Details of the Target

General Information of Target

Target ID LDTP08368
Target Name Diacylglycerol kinase eta (DGKH)
Gene Name DGKH
Gene ID 160851
Synonyms
Diacylglycerol kinase eta; DAG kinase eta; EC 2.7.1.107; Diglyceride kinase eta; DGK-eta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ
IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST
KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA
CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED
EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL
GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA
QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG
NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS
EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA
DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG
DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE
TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII
CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD
AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP
SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH
HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE
DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL
AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER
VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK
QKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGH
VKRILQGIKELGRSTPQSEV
Target Bioclass
Enzyme
Family
Eukaryotic diacylglycerol kinase family
Subcellular location
Cytoplasm
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Uniprot ID
Q86XP1
Ensemble ID
ENST00000261491.9
HGNC ID
HGNC:2854
ChEMBL ID
CHEMBL4105940

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 Substitution: p.E252L DBIA    Probe Info 
GAMG SNV: p.T697N .
HCT15 SNV: p.C192Y .
HT SNV: p.E667G
Substitution: .		 .
HT115 SNV: p.Q49H; p.S315N .
ICC3 Deletion: p.L879WfsTer4 .
K562 SNV: p.E1079Ter .
KMCH1 SNV: p.L1031Q DBIA    Probe Info 
LU65 SNV: p.A927S DBIA    Probe Info 
MCC13 SNV: p.S1144N
Substitution: .		 .
MCC26 SNV: p.R902Ter .
MOLT4 SNV: p.P48L IA-alkyne    Probe Info 
NCIH1793 SNV: p.Q566H .
NCIH2286 SNV: p.F321Y DBIA    Probe Info 
OCILY3 SNV: p.D1192Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.35  LDD0403  [1]
DBIA
 Probe Info  		C1038(29.74)  LDD0209  [2]
ATP probe
 Probe Info  		K1197(0.00); K74(0.00)  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C965(0.00); C388(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C1038(0.00); C388(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C769(0.00); C388(0.00); C410(0.00); C268(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		12.60  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1038(1.02); C516(1.02); C721(1.07); C388(1.01)  LDD1507  [8]
 LDCM0215  AC10 PaTu 8988t C322(1.42)  LDD1094  [9]
 LDCM0226  AC11 PaTu 8988t C322(1.30)  LDD1105  [9]
 LDCM0237  AC12 PaTu 8988t C322(1.24)  LDD1116  [9]
 LDCM0259  AC14 PaTu 8988t C322(1.24)  LDD1138  [9]
 LDCM0263  AC143 PaTu 8988t C322(1.17)  LDD1142  [9]
 LDCM0264  AC144 PaTu 8988t C322(1.03)  LDD1143  [9]
 LDCM0265  AC145 PaTu 8988t C322(0.97)  LDD1144  [9]
 LDCM0266  AC146 PaTu 8988t C322(0.95)  LDD1145  [9]
 LDCM0267  AC147 PaTu 8988t C322(1.07)  LDD1146  [9]
 LDCM0268  AC148 PaTu 8988t C322(1.34)  LDD1147  [9]
 LDCM0269  AC149 PaTu 8988t C322(1.31)  LDD1148  [9]
 LDCM0270  AC15 PaTu 8988t C322(1.33)  LDD1149  [9]
 LDCM0271  AC150 PaTu 8988t C322(1.02)  LDD1150  [9]
