Details of the Target

General Information of Target

Target ID LDTP09384
Target Name Phosphatidylinositol 4-kinase type 2-beta (PI4K2B)
Gene Name PI4K2B
Gene ID 55300
Synonyms
Phosphatidylinositol 4-kinase type 2-beta; EC 2.7.1.67; Phosphatidylinositol 4-kinase type II-beta; PI4KII-BETA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAG
DEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVG
IFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCL
IPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKV
GRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYII
RNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAY
PFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSV
MRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSS
W
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family, Type II PI4K subfamily
Subcellular location
Cytoplasm, cytosol
Function
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
Uniprot ID
Q8TCG2
Ensemble ID
ENST00000264864.8
HGNC ID
HGNC:18215
ChEMBL ID
CHEMBL3220

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.82  LDD0402  [1]
DBIA
 Probe Info  		C446(1.39)  LDD3310  [2]
IA-alkyne
 Probe Info  		C446(9.39)  LDD1704  [3]
ATP probe
 Probe Info  		K161(0.00); K164(0.00); K168(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		8.22  LDD1850  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C446(0.97)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C446(0.99)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C446(0.89)  LDD1509  [10]
 LDCM0230  AC113 PaTu 8988t C446(0.84)  LDD1109  [11]
 LDCM0231  AC114 PaTu 8988t C446(0.92)  LDD1110  [11]
 LDCM0232  AC115 PaTu 8988t C446(1.07)  LDD1111  [11]
 LDCM0233  AC116 PaTu 8988t C446(0.84)  LDD1112  [11]
 LDCM0234  AC117 PaTu 8988t C446(0.92)  LDD1113  [11]
 LDCM0235  AC118 PaTu 8988t C446(1.04)  LDD1114  [11]
 LDCM0236  AC119 PaTu 8988t C446(1.05)  LDD1115  [11]
 LDCM0237  AC12 HEK-293T C446(0.75)  LDD1510  [10]
 LDCM0238  AC120 PaTu 8988t C446(0.92)  LDD1117  [11]
 LDCM0239  AC121 PaTu 8988t C446(0.90)  LDD1118  [11]
 LDCM0240  AC122 PaTu 8988t C446(0.77)  LDD1119  [11]
 LDCM0241  AC123 PaTu 8988t C446(0.89)  LDD1120  [11]
 LDCM0242  AC124 PaTu 8988t C446(1.04)  LDD1121  [11]
 LDCM0243  AC125 PaTu 8988t C446(1.08)  LDD1122  [11]
 LDCM0244  AC126 PaTu 8988t C446(0.86)  LDD1123  [11]
 LDCM0245  AC127 PaTu 8988t C446(0.83)  LDD1124  [11]
 LDCM0259  AC14 HEK-293T C446(0.76)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C446(0.89); C179(1.00)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C446(1.06)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C446(0.63)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C446(0.95)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C446(0.90)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C446(0.75)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C446(0.94)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C446(0.70)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C446(0.83); C179(0.96)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C446(1.04)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C446(1.16)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C446(0.99)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C446(1.01)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C446(0.97)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C446(1.01)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C446(0.94)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C446(1.28)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C446(0.75); C179(0.94)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C446(0.88)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C446(0.85)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C446(0.80)  LDD1534  [10]
