Details of the Target

General Information of Target

Target ID LDTP08844
Target Name F-box/WD repeat-containing protein 8 (FBXW8)
Gene Name FBXW8
Gene ID 26259
Synonyms
FBW6; FBW8; FBX29; FBXO29; FBXW6; F-box/WD repeat-containing protein 8; F-box and WD-40 domain-containing protein 8; F-box only protein 29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLL
EGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLP
YELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLI
FQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTW
DYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDA
RIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVA
VAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLE
AGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSA
VQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRN
ADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions.
Uniprot ID
Q8N3Y1
Ensemble ID
ENST00000455858.2
HGNC ID
HGNC:13597

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE30 SNV: p.A92T .
NUGC3 SNV: p.D2Y .
RL952 SNV: p.A480V .
SW1271 SNV: p.W486Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K427(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C575(1.38)  LDD3382  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C160(0.57); C176(0.57)  LDD1093  [6]
 LDCM0215  AC10 PaTu 8988t C184(0.61); C176(0.72)  LDD1094  [6]
 LDCM0216  AC100 PaTu 8988t C160(1.05); C176(1.05)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C160(0.85); C176(0.85)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C160(0.74); C176(0.74)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C160(1.00); C176(1.00)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C160(0.55); C176(0.55)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C160(0.65); C176(0.65)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C160(0.80); C176(0.80)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C160(1.04); C176(1.04)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C160(0.77); C176(0.77)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C160(0.96); C176(0.96)  LDD1104  [6]
 LDCM0226  AC11 PaTu 8988t C184(0.56); C176(0.45)  LDD1105  [6]
 LDCM0227  AC110 PaTu 8988t C160(0.77); C176(0.77)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C160(0.46); C176(0.46)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C160(1.01); C176(1.01)  LDD1108  [6]
 LDCM0230  AC113 PaTu 8988t C184(1.40); C160(1.34); C176(1.21)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C184(0.86); C160(1.01); C176(0.90)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C184(1.04); C160(1.11); C176(1.04)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C184(1.14); C160(0.94); C176(0.97)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C184(1.46); C160(1.02); C176(0.92)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C184(0.73); C160(0.76); C176(0.77)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C184(0.73); C160(0.96); C176(0.94)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C184(0.58); C176(0.47)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C184(0.91); C160(1.19); C176(1.09)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C184(0.73); C160(0.95); C176(0.79)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C184(0.86); C160(0.90); C176(0.86)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C184(0.94); C160(1.04); C176(1.03)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C184(0.66); C160(1.03); C176(1.00)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C184(0.85); C160(0.90); C176(0.88)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C184(0.89); C160(1.16); C176(1.12)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C184(0.80); C160(0.95); C176(0.93)  LDD1124  [6]
 LDCM0259  AC14 PaTu 8988t C184(0.62); C176(0.41)  LDD1138  [6]
 LDCM0263  AC143 PaTu 8988t C184(0.85); C160(0.83); C176(0.83)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C184(0.89); C160(1.53); C176(1.53)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C184(0.86); C160(1.16); C176(1.16)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C184(0.68); C160(0.85); C176(0.85)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C184(0.83); C160(0.98); C176(0.98)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C184(0.73); C160(0.98); C176(0.98)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C184(0.70); C160(1.06); C176(1.06)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C184(0.63); C176(0.55)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C184(0.69); C160(0.88); C176(0.88)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C184(0.65); C160(1.15); C176(1.15)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C184(0.60); C160(0.88); C176(0.88)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C184(0.62); C160(0.88); C176(0.88)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C184(0.62); C160(0.86); C176(0.86)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C184(0.72); C160(0.76); C176(0.76)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C184(0.63); C160(0.68); C176(0.68)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C184(0.76); C160(1.17); C176(1.17)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C184(1.05); C160(0.92); C176(0.92)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C184(0.85); C160(0.66); C176(0.66)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C184(1.45); C160(0.85); C176(0.85)  LDD1157  [6]