 LDCM0272  AC151 PaTu 8988t C322(1.33)  LDD1151  [9]
 LDCM0273  AC152 PaTu 8988t C322(1.02)  LDD1152  [9]
 LDCM0274  AC153 PaTu 8988t C322(1.31)  LDD1153  [9]
 LDCM0621  AC154 PaTu 8988t C322(1.36)  LDD2166  [9]
 LDCM0622  AC155 PaTu 8988t C322(1.22)  LDD2167  [9]
 LDCM0623  AC156 PaTu 8988t C322(1.17)  LDD2168  [9]
 LDCM0624  AC157 PaTu 8988t C322(1.13)  LDD2169  [9]
 LDCM0276  AC17 PaTu 8988t C322(0.91)  LDD1155  [9]
 LDCM0277  AC18 PaTu 8988t C322(1.10)  LDD1156  [9]
 LDCM0278  AC19 PaTu 8988t C322(0.90)  LDD1157  [9]
 LDCM0279  AC2 HEK-293T C1038(0.80); C516(1.00); C721(1.46); C388(0.96)  LDD1518  [8]
 LDCM0280  AC20 PaTu 8988t C322(0.93)  LDD1159  [9]
 LDCM0281  AC21 PaTu 8988t C322(0.93)  LDD1160  [9]
 LDCM0282  AC22 PaTu 8988t C322(0.95)  LDD1161  [9]
 LDCM0283  AC23 PaTu 8988t C322(1.23)  LDD1162  [9]
 LDCM0284  AC24 PaTu 8988t C322(1.18)  LDD1163  [9]
 LDCM0285  AC25 HEK-293T C1038(0.95); C516(0.95); C721(0.99); C388(1.49)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C1038(1.10); C516(0.95); C721(1.08); C388(1.16)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C1038(1.08); C516(1.02); C721(0.94); C1117(0.98)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C1038(0.84); C516(0.96); C721(1.07); C388(0.86)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C1038(0.90); C721(0.99); C547(0.89); C1117(1.12)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C1038(1.01); C516(0.98); C721(1.07); C1117(0.92)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C1038(1.05); C721(0.93); C388(1.41); C547(1.07)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C1038(0.95); C721(1.03); C547(1.10); C1117(0.99)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C1038(1.13); C516(0.97); C721(1.01); C1117(1.13)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C1038(1.05); C516(0.99); C721(1.25); C388(1.02)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C1038(1.17); C516(0.92); C721(1.06); C388(0.97)  LDD1534  [8]
 LDCM0296  AC35 PaTu 8988t C322(0.97)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C322(1.22)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C322(1.25)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C322(1.23)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C322(1.15)  LDD1179  [9]
 LDCM0301  AC4 HEK-293T C1038(1.03); C516(1.05); C721(1.02); C388(0.92)  LDD1540  [8]
 LDCM0302  AC40 PaTu 8988t C322(1.34)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C322(1.30)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C322(1.08)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C322(1.17)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C322(1.35)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C322(1.18)  LDD1186  [9]
 LDCM0308  AC46 PaTu 8988t C322(0.84)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C322(0.95)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C322(1.09)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C322(1.11)  LDD1190  [9]
 LDCM0312  AC5 HEK-293T C1038(1.10); C721(1.00); C547(0.96); C1117(1.23)  LDD1551  [8]
 LDCM0313  AC50 PaTu 8988t C322(1.06)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C322(0.94)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C322(1.13)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C322(1.25)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C322(1.50)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C322(1.07)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C322(0.97)  LDD1198  [9]
