Details of the Target

General Information of Target

Target ID LDTP09846
Target Name DNA repair and recombination protein RAD54-like (RAD54L)
Gene Name RAD54L
Gene ID 8438
Synonyms
RAD54A; DNA repair and recombination protein RAD54-like; EC 3.6.4.12; RAD54 homolog; hHR54; hRAD54
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANP
DFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRL
PEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSS
WHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAD
PQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVW
LCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEK
STVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRAT
YLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPP
ALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNL
QGNPLCQAVGILEQLAELLPSVSSVLT
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family
Subcellular location
Nucleus
Function
Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks . Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.
Uniprot ID
Q92698
Ensemble ID
ENST00000371975.9
HGNC ID
HGNC:9826
ChEMBL ID
CHEMBL2146297

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C578(12.00)  LDD1704  [1]
DBIA
 Probe Info  		C578(11.37)  LDD0080  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]
Compound 11
 Probe Info  		N.A.  LDD2213  [3]
IPM
 Probe Info  		C578(0.00); C64(0.00)  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C207(1.15); C644(1.06); C295(1.04)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C413(1.11); C414(1.11); C709(1.40)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C709(1.08)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C709(1.08)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C709(0.96)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C709(1.07)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C709(0.93)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C709(0.93)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C709(0.81)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C709(0.96)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C709(0.80)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C709(0.84)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C413(0.89); C414(0.89); C709(1.17)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C709(1.17)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C709(1.67)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C709(1.39)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C709(1.79)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C709(1.37)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C709(1.25)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C709(1.32)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C709(1.30)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C709(1.48)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C709(0.92)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C413(1.09); C414(1.09); C709(1.20)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C709(1.21)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C709(1.13)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C709(1.06)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C709(1.22)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C709(1.02)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C709(1.25)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C709(1.19)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C709(1.22)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C413(0.92); C414(0.92)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C413(0.83); C414(0.83)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C413(0.76); C414(0.76)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C413(1.01); C414(1.01)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C413(0.93); C414(0.93)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C413(0.99); C414(0.99)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C413(1.07); C414(1.07)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C413(1.07); C414(1.07)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C413(0.95); C414(0.95)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C413(1.00); C414(1.00)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C413(1.05); C414(1.05)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C413(0.93); C414(0.93)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C413(0.86); C414(0.86); C709(1.22)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C413(1.02); C414(1.02)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C413(1.05); C414(1.05)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C413(0.97); C414(0.97)  LDD0860  [2]
 LDCM0270  AC15 HEK-293T C413(1.20); C414(1.20); C709(1.02)  LDD0868  [2]
 LDCM0276  AC17 HEK-293T C207(1.03); C644(1.10); C295(0.92)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C578(1.01); C207(1.06)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C578(1.09); C207(1.28); C457(1.09)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C578(1.04); C207(1.00)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C578(0.97); C207(0.91)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C578(1.04); C207(1.00); C644(1.26)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C578(1.01); C207(1.02); C457(1.16); C644(1.15)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C578(1.01); C207(0.99); C644(1.12)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C578(0.87); C207(1.02); C295(1.09); C64(1.17)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C207(1.02); C644(1.14); C295(1.02)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C578(1.03); C207(1.03)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C578(1.00); C207(1.02); C457(1.01)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C578(1.00); C207(1.03)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C578(0.97); C207(0.96); C644(0.97)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C578(1.01); C207(1.14); C457(1.01)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C578(1.13); C207(1.01); C457(1.02); C644(1.10)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C578(1.05); C207(0.93); C644(0.81)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C578(0.94); C207(1.01); C295(1.15); C64(1.03)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C207(1.00); C644(1.23); C295(0.92)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C578(1.07); C207(0.94)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C413(0.88); C414(0.88)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C413(1.13); C414(1.13)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C413(1.24); C414(1.24)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C413(0.93); C414(0.93)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C413(0.91); C414(0.91)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C578(1.06); C207(1.04)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C413(1.12); C414(1.12)