Details of the Target

General Information of Target

Target ID LDTP09604
Target Name RNA polymerase-associated protein LEO1 (LEO1)
Gene Name LEO1
Gene ID 123169
Synonyms
RDL; RNA polymerase-associated protein LEO1; Replicative senescence down-regulated leo1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE
LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG
HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD
DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE
EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS
DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV
EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI
RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ
GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE
ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE
ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE
EEEDDD
Target Bioclass
Enzyme
Family
LEO1 family
Subcellular location
Nucleus
Function
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
Uniprot ID
Q8WVC0
Ensemble ID
ENST00000299601.10
HGNC ID
HGNC:30401

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R285Q DBIA    Probe Info 
IGROV1 SNV: p.R574Ter DBIA    Probe Info 
MFE319 SNV: p.S88P DBIA    Probe Info 
MOLT4 SNV: p.S127C .
NCIH1299 SNV: p.S151G .
NCIH1793 SNV: p.Q153H .
NCIH1975 SNV: p.P636S .
OVK18 SNV: p.E89V; p.P528H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.05  LDD0402  [1]
STPyne
 Probe Info  		K488(5.75)  LDD0277  [2]
Probe 1
 Probe Info  		Y606(11.42)  LDD3495  [3]
BTD
 Probe Info  		C512(1.10)  LDD2123  [4]
AHL-Pu-1
 Probe Info  		C530(2.24)  LDD0169  [5]
DBIA
 Probe Info  		C530(9.70); C530(5.72)  LDD0209  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
N1
 Probe Info  		D172(0.00); D174(0.00)  LDD0245  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		N.A.  LDD0147  [13]
Phosphinate-6
 Probe Info  		C512(0.00); C530(0.00)  LDD0018  [14]
1c-yne
 Probe Info  		K364(0.00); K377(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
AOyne
 Probe Info  		13.10  LDD0443  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C530(2.24)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C530(1.47)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C530(1.11)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C530(0.91)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C530(0.71)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C530(0.63)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C530(0.89)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C530(0.93)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C530(1.13)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C530(1.57)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C530(1.23)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C530(0.94)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C530(1.04)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C530(0.89)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C530(0.89)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C530(0.82)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C530(1.19)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C530(1.08)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C530(0.96)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C530(1.02)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C530(0.89)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C530(1.28)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C530(0.96)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C530(0.94)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C530(0.83)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C530(1.01)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C530(1.01)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C530(0.99)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C530(0.91)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C530(0.85)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C530(0.72)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C530(0.95)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C530(1.25)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C530(0.85)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C530(0.99)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C530(1.14)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C530(0.91)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C530(1.00)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C530(0.97)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C530(0.88)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C530(0.97)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C530(0.89)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C530(1.19)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C530(1.10)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C530(1.06)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C530(1.07)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C530(0.94)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C530(0.96)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C530(0.90)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C530(0.95)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C530(0.90)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C530(1.40)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C530(1.19)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C530(1.34)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C530(1.14)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C530(1.29)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C530(1.30)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C530(1.30)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C530(1.00)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C530(1.37)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C530(1.06)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C530(1.08)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C530(1.07)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C530(1.03)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C530(0.73)  LDD1514  [18]
 LDCM0367  CL1 HEK-293T C530(0.98)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C530(0.22)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C530(1.21)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C530(1.29)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C530(0.94)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C530(0.76)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C530(1.08)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C530(1.17)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C530(0.91)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C530(0.85)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C530(1.09)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C530(1.25)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C530(0.44)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C530(0.95)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C530(0.80)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C530(1.00)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C530(0.97)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C530(1.05)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C530(0.93)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C530(0.93)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C530(1.30)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C530(1.14)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C530(0.79)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C530(0.22)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C530(1.00)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C530(1.34)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C530(1.02)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C530(0.97)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C530(1.12)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C530(1.99)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C530(1.83)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C530(1.45)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C530(1.72)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C530(1.34)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C530(0.68)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C530(0.58)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C530(0.66)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C530(0.59)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C530(0.49)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C530(0.39)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C530(0.63)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C530(0.26)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C530(0.36)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C530(0.18)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C530(0.41)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C530(0.21)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C530(1.54)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C530(0.81)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C530(0.70)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C530(0.71)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C530(0.68)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C530(0.65)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C530(0.55)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C530(0.38)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C530(0.32)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C530(0.40)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C530(0.21)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C530(0.39)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C530(0.21)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C530(1.54)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C530(0.69)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C530(0.94)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C530(0.70)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C530(0.70)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C530(0.77)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C530(0.41)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C530(0.35)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C530(0.53)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C530(0.22)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C530(0.44)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C530(0.29)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C530(1.64)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C530(0.89)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C530(0.71)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C530(0.70)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C530(0.69)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C530(0.60)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C530(0.40)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C530(0.32)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C530(0.52)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C530(0.22)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C530(0.44)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C530(0.78)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C530(0.22)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C530(1.87)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C530(1.10)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C530(0.80)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C530(0.76)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C530(0.81)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C530(0.72)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C530(0.47)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C530(0.33)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C530(0.48)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C530(0.57)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C530(0.24)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C530(0.48)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C530(0.24)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C530(1.76)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C530(1.30)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C530(0.98)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C530(0.90)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C530(0.71)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C530(0.55)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C530(0.46)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C530(0.41)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C530(0.56)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C530(0.31)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C530(0.53)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C530(0.37)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C530(1.57)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C530(2.77)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C530(1.69)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C530(1.99)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C530(1.37)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C530(0.47)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C530(1.15)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C530(0.92)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C530(0.64)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C530(0.63)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C530(0.40)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C530(0.71)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C530(0.99)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C530(1.42)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C530(1.07)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C530(1.24)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C530(0.76)  LDD1698  [18]
 LDCM0625  F8 Ramos C530(1.52)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C530(1.70)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C530(1.25)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C530(0.94)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C530(0.98)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C530(2.04)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C530(0.93)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C530(1.01)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C530(1.21)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C530(1.16)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C530(1.16)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C530(1.14)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C530(1.18)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C530(1.88)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C530(0.95)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C530(0.81)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C530(0.94)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C530(0.87)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C530(1.25)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C530(0.96)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C530(1.11)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C530(1.13)  LDD2188  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C530(1.23)  LDD1492  [18]
 LDCM0023  KB03 Jurkat C530(9.70); C530(5.72)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C530(1.57)  LDD3310  [20]
 LDCM0109  NEM HeLa N.A.  LDD0224  [16]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C512(1.10)  LDD2123  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C512(0.74)  LDD2136  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Parafibromin (CDC73) CDC73 family Q6P1J9
RNA polymerase II-associated factor 1 homolog (PAF1) PAF1 family Q8N7H5
Transcription elongation factor A protein 1 (TCEA1) TFS-II family P23193
Transcription elongation factor A protein 3 (TCEA3) TFS-II family O75764

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840