 LDCM0296  AC35 PaTu 8988t C446(1.15)  LDD1175  [11]
 LDCM0297  AC36 PaTu 8988t C446(1.38)  LDD1176  [11]
 LDCM0298  AC37 PaTu 8988t C446(1.10)  LDD1177  [11]
 LDCM0299  AC38 PaTu 8988t C446(1.33)  LDD1178  [11]
 LDCM0300  AC39 PaTu 8988t C446(1.40)  LDD1179  [11]
 LDCM0301  AC4 HEK-293T C446(0.85)  LDD1540  [10]
 LDCM0302  AC40 PaTu 8988t C446(1.26)  LDD1181  [11]
 LDCM0303  AC41 PaTu 8988t C446(1.20)  LDD1182  [11]
 LDCM0304  AC42 PaTu 8988t C446(1.14)  LDD1183  [11]
 LDCM0305  AC43 PaTu 8988t C446(1.03)  LDD1184  [11]
 LDCM0306  AC44 PaTu 8988t C446(1.22)  LDD1185  [11]
 LDCM0307  AC45 PaTu 8988t C446(1.11)  LDD1186  [11]
 LDCM0308  AC46 PaTu 8988t C446(0.84)  LDD1187  [11]
 LDCM0309  AC47 PaTu 8988t C446(0.89)  LDD1188  [11]
 LDCM0310  AC48 PaTu 8988t C446(0.86)  LDD1189  [11]
 LDCM0311  AC49 PaTu 8988t C446(0.83)  LDD1190  [11]
 LDCM0312  AC5 HEK-293T C446(0.89)  LDD1551  [10]
 LDCM0313  AC50 PaTu 8988t C446(1.05)  LDD1192  [11]
 LDCM0314  AC51 PaTu 8988t C446(0.86)  LDD1193  [11]
 LDCM0315  AC52 PaTu 8988t C446(0.92)  LDD1194  [11]
 LDCM0316  AC53 PaTu 8988t C446(1.05)  LDD1195  [11]
 LDCM0317  AC54 PaTu 8988t C446(1.17)  LDD1196  [11]
 LDCM0318  AC55 PaTu 8988t C446(1.05)  LDD1197  [11]
 LDCM0319  AC56 PaTu 8988t C446(0.93)  LDD1198  [11]
 LDCM0320  AC57 HEK-293T C446(0.93)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C446(1.04)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C446(0.96)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C446(0.89)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C446(0.83)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C446(0.98)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C446(0.91)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C446(0.86); C179(0.89)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C446(0.93)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C446(0.87); C179(1.03)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C446(0.79)  LDD1569  [10]
 LDCM0349  AC83 PaTu 8988t C446(0.92)  LDD1228  [11]
 LDCM0350  AC84 PaTu 8988t C446(1.06)  LDD1229  [11]
 LDCM0351  AC85 PaTu 8988t C446(0.90)  LDD1230  [11]
 LDCM0352  AC86 PaTu 8988t C446(1.05)  LDD1231  [11]
 LDCM0353  AC87 PaTu 8988t C446(0.89)  LDD1232  [11]
 LDCM0354  AC88 PaTu 8988t C446(1.02)  LDD1233  [11]
 LDCM0355  AC89 PaTu 8988t C446(0.96)  LDD1234  [11]
 LDCM0357  AC90 PaTu 8988t C446(1.13)  LDD1236  [11]
 LDCM0358  AC91 PaTu 8988t C446(0.88)  LDD1237  [11]
 LDCM0359  AC92 PaTu 8988t C446(0.89)  LDD1238  [11]
 LDCM0360  AC93 PaTu 8988t C446(0.97)  LDD1239  [11]
 LDCM0361  AC94 PaTu 8988t C446(0.91)  LDD1240  [11]
 LDCM0362  AC95 PaTu 8988t C446(0.94)  LDD1241  [11]
 LDCM0363  AC96 PaTu 8988t C446(0.92)  LDD1242  [11]
 LDCM0364  AC97 PaTu 8988t C446(0.94)  LDD1243  [11]
 LDCM0248  AKOS034007472 HEK-293T C446(0.88)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C446(0.85)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C446(0.82)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 11.74  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C446(1.07)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C446(1.00)  LDD1572  [10]
 LDCM0370  CL101 HEK-293T C446(0.88)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C446(0.77); C179(1.09)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C446(1.01)  LDD1576  [10]
 LDCM0374  CL105 HEK-293T C446(0.45)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C446(1.32); C179(1.10)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C446(1.04)  LDD1580  [10]
 LDCM0378  CL109 HEK-293T C446(0.91)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C446(0.71); C179(1.11)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C446(0.28); C179(1.06)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C446(1.24)  LDD1585  [10]
