Details of the Target

General Information of Target

Target ID LDTP08426
Target Name Homeodomain-interacting protein kinase 1 (HIPK1)
Gene Name HIPK1
Gene ID 204851
Synonyms
KIAA0630; MYAK; NBAK2; Homeodomain-interacting protein kinase 1; EC 2.7.11.1; Nuclear body-associated kinase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH
QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK
CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH
EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR
LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA
TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA
PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT
KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD
MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME
ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL
SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ
TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT
PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI
PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS
LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS
PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA
LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ
SSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQA
PYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSR
HAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLS
PTKISQYSYL
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, HIPK subfamily
Subcellular location
Nucleus
Function
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
Uniprot ID
Q86Z02
Ensemble ID
ENST00000340480.8
HGNC ID
HGNC:19006
ChEMBL ID
CHEMBL5427

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.R1068PfsTer83 .
COLO678 SNV: p.Y1197Ter .
DAOY SNV: p.P750S .
HSC3 SNV: p.Q1108E .
IM95 SNV: p.S1052P .
Ishikawa (Heraklio) 02 ER SNV: p.A796V; p.V1074M .
JHH7 SNV: p.G478E .
JURKAT SNV: p.V216M .
KYSE180 SNV: p.S863F .
MCC26 Substitution: p.S882Y .
NCIH1155 SNV: p.S587N .
PF382 SNV: p.P647L .
SNU478 SNV: p.Q741H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C1024(20.00)  LDD1706  [1]
DBIA
 Probe Info  		C1024(1.22); C1025(1.22)  LDD0078  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C535(0.96); C542(1.05)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C535(1.09)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C535(0.97); C542(0.97)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C535(1.06); C542(1.06)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C535(0.80); C542(0.80)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C535(0.98); C542(0.98)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C535(1.00); C542(1.00)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C535(0.97); C542(0.97)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C535(0.85); C542(0.85)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C535(0.90); C542(0.90)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C535(0.96); C542(0.96)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C535(1.12); C542(1.12)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C535(1.13)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C535(1.21); C542(1.21)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C535(0.93); C542(0.93)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C535(1.04); C542(1.04)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C535(0.95); C542(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C535(1.00); C542(1.02)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C535(1.17); C542(1.20)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C535(1.07); C542(1.11)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C535(0.99); C542(0.99)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C535(1.15); C542(1.09)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C535(1.16); C542(1.17)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C535(1.06)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C535(1.12); C542(1.08)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C535(1.04); C542(1.05)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C535(1.02); C542(1.03)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C535(1.08); C542(0.93)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C535(0.99); C542(1.02)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C535(1.04); C542(1.11)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C535(1.16); C542(1.13)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C535(1.01); C542(0.96)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C535(0.94); C542(0.74)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C535(0.87); C542(0.78)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C535(0.76); C542(0.74)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C535(0.82); C542(0.76)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C535(0.83); C542(0.77)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C535(0.78); C542(0.76)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C535(0.71); C542(0.81)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C535(0.88); C542(0.92)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C535(0.69); C542(0.87)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C535(0.72); C542(0.71)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C535(0.69); C542(0.89)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C535(0.76); C542(0.91)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C535(0.93)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C535(0.79); C542(0.97)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C535(0.79); C542(0.94)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C535(0.68); C542(0.86)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C535(0.98); C542(0.98)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C535(0.99); C542(0.99)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C535(1.00); C542(1.00)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C535(1.05); C542(1.05)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C535(0.98); C542(0.98)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C535(0.94); C542(0.94)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C535(1.12); C542(1.12)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C535(0.97)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C535(1.31); C542(1.31)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C535(0.94); C542(0.94)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C535(1.06); C542(1.06)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C535(1.08); C542(1.08)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C535(0.91); C542(0.91)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C535(1.68); C542(1.68)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C535(0.97); C542(0.97)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C535(1.13); C542(1.13)  LDD2161  [2]
 LDCM0279  AC2 HEK-293T C535(0.90); C542(0.97)  LDD0877  [2]
 LDCM0285  AC25 HEK-293T C535(1.49); C542(1.49)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C535(1.03); C542(1.03)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C535(0.93); C542(0.93)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C535(1.25); C542(1.25)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C535(1.36); C542(1.36)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C535(1.05); C542(1.14)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C535(1.21); C542(1.21)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C535(1.17); C542(1.17)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C535(1.22); C542(1.22)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C535(1.09); C542(1.09)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C535(1.03); C542(1.03)  LDD0893  [2]
 LDCM0301  AC4 HEK-293T C535(1.18); C542(1.36)  LDD0899  [2]
 LDCM0308  AC46 HEK-293T C535(1.02)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C535(0.93)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C535(0.88)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C535(0.85)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C535(1.08); C542(1.20)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C535(0.72)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C535(0.69)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C535(0.71)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C535(0.85)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C535(0.81)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C535(0.81)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C535(0.83)  LDD0917  [2]
 LDCM0323  AC6 HEK-293T C535(1.16)  LDD0921  [2]
