1.05); C137(0.88); C149(1.05)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C65(0.89); C137(1.01)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C65(0.97); C137(1.04); C287(1.13)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C65(0.89); C137(1.01); C149(1.04); C287(1.16)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C65(0.70); C137(0.99); C149(1.14)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C65(0.82); C137(0.93); C149(1.07); C287(0.95)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C65(0.72); C137(0.98); C149(0.94)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C65(0.96); C137(0.93); C149(1.08); C287(0.95)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C65(1.06); C137(1.03)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C65(0.89); C137(1.08); C149(0.99); C62(0.98)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C65(1.05); C137(1.04); C287(1.04)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C65(0.78); C137(1.00); C149(1.16); C287(1.16)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C65(0.94); C137(1.07); C149(1.07); C287(0.99)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C65(0.80); C137(0.94); C149(1.11)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C65(0.85); C137(0.95); C149(1.15); C287(1.11)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C65(0.90); C137(0.87); C149(0.93)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C65(0.81); C137(1.05)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C65(0.92); C137(0.99); C149(1.13); C62(1.14)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C65(1.01); C137(0.96); C149(1.02)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C65(0.98); C137(1.03); C287(1.11)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C65(0.89); C137(1.00); C149(1.04); C287(1.05)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C65(0.83); C137(1.10); C149(1.05); C287(0.99)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C65(0.78); C137(0.94); C149(1.15)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C65(0.82); C137(0.92); C149(1.11); C287(1.14)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C65(0.92); C137(0.99); C149(1.06)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C65(0.91); C137(0.99)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C65(0.96); C137(1.10); C149(1.14); C62(1.15)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C65(0.97); C137(1.00); C287(0.86)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C65(0.88); C137(1.11); C149(1.07); C287(1.18)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C65(0.88); C137(1.04)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C65(1.06); C137(1.05); C149(1.09); C287(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C65(0.79); C137(0.97); C149(1.23)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C65(0.85); C137(0.99); C149(1.14); C287(0.98)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C65(0.94); C137(0.96); C149(1.07)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C65(0.93); C137(1.01)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C65(0.95); C137(1.09); C149(1.16); C62(1.07)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C65(0.94); C137(0.96); C287(1.07)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C65(0.84); C137(1.04); C149(1.10); C287(1.05)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C65(0.97); C137(1.12); C149(1.13); C287(1.10)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C65(0.77); C137(1.04); C149(1.24)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C65(1.11); C137(0.94); C149(1.04); C62(1.16)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C65(0.87); C137(1.05); C149(1.10); C287(1.20)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C65(1.01); C137(0.97); C149(0.99)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C65(0.93); C137(1.04)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C65(0.91); C137(0.99); C149(1.04); C62(1.07)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C65(0.93); C137(1.01); C287(1.29)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C65(0.83); C137(1.13); C149(1.09); C287(1.16)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C65(0.84); C137(0.92); C149(1.04); C287(1.08)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C65(0.90); C137(0.98); C149(1.15)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C65(0.79); C137(0.94); C149(1.15); C287(0.99)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C65(0.97); C137(1.05); C149(0.96)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C65(0.98); C137(0.97); C287(0.95)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C65(0.79); C137(0.97)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C65(0.90); C137(1.06); C149(1.12); C62(1.00)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C65(0.97); C137(1.05); C287(1.03)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C65(0.88); C137(1.17); C149(1.06); C287(1.05)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C65(0.91); C137(1.20); C149(1.14); C287(1.02)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C65(0.84); C137(0.92); C149(1.08); C287(1.14)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C65(1.09); C137(1.08); C149(1.02); C287(1.04)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C65(0.86); C137(1.02); C149(1.04); C62(1.07)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C65(0.76); C137(1.00); C149(1.24)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C65(0.90); C137(1.14); C149(1.00); C287(1.06)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C65(0.95); C137(0.93); C287(0.93)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C65(0.69); C137(0.92); C287(0.86)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C65(0.91); C149(1.10); C287(0.98)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C65(0.88); C137(1.12); C287(1.00)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C65(0.89); C137(0.92); C79(1.02); C286(0.98)