Details of the Target

General Information of Target

Target ID LDTP09009
Target Name Protein SREK1IP1 (SREK1IP1)
Gene Name SREK1IP1
Gene ID 285672
Synonyms
P18SRP; SFRS12IP1; Protein SREK1IP1; SFRS12-interacting protein 1; SREK1-interacting protein 1; Splicing regulatory protein of 18 kDa; p18SRP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVPGCNKDSVRAGCKKCGYPGHLTFECRNFLRVDPKRDIVLDVSSTSSEDSDEENEELN
KLQALQEKRINEEEEKKKEKSKEKIKLKKKRKRSYSSSSTEEDTSKQKKQKYQKKEKKKE
KKSKSKKGKHHKKEKKKRKKEKHSSTPNSSEFSRK
Target Bioclass
Other
Function Possible splicing regulator involved in the control of cellular survival.
Uniprot ID
Q8N9Q2
Ensemble ID
ENST00000513458.9
HGNC ID
HGNC:26716

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C18(0.82); C28(0.82)  LDD0533  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
Phosphinate-6
 Probe Info  		C15(0.00); C6(0.00)  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C28(1.08)  LDD0812  [1]
 LDCM0216  AC100 HCT 116 C18(0.82); C28(0.82)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C18(0.97); C28(0.97)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C18(0.96); C28(0.96)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C18(1.35); C28(1.35)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C18(1.11); C28(1.11)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C18(0.96); C28(0.96)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C18(1.06); C28(1.06)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C18(1.06); C28(1.06)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C18(0.90); C28(0.90)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C18(0.86); C28(0.86)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C18(1.07); C28(1.07)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C18(0.92); C28(0.92)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C18(1.20); C28(1.20)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C18(1.00); C28(1.00)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C18(1.44); C28(1.44)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C18(1.31); C28(1.31)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C18(1.42); C28(1.42)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C18(1.36); C28(1.36)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C18(1.32); C28(1.32)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C18(1.45); C28(1.45)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C18(1.31); C28(1.31)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C18(1.32); C28(1.32)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C18(1.15); C28(1.15)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C18(1.15); C28(1.15)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C18(1.46); C28(1.46)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C18(1.29); C28(1.29)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C18(1.11); C28(1.11)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C18(1.20); C28(1.20)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C18(0.56); C28(0.56)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C18(0.50); C28(0.50)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C18(0.42); C28(0.42)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C18(0.64); C28(0.64)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C18(0.55); C28(0.55)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C18(0.71); C28(0.71)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C18(0.88); C28(0.88)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C18(0.66); C28(0.66)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C18(0.55); C28(0.55)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C18(0.59); C28(0.59)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C18(0.71); C28(0.71)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C18(0.82); C28(0.82)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C28(0.91)  LDD1512  [6]
 LDCM0260  AC140 HCT 116 C18(1.00); C28(1.00)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C18(0.83); C28(0.83)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C18(0.70); C28(0.70)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C18(0.96); C28(0.96)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C18(0.85); C28(0.85)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C18(0.92); C28(0.92)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C18(1.06); C28(1.06)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C18(0.95); C28(0.95)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C18(1.02); C28(1.02)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C18(1.17); C28(1.17)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C28(0.96)  LDD1513  [6]
 LDCM0271  AC150 HCT 116 C18(0.86); C28(0.86)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C18(1.00); C28(1.00)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C18(0.80); C28(0.80)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C18(0.94); C28(0.94)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C18(0.92); C28(0.92)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C18(0.95); C28(0.95)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C18(0.93); C28(0.93)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C18(0.82); C28(0.82)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C28(0.51)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C28(0.70)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C28(0.72)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C28(1.51)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C28(0.65)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C28(0.59)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C28(0.66)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C28(0.48)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C28(0.83)  LDD0882  [1]
 LDCM0289  AC29 HEK-293T C28(1.14)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C28(1.08)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C28(0.92)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C28(0.99)  LDD1531  [6]
 LDCM0298  AC37 HEK-293T C28(0.97)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C28(0.98)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C28(0.97)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C28(1.01)  LDD0899  [1]
 LDCM0307  AC45 HEK-293T C28(0.99)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C28(1.02)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C28(1.03)  LDD1548  [6]
 LDCM0312  AC5 HEK-293T C28(1.00)  LDD0910  [1]
 LDCM0316  AC53 HEK-293T C28(1.10)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C28(0.95)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C28(0.95)  LDD1557  [6]
 LDCM0323  AC6 HEK-293T C28(0.86)  LDD1562  [6]