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C413(1.03); C414(1.03)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C413(1.03); C414(1.03)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C413(0.87); C414(0.87)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C413(1.20); C414(1.20)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C413(0.95); C414(0.95)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C578(1.15); C207(1.06); C457(1.04); C644(1.20)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C578(1.04); C207(1.00); C644(1.01)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C578(1.05); C207(1.07); C295(0.96); C64(1.16)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C207(0.97); C644(1.05); C295(1.02)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C578(0.93); C207(0.97); C644(1.01)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C578(1.07); C207(1.08)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C578(1.06); C207(1.10); C457(1.01)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C578(1.04); C207(0.98)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C578(1.04); C207(0.94); C644(1.02)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C578(1.01); C207(1.04); C457(1.07); C644(1.34)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C578(1.17); C207(1.05); C644(0.88)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C578(1.04); C207(0.97); C295(1.04); C64(1.06)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C207(1.13); C644(1.09); C295(1.06)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C578(1.07); C207(0.91)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C578(0.98); C207(1.10); C457(1.13)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C413(1.06); C414(1.06); C709(1.11)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C578(1.02); C207(1.01)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C578(0.96); C207(1.04); C644(1.07)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C578(1.07); C207(1.07); C457(1.05); C644(1.24)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C578(1.09); C207(1.05); C644(0.87)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C578(0.95); C207(0.98); C295(1.20); C64(1.00)  LDD1567  [7]
 LDCM0332  AC68 HEK-293T C413(0.95); C414(0.95)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C413(0.97); C414(0.97)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C413(1.10); C414(1.10); C709(1.39)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C413(1.23); C414(1.23)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C413(1.23); C414(1.23)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C413(1.05); C414(1.05)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C413(1.11); C414(1.11)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C413(1.49); C414(1.49)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C413(1.11); C414(1.11)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C413(1.13); C414(1.13)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C413(1.13); C414(1.13)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C413(0.99); C414(0.99)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C413(1.31); C414(1.31)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C413(0.96); C414(0.96); C709(0.92)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C413(0.97); C414(0.97)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C413(1.05); C414(1.05)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C413(0.99); C414(0.99)  LDD0946  [2]
 LDCM0365  AC98 HEK-293T C709(0.89)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C709(0.80)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C413(1.03); C414(1.03); C709(1.12)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C413(1.05); C414(1.05); C709(1.23)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C413(0.87); C414(0.87); C709(1.28)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C578(1.28)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C578(1.31)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C578(1.03); C207(1.03); C457(0.98); C644(0.99)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C413(0.97); C414(0.97); C709(0.91)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C413(1.07); C414(1.07); C709(1.09)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C413(1.00); C414(1.00); C709(1.35)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C413(1.09); C414(1.09); C709(1.37)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C578(1.04); C207(1.12); C457(1.02)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C578(1.11); C207(1.17); C457(0.91); C644(0.98)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C578(1.03); C207(1.00); C644(1.08)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C578(1.05); C207(0.97); C457(1.12); C644(1.15)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C578(1.10); C207(1.27); C457(0.96)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C578(1.07)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C578(1.28); C207(1.20); C457(0.97); C644(1.06)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C578(1.01); C207(1.24); C644(0.93)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C578(1.11); C207(0.98); C457(0.97); C644(1.24)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C578(1.05); C207(0.90); C457(0.92)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C578(1.46); C207(1.13); C457(0.93); C644(0.95)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C578(1.08); C207(1.09); C644(1.05)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C578(1.07); C207(0.94); C457(0.95); C644(0.96)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C413(1.19); C414(1.19)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C413(1.38); C414(1.38)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C413(1.21); C414(1.21)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C578(0.96)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C413(1.00); C414(1.00)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C578(1.14); C207(0.80); C457(0.95)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C578(1.15); C207(1.12); C457(0.97); C644(1.04)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C578(1.23); C207(0.95); C644(0.96)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C578(1.09); C207(1.10); C457(1.02); C644(1.03)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C578(1.04); C207(0.97); C457(1.05)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C578(1.13); C207(1.19); C457(0.97); C644(1.01)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C578(1.12); C207(1.21); C644(0.97)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C578(1.02); C207(1.01); C457(1.04); C644(1.03)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C578(0.80)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C578(1.16)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C578(0.76)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C578(2.80)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C578(1.28)