Details of the Target

General Information of Target

Target ID LDTP07126
Target Name Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1)
Gene Name CAMSAP1
Gene ID 157922
Synonyms
Calmodulin-regulated spectrin-associated protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVDASGRAAAEGWRKMEAPPDGAADLVPLDRYDAARAKIAANLQWICAKAYGRDNIPEDL
RDPFYVDQYEQEHIKPPVIKLLLSSELYCRVCSLILKGDQVAALQGHQSVIQALSRKGIY
VMESDDTPVTESDLSRAPIKMSAHMAMVDALMMAYTVEMISIEKVVASVKRFSTFSASKE
LPYDLEDAMVFWINKVNLKMREITEKEVKLKQQLLESPAHQKVRYRREHLSARQSPYFPL
LEDLMRDGSDGAALLAVIHYYCPEQMKLDDICLKEVTSMADSLYNIRLLREFSNEYLNKC
FYLTLEDMLYAPLVLKPNVMVFIAELFWWFENVKPDFVQPRDVQELKDAKTVLHQKSSRP
PVPISNATKRSFLGSPAAGTLAELQPPVQLPAEGCHRHYLHPEEPEYLGKGTAAFSPSHP
LLPLRQKQQKSIQGEDIPDQRHRSNSLTRVDGQPRGAAIAWPEKKTRPASQPTPFALHHA
ASCEVDPSSGDSISLARSISKDSLASNIVNLTPQNQPHPTATKSHGKSLLSNVSIEDEEE
ELVAIVRADVVPQQADPEFPRASPRALGLTANARSPQGQLDTSESKPDSFFLEPLMPAVL
KPAKEKQVITKEDERGEGRPRSIVSRRPSEGPQPLVRRKMTGSRDLNRTFTPIPCSEFPM
GIDPTETGPLSVETAGEVCGGPLALGGFDPFPQGPSTDGFFLHVGRADEDTEGRLYVSCS
KSPNSHDSEPWTLLRQDSDSDVVDIEEAEHDFMGEAHPVVFSRYIGEEESAKLQEDMKVK
EHEDKDDASGRSSPCLSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETKSSTSSSQKT
TPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRAIEAQKKKME
ALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAVSKTEDFLVK
EEQREELLHEPQDVDKESLAFAQQHKAKDPVALHELERNKVISAALLEDTVGEVVDVNEC
DLSIEKLNETISTLQQAILKISQQQEQLLMKSPTVPVPGSKNNSQDHKVKAPVHFVEPLS
PTGVAGHRKAPRLGQGRNSRSGRPAELKVPKDRPQGSSRSKTPTPSVETLPHLRPFPASS
HPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHDESNQRTLTLSSSKDANILSEQMSLKEV
LDASVKEVGSSSSDVSGKESVPVEEPLRSRASLIEVDLSDLKAPDEDGELVSLDGSADLV
SEGDQKPGVGFFFKDEQKAEDELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEAR
RKAEEDRVRKEEEKARRELIKQEYLRRKQQQILEEQGLGKPKSKPKKPRPKSVHREESCS
DSGTKCSSTPDNLSRTQSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILSRNPSR
STDRDWETASAASSLASVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSI
LEELEKCDANHYIILFRDAGCQFRALYCYYPDTEEIYKLTGTGPKNITKKMIDKLYKYSS
DRKQFNLIPAKTMSVSVDALTIHNHLWQPKRPAVPKKAQTRK
Target Bioclass
Other
Family
CAMSAP1 family
Subcellular location
Cytoplasm, cytoskeleton
Function
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth.
Uniprot ID
Q5T5Y3
Ensemble ID
ENST00000312405.10
HGNC ID
HGNC:19946

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L1048R .
CAL120 Substitution: p.L569F .
CAMA1 SNV: p.Q1423Ter DBIA    Probe Info 
CASKI SNV: p.K813N; p.E829Q; p.Q963H .
HCT15 SNV: p.V319A .
HL60 Substitution: p.L569F .
HT115 SNV: p.R791H; p.S978N; p.E1338K .
HUH28 SNV: p.S1101C DBIA    Probe Info 
IGROV1 SNV: p.L1048R .
KMRC3 SNV: p.K1040N .
KMS11 SNV: p.A707P DBIA    Probe Info 
MCC13 Substitution: p.A756V .
MFE280 SNV: p.V812L .
MFE319 SNV: p.L408P DBIA    Probe Info 
MOLM13 Substitution: p.H969P DBIA    Probe Info 
NCIH1155 SNV: p.D1532N DBIA    Probe Info 
NCIH23 SNV: p.P842L .
OVK18 SNV: p.A1004D .
OVTOKO SNV: p.M145I .
PANC0403 Substitution: p.L569F .
RKO Deletion: p.E617KfsTer24
SNV: p.P236L		 DBIA    Probe Info 
RL952 Deletion: p.V388CfsTer37 DBIA    Probe Info 
SKMEL30 SNV: p.A788V DBIA    Probe Info 
SW1783 SNV: p.E17D .
SW1990 Substitution: p.L569F DBIA    Probe Info 
SW403 SNV: p.R36G DBIA    Probe Info 
TOV21G SNV: p.E1299Ter .
