Details of the Target

General Information of Target

Target ID LDTP09622
Target Name Cytoplasmic dynein 2 intermediate chain 1 (DYNC2I1)
Gene Name DYNC2I1
Gene ID 55112
Synonyms
WDR60; Cytoplasmic dynein 2 intermediate chain 1; Dynein 2 intermediate chain 1; WD repeat-containing protein 60
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDLPEHKEPRCRDP
DQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKD
REKEKDRRARKEELRQTVAHHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGD
EDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHREKSSTREKREKY
SKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNR
GASSKRDGTSSQHAENLVRNHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVEIEKEET
DLENARADAYTASCEDDFEDYEDDFEVCDGDDDESSNEPESREKLEELPLAQKKEIQEIQ
RAINAENERIGELSLKLFQKRGRTEFEKEPRTDTNSSPSRASVCGIFVDFASASHRQKSR
TQALKQKMRSTKLLRLIDLDFSFTFSLLDLPPVNEYDMYIRNFGKKNTKQAYVQCNEDNV
ERDIQTEEIETREVWTQHPGESTVVSGGSEQRDTSDAVVMPKIDTPRLCSFLRAACQVMA
VLLEEDRLAAEPSWNLRAQDRALYFSDSSSQLNTSLPFLQNRKVSSLHTSRVQRQMVVSV
HDLPEKSFVPLLDSKYVLCVWDIWQPSGPQKVLICESQVTCCCLSPLKAFLLFAGTAHGS
VVVWDLREDSRLHYSVTLSDGFWTFRTATFSTDGILTSVNHRSPLQAVEPISTSVHKKQS
FVLSPFSTQEEMSGLSFHIASLDESGVLNVWVVVELPKADIAGSISDLGLMPGGRVKLVH
SALIQLGDSLSHKGNEFWGTTQTLNVKFLPSDPNHFIIGTDMGLISHGTRQDLRVAPKLF
KPQQHGIRPVKVNVIDFSPFGEPIFLAGCSDGSIRLHQLSSAFPLLQWDSSTDSHAVTGL
QWSPTRPAVFLVQDDTSNIYIWDLLQSDLGPVAKQQVSPNRLVAMAAVGEPEKAGGSFLA
LVLARASGSIDIQHLKRRWAAPEVDECNRLRLLLQEALWPEGKLHK
Target Bioclass
Transporter and channel
Family
Dynein light intermediate chain family
Subcellular location
Cell projection, cilium
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella. Requires also to maintain a functional transition zone.
Uniprot ID
Q8WVS4
Ensemble ID
ENST00000407559.8
HGNC ID
HGNC:21862

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1047(4.17)  LDD0080  [1]
IA-alkyne
 Probe Info  		C589(0.00); C929(0.00); C535(0.00)  LDD0165  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C57(1.02); C596(1.01); C929(1.16); C535(1.16)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C596(0.90); C929(1.14); C535(0.91)  LDD1508  [7]
 LDCM0216  AC100 HEK-293T C1047(1.06)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C1047(1.04)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C1047(1.08)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C1047(1.14)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C1047(0.98)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C1047(1.13)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C1047(1.02)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C1047(0.97)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C1047(1.21)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C1047(1.10)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C57(1.03); C596(1.12); C929(0.91)  LDD1509  [7]
 LDCM0227  AC110 HEK-293T C1047(1.10)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C1047(1.18)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C1047(1.06)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C1047(1.17)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C1047(1.13)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C1047(0.99)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C1047(0.94)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C1047(1.17)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C1047(1.01)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C1047(1.53)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C596(1.15); C535(0.68)  LDD1510  [7]
 LDCM0238  AC120 HEK-293T C1047(1.02)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C1047(1.49)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C1047(1.38)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C1047(1.05)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C1047(1.56)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C1047(1.22)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C1047(2.07)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C1047(0.97)  LDD0843  [1]
 LDCM0259  AC14 HEK-293T C57(1.08); C596(1.17); C929(1.05); C535(1.54)  LDD1512  [7]
 LDCM0263  AC143 HEK-293T C1047(1.16)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C1047(1.10)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C1047(1.21)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C1047(1.10)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C1047(0.96)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C1047(1.11)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C1047(0.99)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C57(0.99); C596(1.13); C929(1.15); C535(0.98)  LDD1513  [7]
 LDCM0271  AC150 HEK-293T C1047(1.06)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C1047(1.17)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C1047(0.96)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C1047(0.99)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C1047(1.09)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C1047(1.21)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C1047(1.02)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C1047(0.94)  LDD2165  [1]
 LDCM0276  AC17 PaTu 8988t C1047(1.01)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C1047(1.09)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C1047(1.33)  LDD1157  [1]
 LDCM0279  AC2 HEK-293T C596(1.07); C929(1.29); C535(1.26)  LDD1518  [7]
 LDCM0280  AC20 PaTu 8988t C1047(1.11)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C1047(0.90)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C1047(1.06)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C1047(1.49)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C1047(1.11)  LDD1163  [1]
 LDCM0285  AC25 HEK-293T C1047(0.84)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C1047(0.79)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C1047(0.77)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C1047(0.77)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C1047(0.87)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C57(1.06); C596(0.99); C929(0.99)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C1047(0.82)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C1047(0.96)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C1047(0.85)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C1047(0.94)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C1047(0.89)  LDD0893  [1]
 LDCM0296  AC35 PaTu 8988t C1047(0.82)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C1047(1.75)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C1047(1.43)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C1047(1.47)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C1047(1.84)  LDD1179  [1]
