Details of the Target

General Information of Target

Target ID LDTP09315
Target Name Nuclear protein localization protein 4 homolog (NPLOC4)
Gene Name NPLOC4
Gene ID 55666
Synonyms
KIAA1499; NPL4; Nuclear protein localization protein 4 homolog; Protein NPL4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASS
NKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGK
IYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKF
VALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDF
WRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIA
AKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPD
GHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQY
VPDVFYKDVDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLG
ETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELA
QTWKRSEQWATIEQLCSTVGGQLPGLHEYGAVGGSTHTATAAMWACQHCTFMNQPGTGHC
EMCSLPRT
Target Bioclass
Transporter and channel
Family
NPL4 family
Subcellular location
Cytoplasm, cytosol
Function
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.
Uniprot ID
Q8TAT6
Ensemble ID
ENST00000331134.11
HGNC ID
HGNC:18261

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Y447C DBIA    Probe Info 
CHL1 SNV: p.S115N DBIA    Probe Info 
HCT15 SNV: p.A540T DBIA    Probe Info 
HT SNV: p.I204V DBIA    Probe Info 
JURKAT SNV: p.E3K .
LNCaP clone FGC SNV: p.P95Q DBIA    Probe Info 
MFE319 SNV: p.S187N
Substitution: p.G193F		 DBIA    Probe Info 
MOLT4 SNV: p.P595S IA-alkyne    Probe Info 
SKMM2 SNV: p.A34P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K116(8.71); K16(1.61); K31(4.55); K52(0.74)  LDD0277  [1]
Probe 1
 Probe Info  		Y411(25.36); Y426(15.37)  LDD3495  [2]
DBIA
 Probe Info  		C188(1.82); C391(1.73); C355(2.77)  LDD3311  [3]
BTD
 Probe Info  		C355(0.75)  LDD2089  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C208(0.00); C188(0.00); C391(0.00); C341(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C208(0.00); C188(0.00); C391(0.00); C399(0.00)  LDD0037  [6]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
NHS
 Probe Info  		N.A.  LDD0010  [9]
TFBX
 Probe Info  		C188(0.00); C355(0.00); C208(0.00)  LDD0148  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		C188(0.00); C130(0.00)  LDD0236  [13]
NAIA_5
 Probe Info  		C208(0.00); C188(0.00); C403(0.00); C355(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C130(0.89)  LDD2095  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C355(0.75); C188(1.00)  LDD2117  [4]
 LDCM0214  AC1 HEK-293T C130(1.14); C208(0.87); C188(0.80); C391(1.05)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C130(0.98); C208(0.94); C188(1.00); C391(1.03)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C130(0.96); C208(1.09); C188(0.91); C341(0.80)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C130(1.00); C208(1.04); C188(0.94); C341(0.87)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C130(0.92); C208(1.18); C188(1.00); C341(1.02)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C130(1.03); C208(1.01); C188(0.98); C391(1.00)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C130(0.92); C208(1.04); C188(0.92); C391(0.94)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C130(1.03); C208(0.95); C188(0.95); C391(0.66)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C130(0.86); C208(1.03); C188(0.83); C341(0.91)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C130(1.04); C208(0.93); C188(1.05); C391(0.87)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C130(1.04); C208(0.98); C188(0.98); C341(0.94)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C130(0.96); C208(1.07); C188(1.02); C391(1.09)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C130(1.09); C208(0.99); C188(0.95); C341(1.04)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C130(0.85); C208(0.96); C188(1.04); C391(1.29)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C130(0.94); C208(1.07); C188(1.09); C341(0.90)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C130(1.12); C208(0.92); C188(0.84); C391(0.94)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C130(0.92); C208(1.02); C188(1.00); C391(0.71)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C130(0.92); C208(1.06); C188(0.85); C341(0.81)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C130(0.97); C208(1.01); C188(0.96); C341(0.97)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C130(1.03); C208(1.13); C188(0.89); C391(1.16)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C130(1.02); C208(0.91); C188(0.81); C341(0.87)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C130(1.01); C208(1.00); C188(0.96); C341(1.06)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C130(0.97); C208(0.88); C188(1.03); C391(1.02)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C130(0.96); C208(1.16); C188(0.94); C341(0.89)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C130(0.89); C208(0.92); C188(0.80); C391(0.96)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C130(0.93); C208(1.02); C188(1.06); C391(0.78)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C130(1.04); C208(1.04); C188(0.88); C341(0.89)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C130(1.02); C208(1.00); C188(0.99); C341(0.94)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C130(1.02); C208(1.12); C188(1.02); C391(0.83)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C130(1.37); C208(1.06); C188(1.00); C341(1.11)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C130(1.06); C208(0.99); C188(1.04); C391(1.24)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C130(1.07); C208(0.88); C188(1.00); C341(0.98)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C130(0.82); C208(1.00); C188(1.02); C341(0.99)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C130(0.97); C208(1.03); C188(0.85); C391(1.14)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C130(0.93); C208(0.91); C188(0.93); C391(0.85)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C130(1.03); C208(1.04); C188(0.94); C341(0.90)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C130(1.00); C208(0.96); C188(1.07); C341(0.86)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C130(1.12); C208(1.07); C188(0.86); C391(0.95)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C130(1.00); C208(0.99); C188(0.97); C