 LDCM0383  CL113 HEK-293T C446(0.70)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C446(0.84); C179(1.08)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C446(0.99)  LDD1589  [10]
 LDCM0387  CL117 PaTu 8988t C446(1.09)  LDD1266  [11]
 LDCM0388  CL118 PaTu 8988t C446(0.84)  LDD1267  [11]
 LDCM0389  CL119 PaTu 8988t C446(1.18)  LDD1268  [11]
 LDCM0390  CL12 HEK-293T C446(0.84)  LDD1594  [10]
 LDCM0391  CL120 PaTu 8988t C446(1.23)  LDD1270  [11]
 LDCM0392  CL121 PaTu 8988t C446(0.98)  LDD1271  [11]
 LDCM0393  CL122 PaTu 8988t C446(0.87)  LDD1272  [11]
 LDCM0394  CL123 PaTu 8988t C446(1.46)  LDD1273  [11]
 LDCM0395  CL124 PaTu 8988t C446(0.89)  LDD1274  [11]
 LDCM0396  CL125 HEK-293T C446(0.92)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C446(1.06); C179(0.93)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C446(1.11)  LDD1602  [10]
 LDCM0400  CL13 HEK-293T C446(1.01)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C446(2.45); C179(1.31)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C446(0.90)  LDD1606  [10]
 LDCM0404  CL17 HEK-293T C446(0.88)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C446(1.00)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C446(1.02)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C446(1.31); C179(0.99)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C446(0.88)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C446(0.94)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C446(0.98)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C446(0.76); C179(0.98)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C446(0.74)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C446(1.26)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C446(1.28); C179(1.32)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C446(1.19)  LDD1619  [10]
 LDCM0417  CL29 HEK-293T C446(0.90)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C446(1.12)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C446(0.70)  LDD1623  [10]
 LDCM0420  CL31 PaTu 8988t C446(1.30)  LDD1299  [11]
 LDCM0421  CL32 PaTu 8988t C446(1.13)  LDD1300  [11]
 LDCM0422  CL33 PaTu 8988t C446(1.83)  LDD1301  [11]
 LDCM0423  CL34 PaTu 8988t C446(1.49)  LDD1302  [11]
 LDCM0424  CL35 PaTu 8988t C446(1.28)  LDD1303  [11]
 LDCM0425  CL36 PaTu 8988t C446(0.67)  LDD1304  [11]
 LDCM0426  CL37 PaTu 8988t C446(1.43)  LDD1305  [11]
 LDCM0428  CL39 PaTu 8988t C446(1.48)  LDD1307  [11]
 LDCM0430  CL40 PaTu 8988t C446(1.33)  LDD1309  [11]
 LDCM0431  CL41 PaTu 8988t C446(1.37)  LDD1310  [11]
 LDCM0432  CL42 PaTu 8988t C446(1.20)  LDD1311  [11]
 LDCM0433  CL43 PaTu 8988t C446(1.33)  LDD1312  [11]
 LDCM0434  CL44 PaTu 8988t C446(1.37)  LDD1313  [11]
 LDCM0435  CL45 PaTu 8988t C446(1.84)  LDD1314  [11]
 LDCM0436  CL46 PaTu 8988t C446(1.20)  LDD1315  [11]
 LDCM0437  CL47 PaTu 8988t C446(1.21)  LDD1316  [11]
 LDCM0438  CL48 PaTu 8988t C446(1.22)  LDD1317  [11]
 LDCM0439  CL49 PaTu 8988t C446(1.22)  LDD1318  [11]
 LDCM0440  CL5 HEK-293T C446(1.00)  LDD1644  [10]
 LDCM0441  CL50 PaTu 8988t C446(1.25)  LDD1320  [11]
 LDCM0442  CL51 PaTu 8988t C446(1.47)  LDD1321  [11]
 LDCM0443  CL52 PaTu 8988t C446(1.32)  LDD1322  [11]
 LDCM0444  CL53 PaTu 8988t C446(1.44)  LDD1323  [11]
 LDCM0445  CL54 PaTu 8988t C446(1.08)  LDD1324  [11]
 LDCM0446  CL55 PaTu 8988t C446(1.16)  LDD1325  [11]
 LDCM0447  CL56 PaTu 8988t C446(1.25)  LDD1326  [11]
 LDCM0448  CL57 PaTu 8988t C446(1.33)  LDD1327  [11]
 LDCM0449  CL58 PaTu 8988t C446(1.25)  LDD1328  [11]
 LDCM0450  CL59 PaTu 8988t C446(1.22)  LDD1329  [11]
 LDCM0451  CL6 HEK-293T C446(0.81)  LDD1654  [10]
 LDCM0452  CL60 PaTu 8988t C446(1.26)  LDD1331  [11]
 LDCM0453  CL61 PaTu 8988t C446(0.89)  LDD1332  [11]
 LDCM0454  CL62 PaTu 8988t C446(1.15)  LDD1333  [11]
 LDCM0455  CL63 PaTu 8988t C446(1.15)  LDD1334  [11]
 LDCM0456  CL64 PaTu 8988t C446(1.41)  LDD1335  [11]