 LDCM0301  AC4 HEK-293T C596(0.96); C535(0.91)  LDD1540  [7]
 LDCM0302  AC40 PaTu 8988t C1047(1.80)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C1047(1.86)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C1047(1.22)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C1047(1.20)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C1047(3.25)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C1047(1.53)  LDD1186  [1]
 LDCM0308  AC46 HEK-293T C57(1.02); C596(0.99); C929(0.90); C535(1.20)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C57(1.04); C596(1.02); C929(1.13); C535(1.00)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C596(1.03); C535(1.09)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C57(1.08); C596(1.02); C929(1.02); C535(1.15)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C57(0.97); C596(1.25); C929(0.94); C535(0.80)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C596(1.07); C929(1.08); C535(1.10)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C57(0.99); C596(1.06); C929(1.04)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C596(0.92); C535(1.08)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C57(1.06); C596(1.01); C929(1.05); C535(0.86)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C57(1.11); C596(0.95); C929(1.11); C535(1.27)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C57(1.02); C596(1.01); C929(1.25); C535(0.98)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C596(0.93); C535(1.13)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C57(1.02); C596(0.98); C929(1.12); C535(1.14)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C596(0.94); C929(1.27); C535(0.97)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C57(1.01); C596(1.17); C929(0.98)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C57(1.01); C596(0.98); C929(0.96); C535(1.47)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C596(0.94); C535(0.70)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C57(1.05); C596(1.18); C929(0.94); C535(1.00)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C57(1.05); C596(0.94); C929(0.97); C535(1.15)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C57(0.99); C596(1.04); C929(0.91); C535(0.92)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C596(1.07); C535(1.18)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C57(0.98); C596(1.04); C929(1.00); C535(0.88)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C596(0.99); C535(0.95)  LDD1569  [7]
 LDCM0349  AC83 HEK-293T C1047(0.85)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C1047(1.00)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C1047(0.94)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C1047(0.95)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C1047(1.11)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C1047(0.92)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C1047(0.97)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C1047(0.90)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C1047(1.01)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C1047(1.00)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C1047(0.71)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C1047(0.92)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C1047(1.05)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C1047(0.88)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C1047(1.00)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C1047(1.07)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C1047(0.97)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C57(1.05); C596(1.32); C929(0.94); C535(1.28)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C57(1.09); C596(0.99); C929(1.05); C535(1.44)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C596(1.03); C535(0.99)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C1047(0.95)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C1047(0.83)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C596(0.80); C929(1.10)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C57(1.03); C596(1.03); C929(1.30)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C57(0.99); C596(1.05); C929(1.01)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C57(1.02); C596(1.05); C929(1.04); C679(1.01)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C596(1.05); C929(0.87)  LDD1577  [7]
 LDCM0374  CL105 PaTu 8988t C1047(1.10)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C1047(1.33)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C1047(0.90)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C1047(1.01)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C1047(1.10)  LDD1257  [1]
 LDCM0379  CL11 HEK-293T C1047(1.05)  LDD0977  [1]
 LDCM0380  CL110 PaTu 8988t C1047(1.50)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C1047(1.37)  LDD1260  [1]
 LDCM0382  CL112 HEK-293T C1047(0.65)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C1047(1.00)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C1047(1.07)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C1047(0.78)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C1047(1.16)  LDD0984  [1]
 LDCM0387  CL117 PaTu 8988t C1047(1.17)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C1047(1.27)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C1047(1.60)  LDD1268  [1]
 LDCM0390  CL12 HEK-293T C1047(1.30)  LDD0988  [1]
 LDCM0391  CL120 PaTu 8988t C1047(0.81)  LDD1270  [1]
 LDCM0392  CL121 HEK-293T C57(1.08); C596(0.90); C929(1.11)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C57(1.02); C596(1.10); C929(1.03)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C57(0.90); C596(1.02); C929(1.06); C679(1.13)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C596(0.89); C929(0.79)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C57(1.09); C596(0.95); C929(1.30)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C57(0.99); C596(1.13); C929(1.26)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C57(1.01); C596(0.93); C929(1.03); C679(1.14)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C596(0.94); C929(0.78)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C1047(0.95)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C1047(1.07)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C1047(1.19)  LDD1000  [1]