341(1.01)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C130(0.97); C208(0.91); C188(1.00); C391(1.03)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C130(1.12); C208(1.05); C188(1.09); C341(0.92)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C130(1.43); C208(0.97); C188(0.89); C391(1.02)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C130(0.97); C208(0.95); C188(1.01); C391(1.16)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C130(1.09); C208(0.89); C188(1.04); C391(0.93)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C130(1.00); C208(0.99); C188(0.99); C341(0.93)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C130(0.93); C208(0.92); C188(0.97); C341(0.96)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C130(0.97); C208(1.07); C188(1.03); C391(1.14)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C130(0.88); C208(1.06); C188(0.97); C341(1.08)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C130(1.07); C208(1.02); C188(1.04); C391(1.11)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C130(0.81); C208(1.07); C188(0.99); C341(0.86)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C130(1.09); C208(0.85); C188(0.93); C391(1.02)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C130(0.98); C208(0.91); C188(1.05); C391(0.89)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C130(0.99); C208(0.89); C188(0.89); C341(0.77)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C130(1.18); C208(0.92); C188(1.00); C341(0.96)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C130(1.01); C208(0.91); C188(0.90); C341(0.80)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C130(0.91); C208(0.94); C188(0.92); C391(0.87)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C130(0.96); C208(0.93); C188(0.99); C341(1.04)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C130(1.14); C208(0.92); C188(0.98); C391(1.02)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C130(0.95); C208(0.92); C188(1.03); C341(1.05)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C130(0.91); C208(0.89); C188(1.03); C391(1.02)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C130(1.09); C208(0.98); C188(1.00); C341(1.05)  LDD1569  [17]
 LDCM0545  Acetamide MDA-MB-231 C355(0.68)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C130(0.97); C208(1.08); C188(0.93); C391(0.94)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C130(0.76); C208(0.99); C188(0.81); C391(1.05)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C130(0.84); C208(1.01); C188(0.97); C341(1.04)  LDD1514  [17]
 LDCM0498  BS-3668 MDA-MB-231 C355(0.64)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C130(0.00); C355(0.00); H222(0.00); C188(0.00)  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C130(0.87); C208(0.99); C188(1.03); C341(1.02)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C130(0.78); C208(1.98); C188(0.85); C341(1.05)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C130(1.17); C208(0.91); C188(0.95); C194(0.95)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C130(1.02); C208(0.95); C188(0.98); C341(1.00)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C130(1.00); C208(0.99); C188(0.82); C194(0.95)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C130(1.09); C208(1.15); C188(0.96); C391(1.05)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C130(1.34); C208(1.01); C188(1.01); C194(1.05)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C130(0.95); C208(0.96); C188(0.94); C341(0.92)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C130(0.93); C208(0.98); C188(0.93); C194(0.90)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C130(1.02); C208(1.08); C188(1.04); C391(1.12)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C130(1.10); C208(1.01); C188(1.00); C194(1.07)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C130(1.15); C208(0.87); C188(0.97); C341(0.91)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C130(1.03); C208(0.83); C188(0.98); C391(1.22)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C130(0.89); C208(0.95); C188(0.86); C194(0.90)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C130(0.94); C208(1.00); C188(0.88); C391(1.06)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C130(1.08); C208(1.00); C188(0.94); C194(0.95)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C130(0.93); C208(0.98); C188(0.96); C341(0.94)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C130(1.00); C208(1.04); C188(0.91); C194(0.98)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C130(1.06); C208(1.10); C188(0.96); C391(1.06)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C130(1.11); C208(1.00); C188(0.94); C194(1.05)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C130(0.98); C208(0.99); C188(1.05); C341(0.98)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C130(1.18); C208(1.06); C188(0.96); C194(0.89)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C130(1.16); C208(1.13); C188(0.97); C391(1.15)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C130(1.10); C208(0.80); C188(1.06); C341(0.89)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C130(1.14); C208(0.97); C188(0.94); C194(1.03)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C130(1.14); C208(0.95); C188(0.97); C341(0.90)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C130(1.05); C208(1.00); C188(0.96); C194(0.97)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C130(1.06); C208(0.96); C188(0.90); C391(1.07)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C130(1.09); C208(1.05); C188(0.93); C194(1.01)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C130(1.40); C208(0.81); C188(0.99); C341(0.95)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C130(0.98); C208(0.76); C188(0.95); C194(0.97)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C130(1.21); C208(0.81); C188(1.01); C391(1.07)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C130(1.16); C208(1.07); C188(0.95); C194(1.02)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C130(1.04); C208(0.95); C188(0.95); C341(1.07)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C130(1.03); C208(1.13); C188(0.97); C194(1.01)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C130(0.94); C208(1.04); C188(0.89); C391(1.17)