WM115 Substitution: p.L569F .
WM2664 Substitution: p.L569F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K898(1.92)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C947(5.68)  LDD0168  [3]
DBIA
 Probe Info  		C1164(6.70)  LDD0209  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1379(0.00); C1386(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		C395(0.00); C848(0.00)  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2225  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		C395(0.00); C1386(0.00)  LDD0007  [8]
YN-1
 Probe Info  		D59(0.00); E58(0.00)  LDD0447  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
AOyne
 Probe Info  		9.30  LDD0443  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C947(5.68)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C947(2.93); C719(2.60); C1020(3.52)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C1164(0.82); C395(0.94); C719(1.02); C1020(0.93)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C947(1.06); C1164(0.93); C395(0.84); C262(1.13)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C1164(0.97); C262(0.76); C719(1.05); C848(0.88)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C262(1.19); C719(1.00); C1020(0.90); C1386(1.11)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C1164(0.91); C262(1.02); C848(0.89); C1020(1.02)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C1164(0.98); C262(0.86); C719(1.00); C272(1.07)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C1164(1.11); C395(1.03); C719(1.03); C1020(0.83)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C947(0.77); C1164(0.90); C395(0.92); C262(1.13)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C1164(1.00); C262(0.76); C719(1.35); C848(0.77)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C947(0.89); C1164(1.03); C395(0.97); C262(1.12)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C262(1.16); C719(1.01); C1020(1.01); C1386(0.98)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C1164(0.92); C395(1.24); C262(0.97); C848(1.12)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C1164(0.90); C262(1.12); C848(1.02); C1020(0.95)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C1164(1.05); C262(1.05); C719(1.06); C272(0.93)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C1164(1.08); C262(0.91); C848(0.94); C1020(0.88)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C1164(0.98); C395(1.05); C719(1.01); C1020(0.94)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C947(0.72); C1164(1.06); C395(0.91); C262(1.31)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C1164(1.01); C262(0.84); C719(1.03); C848(0.87)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C262(0.94); C719(0.97); C1020(0.98); C1386(1.20)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C1164(0.93); C395(1.12); C262(0.91); C848(0.89)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C1164(1.01); C262(0.88); C719(1.01); C848(0.86)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C1164(0.73); C262(1.02); C848(0.88); C1020(1.04)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C1164(0.94); C262(0.95); C719(0.93); C272(0.97)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C1164(1.05); C262(0.81); C848(0.96); C1020(1.04)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C1164(0.93); C395(0.99); C719(1.11); C1020(1.14)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C947(1.10); C1164(0.92); C395(1.04); C262(1.15)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C1164(0.90); C262(0.83); C719(0.96); C848(0.97)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C262(1.32); C719(0.98); C1020(0.85); C1386(1.07)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C1164(0.96); C395(0.95); C262(0.89); C848(1.16)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C1164(0.89); C262(0.97); C848(0.94); C1020(1.07)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C1164(0.92); C262(1.04); C719(1.02); C272(0.96)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C262(1.21); C719(0.98); C1020(0.86); C1386(1.54)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C1164(1.01); C262(0.89); C848(0.94); C1020(0.84)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C1164(0.88); C395(0.98); C719(1.03); C1020(1.13)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C947(0.93); C1164(1.21); C395(1.08); C262(1.07)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C1164(0.84); C262(0.80); C719(0.97); C848(0.81)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C262(1.11); C719(1.01); C1020(0.94); C1386(1.07)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C1164(0.81); C395(1.22); C262(1.01); C848(0.93)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C1164(0.82); C262(1.00); C848(0.91); C1020(1.03)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C1164(1.26); C262(0.98); C719(1.10); C272(1.00)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C1164(1.10); C262(1.02); C848(0.97); C1020(0.94)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C1164(1.07); C395(0.90); C719(1.03); C1020(0.88)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C1164(1.03); C395(1.45); C262(0.98); C848(1.06)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C947(1.09); C1164(0.98); C395(1.01); C262(1.10)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C1164(0.98); C262(1.04); C719(0.94); C848(1.23)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C262(1.05); C719(0.98); C1020(1.03); C1386(1.02)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C1164(1.14); C395(1.09); C262(0.97); C848(1.00)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C1164(0.85); C262(0.99); C848(0.84); C1020(1.10)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C1164(1.13); C262(0.86); C719(1.02); C272(1.03)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C1164(1.00); C262(0.98); C848(0.96); C1020(0.88)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C1164(0.99); C395(0.80); C719(0.97); C1020(1.19)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C947(0.82); C1164(0.96); C395(0.99); C262(1.25)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C1164(0.80); C262(1.06); C719(0.99); C848(0.77)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C1164(0.83); C262(0.95); C848(0.85); C1020(1.14)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C262(1.03); C719(1.02); C1020(1.05); C1386(1.14)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C1164(1.09); C395(0.83); C262(1.06); C848(1.04)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C1164(0.84); C262(1.00); C848(0.92); C1020(0.98)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C1164(1.14); C262(0.91); C719(1.06); C272(1.00)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C1164(0.99); C262(1.07); C848(0.91); C1020(0.92)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C1164(1.05); C262(0.85); C719(0.94); C272(0.94)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C1164(1.08); C262(0.85); C848(0.92); C1020(0.96)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C1164(1.08); C395(0.96); C262(0.94); C848(1.10)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C1164(0.94); C395(0.87); C719(1.01); C1020(1.09)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C1164(1.20); C262(1.03); C848(0.96); C1020(0.87)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 