Details of the Target

General Information of Target

Target ID LDTP07920
Target Name Putative Polycomb group protein ASXL2 (ASXL2)
Gene Name ASXL2
Gene ID 55252
Synonyms
ASXH2; KIAA1685; Putative Polycomb group protein ASXL2; Additional sex combs-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAML
HTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDG
GSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQ
QCRPSISISSNQHLSLKTVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVEN
TLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQ
QRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEI
EKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLI
RIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHELSSILPI
KCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKP
TAGAGPQETNMKEPLATLVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVS
PQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGARTLADI
KAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRV
SETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVP
PTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPSPTGPAL
ISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLP
VPQVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGK
DVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEVNERQSHPATQQQL
GKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLL
SVVPPSQFNFAHSGFQLEDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRR
THSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTGDEQESVTVKEEPQ
VSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKT
LARDLIQAAQKQMAHAVRGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSP
TQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTIPASQAMNPSSHGQ
TIPVQAFSEENSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR
Target Bioclass
Other
Family
Asx family
Subcellular location
Nucleus
Function
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.
Uniprot ID
Q76L83
Ensemble ID
ENST00000404843.5
HGNC ID
HGNC:23805

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.Q1096Ter .
DANG SNV: p.P938H DBIA    Probe Info 
FUOV1 SNV: p.P861A .
HT115 SNV: p.E330D .
KASUMI2 SNV: p.G1162V .
KMS11 SNV: p.S110N .
KYSE30 SNV: p.G707R .
MDAMB436 Deletion: p.A669SfsTer34; p.A674QfsTer117 .
MDAMB453 SNV: p.S344Ter .
NCIH1048 SNV: p.K484N .
NCIH2286 SNV: p.R47I .
SBC5 SNV: p.P752A .
SUPT1 Insertion: p.T734NfsTer22 DBIA    Probe Info 
SW756 SNV: p.E486Ter .
UMUC3 SNV: p.A542E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C266(11.61)  LDD1706  [1]
DBIA
 Probe Info  		C1166(1.62)  LDD0080  [2]
NAIA_5
 Probe Info  		C827(0.00); C1151(0.00); C55(0.00); C144(0.00)  LDD2224  [3]
IPM
 Probe Info  		C299(0.00); C1225(0.00); C827(0.00)  LDD0147  [4]
TFBX
 Probe Info  		C299(0.00); C55(0.00)  LDD0148  [4]
Phosphinate-6
 Probe Info  		C266(0.00); C1225(0.00); C746(0.00)  LDD0018  [5]
AOyne
 Probe Info  		12.10  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1428(1.14); C1431(1.14)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C827(1.01); C431(1.00); C1151(1.18); C1225(1.18)  LDD1508  [7]
 LDCM0216  AC100 PaTu 8988t C1428(0.99); C1431(0.99)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C1428(1.18); C1431(1.18)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C1428(1.21); C1431(1.21)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C1428(1.09); C1431(1.09)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C1428(1.17); C1431(1.17)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C1428(1.10); C1431(1.10)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C1428(1.00); C1431(1.00)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C1428(0.94); C1431(0.94)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C1428(1.29); C1431(1.29)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C1428(1.31); C1431(1.31)  LDD1104  [2]
 LDCM0226  AC11 HEK-293T C827(0.89); C266(0.98); C1225(0.87); C746(1.07)  LDD1509  [7]
 LDCM0227  AC110 PaTu 8988t C1428(1.37); C1431(1.37)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C1428(1.27); C1431(1.27)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C1428(1.10); C1431(1.10)  LDD1108  [2]
 LDCM0237  AC12 HEK-293T C827(1.05); C1166(1.07); C431(1.09); C1151(1.01)  LDD1510  [7]
 LDCM0246  AC128 PaTu 8988t C1428(0.85); C1431(0.85)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C1428(0.83); C1431(0.83)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C1428(0.65); C1431(0.65)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C1428(0.90); C1431(0.90)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C1428(0.89); C1431(0.89)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C1428(1.31); C1431(1.31)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C1428(1.06); C1431(1.06)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C1428(1.43); C1431(1.43)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C1428(0.86); C1431(0.86)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C1428(1.12); C1431(1.12)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C1428(0.99); C1431(0.99)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C1428(0.93); C1431(0.93)  LDD1137  [2]
 LDCM0259  AC14 HEK-293T C827(0.95); C1166(1.09); C431(1.11); C266(0.86)  LDD1512  [7]
 LDCM0260  AC140 PaTu 8988t C1428(0.89); C1431(0.89)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C1428(0.76); C1431(0.76)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C1428(0.86); C1431(0.86)  LDD1141  [2]
 LDCM0270  AC15 HEK-293T C827(1.17); C1166(0.96); C55(1.00); C431(1.05)  LDD1513  [7]