 LDCM0320  AC57 PaTu 8988t C322(1.10)  LDD1199  [9]
 LDCM0321  AC58 PaTu 8988t C322(1.04)  LDD1200  [9]
 LDCM0322  AC59 PaTu 8988t C322(0.94)  LDD1201  [9]
 LDCM0323  AC6 PaTu 8988t C322(1.00)  LDD1202  [9]
 LDCM0324  AC60 PaTu 8988t C322(0.95)  LDD1203  [9]
 LDCM0325  AC61 PaTu 8988t C322(0.99)  LDD1204  [9]
 LDCM0326  AC62 PaTu 8988t C322(1.09)  LDD1205  [9]
 LDCM0327  AC63 PaTu 8988t C322(0.99)  LDD1206  [9]
 LDCM0328  AC64 PaTu 8988t C322(1.15)  LDD1207  [9]
 LDCM0329  AC65 PaTu 8988t C322(0.88)  LDD1208  [9]
 LDCM0330  AC66 PaTu 8988t C322(0.95)  LDD1209  [9]
 LDCM0331  AC67 PaTu 8988t C322(1.03)  LDD1210  [9]
 LDCM0332  AC68 PaTu 8988t C322(0.97)  LDD1211  [9]
 LDCM0333  AC69 PaTu 8988t C322(1.08)  LDD1212  [9]
 LDCM0334  AC7 PaTu 8988t C322(0.91)  LDD1213  [9]
 LDCM0335  AC70 PaTu 8988t C322(1.08)  LDD1214  [9]
 LDCM0336  AC71 PaTu 8988t C322(0.97)  LDD1215  [9]
 LDCM0337  AC72 PaTu 8988t C322(0.94)  LDD1216  [9]
 LDCM0338  AC73 PaTu 8988t C322(0.98)  LDD1217  [9]
 LDCM0339  AC74 PaTu 8988t C322(1.03)  LDD1218  [9]
 LDCM0340  AC75 PaTu 8988t C322(1.08)  LDD1219  [9]
 LDCM0341  AC76 PaTu 8988t C322(0.95)  LDD1220  [9]
 LDCM0342  AC77 PaTu 8988t C322(1.03)  LDD1221  [9]
 LDCM0343  AC78 PaTu 8988t C322(1.02)  LDD1222  [9]
 LDCM0344  AC79 PaTu 8988t C322(1.02)  LDD1223  [9]
 LDCM0345  AC8 PaTu 8988t C322(1.11)  LDD1224  [9]
 LDCM0346  AC80 PaTu 8988t C322(1.05)  LDD1225  [9]
 LDCM0347  AC81 PaTu 8988t C322(1.08)  LDD1226  [9]
 LDCM0348  AC82 PaTu 8988t C322(1.13)  LDD1227  [9]
 LDCM0349  AC83 PaTu 8988t C322(0.79)  LDD1228  [9]
 LDCM0350  AC84 PaTu 8988t C322(0.84)  LDD1229  [9]
 LDCM0351  AC85 PaTu 8988t C322(0.80)  LDD1230  [9]
 LDCM0352  AC86 PaTu 8988t C322(0.81)  LDD1231  [9]
 LDCM0353  AC87 PaTu 8988t C322(0.82)  LDD1232  [9]
 LDCM0354  AC88 PaTu 8988t C322(0.79)  LDD1233  [9]
 LDCM0355  AC89 PaTu 8988t C322(0.84)  LDD1234  [9]
 LDCM0357  AC90 PaTu 8988t C322(0.70)  LDD1236  [9]
 LDCM0358  AC91 PaTu 8988t C322(0.74)  LDD1237  [9]
 LDCM0359  AC92 PaTu 8988t C322(0.93)  LDD1238  [9]
 LDCM0360  AC93 PaTu 8988t C322(0.71)  LDD1239  [9]
 LDCM0361  AC94 PaTu 8988t C322(0.72)  LDD1240  [9]
 LDCM0362  AC95 PaTu 8988t C322(0.80)  LDD1241  [9]
 LDCM0363  AC96 PaTu 8988t C322(0.71)  LDD1242  [9]
 LDCM0364  AC97 PaTu 8988t C322(0.78)  LDD1243  [9]
 LDCM0248  AKOS034007472 PaTu 8988t C322(1.63)  LDD1127  [9]
 LDCM0356  AKOS034007680 PaTu 8988t C322(1.11)  LDD1235  [9]
 LDCM0275  AKOS034007705 PaTu 8988t C322(1.21)  LDD1154  [9]
 LDCM0156  Aniline NCI-H1299 12.35  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C1038(1.06); C516(0.92); C647(1.10); C721(1.27)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C1038(1.16); C721(1.95); C388(2.10); C547(0.72)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C1038(1.02); C721(1.15); C1117(1.27); C329(1.00)  LDD1573  [8]
 LDCM0370  CL101 PaTu 8988t C322(1.03)  LDD1249  [9]
 LDCM0371  CL102 PaTu 8988t C322(1.10)  LDD1250  [9]
 LDCM0372  CL103 PaTu 8988t C322(1.65)  LDD1251  [9]
 LDCM0373  CL104 PaTu 8988t C322(1.10)  LDD1252  [9]
 LDCM0374  CL105 PaTu 8988t C322(1.04)  LDD1253  [9]
 LDCM0375  CL106 PaTu 8988t C322(0.99)  LDD1254  [9]
 LDCM0376  CL107 PaTu 8988t C322(0.92)  LDD1255  [9]
 LDCM0377  CL108 PaTu 8988t C322(0.93)  LDD1256  [9]
 LDCM0378  CL109 PaTu 8988t C322(1.06)  LDD1257  [9]
 LDCM0379  CL11 HEK-293T C1038(0.87); C721(1.42); C547(1.01); C1117(0.98)  LDD1583  [8]
 LDCM0380  CL110 PaTu 8988t C322(1.17)  LDD1259  [9]