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C65(0.94); C137(1.11); C149(1.20)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C65(0.92); C149(1.09); C287(1.00)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C65(0.89); C137(1.05); C287(0.98)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C65(0.90); C137(0.96); C79(0.93); C286(0.99)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C65(0.84); C137(0.99); C149(1.13)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C65(0.80); C149(1.08); C287(1.12)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C65(0.95); C137(1.16); C287(0.91)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C65(0.65); C137(1.36); C149(0.99); C287(1.11)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C65(0.82); C137(0.98); C79(0.92); C286(0.91)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C65(0.89); C137(0.88); C149(1.20)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C65(0.89); C149(1.15); C287(1.08)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C65(0.87); C137(1.08); C287(0.99)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C65(0.89); C137(0.99); C79(0.99); C286(1.09)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C65(0.93); C137(1.00); C149(1.14)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C65(0.78); C149(1.18); C287(1.14)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C65(0.85); C137(1.17); C287(0.98)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C65(0.92); C137(0.98); C79(1.10); C286(1.10)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C65(0.87); C137(1.03); C149(1.15)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C65(0.87); C137(0.77); C149(0.86); C287(1.04)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C65(0.92); C149(1.12); C287(1.02)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C65(0.88); C137(1.04); C287(1.00)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C65(0.86); C137(1.02); C79(0.99); C286(1.07)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C65(0.76); C137(0.85); C149(0.97)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C65(1.02); C149(1.11); C287(1.10)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C65(0.96); C137(1.10); C287(1.03)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C65(0.95); C137(1.05); C79(0.91); C286(1.09)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C65(0.93); C137(0.96); C149(1.16)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C65(0.84); C149(1.16); C287(1.05)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C65(0.84); C137(0.80); C287(0.97)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C65(0.93); C137(1.00); C79(1.14); C286(1.04)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C65(0.86); C137(0.95); C149(1.09)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C65(0.95); C149(1.28); C287(1.07)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C65(0.72); C137(0.93); C149(1.11)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C65(0.83); C137(1.00); C149(1.23); C287(1.13)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C65(0.78); C137(1.26); C149(1.07)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C65(0.96); C137(1.02); C79(1.05); C286(1.13)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C65(0.74); C137(1.09)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C65(0.78); C137(0.91); C149(0.88); C62(1.12)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C65(0.78); C137(0.95); C287(0.97)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C65(0.72); C137(1.10); C149(1.02); C287(1.27)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C65(0.81); C137(0.39); C149(0.78); C287(1.20)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C65(0.77); C137(1.36); C287(0.85)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C65(0.86); C137(1.06); C79(1.03); C286(1.15)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C65(0.86); C137(1.07); C149(1.16)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C65(0.62); C149(1.14); C287(0.97)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C65(0.65); C137(0.80); C149(1.12)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C65(0.88); C137(0.97); C149(1.19)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C65(0.73); C137(0.85); C149(1.14); C287(1.18)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C65(0.79); C137(0.83); C149(0.86)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C65(0.81); C137(0.93)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C65(0.64); C137(0.83); C149(0.80); C62(1.03)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C65(0.79); C137(0.93); C287(0.82)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C65(0.63); C137(1.03); C149(0.97); C287(1.16)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C65(0.71); C137(0.89); C149(0.75); C287(1.06)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C65(0.81); C137(1.05); C287(0.86)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C65(0.81); C137(0.96); C149(1.05)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C65(0.92); C149(1.05); C287(1.01)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C65(0.83); C149(1.20); C287(0.88)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C65(0.72); C137(0.89); C149(1.19)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C65(0.79); C137(1.03); C149(1.06); C287(0.98)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C65(1.03); C137(1.05); C149(0.97)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C65(0.86); C137(1.00)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C65(0.75); C137(1.03); C149(0.82); C62(0.88)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C65(0.91); C137(1.00); C287(1.00)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C65(0.74); C137(1.05); C149(0.96); C287(1.05)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C65(0.88); C137(0.76); C149(0.68); C287(1.18)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C65(0.76); C137(1.15); C287(0.89)