 LDCM0276  AC17 PaTu 8988t C1428(1.29); C1431(1.29)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C1428(1.20); C1431(1.20)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C1428(1.19); C1431(1.19)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C1428(1.04); C1431(1.04)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C1428(1.18); C1431(1.18)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C1428(1.60); C1431(1.60)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C1428(1.28); C1431(1.28)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C1428(1.39); C1431(1.39)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C1428(1.25); C1431(1.25)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C1428(1.04); C1431(1.04)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C1428(1.08); C1431(1.08)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C1428(1.24); C1431(1.24)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C1428(1.06); C1431(1.06)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C1428(1.09); C1431(1.09)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C1428(0.97); C1431(0.97)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C1428(1.16); C1431(1.16)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C1428(0.92); C1431(0.92)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C1428(1.44); C1431(1.44)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C1428(1.03); C1431(1.03)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C1428(1.22); C1431(1.22)  LDD1174  [2]
 LDCM0296  AC35 PaTu 8988t C1428(0.84); C1431(0.84)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C1428(0.92); C1431(0.92)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C1428(1.00); C1431(1.00)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C1428(1.24); C1431(1.24)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C1428(1.08); C1431(1.08)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C1428(1.02); C1431(1.02)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C1428(1.13); C1431(1.13)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C1428(1.38); C1431(1.38)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C1428(1.22); C1431(1.22)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C1428(1.19); C1431(1.19)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C1428(1.38); C1431(1.38)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C1428(1.14); C1431(1.14)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C827(1.06); C1166(1.19); C431(0.94); C266(0.88)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C827(1.03); C1166(0.94); C55(1.10); C431(1.06)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C827(1.09); C1166(1.12); C55(1.15); C431(1.03)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C827(0.90); C55(1.21); C431(0.96); C1151(1.02)  LDD1550  [7]
 LDCM0312  AC5 PaTu 8988t C1428(1.23); C1431(1.23)  LDD1191  [2]
 LDCM0313  AC50 HEK-293T C827(1.22); C431(0.96); C1151(1.05); C1225(1.03)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C827(0.91); C266(0.97); C1225(1.07); C746(0.96)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C827(0.82); C1166(1.00); C431(1.14); C1151(0.99)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C827(0.94); C431(1.06); C1225(0.94); C1428(0.86)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C827(0.80); C1166(1.12); C431(0.93); C266(0.98)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C827(1.23); C1166(0.92); C55(1.24); C431(0.99)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C827(0.90); C1166(0.98); C55(0.99); C431(1.07)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C827(0.86); C55(1.19); C431(1.07); C1151(1.09)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C827(0.92); C431(1.03); C1151(1.12); C1225(1.29)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C827(0.86); C266(1.02); C1225(0.89); C746(1.09)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C827(1.09); C1166(1.12); C431(1.13); C266(0.90)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C827(0.94); C1166(1.02); C431(1.06); C1151(1.06)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C827(0.94); C431(1.08); C1225(0.98); C1428(1.05)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C827(0.98); C1166(1.06); C431(0.93); C266(0.89)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C827(1.04); C1166(1.15); C55(1.08); C431(1.12)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C827(0.93); C1166(1.03); C55(1.04); C431(1.03)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C827(1.12); C1166(0.97); C55(1.16); C431(1.01)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C827(0.91); C1166(0.97); C55(0.96); C431(0.88)  LDD1569  [7]
 LDCM0365  AC98 PaTu 8988t C1428(1.29); C1431(1.29)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C1428(1.00); C1431(1.00)  LDD1245  [2]
 LDCM0248  AKOS034007472 HEK-293T C827(0.81); C431(0.95); C1225(1.00); C1428(0.73)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C827(1.00); C55(1.06); C431(1.03); C1151(1.03)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C827(1.04); C1166(0.90); C55(0.93); C431(1.01)  LDD1514  [7]
 LDCM0632  CL-Sc Hep-G2 C55(0.90); C827(0.49)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C827(0.92); C1166(0.97); C55(0.91); C431(0.92)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C827(1.21); C1166(1.25); C431(0.86); C266(1.02)  LDD1572  [7]
