Details of the Target

General Information of Target

Target ID LDTP08086
Target Name BRCA2-interacting transcriptional repressor EMSY (EMSY)
Gene Name EMSY
Gene ID 56946
Synonyms
C11orf30; BRCA2-interacting transcriptional repressor EMSY
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSIST
ERHRAEVRRAVNDERLTTIAHNMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAVA
NAAIQHNASLPVPAETGSKEVVCYSYTSTTSTPTSTPVPSGSIATVKSPRPASPASNVVV
LPSGSTVYVKSVSCSDEDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPK
MSNIMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNY
AAVTKLVPTSVIASTTQKPPVVITASQSSLVSNSSSGSSSSTPSPIPNTVAVTAVVSSTP
SVVMSTVAQGVSTSAIKMASTRLPSPKSLVSAPTQILAQFPKQHQQSPKQQLYQVQQQTQ
QQVAQPSPVSHQQQPQQSPLPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTS
SNSPIMVVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSIGRMAATPGAATYVKTTSGSII
TVVPKSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVV
TTLLNAGGEKTIQTVPTGAKPAILTATRPITKMIVTQPKGIGSTVQPAAKIIPTKIVYGQ
QGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVAEAGNSSIQEGKEEPQNYTDSS
SSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALL
ELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTER
TDEGTEVAFPLLVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHI
MQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSAKQQKLSQPPLE
QTQLQVKTLQCFQTKQKQTIHLQADQLQHKLPQMPQLSIRHQKLTPLQQEQAQPKPDVQH
TQHPMVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMSL
PASSEKQTASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQA
SEKTAVSDILKMSLMEAQIDTNVEHMIVDPPKKALATSMLTGEAGSLPSTHMVVAGMANS
TPQQQKCRESCSSPSTVGSSLTTRKIDPPAVPATGQFMRIQNVGQKKAEESPAEIIIQAI
PQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDEETAMEQDIDSSTEDGTEPSPSQSSAE
RS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors.
Uniprot ID
Q7Z589
Ensemble ID
ENST00000334736.7
HGNC ID
HGNC:18071