 LDCM0381  CL111 PaTu 8988t C322(1.28)  LDD1260  [9]
 LDCM0382  CL112 HEK-293T C1038(1.05); C721(1.06); C1117(1.06); C329(1.02)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C1038(1.06); C516(1.09); C647(1.66); C721(1.02)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C1038(1.22); C388(0.98); C547(0.95); C329(0.89)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C1038(1.08); C721(1.02); C388(1.35); C547(1.03)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C1038(1.17); C721(0.98); C1117(1.08); C329(1.00)  LDD1590  [8]
 LDCM0387  CL117 PaTu 8988t C322(1.12)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C322(1.12)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C322(1.19)  LDD1268  [9]
 LDCM0390  CL12 HEK-293T C1038(0.96); C516(0.99); C721(1.18); C1117(1.05)  LDD1594  [8]
 LDCM0391  CL120 PaTu 8988t C322(1.08)  LDD1270  [9]
 LDCM0392  CL121 PaTu 8988t C322(1.15)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C322(0.86)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C322(1.29)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C322(1.13)  LDD1274  [9]
 LDCM0396  CL125 PaTu 8988t C322(1.02)  LDD1275  [9]
 LDCM0397  CL126 PaTu 8988t C322(0.96)  LDD1276  [9]
 LDCM0398  CL127 PaTu 8988t C322(0.92)  LDD1277  [9]
 LDCM0399  CL128 PaTu 8988t C322(1.04)  LDD1278  [9]
 LDCM0400  CL13 HEK-293T C1038(0.99); C516(1.00); C647(1.28); C721(1.12)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C1038(0.99); C388(1.06); C547(0.97); C329(1.01)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C1038(1.02); C721(1.40); C388(1.62); C547(1.27)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C1038(1.12); C721(0.97); C1117(1.16); C329(1.06)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C1038(1.03); C516(1.06); C721(1.91); C388(0.88)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C1038(0.93); C516(0.91); C721(1.23); C388(1.28)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C1038(0.99); C516(0.99); C721(1.27); C1117(1.10)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C1038(0.99); C388(1.08); C547(1.03); C329(0.92)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C1038(0.97); C516(1.01); C721(1.18); C388(1.22)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C1038(1.35); C721(1.51); C547(1.01); C1117(0.94)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C1038(1.13); C721(1.19); C388(1.31); C547(0.77)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C1038(1.02); C721(1.04); C547(0.98); C1117(1.00)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C1038(1.01); C516(1.00); C721(1.17); C1117(0.98)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C1038(1.00); C516(0.93); C647(0.77); C721(1.21)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C1038(1.10); C388(1.22); C547(1.11); C329(0.98)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C1038(1.08); C721(0.98); C388(1.46); C547(1.10)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C1038(0.98); C721(1.06); C1117(1.17); C329(0.97)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C1038(0.97); C516(0.91); C721(1.01); C388(1.09)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C1038(0.99); C721(1.06); C388(1.07); C547(1.13)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C1038(0.91); C516(0.91); C721(1.16); C388(1.02)  LDD1623  [8]
 LDCM0420  CL31 PaTu 8988t C322(1.08)  LDD1299  [9]
 LDCM0421  CL32 PaTu 8988t C322(1.18)  LDD1300  [9]