 LDCM0279  AC2 PaTu 8988t C160(0.57); C176(0.57)  LDD1158  [6]
 LDCM0280  AC20 PaTu 8988t C184(1.09); C160(0.68); C176(0.68)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C184(1.08); C160(0.81); C176(0.81)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C184(0.92); C160(0.64); C176(0.64)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C184(0.71); C160(0.55); C176(0.55)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C184(0.71); C160(0.70); C176(0.70)  LDD1163  [6]
 LDCM0285  AC25 HEK-293T C184(0.91)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C184(1.04)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C184(1.09)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C184(0.75)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C184(1.22)  LDD0887  [6]
 LDCM0290  AC3 PaTu 8988t C160(0.69); C176(0.69)  LDD1169  [6]
 LDCM0291  AC30 HEK-293T C184(1.26)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C184(1.08)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C184(1.14)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C184(1.38)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C184(1.45)  LDD0893  [6]
 LDCM0296  AC35 PaTu 8988t C184(0.82)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C184(0.77)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C184(0.70)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C184(0.82)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C184(0.81)  LDD1179  [6]
 LDCM0301  AC4 PaTu 8988t C160(0.74); C176(0.74)  LDD1180  [6]
 LDCM0302  AC40 PaTu 8988t C184(0.69)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C184(0.90)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C184(0.92)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C184(0.87)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C184(0.90)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C184(0.85)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C184(0.96); C160(0.80); C176(0.80)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C184(0.76); C160(0.74); C176(0.74)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C184(0.72); C160(0.64); C176(0.64)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C184(0.69); C160(0.38); C176(0.38)  LDD1190  [6]
 LDCM0312  AC5 PaTu 8988t C160(0.47); C176(0.47)  LDD1191  [6]
 LDCM0313  AC50 PaTu 8988t C184(0.60); C160(0.38); C176(0.38)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C184(0.66); C160(0.12); C176(0.12)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C184(0.67); C160(0.60); C176(0.60)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C184(0.56); C160(0.38); C176(0.38)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C184(0.67); C160(0.40); C176(0.40)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C184(0.70); C160(0.50); C176(0.50)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C184(0.85); C160(0.47); C176(0.47)  LDD1198  [6]
 LDCM0320  AC57 PaTu 8988t C160(0.77); C176(0.77)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C160(0.94); C176(0.94)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C160(1.11); C176(1.11)  LDD1201  [6]
 LDCM0323  AC6 PaTu 8988t C184(0.81); C176(0.68)  LDD1202  [6]
 LDCM0324  AC60 PaTu 8988t C160(0.85); C176(0.85)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C160(0.90); C176(0.90)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C160(0.84); C176(0.84)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C160(0.86); C176(0.86)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C160(0.99); C176(0.99)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C160(1.16); C176(1.16)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C160(0.91); C176(0.91)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C160(0.84); C176(0.84)  LDD1210  [6]
 LDCM0332  AC68 PaTu 8988t C160(0.93); C176(0.93)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C160(0.91); C176(0.91)  LDD1212  [6]
 LDCM0334  AC7 PaTu 8988t C184(0.95); C176(0.54)  LDD1213  [6]
 LDCM0335  AC70 PaTu 8988t C160(0.81); C176(0.81)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C160(1.02); C176(1.02)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C160(1.05); C176(1.05)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C160(1.07); C176(1.07)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C160(0.88); C176(0.88)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C160(0.73); C176(0.73)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C160(0.89); C176(0.89)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C160(0.89); C176(0.89)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C160(0.91); C176(0.91)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C160(0.78); C176(0.78)  LDD1223  [6]
 LDCM0345  AC8 PaTu 8988t C184(0.74); C176(0.39)  LDD1224  [6]
 LDCM0346  AC80 PaTu 8988t C160(0.85); C176(0.85)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C160(0.81); C176(0.81)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C160(0.77); C176(0.77)  LDD1227  [6]
