General Information of Target

Target ID LDTP09656
Target Name Cytoglobin (CYGB)
Gene Name CYGB
Gene ID 114757
Synonyms
STAP; Cytoglobin; Histoglobin; HGb; Nitric oxygen dioxygenase CYGB; NOD; EC 1.14.12.-; Nitrite reductase CYGB; EC 1.7.-.-; Pseudoperoxidase CYGB; EC 1.11.1.-; Stellate cell activation-associated protein; Superoxide dismutase CYGB; EC 1.15.1.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFFVNFPSAKQYF
SQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVE
PVYFKILSGVILEVVAEEFASDFPPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATT
PPATLPSSGP
Target Bioclass
Enzyme
Family
Globin family
Subcellular location
Cytoplasm
Function
Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability . Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier.
Uniprot ID
Q8WWM9
Ensemble ID
ENST00000293230.10
HGNC ID
HGNC:16505

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C38(1.86)  LDD3332  [1]
HHS-482
 Probe Info 
Y123(1.13); Y159(1.66)  LDD0285  [2]
HHS-475
 Probe Info 
Y159(0.80); Y123(1.12)  LDD0264  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y159(0.80); Y123(1.12)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y159(0.66); Y123(0.97)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y159(0.75); Y123(1.33)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y159(1.29); Y123(1.31)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y159(0.60); Y123(1.14)  LDD0268  [3]
 LDCM0123  JWB131 DM93 Y123(1.13); Y159(1.66)  LDD0285  [2]
 LDCM0124  JWB142 DM93 Y123(1.24); Y159(3.24)  LDD0286  [2]
 LDCM0125  JWB146 DM93 Y123(1.29); Y159(1.00)  LDD0287  [2]
 LDCM0126  JWB150 DM93 Y123(3.71); Y159(3.80)  LDD0288  [2]
 LDCM0127  JWB152 DM93 Y123(2.34); Y159(3.29)  LDD0289  [2]
 LDCM0128  JWB198 DM93 Y123(0.95); Y159(1.63)  LDD0290  [2]
 LDCM0129  JWB202 DM93 Y123(0.92); Y159(0.52)  LDD0291  [2]
 LDCM0130  JWB211 DM93 Y123(1.51); Y159(0.98)  LDD0292  [2]
 LDCM0022  KB02 A2058 C38(1.37)  LDD2253  [1]
 LDCM0023  KB03 A2058 C38(2.22)  LDD2670  [1]
 LDCM0024  KB05 MKN45 C38(1.86)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) Aldo/keto reductase family O43488
Protein DDI1 homolog 1 (DDI1) DDI1 family Q8WTU0
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein LRATD1 (LRATD1) LRATD family Q96KN4
Mitotic-spindle organizing protein 1 (MZT1) MOZART1 family Q08AG7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.