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C130(1.04); C208(1.13); C188(0.96); C194(1.08)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C130(0.71); C208(0.97); C188(0.79); C391(1.00)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C130(0.98); C208(1.40); C188(1.04); C391(1.02)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C130(0.96); C208(1.74); C188(0.88); C341(0.84)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C130(0.91); C208(1.01); C188(0.91); C194(0.97)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C130(0.99); C208(0.95); C188(0.98); C341(1.02)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C130(0.86); C208(1.94); C188(0.80); C391(0.97)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C130(0.95); C208(2.30); C188(0.96); C341(1.20)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C130(1.02); C208(0.98); C188(1.02); C391(1.12)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C130(0.98); C208(0.96); C188(1.05); C341(1.00)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C130(1.51); C208(0.80); C188(0.88); C341(0.99)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C130(1.18); C208(1.02); C188(0.95); C194(1.05)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C130(0.97); C208(1.21); C188(0.96); C391(1.00)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C130(1.11); C208(0.99); C188(0.98); C194(0.89)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C130(0.98); C208(1.20); C188(0.89); C391(1.10)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C130(1.01); C208(1.09); C188(0.91); C391(1.24)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C130(1.01); C208(1.29); C188(1.05); C391(0.99)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C130(0.98); C208(1.70); C188(0.86); C341(0.87)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C130(1.03); C208(1.04); C188(0.99); C341(1.02)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C130(0.83); C208(1.68); C188(0.83); C391(0.92)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C130(1.00); C208(2.39); C188(0.98); C341(1.09)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C130(1.10); C208(0.94); C188(0.97); C391(1.03)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C130(0.97); C208(1.04); C188(0.99); C341(0.74)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C130(1.03); C208(0.84); C188(1.04); C341(0.92)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C130(0.96); C208(1.14); C188(0.88); C391(1.07)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C130(1.12); C208(1.10); C188(0.88); C194(1.07)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C130(1.20); C208(1.05); C188(0.99); C194(0.99)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C130(0.97); C208(1.08); C188(0.80); C391(1.18)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C130(1.05); C208(1.35); C188(1.05); C391(0.94)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C130(0.98); C208(1.65); C188(0.93); C341(0.98)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C130(0.98); C208(1.08); C188(0.97); C341(1.04)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C130(0.83); C208(1.81); C188(0.83); C391(0.91)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C130(0.90); C208(2.30); C188(0.97); C341(1.04)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C130(0.97); C208(0.93); C188(0.97); C391(1.11)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C130(1.15); C208(0.97); C188(1.01); C341(1.01)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C130(1.20); C208(0.86); C188(0.96); C341(1.09)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C130(0.99); C208(1.02); C188(0.88); C391(1.10)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C130(0.93); C208(1.06); C188(0.84); C194(0.89)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C130(1.20); C208(0.99); C188(0.95); C194(0.89)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C130(1.43); C208(1.03); C188(0.84); C391(1.00)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C130(0.93); C208(1.29); C188(0.88); C391(0.70)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C130(0.98); C208(1.63); C188(0.97); C341(0.94)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C130(1.06); C208(0.88); C188(0.95); C341(1.02)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C130(0.91); C208(1.79); C188(0.81); C391(0.88)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C130(0.88); C208(2.42); C188(0.96); C341(1.13)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C130(1.03); C208(0.99); C188(1.00); C391(1.23)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C130(1.17); C208(1.13); C188(0.93); C391(0.81)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C130(1.09); C208(1.01); C188(0.95); C341(0.94)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C130(1.28); C208(0.81); C188(0.99); C341(1.03)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C130(1.06); C208(1.00); C188(0.95); C194(0.84)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C130(1.11); C208(1.10); C188(1.02); C391(0.90)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C130(1.12); C208(0.93); C188(0.87); C194(0.92)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C130(0.83); C208(1.04); C188(0.85); C391(0.85)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C130(0.92); C208(1.20); C188(0.93); C391(0.84)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C130(1.00); C208(1.57); C188(0.95); C341(0.95)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C130(1.05); C208(0.99); C188(0.99); C341(1.04)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C130(1.04); C208(2.02); C188(0.88); C391(1.14)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C130(1.09); C208(1.42); C188(0.99); C341(0.95)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C130(0.98); C208(2.14); C188(0.98); C341(1.16)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C130(1.07); C208(1.01); C188(0.99); C391(1.18)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C130(1.18); C208(1.03); C188(0.91); C341(1.05)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C130(1.41); C208(0.79); C188(1.00); C341(1.16)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C130(1.15); C208(0.97); C188(0.93); C194(0.87)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