 LDCM0349  AC83 HEK-293T C184(0.79)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C184(0.98)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C184(0.86)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C184(0.70)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C184(0.67)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C184(0.96)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C184(1.58)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C184(1.60)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C184(1.36)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C184(0.86)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C184(1.05)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C184(1.24)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C184(0.91)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C184(1.06)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C184(2.54)  LDD0962  [6]
 LDCM0365  AC98 PaTu 8988t C160(0.72); C176(0.72)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C160(0.67); C176(0.67)  LDD1245  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C184(0.70); C176(0.53)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C184(0.64); C176(0.47)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C184(0.66); C176(0.64)  LDD1154  [6]
 LDCM0367  CL1 PaTu 8988t C184(0.87); C160(0.82); C176(0.82)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C184(0.55); C160(0.48); C176(0.48)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C160(0.74); C176(0.74)  LDD1248  [6]
 LDCM0370  CL101 PaTu 8988t C184(0.83); C176(0.47)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C184(0.79); C176(0.55)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C184(0.77); C176(0.57)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C184(0.58); C176(0.56)  LDD1252  [6]
 LDCM0374  CL105 PaTu 8988t C184(0.89); C160(0.85); C176(0.85)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C184(1.06); C160(0.87); C176(0.87)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C184(0.96); C160(1.01); C176(1.01)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C184(0.83); C160(0.91); C176(0.91)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C184(1.01); C160(0.72); C176(0.72)  LDD1257  [6]
 LDCM0379  CL11 PaTu 8988t C184(0.81); C160(0.79); C176(0.79)  LDD1258  [6]
 LDCM0380  CL110 PaTu 8988t C184(0.76); C160(0.69); C176(0.69)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C184(0.62); C160(0.58); C176(0.58)  LDD1260  [6]
 LDCM0382  CL112 HEK-293T C184(1.34)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C184(1.03)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C184(1.69)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C184(1.21)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C184(1.35)  LDD0984  [6]
 LDCM0387  CL117 PaTu 8988t C184(0.98)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C184(1.06)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C184(0.83)  LDD1268  [6]
 LDCM0390  CL12 PaTu 8988t C184(0.71); C160(0.65); C176(0.65)  LDD1269  [6]
 LDCM0391  CL120 PaTu 8988t C184(0.79)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C184(0.92); C160(0.74); C176(0.74)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C184(0.80); C160(0.59); C176(0.59)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C184(0.54); C160(0.49); C176(0.49)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C184(0.60); C160(0.42); C176(0.42)  LDD1274  [6]
 LDCM0396  CL125 PaTu 8988t C160(0.97); C176(0.97)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C160(0.91); C176(0.91)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C160(0.98); C176(0.98)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C160(0.84); C176(0.84)  LDD1278  [6]
 LDCM0400  CL13 PaTu 8988t C184(0.75); C160(0.62); C176(0.62)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C184(0.73); C160(0.73); C176(0.73)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C184(0.62); C160(0.54); C176(0.54)  LDD1281  [6]
 LDCM0403  CL16 HEK-293T C184(0.67)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C184(0.97)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C184(1.07)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C184(1.06)  LDD1004  [6]
 LDCM0407  CL2 PaTu 8988t C184(0.72); C160(0.57); C176(0.57)  LDD1286  [6]
 LDCM0408  CL20 HEK-293T C184(1.04)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C184(1.32)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C184(1.41)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C184(0.97)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C184(0.97)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C184(1.02)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C184(1.06)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C184(0.97)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C184(0.84)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C184(0.92)  LDD1015  [6]
 LDCM0418  CL3 PaTu 8988t C184(0.58); C160(0.54); C176(0.54)  LDD1297  [6]
 LDCM0419  CL30 HEK-293T C184(1.79)  LDD1017  [6]
 LDCM0420  CL31 PaTu 8988t C184(1.02); C160(0.86); C176(0.86)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C184(0.64); C160(0.66); C176(0.66)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C184(0.62); C160(0.59); C176(0.59)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C184(0.67); C160(0.62); C176(0.62)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C184(0.78); C160(0.63); C176(0.63)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C184(0.69); C160(0.44); C176(0.44)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C184(0.90); C160(0.61); C176(0.61)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C184(1.01); C160(0.61); C176(0.61)  LDD1307  [6]
 LDCM0429  CL4 PaTu 8988t C184(0.62); C160(0.55); C176(0.55)  LDD1308  [6]