 LDCM0422  CL33 PaTu 8988t C322(1.13)  LDD1301  [9]
 LDCM0423  CL34 PaTu 8988t C322(1.22)  LDD1302  [9]
 LDCM0424  CL35 PaTu 8988t C322(1.15)  LDD1303  [9]
 LDCM0425  CL36 PaTu 8988t C322(0.69)  LDD1304  [9]
 LDCM0426  CL37 PaTu 8988t C322(1.03)  LDD1305  [9]
 LDCM0428  CL39 PaTu 8988t C322(1.20)  LDD1307  [9]
 LDCM0429  CL4 HEK-293T C1038(1.14); C721(1.05); C1117(1.22); C329(1.05)  LDD1633  [8]
 LDCM0430  CL40 PaTu 8988t C322(1.15)  LDD1309  [9]
 LDCM0431  CL41 PaTu 8988t C322(0.95)  LDD1310  [9]
 LDCM0432  CL42 PaTu 8988t C322(1.08)  LDD1311  [9]
 LDCM0433  CL43 PaTu 8988t C322(1.25)  LDD1312  [9]
 LDCM0434  CL44 PaTu 8988t C322(1.21)  LDD1313  [9]
 LDCM0435  CL45 PaTu 8988t C322(1.29)  LDD1314  [9]
 LDCM0436  CL46 HEK-293T C1038(1.02); C721(1.11); C388(1.01); C547(0.92)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C1038(0.87); C721(1.15); C547(0.97); C1117(0.94)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C1038(1.16); C516(1.06); C721(1.11); C1117(1.04)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C1038(1.07); C516(1.05); C647(0.98); C721(1.08)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C1038(1.00); C516(0.99); C721(1.27); C388(1.15)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C1038(1.06); C388(1.00); C547(1.00); C329(0.95)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C1038(1.18); C721(1.06); C1117(1.15); C329(0.99)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C1038(1.14); C516(1.07); C721(1.69); C388(0.95)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C1038(1.00); C516(1.01); C721(1.76); C388(0.97)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C1038(1.00); C516(1.09); C721(1.18); C1117(1.12)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C1038(0.99); C516(1.11); C721(1.17); C388(1.32)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C1038(1.20); C721(1.55); C547(0.91); C1117(1.30)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C1038(1.07); C721(1.27); C388(1.45); C547(0.99)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C1038(1.00); C721(1.25); C547(1.07); C1117(0.93)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C1038(0.93); C516(0.88); C721(1.44); C388(1.06)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C1038(1.13); C516(0.98); C721(1.30); C1117(0.99)  LDD1655  [8]
 LDCM0453  CL61 PaTu 8988t C322(0.94)  LDD1332  [9]
 LDCM0454  CL62 PaTu 8988t C322(1.38)  LDD1333  [9]
 LDCM0455  CL63 PaTu 8988t C322(1.25)  LDD1334  [9]
 LDCM0456  CL64 PaTu 8988t C322(1.45)  LDD1335  [9]
 LDCM0457  CL65 PaTu 8988t C322(1.21)  LDD1336  [9]
 LDCM0458  CL66 PaTu 8988t C322(1.45)  LDD1337  [9]
 LDCM0459  CL67 PaTu 8988t C322(1.33)  LDD1338  [9]
 LDCM0460  CL68 PaTu 8988t C322(1.33)  LDD1339  [9]
 LDCM0461  CL69 PaTu 8988t C322(1.57)  LDD1340  [9]
 LDCM0462  CL7 HEK-293T C1038(1.00); C516(0.99); C721(1.12); C1117(1.04)  LDD1665  [8]
 LDCM0463  CL70 PaTu 8988t C322(1.33)  LDD1342  [9]
 LDCM0464  CL71 PaTu 8988t C322(1.16)  LDD1343  [9]
 LDCM0465  CL72 PaTu 8988t C322(1.19)  LDD1344  [9]
 LDCM0466  CL73 PaTu 8988t C322(1.54)  LDD1345  [9]
 LDCM0467  CL74 PaTu 8988t C322(1.32)  LDD1346  [9]