 LDCM0457  CL65 PaTu 8988t C446(1.19)  LDD1336  [11]
 LDCM0458  CL66 PaTu 8988t C446(1.23)  LDD1337  [11]
 LDCM0459  CL67 PaTu 8988t C446(1.47)  LDD1338  [11]
 LDCM0460  CL68 PaTu 8988t C446(1.41)  LDD1339  [11]
 LDCM0461  CL69 PaTu 8988t C446(1.47)  LDD1340  [11]
 LDCM0462  CL7 HEK-293T C446(0.97)  LDD1665  [10]
 LDCM0463  CL70 PaTu 8988t C446(1.10)  LDD1342  [11]
 LDCM0464  CL71 PaTu 8988t C446(1.11)  LDD1343  [11]
 LDCM0465  CL72 PaTu 8988t C446(1.09)  LDD1344  [11]
 LDCM0466  CL73 PaTu 8988t C446(1.60)  LDD1345  [11]
 LDCM0467  CL74 PaTu 8988t C446(1.17)  LDD1346  [11]
 LDCM0470  CL77 HEK-293T C446(0.92)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C446(0.97)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C446(1.00)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C446(0.74)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C446(0.99)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C446(0.84)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C446(0.93)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C446(0.71); C179(1.07)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C446(0.45)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C446(0.66)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C446(1.22); C179(1.30)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C446(1.16)  LDD1684  [10]
 LDCM0483  CL89 HEK-293T C446(1.12)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C446(0.94)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C446(0.92)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C446(1.00)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C446(0.65)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C446(0.83)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C446(0.89)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C446(0.82); C179(0.72)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C446(1.07)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C446(0.90)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C446(1.12); C179(1.47)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C446(0.99)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C446(1.10)  LDD1698  [10]
 LDCM0625  F8 Ramos C473(0.67)  LDD2187  [12]
 LDCM0573  Fragment11 Ramos C473(1.07)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C473(0.63)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C473(0.55)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C473(0.80)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C473(0.59)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C473(0.53)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C473(0.67)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C473(1.49)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C473(0.96)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C473(0.77)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C473(0.60)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C473(0.57)  LDD2201  [12]
 LDCM0468  Fragment33 PaTu 8988t C446(1.22)  LDD1347  [11]
 LDCM0596  Fragment38 Ramos C473(1.38)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C473(0.73)  LDD2184  [12]
 LDCM0427  Fragment51 PaTu 8988t C446(1.52)  LDD1306  [11]
 LDCM0610  Fragment52 Ramos C473(1.09)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C473(0.57)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C473(0.83)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C473(0.60)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C446(1.03)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C446(1.03)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C446(1.39)  LDD3310  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Resveratrol Small molecular drug DB02709

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578