Details of the Target

General Information of Target

Target ID LDTP09042
Target Name Protein unc-13 homolog C (UNC13C)
Gene Name UNC13C
Gene ID 440279
Synonyms
Protein unc-13 homolog C; Munc13-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFK
STVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQEL
SSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGA
LRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTH
DVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRR
ETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFA
QRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKG
IPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTS
KPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSD
FFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDS
PKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEW
NQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNS
SPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWH
SRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQST
ANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDE
QMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPV
EITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQ
VCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHV
FKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQ
DLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDF
VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIF
GNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLS
GEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSN
GGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAV
MSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREN
FPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDN
CHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQE
LNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKD
AVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQL
NQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNN
IQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQ
MSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELW
KLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEV
VLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSK
DAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRK
QGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIA
EKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA
Target Bioclass
Other
Family
Unc-13 family
Subcellular location
Cytoplasm
Function
May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses.
Uniprot ID
Q8NB66
Ensemble ID
ENST00000260323.16
HGNC ID
HGNC:23149

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1139(0.77); C1147(0.77)  LDD0533  [1]
CY4
 Probe Info  		T46(0.00); T50(0.00)  LDD0247  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C1139(0.77); C1147(0.77)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C1139(0.76); C1147(0.76)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C1139(0.61); C1147(0.61)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C1139(0.76); C1147(0.76)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C1139(0.43); C1147(0.43)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C1139(0.65); C1147(0.65)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C1139(0.65); C1147(0.65)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C1139(0.92); C1147(0.92)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C1139(0.59); C1147(0.59)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C1139(0.85); C1147(0.85)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C1139(0.62); C1147(0.62)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C1139(0.68); C1147(0.68)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C1139(0.61); C1147(0.61)  LDD0546  [1]
 LDCM0263  AC143 HCT 116 C1139(0.98); C1147(0.98)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C1139(1.04); C1147(1.04)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C1139(1.02); C1147(1.02)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C1139(0.99); C1147(0.99)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C1139(0.95); C1147(0.95)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C1139(1.00); C1147(1.00)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C1139(1.15); C1147(1.15)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C1139(0.99); C1147(0.99)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C1139(1.24); C1147(1.24)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C1139(0.72); C1147(0.72)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C1139(0.93); C1147(0.93)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C1139(1.11); C1147(1.11)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C1139(0.88); C1147(0.88)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C1139(1.74); C1147(1.74)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C1139(2.01); C1147(2.01)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C1139(0.99); C1147(0.99)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C1139(0.47); C1147(0.47)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C1139(0.80); C1147(0.80)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C1139(0.93); C1147(0.93)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C1139(1.05); C1147(1.05)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C1139(0.92); C1147(0.92)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C1139(0.79); C1147(0.79)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C1139(0.93); C1147(0.93)  LDD0601  [1]
 LDCM0296  AC35 HCT 116 C1139(0.75); C1147(0.75)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C1139(1.07); C1147(1.07)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C1139(1.13); C1147(1.13)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C1139(0.94); C1147(0.94)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C1139(0.79); C1147(0.79)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C1139(1.00); C1147(1.00)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C1139(1.05); C1147(1.05)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C1139(0.91); C1147(0.91)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C1139(0.90); C1147(0.90)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C1139(0.94); C1147(0.94)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C1139(0.97); C1147(0.97)  LDD0624  [1]
 LDCM0332  AC68 HCT 116 C1139(1.10); C1147(1.10)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C1139(1.15); C1147(1.15)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C1139(1.04); C1147(1.04)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C1139(1.33); C1147(1.33)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C1139(0.83); C1147(0.83)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C1139(1.21); C1147(1.21)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C1139(1.17); C1147(1.17)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C1139(1.24); C1147(1.24)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C1139(1.10); C1147(1.10)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C1139(1.26); C1147(1.26)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C1139(1.04); C1147(1.04)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C1139(1.18); C1147(1.18)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C1139(1.02); C1147(1.02)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C1139(0.98); C1147(0.98)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C1139(1.16); C1147(1.16)  LDD0665  [1]
 LDCM0365  AC98 HCT 116 C1139(0.50); C1147(0.50)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C1139(0.68); C1147(0.68)  LDD0683  [1]
 LDCM0367  CL1 HCT 116 C1139(1.36); C1147(1.36)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C1139(1.14); C1147(1.14)  LDD0685  [1]
 LDCM0374  CL105 HCT 116 C1139(0.71); C1147(0.71)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C1139(0.69); C1147(0.69)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C1139(0.63); C1147(0.63)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C1139(0.51); C1147(0.51)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C1139(0.78); C1147(0.78)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C1139(1.24); C1147(1.24)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C1139(0.69); C1147(0.69)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C1139(0.69); C1147(0.69)  LDD0698  [1]
 LDCM0387  CL117 HCT 116 C1139(1.02); C1147(1.02)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C1139(0.88); C1147(0.88)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C1139(0.71); C1147(0.71)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C1139(1.27); C1147(1.27)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C1139(0.97); C1147(0.97)  LDD0708  [1]
 LDCM0400  CL13 HCT 116 C1139(1.29); C1147(1.29)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C1139(1.64); C1147(1.64)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C1139(1.63); C1147(1.63)  LDD0719  [1]
 LDCM0407  CL2 HCT 116 C1139(1.36); C1147(1.36)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C1139(1.17); C1147(1.17)  LDD0735  [1]
 LDCM0420  CL31 HCT 116 C1139(0.93); C1147(0.93)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C1139(0.98); C1147(0.98)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C1139(0.89); C1147(0.89)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C1139(0.91); C1147(0.91)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C1139(0.99); C1147(0.99)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C1139(1.07); C1147(1.07)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C1139(1.17); C1147(1.17)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C1139(0.97); C1147(0.97)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C1139(1.29); C1147(1.29)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C1139(0.97); C1147(0.97)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C1139(0.91); C1147(0.91)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C1139(1.08); C1147(1.08)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C1139(1.01); C1147(1.01)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C1139(0.89); C1147(0.89)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C1139(0.93); C1147(0.93)  LDD0752  [1]
 LDCM0440  CL5 HCT 116 C1139(1.23); C1147(1.23)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C1139(1.21); C1147(1.21)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C1139(1.01); C1147(1.01)  LDD0779  [1]
 LDCM0473  CL8 HCT 116 C1139(1.13); C1147(1.13)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C1139(0.99); C1147(0.99)  LDD0801  [1]
 LDCM0427  Fragment51 HCT 116 C1139(1.16); C1147(1.16)  LDD0744  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.