 LDCM0325  AC61 HEK-293T C28(1.04)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C28(0.95)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C28(1.02)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C28(0.94)  LDD1568  [6]
 LDCM0365  AC98 HCT 116 C18(1.13); C28(1.13)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C18(0.99); C28(0.99)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C28(1.00)  LDD1511  [6]
 LDCM0367  CL1 HEK-293T C28(0.90)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C28(0.92)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C28(0.87)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C28(0.98)  LDD1574  [6]
 LDCM0374  CL105 HEK-293T C28(0.81)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C28(0.82)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C28(0.84)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C28(0.68)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C28(0.62)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C28(1.02)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C28(0.64)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C28(0.67)  LDD0979  [1]
 LDCM0383  CL113 HEK-293T C28(1.00)  LDD1587  [6]
 LDCM0387  CL117 HEK-293T C28(0.97)  LDD1591  [6]
 LDCM0392  CL121 HEK-293T C28(0.90)  LDD1596  [6]
 LDCM0396  CL125 HEK-293T C28(0.83)  LDD1600  [6]
 LDCM0400  CL13 HEK-293T C28(0.93)  LDD1604  [6]
 LDCM0409  CL21 HEK-293T C28(0.95)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C28(0.89)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C28(0.90)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C28(0.80)  LDD1617  [6]
 LDCM0420  CL31 HEK-293T C28(0.91)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C28(0.79)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C28(0.52)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C28(0.69)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C28(0.67)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C28(0.73)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C28(0.68)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C28(0.39)  LDD1026  [1]
 LDCM0430  CL40 HEK-293T C28(0.61)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C28(0.47)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C28(0.50)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C28(0.50)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C28(0.70)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C28(0.47)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C18(1.00); C28(1.00)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C18(0.93); C28(0.93)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C18(1.28); C28(1.28)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C18(1.07); C28(1.07)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C18(1.32); C28(1.32)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C18(1.29); C28(1.29)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C18(1.35); C28(1.35)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C18(1.23); C28(1.23)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C18(1.20); C28(1.20)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C18(1.22); C28(1.22)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C18(1.15); C28(1.15)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C18(1.10); C28(1.10)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C18(1.18); C28(1.18)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C18(1.12); C28(1.12)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C18(1.30); C28(1.30)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C28(1.12)  LDD1656  [6]
 LDCM0461  CL69 HEK-293T C28(1.04)  LDD1664  [6]
 LDCM0463  CL70 HEK-293T C28(0.96)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C28(1.04)  LDD1667  [6]
 LDCM0466  CL73 HEK-293T C28(0.91)  LDD1669  [6]
 LDCM0469  CL76 HEK-293T C28(0.98)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C28(0.86)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C28(0.89)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C28(0.88)  LDD1070  [1]
 LDCM0474  CL80 HEK-293T C28(1.03)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C28(0.94)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C28(0.87)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C28(0.79)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C28(0.92)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C28(0.93)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C28(0.99)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C28(0.98)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C28(1.08)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C28(0.84)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C28(0.94)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C28(0.82)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C28(1.35)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C28(1.15)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C28(1.24)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C28(1.31)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C28(1.61)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C28(1.08)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C28(1.87)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C28(1.25)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C28(1.26)  LDD1092  [1]
 LDCM0427  Fragment51 HEK-293T C28(0.65)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C28(1.00)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C28(0.93)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C28(0.93)  LDD1502  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ7
Phosphopantothenoylcysteine decarboxylase (PPCDC) HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily Q96CD2
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) Purine/pyrimidine phosphoribosyltransferase family P00492
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Cell growth-regulating nucleolar protein (LYAR) . Q9NX58
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cancer/testis antigen family 45 member A1 (CT45A1) CT45 family Q5HYN5
Cyclin-L1 (CCNL1) Cyclin family Q9UK58
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Fibroblast growth factor 10 (FGF10) Heparin-binding growth factors family O15520
Core histone macro-H2A.1 (MACROH2A1) Histone H2A family O75367
NKAP-like protein (NKAPL) NKAP family Q5M9Q1
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
General transcription factor IIH subunit 4 (GTF2H4) TFB2 family Q92759
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Elongin-A2 (ELOA2) . Q8IYF1
Proline-rich protein 13 (PRR13) . Q9NZ81
Protein SPMIP2 (SPMIP2) . Q96LM5
Retinitis pigmentosa 9 protein (RP9) . Q8TA86
RING finger protein 151 (RNF151) . Q2KHN1
SH3 and cysteine-rich domain-containing protein 3 (STAC3) . Q96MF2
Syntenin-2 (SDCBP2) . Q9H190
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402