Details of the Target

General Information of Target

Target ID LDTP08299
Target Name Thioredoxin reductase 3 (TXNRD3)
Gene Name TXNRD3
Gene ID 114112
Synonyms
TGR; TRXR3; Thioredoxin reductase 3; EC 1.8.1.9; Thioredoxin and glutathione reductase; Thioredoxin reductase TR2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLV
GLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTV
PNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGK
KVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRH
NWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQ
FVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDV
TVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEG
TETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDIL
EDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKK
ENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAM
KCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Class-I pyridine nucleotide-disulfide oxidoreductase family
Subcellular location
Cytoplasm
Function
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.
TTD ID
T89466
Uniprot ID
Q86VQ6
DrugMap ID
TTDYFVB
Ensemble ID
ENST00000524230.9
HGNC ID
HGNC:20667
ChEMBL ID
CHEMBL2096978

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C333(1.08)  LDD3316  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C76(0.00); C133(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		C565(0.00); C133(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C76(0.00); C133(0.00)  LDD0037  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C321(1.36)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C333(0.88)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C333(0.97)  LDD1509  [5]
 LDCM0230  AC113 PaTu 8988t C321(0.91); C333(0.91)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C321(0.86); C333(0.86)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C321(0.97); C333(0.97)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C321(1.17); C333(1.17)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C321(1.06); C333(1.06)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C321(1.01); C333(1.01)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C321(1.04); C333(1.04)  LDD1115  [4]
 LDCM0237  AC12 HEK-293T C225(0.96); C333(1.28)  LDD1510  [5]
 LDCM0238  AC120 PaTu 8988t C321(0.87); C333(0.87)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C321(1.01); C333(1.01)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C321(0.97); C333(0.97)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C321(1.03); C333(1.03)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C321(1.10); C333(1.10)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C321(1.17); C333(1.17)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C321(1.19); C333(1.19)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C321(1.30); C333(1.30)  LDD1124  [4]
 LDCM0246  AC128 HEK-293T C321(1.20)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C321(0.55)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C321(0.69)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C321(0.89)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C321(1.19)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C321(0.70)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C321(0.64)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C321(0.80)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C321(0.97)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C321(0.69)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C321(0.87)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C321(1.05)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C225(1.08); C333(0.95)  LDD1512  [5]
 LDCM0260  AC140 HEK-293T C321(0.92)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C321(1.13)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C321(0.65)  LDD0860  [4]
 LDCM0263  AC143 PaTu 8988t C321(1.27); C333(1.27)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C321(1.48); C333(1.48)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C321(1.45); C333(1.45)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C321(1.38); C333(1.38)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C321(1.72); C333(1.72)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C321(1.32); C333(1.32)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C321(1.34); C333(1.34)  LDD1148  [4]
 LDCM0270  AC15 HEK-293T C333(1.09)  LDD1513  [5]
 LDCM0271  AC150 PaTu 8988t C321(1.24); C333(1.24)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C321(1.26); C333(1.26)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C321(1.60); C333(1.60)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C321(1.46); C333(1.46)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C321(1.26); C333(1.26)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C321(1.35); C333(1.35)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C321(1.49); C333(1.49)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C321(1.29); C333(1.29)  LDD2169  [4]
 LDCM0276  AC17 HEK-293T C321(1.12)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C321(1.04)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C321(0.94)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C321(1.09)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C321(1.04)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C321(1.12)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C321(1.24)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C321(1.36)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C321(1.04)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C321(0.83)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C321(0.96)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C321(0.97)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C321(1.04)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C321(1.06)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C321(0.89)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C321(1.00)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C321(0.85)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C321(0.91)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C321(1.09)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C321(0.93)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C321(1.18)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C321(0.86)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C321(0.94)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C321(0.96)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C321(1.04)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C321(1.31)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C321(0.86)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C321(0.81)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C321(0.86)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C321(1.02)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C321(0.90)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C321(0.93)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C321(1.08)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C321(1.38)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C321(1.14)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C321(1.12)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C321(1.13)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C321(1.16)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C321(1.30)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C321(1.25)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C321(1.10)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C321(1.42)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C321(1.27)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C321(1.12)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C321(0.87)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C321(0.90)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C321(0.87)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C225(0.89); C333(1.41)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C321(0.68)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C321(1.02)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C321(0.88)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C321(1.02)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C321(0.85)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C321(1.02)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C321(0.97)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C321(0.95)  LDD0929  [4]
 LDCM0332  AC68 PaTu 8988t C321(0.90); C333(0.90)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C321(1.01); C333(1.01)  LDD1212  [4]
 LDCM0334  AC7 HEK-293T C333(1.08)  LDD1568  [5]
 LDCM0335  AC70 PaTu 8988t C321(0.91); C333(0.91)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C321(0.92); C333(0.92)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C321(0.97); C333(0.97)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C321(0.91); C333(0.91)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C321(1.00); C333(1.00)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C321(0.95); C333(0.95)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C321(0.89); C333(0.89)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C321(0.95); C333(0.95)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C321(0.98); C333(0.98)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C321(0.93); C333(0.93)  LDD1223  [4]
 LDCM0345  AC8 HEK-293T C225(0.97); C333(0.89)  LDD1569  [5]
 LDCM0346  AC80 PaTu 8988t C321(1.07); C333(1.07)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C321(1.00); C333(1.00)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C321(1.06); C333(1.06)  LDD1227  [4]