 LDCM0369  CL100 PaTu 8988t C1428(0.92); C1431(0.92)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C827(1.02); C1166(0.86); C55(1.09); C431(1.14)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C827(0.92); C431(0.95); C1151(1.08); C266(1.13)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C827(1.00); C1166(0.85); C431(0.96); C1151(0.79)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C55(0.85); C431(1.01); C1428(1.32)  LDD1577  [7]
 LDCM0374  CL105 PaTu 8988t C1428(1.22); C1431(1.22)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C1428(1.07); C1431(1.07)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C1428(1.09); C1431(1.09)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C1428(1.05); C1431(1.05)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C1428(1.23); C1431(1.23)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C827(1.12); C1166(1.12); C55(0.86); C431(1.08)  LDD1583  [7]
 LDCM0380  CL110 PaTu 8988t C1428(1.20); C1431(1.20)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C1428(1.50); C1431(1.50)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C1428(1.14); C1431(1.14)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C1428(1.04); C1431(1.04)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C1428(0.97); C1431(0.97)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C1428(0.90); C1431(0.90)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C1428(1.26); C1431(1.26)  LDD1265  [2]
 LDCM0387  CL117 PaTu 8988t C1428(1.16); C1431(1.16)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C1428(1.14); C1431(1.14)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C1428(1.10); C1431(1.10)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C827(1.02); C1166(0.94); C55(0.75); C431(1.08)  LDD1594  [7]
 LDCM0391  CL120 PaTu 8988t C1428(0.90); C1431(0.90)  LDD1270  [2]
 LDCM0392  CL121 HEK-293T C827(0.93); C1166(0.75); C55(1.34); C431(1.03)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C827(0.86); C431(1.03); C1151(1.14); C266(1.01)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C827(0.84); C1166(0.74); C431(0.88); C1151(1.13)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C55(1.00); C431(1.04); C1428(0.58)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C827(0.72); C1166(0.93); C55(1.13); C431(1.00)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C827(0.77); C431(1.08); C1151(1.16); C266(0.98)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C827(0.91); C1166(1.06); C431(0.97); C1151(1.18)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C55(0.91); C431(1.06); C1428(1.23)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C827(0.96); C1166(0.88); C55(1.37); C431(1.22)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C827(1.14); C431(1.10); C1151(1.15); C266(1.12)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C827(1.15); C1166(1.02); C431(1.07); C1151(1.13)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C55(0.88); C431(1.03); C1428(1.11)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C827(0.99); C55(0.95); C431(1.11); C1151(1.17)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C827(0.93); C431(1.06); C1151(1.06); C1225(1.37)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C827(0.94); C266(1.00); C1225(0.98); C746(0.90)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C827(0.88); C431(1.05); C1151(1.33); C266(0.97)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C827(0.99); C1166(0.95); C431(1.09); C1151(1.20)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C827(1.04); C431(0.95); C1225(1.03); C1428(0.50)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C827(1.10); C1166(1.03); C431(1.25); C266(1.06)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C827(0.98); C1166(1.00); C55(0.98); C431(1.06)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C827(0.96); C1166(0.98); C55(0.94); C431(1.03)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C827(0.93); C1166(0.81); C55(0.94); C431(0.97)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C827(1.14); C431(0.94); C1151(1.05); C266(0.97)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C827(0.92); C1166(0.78); C431(0.88); C1151(0.96)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C55(0.79); C431(0.97); C1428(0.72)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C827(1.17); C55(1.02); C431(1.11); C1151(0.99)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C827(1.13); C1166(1.04); C431(1.03); C1151(1.14)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C827(0.78); C431(1.00); C1151(1.14); C1225(0.83)  LDD1623  [7]
 LDCM0420  CL31 PaTu 8988t C1428(1.20); C1431(1.20)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C1428(1.16); C1431(1.16)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C1428(1.07); C1431(1.07)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C1428(1.28); C1431(1.28)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C1428(1.35); C1431(1.35)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C1428(1.28); C1431(1.28)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C1428(1.48); C1431(1.48)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C1428(1.25); C1431(1.25)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C55(0.98); C431(1.01); C1428(0.69)  LDD1633  [7]
