Details of the Target

General Information of Target

Target ID LDTP07576
Target Name DCN1-like protein 2 (DCUN1D2)
Gene Name DCUN1D2
Gene ID 55208
Synonyms
C13orf17; DCUN1L2; DCN1-like protein 2; DCNL2; DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSFFQNPDSLHRESMRNAV
DKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRK
EFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVA
YWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLI
DDFVEYARPVVTGGKRSLF
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity.
Uniprot ID
Q6PH85
Ensemble ID
ENST00000375403.6
HGNC ID
HGNC:20328
ChEMBL ID
CHEMBL4295866

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K9N .
HEC1 SNV: p.D74Y .
ZR751 SNV: p.F259L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C115(34.67)  LDD0209  [1]
TFBX
 Probe Info  		N.A.  LDD0027  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C115(0.97)  LDD1507  [4]
 LDCM0215  AC10 PaTu 8988t C115(1.15)  LDD1094  [5]
 LDCM0216  AC100 HCT 116 C115(1.02)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C115(0.85)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C115(0.97)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C115(1.33)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C115(1.19)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C115(1.88)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C115(0.87)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C115(0.92)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C115(0.86)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C115(0.78)  LDD0542  [5]
 LDCM0226  AC11 PaTu 8988t C115(1.72)  LDD1105  [5]
 LDCM0227  AC110 HCT 116 C115(1.37)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C115(1.43)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C115(0.79)  LDD0546  [5]
 LDCM0237  AC12 PaTu 8988t C115(0.89)  LDD1116  [5]
 LDCM0259  AC14 PaTu 8988t C115(1.34)  LDD1138  [5]
 LDCM0270  AC15 PaTu 8988t C115(1.11)  LDD1149  [5]
 LDCM0276  AC17 HCT 116 C115(0.94)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C115(1.01)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C115(1.15)  LDD0595  [5]
 LDCM0280  AC20 HCT 116 C115(0.91)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C115(0.94)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C115(0.86)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C115(0.83)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C115(0.93)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C115(1.07)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C115(1.01)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C115(1.03)  LDD1529  [4]
 LDCM0294  AC33 HEK-293T C115(0.99)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C115(1.12)  LDD1535  [4]
 LDCM0303  AC41 HEK-293T C115(1.04)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C115(1.16)  LDD1544  [4]
 LDCM0308  AC46 HCT 116 C115(1.67)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C115(1.06)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C115(0.91)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C115(1.31)  LDD0628  [5]
 LDCM0313  AC50 HCT 116 C115(1.40)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C115(0.72)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C115(0.91)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C115(1.82)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C115(1.02)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C115(1.21)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C115(3.17)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C115(1.89)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C115(1.31)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C115(1.84)  LDD0639  [5]
 LDCM0323  AC6 PaTu 8988t C115(0.86)  LDD1202  [5]
 LDCM0324  AC60 HCT 116 C115(1.96)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C115(1.38)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C115(1.67)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C115(1.56)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C115(1.75)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C115(2.14)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C115(1.91)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C115(2.13)  LDD0648  [5]
 LDCM0334  AC7 PaTu 8988t C115(1.41)  LDD1213  [5]
 LDCM0345  AC8 PaTu 8988t C115(1.19)  LDD1224  [5]
 LDCM0365  AC98 HCT 116 C115(0.88)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C115(0.63)  LDD0683  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C115(0.96)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C115(1.14)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C115(1.26)  LDD1154  [5]
 LDCM0367  CL1 HCT 116 C115(0.86)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C115(1.55)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C115(1.05)  LDD1573  [4]
 LDCM0370  CL101 PaTu 8988t C115(1.22)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C115(1.03)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C115(1.30)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C115(1.07)  LDD1252  [5]
 LDCM0374  CL105 HCT 116 C115(1.30)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C115(1.44)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C115(1.37)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C115(1.36)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C115(1.05)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C115(1.73)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C115(1.08)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C115(1.11)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C115(0.99)  LDD1586  [4]
 LDCM0386  CL116 HEK-293T C115(1.06)  LDD1590  [4]
 LDCM0390  CL12 HCT 116 C115(3.60)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C115(1.16)  LDD1595  [4]
 LDCM0392  CL121 HCT 116 C115(0.88)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C115(0.95)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C115(1.33)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C115(2.53)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C115(1.19)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C115(0.92)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C115(0.94)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C115(2.05)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C115(1.71)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C115(1.22)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C115(0.98)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C115(0.91)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C115(0.88)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C115(1.05)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C115(1.02)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C115(0.70)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C115(1.30)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C115(1.31)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C115(2.29)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C115(1.11)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C115(1.75)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C115(0.93)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C115(1.20)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C115(0.98)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C115(1.14)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C115(1.18)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C115(0.90)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C115(1.20)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C115(0.84)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C115(1.35)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C115(1.10)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C115(2.14)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C115(1.65)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C115(1.04)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C115(1.30)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C115(1.44)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C115(1.31)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C115(1.03)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C115(1.14)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C115(1.73)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C115(1.61)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C115(1.15)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C115(1.76)  LDD0752  [5]
 LDCM0440  CL5 HCT 116 C115(2.59)  LDD0757  [5]
 LDCM0443  CL52 HEK-293T C115(1.12)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C115(1.08)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C115(1.19)  LDD1649  [4]
 LDCM0451  CL6 HCT 116 C115(1.44)  LDD0768  [5]
 LDCM0453  CL61 PaTu 8988t C115(1.29)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C115(1.57)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C115(1.29)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C115(2.51)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C115(1.57)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C115(1.39)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C115(1.20)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C115(2.16)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C115(2.32)  LDD1340  [5]
 LDCM0462  CL7 HCT 116 C115(1.68)  LDD0779  [5]
 LDCM0463  CL70 PaTu 8988t C115(1.33)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C115(1.16)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C115(1.31)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C115(2.75)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C115(1.47)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C115(0.98)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C115(0.69)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C115(0.89)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C115(0.99)  LDD1351  [5]
 LDCM0473  CL8 HCT 116 C115(1.72)  LDD0790  [5]
 LDCM0474  CL80 PaTu 8988t C115(1.23)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C115(1.19)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C115(1.03)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C115(0.81)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C115(1.43)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C115(0.88)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C115(1.34)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C115(1.27)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C115(1.22)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C115(1.40)  LDD1362  [5]
 LDCM0484  CL9 HCT 116 C115(0.97)  LDD0801  [5]
 LDCM0485  CL90 PaTu 8988t C115(0.92)  LDD1364  [5]
 LDCM0486  CL91 HEK-293T C115(0.98)  LDD1689  [4]
 LDCM0468  Fragment33 PaTu 8988t C115(2.09)  LDD1347  [5]
 LDCM0427  Fragment51 HCT 116 C115(1.68)  LDD0744  [5]
 LDCM0022  KB02 A3-KAW C115(2.58)  LDD2257  [6]
 LDCM0023  KB03 Jurkat C115(34.67)  LDD0209  [1]
 LDCM0024  KB05 NALM-6 C115(2.77)  LDD3339  [6]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840