 LDCM0332  AC68 HCT 116 C535(0.98); C542(0.98)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C535(0.93); C542(0.93)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C535(1.01)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C535(0.96); C542(0.96)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C535(1.01); C542(1.01)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C535(1.09); C542(1.09)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C535(1.13); C542(1.13)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C535(1.12); C542(1.12)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C535(1.30); C542(1.30)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C535(1.11); C542(1.11)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C535(0.98); C542(0.98)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C535(0.97); C542(0.97)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C535(1.19); C542(1.19)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C535(0.98)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C535(1.13); C542(1.13)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C535(1.17); C542(1.17)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C535(1.30); C542(1.30)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C535(0.78); C542(0.78)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C535(0.94); C542(0.94)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C535(1.00)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C535(0.97)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C535(1.00)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C1024(1.22); C1025(1.22)  LDD0078  [2]
 LDCM0369  CL100 HEK-293T C535(1.02); C542(1.22)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C535(0.85)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C535(0.92)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C535(0.87)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C535(1.00)  LDD0971  [2]
 LDCM0382  CL112 HEK-293T C535(1.06); C542(1.06)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C535(1.20); C542(1.20)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C535(1.84); C542(1.84)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C535(1.09); C542(1.09)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C535(1.35); C542(1.35)  LDD0984  [2]
 LDCM0392  CL121 HEK-293T C535(0.84)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C535(0.87)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C535(0.91)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C535(0.93)  LDD0993  [2]
 LDCM0403  CL16 HEK-293T C535(0.71); C542(0.90)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C535(0.35); C542(0.79)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C535(0.81); C542(0.82)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C535(0.44); C542(0.96)  LDD1004  [2]
 LDCM0408  CL20 HEK-293T C535(0.53); C542(0.97)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C535(0.49); C542(0.75)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C535(0.34); C542(0.77)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C535(0.62); C542(0.83)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C535(0.56); C542(0.94)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C535(0.46); C542(0.84)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C535(0.38); C542(0.78)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C535(0.40); C542(0.79)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C535(0.52); C542(0.79)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C535(0.43); C542(0.81)  LDD1015  [2]
 LDCM0419  CL30 HEK-293T C535(0.50); C542(0.77)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C535(0.91); C542(0.92)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C535(0.94); C542(0.88)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C535(0.75); C542(0.73)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C535(0.94); C542(0.95)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C535(0.93); C542(0.96)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C535(0.90); C542(0.88)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C535(0.88); C542(0.86)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C535(0.74); C542(0.87)  LDD1026  [2]
 LDCM0430  CL40 HEK-293T C535(0.89); C542(0.95)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C535(0.80); C542(0.92)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C535(0.82); C542(0.87)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C535(0.78); C542(0.88)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C535(0.93); C542(0.88)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C535(0.72); C542(0.87)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C535(0.89); C542(0.86)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C535(0.91); C542(0.87)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C535(0.96); C542(0.81)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C535(0.98); C542(0.96)  LDD1037  [2]
 LDCM0441  CL50 HEK-293T C535(1.04); C542(1.18)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C535(1.02); C542(1.14)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C535(1.08); C542(1.00)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C535(0.94); C542(0.86)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C535(1.01); C542(1.07)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C535(1.19); C542(1.30)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C535(0.88); C542(0.84)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C535(0.97); C542(1.08)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C535(0.96); C542(0.92)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C535(0.82); C542(0.71)  LDD1048  [2]
 LDCM0452  CL60 HEK-293T C535(0.85); C542(0.72)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C535(0.79); C542(0.79)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C535(0.60); C542(0.60)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C535(0.92); C542(0.92)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C535(0.81); C542(0.81)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C535(0.70); C542(0.70)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C535(0.82); C542(0.82)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C535(0.71); C542(0.71)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C535(0.63); C542(0.63)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C535(0.74); C542(0.74)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C535(0.75); C542(0.75)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C535(0.66); C542(0.66)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C535(0.83); C542(0.83)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C535(0.79); C542(0.79)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C535(0.93); C542(0.93)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C535(1.02)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C535(0.93)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C535(1.61)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C535(1.24)  LDD1070  [2]
 LDCM0474  CL80 HEK-293T C535(1.21)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C535(1.14)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C535(0.83)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C535(0.73)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C535(1.29)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C535(1.23)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C535(1.56)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C535(1.13)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C535(0.90)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C535(1.01)  LDD1081  [2]
 LDCM0485  CL90 HEK-293T C535(0.74)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C535(1.12); C542(1.16)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C535(1.14); C542(1.26)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C535(0.92); C542(1.03)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C535(0.74); C542(0.77)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C535(0.97); C542(1.18)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C535(0.92); C542(0.91)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C535(0.96); C542(0.96)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C535(0.88); C542(0.93)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C535(0.93); C542(0.95)  LDD1092  [2]
 LDCM0468  Fragment33 HCT 116 C535(0.70); C542(0.70)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C535(0.95); C542(1.07)  LDD1025  [2]
 LDCM0024  KB05 T cell-activated C1024(20.00)  LDD1706  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Four and a half LIM domains protein 3 (FHL3) . Q13643

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.