 LDCM0430  CL40 PaTu 8988t C1428(1.21); C1431(1.21)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C1428(1.40); C1431(1.40)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C1428(1.56); C1431(1.56)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C1428(2.34); C1431(2.34)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C1428(1.37); C1431(1.37)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C1428(1.25); C1431(1.25)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C1428(1.04); C1431(1.04)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C1428(0.77); C1431(0.77)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C1428(0.93); C1431(0.93)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C1428(0.82); C1431(0.82)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C827(0.85); C55(1.03); C431(1.00); C1151(1.16)  LDD1644  [7]
 LDCM0441  CL50 PaTu 8988t C1428(0.94); C1431(0.94)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C1428(0.92); C1431(0.92)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C1428(0.98); C1431(0.98)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C1428(1.08); C1431(1.08)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C1428(0.93); C1431(0.93)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C1428(1.15); C1431(1.15)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C1428(1.16); C1431(1.16)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C1428(0.99); C1431(0.99)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C1428(0.93); C1431(0.93)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C1428(0.99); C1431(0.99)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C827(0.99); C431(1.09); C1151(1.05); C1225(1.02)  LDD1654  [7]
 LDCM0452  CL60 PaTu 8988t C1428(0.73); C1431(0.73)  LDD1331  [2]
 LDCM0453  CL61 HEK-293T C827(0.85); C1166(0.88); C55(1.36); C431(0.94)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C827(0.99); C431(1.12); C1151(1.22); C266(0.94)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C827(1.08); C1166(0.87); C431(0.92); C1151(0.98)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C55(0.75); C431(1.01); C1428(0.90)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C827(1.07); C55(1.00); C431(1.17); C1151(1.10)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C827(0.81); C431(1.09); C1151(1.10); C1225(1.48)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C827(0.96); C266(0.93); C1225(1.16); C746(1.05)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C827(0.90); C1166(0.96); C431(1.10); C1151(1.23)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C827(0.96); C431(1.09); C1225(1.00); C1428(0.57)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C827(0.88); C266(1.12); C1225(0.69); C746(1.01)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C827(0.86); C1166(1.08); C431(1.19); C266(1.03)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C827(0.94); C1166(1.06); C55(0.87); C431(0.98)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C827(1.14); C1166(0.96); C55(0.96); C431(1.10)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C827(0.94); C1166(1.01); C55(1.05); C431(0.92)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C827(0.92); C431(0.98); C1151(1.09); C266(1.10)  LDD1670  [7]
 LDCM0469  CL76 PaTu 8988t C1428(0.87); C1431(0.87)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C1428(1.05); C1431(1.05)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C1428(1.00); C1431(1.00)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C1428(0.94); C1431(0.94)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C827(0.98); C1166(1.01); C431(1.11); C1151(1.22)  LDD1676  [7]
 LDCM0474  CL80 PaTu 8988t C1428(1.04); C1431(1.04)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C1428(1.11); C1431(1.11)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C1428(1.20); C1431(1.20)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C1428(0.89); C1431(0.89)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C1428(1.18); C1431(1.18)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C1428(0.91); C1431(0.91)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C1428(1.02); C1431(1.02)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C1428(1.19); C1431(1.19)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C1428(0.95); C1431(0.95)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C1428(1.13); C1431(1.13)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C827(1.03); C431(1.14); C1225(1.03); C1428(0.54)  LDD1687  [7]
 LDCM0485  CL90 PaTu 8988t C1428(0.94); C1431(0.94)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C1428(0.95); C1431(0.95)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C1428(1.07); C1431(1.07)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C1428(0.89); C1431(0.89)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C1428(1.12); C1431(1.12)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C1428(1.12); C1431(1.12)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C1428(1.13); C1431(1.13)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C1428(1.01); C1431(1.01)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C1428(1.54); C1431(1.54)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C1428(1.14); C1431(1.14)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C827(1.24); C1166(0.79); C431(1.00); C1151(0.92)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C827(0.97); C1166(0.83); C431(1.03); C1151(1.16)  LDD1671  [7]
 LDCM0427  Fragment51 PaTu 8988t C1428(1.49); C1431(1.49)  LDD1306  [2]
 LDCM0022  KB02 HCT 116 C1166(1.62)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1166(1.43)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1166(1.99)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methyl-CpG-binding domain protein 6 (MBD6) . Q96DN6

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402