C130(1.29); C208(1.05); C188(0.92); C194(1.05)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C130(0.71); C208(0.95); C188(0.76); C391(1.18)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C130(1.03); C208(1.29); C188(1.02); C391(1.09)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C130(0.95); C208(1.45); C188(0.92); C341(0.96)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C130(0.80); C208(0.65); C188(0.71); C341(1.04)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C130(1.08); C208(1.03); C188(1.01); C341(0.93)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C130(0.96); C208(1.86); C188(0.90); C391(1.25)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C130(1.02); C208(1.78); C188(0.98); C341(1.03)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C130(0.99); C208(1.02); C188(0.97); C391(1.26)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C130(1.00); C208(0.97); C188(0.95); C341(0.86)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C130(2.66); C208(0.71); C188(1.02); C341(0.97)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C130(1.41); C208(0.77); C188(0.95); C194(1.02)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C130(1.27); C208(0.88); C188(0.96); C391(1.19)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C130(1.30); C208(1.06); C188(1.03); C194(0.95)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C130(0.87); C208(0.91); C188(0.83); C391(1.20)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C130(0.92); C208(1.79); C188(0.85); C391(0.76)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C130(0.93); C208(0.82); C188(0.81); C391(0.89)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C130(1.09); C208(1.16); C188(0.90); C341(1.03)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C130(1.04); C208(0.93); C188(0.83); C341(1.03)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C130(0.98); C208(1.51); C188(0.86); C391(1.09)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C130(1.10); C208(1.67); C188(0.99); C341(1.15)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C130(1.02); C208(0.71); C188(0.84); C391(0.91)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C130(1.44); C208(0.86); C188(0.91); C341(0.90)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C130(1.17); C208(0.88); C188(0.88); C341(0.91)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C130(0.98); C208(0.93); C188(0.93); C194(0.96)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C130(1.04); C208(0.91); C188(0.95); C391(0.84)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C130(1.14); C208(1.15); C188(0.96); C391(0.94)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C355(1.20); C188(1.08); C130(0.99)  LDD1702  [4]
 LDCM0625  F8 Ramos C188(1.11)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C188(1.02)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C188(2.81)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C188(1.01)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C188(0.81)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C188(0.57)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C188(0.82)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C188(1.09)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C188(0.89)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C188(1.06)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C188(0.55)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C188(0.86)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C188(1.04)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C188(0.81)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C130(1.06); C208(1.04); C188(0.98); C391(1.00)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C188(0.92)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C188(1.17)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C130(1.15); C208(1.07); C188(1.00); C194(0.88)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C188(0.99)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C188(0.96)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C188(0.76)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C188(0.92)  LDD2188  [18]
 LDCM0107  IAA HeLa C399(0.00); H222(0.00); H362(0.00)  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C130(0.99); C208(0.88); C188(0.99); C341(1.11)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C130(0.95); C208(1.05); C188(0.95); C341(1.15)  LDD1497  [17]
 LDCM0024  KB05 G361 C188(1.82); C391(1.73); C355(2.77)  LDD3311  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C355(0.95)  LDD2121  [4]
 LDCM0109  NEM HeLa H231(0.00); H222(0.00); H362(0.00)  LDD0223  [12]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C355(0.75)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C355(1.14)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C355(1.72)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C355(1.10)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C355(0.86)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C188(1.14)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C130(1.23); C188(1.15)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C355(0.81); C188(0.64)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C130(0.74); C205(0.72)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C355(1.94)  LDD2119  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C355(0.82)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C355(0.83); C188(1.10)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C355(0.93)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C355(0.40)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C355(1.16)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C355(0.85); C188(1.08)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C130(1.36); C355(0.80); C188(0.85)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C188(1.61)  LDD2144  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C355(1.41)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C130(0.58); C355(0.54)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 26B (VPS26B) VPS26 family Q4G0F5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1) UFD1 family Q92890

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578