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C578(1.12)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C578(1.34)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C578(1.34)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C578(1.20)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C578(0.85)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C578(1.25)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C578(0.92)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C578(1.32)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C578(0.99)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C578(1.24)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C578(1.04)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C578(1.03)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C578(1.24)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C578(1.49)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C578(1.03)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C578(1.94)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C578(1.95)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C578(1.13)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C578(0.94)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C578(1.02)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C578(0.89)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C578(1.05)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C578(1.18)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C578(0.94)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C578(0.78)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C578(1.02)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C578(0.87)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C578(0.80)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C578(1.01)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C578(0.99)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C413(0.89); C414(0.89); C578(1.76)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C413(0.96); C414(0.96); C578(1.55)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C413(0.90); C414(0.90); C578(1.59)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C413(0.92); C414(0.92); C578(1.03)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C578(1.07)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C413(0.78); C414(0.78); C578(0.95)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C413(0.81); C414(0.81); C578(0.73)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C413(0.59); C414(0.59); C578(0.94)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C413(0.70); C414(0.70); C578(1.10)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C413(0.50); C414(0.50); C578(0.84)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C413(0.84); C414(0.84); C578(0.81)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C413(0.97); C414(0.97); C578(1.14)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C413(1.13); C414(1.13); C578(1.06)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C413(1.05); C414(1.05); C578(0.68)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C413(0.90); C414(0.90); C578(0.78)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C578(0.98)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C413(0.84); C414(0.84); C578(1.16)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C413(1.21); C414(1.21); C709(0.83)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C413(0.97); C414(0.97); C709(0.83)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C413(1.04); C414(1.04); C709(1.12)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C413(1.46); C414(1.46); C709(0.78)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C413(1.09); C414(1.09); C709(1.08)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C413(1.17); C414(1.17); C709(1.00)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C413(1.14); C414(1.14); C709(0.99)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C413(1.09); C414(1.09); C709(0.78)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C413(1.24); C414(1.24); C709(0.90)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C578(1.20)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C413(1.27); C414(1.27); C709(0.93)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C413(1.34); C414(1.34); C709(0.97)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C413(1.11); C414(1.11); C709(0.88)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C413(0.99); C414(0.99); C709(1.09)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C413(1.08); C414(1.08); C709(1.12)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C578(1.06)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C578(0.95)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C578(2.32)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C578(1.04)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C578(1.36); C207(1.22)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C578(1.30)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C578(1.11)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C578(0.66)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C578(0.72)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C578(2.27)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C578(1.43)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C578(1.20)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C578(1.26)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C578(0.83)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C578(1.09)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C578(1.14); C207(1.00); C644(1.37)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C578(0.79)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C578(1.12); C207(1.17); C457(1.13)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C578(0.99); C207(0.86)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C578(1.11); C207(1.10); C644(1.41)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C578(1.14); C207(1.04); C457(1.13); C644(1.39)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C578(2.21); C207(1.12); C644(1.03)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C578(1.27); C207(1.04); C295(0.94); C64(0.84)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C578(1.16); C207(1.00); C457(0.91)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C578(1.25); C207(1.05); C457(0.84); C644(0.94)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C578(1.10); C207(1.18); C644(1.05)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C578(1.19); C207(0.96); C644(1.03)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C578(0.82)  LDD1702  [8]
 LDCM0468  Fragment33 HEK-293T C413(1.25); C414(1.25); C709(1.12)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C578(1.10)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C578(11.37)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C578(2.38)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C578(6.14)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761