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C194(3.61)  LDD0170  [2]
DBIA
 Probe Info  		C971(1.75)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_5
 Probe Info  		C1211(0.00); C194(0.00)  LDD2224  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		C971(0.00); C194(0.00)  LDD0147  [6]
VSF
 Probe Info  		N.A.  LDD0007  [7]
AOyne
 Probe Info  		13.50  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C194(3.61)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C194(2.15)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C971(1.50)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C1211(1.01); C971(1.04)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C1211(1.08); C194(0.83); C971(1.06)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C1211(1.18); C194(1.21); C971(1.02)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C1211(0.80); C194(1.06); C971(1.02)  LDD1512  [9]
 LDCM0263  AC143 HCT 116 C971(1.25)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C971(0.95)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C971(1.10)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C971(0.80)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C971(1.30)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C971(0.78)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C971(0.71)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C1211(1.21); C971(0.99)  LDD1513  [9]
 LDCM0271  AC150 HCT 116 C971(0.86)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C971(1.02)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C971(0.87)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C971(0.57)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C971(0.83)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C971(0.75)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C971(0.81)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C971(0.85)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C971(0.51)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C971(0.69)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C971(0.65)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C971(0.76)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C971(0.62)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C971(0.55)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C971(0.57)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C971(0.61)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C971(0.49)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C971(1.06)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C971(1.15)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C971(1.27)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C971(1.70)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C971(1.17)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C971(0.87)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C971(1.11)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C971(1.30)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C971(1.24)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C971(1.44)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C971(1.06)  LDD1174  [3]
 LDCM0296  AC35 PaTu 8988t C971(1.25)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C971(1.51)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C971(1.31)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C971(1.41)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C971(1.76)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C971(0.89)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C971(1.53)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C971(1.17)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C971(1.27)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C971(1.33)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C971(1.40)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C971(1.18)  LDD1186  [3]
 LDCM0308  AC46 HEK-293T C1211(0.82); C194(1.05); C971(1.13)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C1211(1.11); C971(1.06)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C194(1.05); C971(0.98)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C971(1.08)  LDD1550  [9]
 LDCM0312  AC5 HCT 116 C971(0.72)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C1211(1.28); C971(1.00)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C1211(0.99); C194(0.80); C971(1.04)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C1211(1.20); C194(1.12); C971(1.01)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C1211(1.07); C194(1.06); C971(0.95)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C1211(0.83); C194(1.03); C971(1.05)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C1211(1.17); C971(1.07)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C194(1.12); C971(0.99)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C971(1.09)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C1211(1.17); C971(1.01)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C1211(1.08); C194(0.94); C971(1.09)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C1211(0.85); C194(1.02); C971(1.16)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C1211(1.26); C194(1.14); C971(1.09)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C1211(1.52); C194(1.08); C971(1.10)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C1211(1.02); C194(1.01); C971(1.17)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C1211(1.16); C971(1.03)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C194(1.07); C971(0.98)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C1211(1.02); C971(1.00)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C194(1.15); C971(0.91)  LDD1569  [9]
 LDCM0349  AC83 PaTu 8988t C971(0.77)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C971(0.74)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C971(0.79)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C971(0.76)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C971(0.80)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C971(0.91)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C971(0.82)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C971(1.01)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C971(0.82)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C971(0.80)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C971(0.81)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C971(1.00)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C971(0.87)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C971(0.84)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C971(0.89)  LDD1243  [3]
 LDCM0248  AKOS034007472 HEK-293T C1211(1.23); C194(1.08); C971(1.00)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C971(1.10)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C194(1.11); C971(0.97)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C16(0.48)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C971(1.01)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C971(1.29)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C971(0.94)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C194(0.95)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C1211(0.90); C194(0.86)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C1211(1.10); C194(0.88); C971(1.05)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C1211(1.07); C971(1.07)  LDD1577  [9]
 LDCM0374  CL105 HCT 116 C971(0.62)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C971(0.65)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C971(0.63)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C971(0.52)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C971(0.75)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C971(0.81)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C971(0.46)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C971(0.65)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C971(1.19)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C971(1.02)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C971(1.15)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C971(1.05)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C971(1.37)  LDD1265  [3]
 LDCM0387  CL117 PaTu 8988t C971(1.23)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C971(0.96)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C971(1.35)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C971(1.38)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C971(1.41)  LDD1270  [3]
 LDCM0392  CL121 HEK-293T C194(0.99)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C1211(0.94); C194(1.01)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C1211(1.14); C194(0.93); C971(0.99)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C1211(0.82); C971(1.06)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C194(0.95)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C1211(0.89); C194(0.99)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C1211(1.11); C194(1.03); C971(1.06)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C1211(1.06); C971(0.97)  LDD1603  [9]
 LDCM0400  CL13 HCT 116 C971(1.19)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C971(1.56)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C971(1.20)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C1211(1.34); C971(1.02)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C971(1.03)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C1211(1.47); C971(1.06)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C1211(1.12); C194(1.05); C971(1.10)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C971(0.81)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C1211(1.15); C194(1.05); C971(1.07)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C1211(1.53); C194(1.06); C971(0.98)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C1211(1.25); C194(0.88); C971(1.06)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C1211(1.59); C971(0.97)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C194(0.77); C971(0.99)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C194(0.91)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C1211(0.82); C194(1.05)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C1211(1.09); C194(0.89); C971(0.95)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C1211(1.14); C971(0.97)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C971(1.02)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C971(0.80)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C1211(1.31); C971(1.00)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C1211(1.16); C194(0.91); C971(1.09)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C1211(1.24); C194(1.15); C971(1.01)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C1211(1.42); C194(0.76); C971(1.02)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C1211(0.75); C194(0.90); C971(1.16)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C1211(1.33); C971(1.11)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C194(0.71); C971(0.99)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C194(0.85)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C1211(1.28); C194(0.82); C971(1.06)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C971(0.91)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C1211(0.96); C971(1.04)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C971(1.27)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C1211(1.21); C971(0.99)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C1211(0.98); C194(1.17); C971(0.99)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C1211(1.12); C194(1.00); C971(1.00)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C1211(1.31); C194(0.93); C971(1.05)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C1211(1.06); C194(0.79); C971(1.19)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C1211(1.46); C971(1.03)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C194(0.62); C971(1.13)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C194(0.91)  LDD1643  [9]
 LDCM0440  CL5 HCT 116 C971(0.95)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C1211(1.13); C194(1.15)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C1211(1.16); C971(1.05)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C971(1.04)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C1211(0.96); C971(1.01)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C1211(0.99); C194(1.00); C971(1.09)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C1211(1.46); C194(1.08); C971(1.10)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C1211(1.03); C194(0.98); C971(1.03)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C1211(1.21); C194(0.91); C971(1.15)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C1211(1.78); C971(1.09)  LDD1653  [9]
 LDCM0451  CL6 HCT 116 C971(0.87)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C194(0.77); C971(1.02)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C194(0.91)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C1211(1.07); C194(0.95)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C1211(0.95); C194(0.88); C971(1.07)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C1211(0.89); C971(1.00)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C971(1.03)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C1211(0.98); C971(1.03)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C1211(1.12); C194(1.07); C971(1.06)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C1211(1.21); C194(0.97); C971(1.02)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C1211(1.11); C194(1.06); C971(1.03)  LDD1664  [9]
 LDCM0462  CL7 HCT 116 C971(1.45)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C1211(0.92); C194(0.88); C971(1.11)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C1211(1.45); C971(1.06)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C194(0.85); C971(0.99)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C194(0.84)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C1211(0.86); C194(1.15)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C1211(0.83); C971(0.99)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C971(0.94)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C1211(1.15); C971(1.05)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C1211(1.03); C194(1.03); C971(1.02)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C971(0.55)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C1211(1.17); C194(1.11); C971(0.99)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C1211(1.27); C194(1.16); C971(0.95)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C1211(0.82); C194(0.90); C971(1.09)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C1211(1.22); C971(0.96)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C194(0.88); C971(1.02)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C194(0.94)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C1211(1.17); C194(1.04)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C1211(1.27); C194(0.90); C971(1.08)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C1211(0.90); C971(1.05)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C971(1.13)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C971(0.95)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C1211(1.43); C971(0.91)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C971(1.31)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C971(1.73)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C971(1.20)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C971(1.53)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C971(0.79)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C971(1.05)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C971(0.92)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C971(2.07)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C971(0.59)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C1211(1.20); C194(0.85); C971(1.11)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C1211(1.10); C194(1.11); C971(1.01)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C1211(0.98); C194(0.85)  LDD1631  [9]
 LDCM0022  KB02 HCT 116 C971(1.75)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C971(1.31)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C971(1.79)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase GET3 (GET3) ArsA ATPase family O43681
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 3 protein (DDIT3) BZIP family P35638
Zinc finger protein 646 (ZNF646) Krueppel C2H2-type zinc-finger protein family O15015
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Axin interactor, dorsalization-associated protein (AIDA) AIDA family Q96BJ3
Protein limb expression 1 homolog (LIX1) LIX1 family Q8N485
Chromobox protein homolog 1 (CBX1) . P83916
Clavesin-2 (CLVS2) . Q5SYC1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402