 LDCM0430  CL40 PaTu 8988t C184(0.87); C160(0.68); C176(0.68)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C184(0.71); C160(0.60); C176(0.60)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C184(0.70); C160(0.61); C176(0.61)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C184(1.16); C160(0.68); C176(0.68)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C184(0.70); C160(0.45); C176(0.45)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C184(0.72); C160(0.56); C176(0.56)  LDD1314  [6]
 LDCM0436  CL46 HEK-293T C184(1.03)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C184(0.96)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C184(0.93)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C184(0.94)  LDD1037  [6]
 LDCM0440  CL5 PaTu 8988t C184(0.61); C160(0.57); C176(0.57)  LDD1319  [6]
 LDCM0441  CL50 HEK-293T C184(1.58)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C184(1.40)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C184(0.63)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C184(0.92)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C184(1.09)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C184(1.46)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C184(1.08)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C184(1.32)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C184(1.43)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C184(1.59)  LDD1048  [6]
 LDCM0451  CL6 PaTu 8988t C184(0.58); C160(0.49); C176(0.49)  LDD1330  [6]
 LDCM0452  CL60 HEK-293T C184(1.70)  LDD1050  [6]
 LDCM0453  CL61 PaTu 8988t C184(0.91); C160(0.80); C176(0.89)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C184(0.93); C160(0.82); C176(0.82)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C184(0.97); C160(0.82); C176(1.10)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C184(0.68); C160(0.73); C176(0.78)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C184(0.87); C160(0.75); C176(0.95)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C184(0.72); C160(0.68); C176(0.73)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C184(0.75); C160(0.60); C176(0.71)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C184(0.78); C160(0.62); C176(0.65)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C184(0.68); C160(0.54); C176(0.61)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C184(0.61); C160(0.62); C176(0.62)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C184(0.79); C160(0.62); C176(0.75)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C184(0.91); C160(0.92); C176(0.90)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C184(1.04); C160(1.24); C176(1.12)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C184(0.58); C160(0.55); C176(0.68)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C184(0.78); C160(0.77); C176(0.81)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C184(0.78); C160(0.73); C176(0.73)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C184(0.63); C160(0.86); C176(0.86)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C184(0.46); C160(0.63); C176(0.63)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C184(0.45); C160(0.85); C176(0.85)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C184(0.67); C160(0.53); C176(0.53)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C184(0.53); C160(0.52); C176(0.52)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C184(0.45); C160(0.60); C176(0.60)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C184(0.54); C160(0.73); C176(0.73)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C184(0.41); C160(0.69); C176(0.69)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C184(0.58); C160(0.52); C176(0.52)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C184(0.53); C160(0.87); C176(0.87)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C184(0.47); C160(0.61); C176(0.61)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C184(0.43); C160(0.63); C176(0.63)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C184(0.41); C160(0.55); C176(0.55)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C184(0.58); C160(0.59); C176(0.59)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C184(0.57); C160(0.49); C176(0.49)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C184(0.36); C160(0.53); C176(0.53)  LDD1364  [6]
 LDCM0486  CL91 PaTu 8988t C160(0.76); C176(0.76)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C160(0.56); C176(0.56)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C160(0.64); C176(0.64)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C160(0.55); C176(0.55)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C160(0.51); C176(0.51)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C160(0.75); C176(0.75)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C160(0.61); C176(0.61)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C160(0.45); C176(0.45)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C160(0.55); C176(0.55)  LDD1373  [6]
 LDCM0495  E2913 HEK-293T C579(1.36); C575(0.88)  LDD1698  [7]
 LDCM0468  Fragment33 PaTu 8988t C184(0.65); C160(0.67); C176(0.73)  LDD1347  [6]
 LDCM0427  Fragment51 PaTu 8988t C184(0.75); C160(0.50); C176(0.50)  LDD1306  [6]
 LDCM0022  KB02 HEK-293T C579(1.06)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C579(1.06)  LDD1497  [7]
 LDCM0024  KB05 OVCAR-4 C575(1.38)  LDD3382  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myc proto-oncogene protein (MYC) . P01106

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402