 LDCM0349  AC83 PaTu 8988t C321(1.45); C333(1.45)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C321(0.96); C333(0.96)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C321(0.82); C333(0.82)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C321(0.71); C333(0.71)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C321(0.78); C333(0.78)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C321(0.69); C333(0.69)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C321(0.95); C333(0.95)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C321(1.02); C333(1.02)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C321(1.06); C333(1.06)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C321(0.93); C333(0.93)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C321(1.02); C333(1.02)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C321(0.85); C333(0.85)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C321(1.01); C333(1.01)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C321(1.02); C333(1.02)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C321(2.02); C333(2.02)  LDD1243  [4]
 LDCM0248  AKOS034007472 HEK-293T C333(1.13)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C225(0.90); C333(0.87)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C225(1.00); C333(0.92)  LDD1514  [5]
 LDCM0367  CL1 PaTu 8988t C225(1.30)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C225(1.69)  LDD1247  [4]
 LDCM0369  CL100 HEK-293T C321(1.38)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C225(1.05); C133(1.18); C333(0.74)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C225(1.69); C133(0.88); C333(0.66)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C225(1.15); C333(1.01)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C225(0.84); C133(1.14); C333(0.94)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C321(1.07)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C321(1.10)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C321(0.88)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C321(0.90)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C321(1.06)  LDD0976  [4]
 LDCM0379  CL11 PaTu 8988t C225(1.42)  LDD1258  [4]
 LDCM0380  CL110 HEK-293T C321(1.05)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C321(1.02)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C321(1.08)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C321(0.98)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C321(1.28)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C321(0.94)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C321(1.07)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C321(1.39)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C321(1.06)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C321(1.24)  LDD0987  [4]
 LDCM0390  CL12 PaTu 8988t C225(1.70)  LDD1269  [4]
 LDCM0391  CL120 HEK-293T C321(0.95)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C321(1.13)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C321(1.30)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C321(1.16)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C321(1.07)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C321(1.00)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C321(0.91)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C321(0.99)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C321(0.88)  LDD0997  [4]
 LDCM0400  CL13 PaTu 8988t C225(1.18)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C225(1.35)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C225(1.58)  LDD1281  [4]
 LDCM0403  CL16 HEK-293T C225(1.21); C133(1.19); C333(0.91)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C225(1.07); C333(0.96)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C333(0.95)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C333(1.17)  LDD1610  [5]
 LDCM0407  CL2 PaTu 8988t C225(1.56)  LDD1286  [4]
 LDCM0408  CL20 HEK-293T C225(0.80); C333(1.21)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C333(1.15)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C225(0.97); C333(1.78)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C333(1.10)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C225(1.10); C333(1.12)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C225(1.16); C133(1.24); C333(0.85)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C225(1.34); C133(0.87); C333(0.84)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C225(1.23); C333(0.95)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C225(1.24); C133(1.16); C333(1.25)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C225(1.07); C333(1.22)  LDD1621  [5]
 LDCM0418  CL3 PaTu 8988t C225(1.38)  LDD1297  [4]
 LDCM0419  CL30 HEK-293T C333(1.11)  LDD1623  [5]
 LDCM0420  CL31 PaTu 8988t C225(0.96)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C225(1.12)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C225(1.47)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C225(1.12)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C225(1.29)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C225(1.16)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C225(1.50)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C225(0.94)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C225(2.11)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C225(1.02)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C225(1.14)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C225(1.41)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C225(1.62)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C225(1.26)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C225(1.24)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C321(1.86); C333(1.86)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C321(1.02); C333(1.02)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C321(1.84); C333(1.84)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C321(1.21); C333(1.21)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C225(1.28)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C321(1.28); C333(1.28)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C321(2.02); C333(2.02)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C321(1.56); C333(1.56)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C321(1.75); C333(1.75)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C321(1.50); C333(1.50)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C321(2.17); C333(2.17)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C321(0.53); C333(0.53)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C321(1.59); C333(1.59)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C321(2.94); C333(2.94)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C321(1.29); C333(1.29)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C225(1.76)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C321(1.10); C333(1.10)  LDD1331  [4]
 LDCM0453  CL61 HEK-293T C321(0.90)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C321(1.06)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C321(1.03)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C321(1.12)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C321(1.13)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C321(1.24)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C321(1.22)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C321(1.25)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C321(1.18)  LDD1059  [4]
 LDCM0462  CL7 PaTu 8988t C225(1.64)  LDD1341  [4]
 LDCM0463  CL70 HEK-293T C321(1.10)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C321(1.41)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C321(0.95)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C321(1.08)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C321(1.53)  LDD1065  [4]
 LDCM0469  CL76 PaTu 8988t C321(1.40); C333(1.40)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C321(0.89); C333(0.89)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C321(1.17); C333(1.17)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C321(0.84); C333(0.84)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C225(1.70)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C321(1.20); C333(1.20)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C321(1.12); C333(1.12)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C321(1.06); C333(1.06)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C321(1.07); C333(1.07)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C321(1.02); C333(1.02)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C321(0.91); C333(0.91)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C321(0.91); C333(0.91)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C321(1.27); C333(1.27)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C321(1.06); C333(1.06)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C321(1.13); C333(1.13)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C225(1.93)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C321(1.29); C333(1.29)  LDD1364  [4]
 LDCM0486  CL91 HEK-293T C321(0.88)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C321(1.11)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C321(0.98)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C321(1.14)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C321(1.50)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C321(1.38)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C321(1.10)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C321(1.13)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C321(1.22)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C225(0.90); C333(1.14)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C203(0.53)  LDD1702  [6]
 LDCM0468  Fragment33 HEK-293T C321(1.41)  LDD1066  [4]
 LDCM0427  Fragment51 PaTu 8988t C225(1.37)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C76(0.88); C333(1.17)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C76(1.08); C333(0.95)  LDD1497  [5]
 LDCM0024  KB05 MEL167 C333(1.08)  LDD3316  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761