 LDCM0469  CL76 HEK-293T C1038(1.12); C721(1.07); C1117(1.29); C329(0.93)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C1038(1.14); C516(0.92); C721(1.55); C388(0.78)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C1038(1.06); C516(0.91); C721(1.25); C388(0.92)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C1038(1.17); C516(0.99); C721(1.10); C1117(1.17)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C1038(1.07); C516(1.77); C721(2.01); C388(1.24)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C1038(1.09); C516(0.98); C721(1.07); C388(1.20)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C1038(0.96); C721(1.05); C547(0.93); C1117(0.97)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C1038(0.98); C721(1.07); C388(1.16); C547(0.91)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C1038(1.14); C721(1.21); C547(1.04); C1117(0.85)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C1038(1.18); C516(1.11); C721(1.16); C1117(1.00)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C1038(0.98); C516(1.10); C647(1.63); C721(1.13)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C1038(0.93); C388(1.09); C547(1.02); C329(1.02)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C1038(1.05); C721(0.99); C388(1.07); C547(1.00)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C1038(1.15); C721(0.96); C1117(1.51); C329(1.01)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C1038(1.02); C516(1.00); C721(1.07); C388(1.23)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C1038(1.30); C721(1.22); C547(0.95); C1117(1.15)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C1038(1.22); C516(0.93); C721(1.51); C388(1.11)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C1038(1.15); C516(1.04); C721(0.91); C1117(0.84)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C1038(0.99); C516(1.07); C721(1.47); C388(1.15)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C1038(1.08); C721(1.36); C547(1.01); C1117(0.93)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C1038(0.88); C721(0.89); C388(1.45); C547(0.89)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C1038(1.09); C721(1.82); C547(1.02); C1117(0.98)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C1038(1.13); C516(0.99); C721(1.29); C1117(1.01)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C1038(1.08); C516(1.03); C647(0.92); C721(1.13)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C1038(1.20); C388(1.12); C547(1.00); C329(0.99)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C1038(0.92); C721(1.07); C388(1.04); C547(0.99)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C1038(1.10); C721(1.18); C388(0.93); C547(1.00)  LDD1698  [8]
 LDCM0625  F8 Ramos C721(2.08)  LDD2187  [10]
 LDCM0575  Fragment13 Ramos C721(1.19)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C721(1.74)  LDD2193  [10]
 LDCM0580  Fragment21 Ramos C721(1.93)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C721(1.29)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C721(0.64)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C721(1.02)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C721(1.50)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C721(1.46)  LDD2200  [10]
 LDCM0468  Fragment33 PaTu 8988t C322(1.52)  LDD1347  [9]
 LDCM0596  Fragment38 Ramos C721(1.42)  LDD2203  [10]
 LDCM0427  Fragment51 PaTu 8988t C322(1.24)  LDD1306  [9]
 LDCM0614  Fragment56 Ramos C721(0.96)  LDD2205  [10]
 LDCM0022  KB02 HEK-293T C322(1.13); C1117(0.97); C388(0.78); C329(0.80)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C1038(29.74)  LDD0209  [2]
 LDCM0024  KB05 G361 C89(3.21)  LDD3311  [11]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-tocopherol Succinate . DB14001

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840