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C65(0.78); C137(0.98); C149(1.12)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C65(0.79); C137(0.96); C79(1.04); C286(1.01)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C65(0.78); C149(1.13); C287(1.12)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C65(0.71); C137(0.69); C149(1.27)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C65(0.65); C137(0.62); C149(1.13); C287(0.91)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C65(0.86); C137(0.80); C149(0.97)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C65(0.84); C137(0.83)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C65(0.69); C137(0.93); C149(0.85); C62(1.26)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C65(0.70); C137(0.82); C287(0.95)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C65(0.65); C137(0.91); C149(0.97); C287(1.06)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C65(0.84); C137(0.90); C149(1.14); C287(0.90)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C65(0.81); C137(1.05); C149(0.76); C287(1.06)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C65(0.93); C137(1.15); C287(0.98)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C65(0.91); C137(1.00); C79(0.96); C286(1.04)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C65(0.83); C137(1.02); C149(1.19)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C65(0.80); C149(1.13); C287(1.05)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C65(0.76); C137(0.93); C149(1.21)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C65(0.73); C137(0.89); C149(1.18); C287(1.10)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C65(0.89); C137(0.92); C149(0.91)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C65(0.77); C137(0.97)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C65(0.80); C137(1.05); C149(0.82); C62(1.08)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C65(0.90); C137(1.11); C149(0.95)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C65(0.89); C137(1.02); C287(1.21)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C65(0.65); C137(1.07); C149(0.90); C287(1.16)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C65(0.79); C137(1.12); C149(0.84); C287(1.07)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C65(0.94); C137(1.04); C287(1.01)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C65(0.96); C137(1.00); C79(0.98); C286(1.05)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C65(0.71); C149(1.33); C287(0.91)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C65(0.67); C137(0.93); C149(1.15)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C65(0.66); C137(1.15); C149(1.11); C287(0.97)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C65(0.87); C137(1.16); C149(0.97)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C65(0.70); C137(0.77)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C65(0.90); C137(1.02)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C65(0.78); C137(1.04); C149(0.86); C62(1.12)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C65(0.90); C137(1.06); C287(0.96)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C65(0.57); C137(1.07); C149(0.95); C287(1.20)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C65(0.81); C137(1.13); C149(0.78); C287(1.15)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C65(0.97); C137(1.02); C287(0.88)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C65(0.90); C137(1.02); C79(0.98); C286(1.12)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C65(0.96); C137(1.13); C149(1.08)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C65(0.93); C149(1.21); C287(1.00)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C65(0.87); C137(1.08); C149(1.31)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C65(0.78); C137(1.17); C149(0.87); C62(1.12)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C65(0.74); C137(0.97); C149(0.91); C287(1.01)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C65(0.89); C137(0.95); C149(0.94)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C65(0.81); C137(0.98)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C65(0.88); C137(1.29); C149(0.90); C62(0.98)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C65(0.78); C137(1.12); C287(1.04)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C65(0.71); C137(0.89); C149(0.85); C287(1.10)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C65(0.96); C137(0.77); C149(0.87); C287(1.01)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C65(0.90); C137(1.03); C287(0.90)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C65(0.85); C137(0.94); C79(0.95); C286(1.02)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C65(0.87); C137(0.91); C149(1.05)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C65(0.83); C137(1.00); C149(1.09)  LDD1698  [7]
 LDCM0572  Fragment10 Ramos C137(1.07)  LDD2189  [8]
 LDCM0574  Fragment12 Ramos C137(1.11)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C137(0.90)  LDD2192  [8]
 LDCM0580  Fragment21 Ramos C137(0.88)  LDD2195  [8]
 LDCM0578  Fragment27 Ramos C137(1.39)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C137(0.43)  LDD2198  [8]
 LDCM0590  Fragment32 Ramos C137(0.86)  LDD2201  [8]
 LDCM0468  Fragment33 HEK-293T C65(0.87); C137(0.96); C149(1.07)  LDD1671  [7]
 LDCM0596  Fragment38 Ramos C137(1.12)  LDD2203  [8]
 LDCM0427  Fragment51 HEK-293T C65(1.08); C137(0.99); C79(1.02); C286(0.95)  LDD1631  [7]
 LDCM0614  Fragment56 Ramos C137(1.48)  LDD2205  [8]
 LDCM0571  Fragment9 Ramos C137(0.94)  LDD2188  [8]
 LDCM0022  KB02 HEK-293T C137(0.97); C65(1.15); C149(1.04)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C65(49.02)  LDD0209  [2]
 LDCM0024  KB05 IGR37 C66(1.40)  LDD3314  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-8 (CASP8) Peptidase C14A family Q14790
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Amyloid protein-binding protein 2 (APPBP2) . Q92624
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840