 LDCM0403  CL16 PaTu 8988t C1047(1.31)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C1047(2.36)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C1047(1.87)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C1047(1.24)  LDD1285  [1]
 LDCM0407  CL2 HEK-293T C1047(1.08)  LDD1005  [1]
 LDCM0408  CL20 PaTu 8988t C1047(1.19)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C1047(4.26)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C1047(1.62)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C1047(1.30)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C1047(1.07)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C1047(2.00)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C1047(1.60)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C1047(1.13)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C1047(2.73)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C1047(1.54)  LDD1296  [1]
 LDCM0418  CL3 HEK-293T C1047(0.84)  LDD1016  [1]
 LDCM0419  CL30 PaTu 8988t C1047(1.33)  LDD1298  [1]
 LDCM0420  CL31 HEK-293T C57(0.97); C596(1.12); C929(0.94)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C596(0.98); C535(0.78)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C57(0.88); C596(1.32); C929(1.10); C535(0.63)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C57(1.02); C596(1.11); C929(0.93); C535(0.68)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C57(0.98); C596(1.31); C929(1.03); C535(0.79)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C596(1.29); C535(0.82)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C57(1.00); C596(1.22); C929(1.33)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C57(0.94); C596(1.20); C929(0.97); C679(0.98)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C1047(0.92)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C596(0.91); C929(0.79)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C57(0.98); C596(0.95); C929(1.01); C535(1.29)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C596(1.32); C929(1.17); C535(1.09)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C57(1.02); C596(1.38); C929(0.85)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C596(0.99); C535(0.82)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C57(1.00); C596(1.06); C929(1.08); C535(0.67)  LDD1639  [7]
 LDCM0436  CL46 PaTu 8988t C1047(0.98)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C1047(1.06)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C1047(1.11)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C1047(1.32)  LDD1318  [1]
 LDCM0440  CL5 HEK-293T C1047(0.81)  LDD1038  [1]
 LDCM0441  CL50 PaTu 8988t C1047(1.23)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C1047(1.59)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C1047(1.54)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C1047(1.96)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C1047(1.46)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C1047(1.22)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C1047(1.54)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C1047(1.36)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C1047(1.49)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C1047(1.12)  LDD1329  [1]
 LDCM0451  CL6 HEK-293T C1047(0.91)  LDD1049  [1]
 LDCM0452  CL60 PaTu 8988t C1047(1.22)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C1047(0.98)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C1047(0.93)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C1047(0.86)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C1047(1.31)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C1047(1.38)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C1047(0.91)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C1047(1.43)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C1047(1.35)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C1047(1.58)  LDD1340  [1]
 LDCM0462  CL7 HEK-293T C1047(0.80)  LDD1060  [1]
 LDCM0463  CL70 PaTu 8988t C1047(1.52)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C1047(0.95)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C1047(0.96)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C1047(1.36)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C1047(0.96)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C1047(1.01)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C1047(0.91)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C1047(0.86)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C1047(0.80)  LDD1351  [1]
 LDCM0473  CL8 HEK-293T C1047(0.70)  LDD1071  [1]
 LDCM0474  CL80 PaTu 8988t C1047(1.13)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C1047(0.98)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C1047(0.99)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C1047(1.20)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C1047(1.38)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C1047(0.95)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C1047(0.99)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C1047(1.29)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C1047(1.05)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C1047(1.03)  LDD1362  [1]
 LDCM0484  CL9 HEK-293T C1047(0.83)  LDD1082  [1]
 LDCM0485  CL90 PaTu 8988t C1047(1.36)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C57(1.04); C596(1.04); C929(1.11)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C596(0.93); C535(0.96)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C57(0.96); C596(1.54); C929(1.14); C535(0.74)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C57(1.03); C596(1.15); C929(0.99); C535(0.90)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C57(0.92); C596(0.90); C929(1.38); C535(0.83)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C596(1.21); C535(0.85)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C57(1.01); C596(0.89); C929(1.00)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C57(0.97); C596(1.00); C929(1.13)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C57(1.05); C596(0.96); C929(1.01); C679(1.00)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C57(1.05); C596(1.22); C929(0.96); C679(1.13)  LDD1698  [7]
 LDCM0468  Fragment33 PaTu 8988t C1047(1.19)  LDD1347  [1]
 LDCM0427  Fragment51 HEK-293T C57(0.92); C596(1.07); C929(1.22)  LDD1631  [7]
 LDCM0022  KB02 HCT 116 C1047(4.17)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C1047(2.12)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C1047(2.64)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear migration protein nudC (NUDC) NudC family Q9Y266

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402