Details of the Target

General Information of Target

Target ID LDTP09005
Target Name Transmembrane protein 102 (TMEM102)
Gene Name TMEM102
Gene ID 284114
Synonyms
Transmembrane protein 102; Common beta-chain associated protein; CBAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASAVWGSAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWSDGPKPGADL
LRAKDFVFSLLGLVHRRDPRFPPQAELLLLRGGIREGSLDLGHAPLGPYARGPHYDAGFT
LLVPMFSLDGTELQLDLESCYAQVCLPEMVCGTPIREMWQDCLGPPVPGARDSIHRTESE
ESSKDWQSSVDQPHSYVTEHEAPVSLEKSPSDVSASESPQHDVVDLGSTAPLKTMSSDVT
KAAVESPVPKPSEAREAWPTLCSAQVAAWFFATLAAVAESLIPVPGAPRLVHAARHAGFT
TVLLATPEPPRRLLLFDLIPVVSVAGWPEGARSHSWAGPLASESASFYLVPGGGTERPCA
SAWQLCFARQELALKARIPAPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLP
ALYLARPENAGACCLGLLDELGRVLEAGTLPHYFLNGRQLRTGDDSAALLGELARLRGDP
ARALRAAVEEAKVARKGGGLAGVGGGAH
Target Bioclass
Enzyme
Subcellular location
Cell membrane
Function Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.
Uniprot ID
Q8N9M5
Ensemble ID
ENST00000323206.2
HGNC ID
HGNC:26722

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
DBIA
 Probe Info  		C416(0.88)  LDD0532  [2]
AOyne
 Probe Info  		14.40  LDD0443  [3]
NAIA_5
 Probe Info  		C145(0.00); C140(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C416(0.88)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C416(0.84)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C416(1.05)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C416(0.98)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C416(0.88)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C416(1.07)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C416(1.03)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C416(0.98)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C416(0.82)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C416(0.96)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C416(0.90)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C416(1.04)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C416(1.24)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C416(1.10)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C416(1.32)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C416(1.21)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C416(1.21)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C416(1.14)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C416(0.91)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C416(0.93)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C416(1.02)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C416(0.98)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C416(1.12)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C416(1.10)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C416(0.96)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C416(1.11)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C416(0.97)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C416(1.00)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C416(0.92)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C416(1.07)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C416(0.94)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C416(0.97)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C416(0.93)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C416(1.01)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C416(0.79)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C416(0.61)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C416(0.78)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C416(0.65)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C416(0.67)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C416(0.71)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C416(0.68)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C416(0.86)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C416(0.69)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C416(0.75)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C416(0.60)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C416(0.71)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C416(0.64)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C416(0.64)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C416(0.84)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C416(0.84)  LDD2161  [2]
 LDCM0285  AC25 HCT 116 C416(0.69)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C416(0.67)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C416(0.73)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C416(0.58)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C416(0.68)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C416(0.75)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C416(0.58)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C416(0.54)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C416(0.58)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C416(0.58)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C416(1.05)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C416(0.94)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C416(1.14)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C416(1.06)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C416(1.00)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C416(0.92)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C416(0.97)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C416(1.03)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C416(1.01)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C416(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C416(0.97)  LDD0624  [2]
 LDCM0323  AC6 HCT 116 C416(0.97)  LDD0640  [2]
 LDCM0334  AC7 HCT 116 C416(0.92)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C416(0.93)  LDD0662  [2]
 LDCM0248  AKOS034007472 HCT 116 C416(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C416(0.97)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C416(0.84)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C416(1.02)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C416(0.96)  LDD0685  [2]
 LDCM0370  CL101 HCT 116 C416(0.84)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C416(1.02)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C416(1.04)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C416(0.98)  LDD0690  [2]
 LDCM0379  CL11 HCT 116 C416(0.88)  LDD0696  [2]
 LDCM0382  CL112 HCT 116 C416(0.91)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C416(0.55)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C416(0.74)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C416(0.67)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C416(0.67)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C416(1.12)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C416(0.98)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C416(0.97)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C416(0.98)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C416(1.01)  LDD0708  [2]
 LDCM0400  CL13 HCT 116 C416(0.88)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C416(1.12)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C416(0.94)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C416(0.99)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C416(0.87)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C416(0.70)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C416(0.84)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C416(1.00)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C416(0.87)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C416(0.86)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C416(1.00)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C416(0.87)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C416(0.81)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C416(0.78)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C416(0.85)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C416(0.79)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C416(0.75)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C416(0.83)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C416(0.88)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C416(0.78)  LDD0736  [2]
 LDCM0429  CL4 HCT 116 C416(0.93)  LDD0746  [2]
 LDCM0436  CL46 HCT 116 C416(0.81)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C416(0.84)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C416(0.81)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C416(1.00)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C416(0.88)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C416(0.88)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C416(0.74)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C416(0.85)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C416(0.87)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C416(0.96)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C416(0.97)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C416(0.90)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C416(0.79)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C416(0.83)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C416(1.04)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C416(0.94)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C416(0.78)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C416(0.87)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C416(0.85)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C416(0.84)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C416(0.92)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C416(0.99)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C416(0.84)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C416(0.81)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C416(0.82)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C416(0.80)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C416(0.90)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C416(0.79)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C416(0.76)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C416(0.90)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C416(0.92)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C416(0.89)  LDD0784  [2]
 LDCM0473  CL8 HCT 116 C416(0.96)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C416(0.98)  LDD0801  [2]
 LDCM0468  Fragment33 HCT 116 C416(0.88)  LDD0785  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 12 member 4 (SLC12A4) SLC12A transporter family Q9UP95

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264