11.51  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C1164(0.84); C47(0.73)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C947(0.96); C1164(1.10); C395(0.89); C262(1.22)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C1164(0.95); C262(1.08); C848(0.96); C1020(0.92)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C1164(0.61); C395(0.98); C262(0.96); C719(1.06)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C947(0.78); C1164(1.02); C395(0.97); C262(1.06)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C1164(0.89); C262(1.09); C1020(0.95); C1379(0.94)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C1164(0.98); C395(0.93); C262(0.86); C719(1.03)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C1164(0.87); C395(1.03); C262(1.02); C719(1.08)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C947(0.69); C1164(0.98); C395(0.99); C262(1.23)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C1164(0.86); C262(0.92); C1020(1.34); C1379(0.82)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C1164(0.99); C395(1.39); C262(1.12); C719(1.04)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C1164(0.88); C395(0.98); C262(0.82); C719(1.06)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C947(0.64); C1164(1.02); C395(0.86); C262(1.08)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C1164(1.02); C262(0.90); C719(1.05); C272(1.21)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C1164(1.27); C262(1.10); C1020(1.07); C1379(0.94)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C1164(1.11); C395(1.32); C262(1.14); C719(0.99)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C1164(1.24); C395(1.06); C262(1.07); C719(1.02)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C947(0.65); C1164(1.01); C395(1.19); C262(1.14)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C1164(0.91); C262(1.08); C1020(1.06); C1379(1.37)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C1164(1.07); C395(0.95); C262(1.11); C719(1.02)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C1164(0.78); C395(1.11); C262(1.03); C719(1.09)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C947(1.02); C1164(0.88); C395(1.11); C262(1.05)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C1164(1.22); C262(1.14); C1020(1.26); C1379(1.28)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C1164(0.81); C395(1.02); C262(1.12); C719(1.01)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C1164(0.97); C262(0.44); C848(1.02); C1020(1.01)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C1164(0.88); C395(1.01); C262(1.09); C719(1.10)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C947(1.09); C1164(0.95); C395(0.92); C262(1.11)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C1164(0.90); C262(1.11); C1020(1.14); C1379(1.13)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C1164(0.90); C395(1.02); C262(0.87); C719(1.05)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C1164(1.28); C395(0.97); C262(0.93); C719(1.00)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C947(0.63); C1164(0.98); C395(1.18); C262(1.38)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C1164(0.78); C262(1.23); C1020(1.29); C1379(1.03)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C1164(0.85); C395(1.06); C262(0.97); C719(1.11)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C1164(0.77); C395(1.09); C262(1.06); C719(1.09)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C947(0.88); C1164(1.08); C395(0.86); C262(1.16)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C1164(0.91); C262(1.28); C1020(1.18); C1379(0.83)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C1164(0.94); C395(1.14); C262(0.82); C719(0.98)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C1164(1.00); C395(0.97); C262(1.10); C719(1.12)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C1164(1.34); C395(0.80); C719(0.99); C1020(1.23)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C947(0.85); C1164(0.94); C395(0.93); C262(1.41)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C1164(0.83); C262(0.84); C719(0.99); C848(1.03)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C1164(1.01); C262(0.99); C1020(1.11); C1379(0.86)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C262(1.27); C719(1.08); C1020(1.01); C1386(1.10)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C1164(1.13); C395(1.20); C262(1.02); C848(1.05)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C1164(1.11); C262(1.05); C848(1.03); C1020(1.08)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C1164(1.33); C262(1.06); C719(1.12); C272(1.09)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C1164(1.09); C262(0.93); C848(0.99); C1020(0.85)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C947(0.76); C1164(0.93); C395(0.85); C262(0.95)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C1164(1.11); C262(0.97); C1020(1.08); C1379(0.78)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C1164(0.94); C395(0.97); C262(0.85); C719(1.01)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C1164(0.71); C395(0.93); C262(1.32); C719(0.96)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C1164(0.85); C395(0.88); C719(0.96); C1020(0.84)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C1164(0.99); C395(1.32); C262(1.00); C719(1.00)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C947(0.90); C1164(1.02); C395(0.79); C262(1.26)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C1164(1.05); C262(0.80); C719(0.99); C848(0.73)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C262(0.99); C719(1.01); C1020(1.02); C1386(0.91)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C1164(1.18); C395(1.23); C262(0.90); C848(1.12)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C1164(0.90); C262(0.96); C848(1.03); C1020(1.02)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C1164(1.21); C262(0.87); C719(1.06); C272(1.21)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C1164(0.97); C262(0.87); C848(0.91); C1020(0.96)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C947(0.75); C1164(0.86); C395(0.96); C262(0.93)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C1164(1.29); C395(0.93); C262(1.07); C719(0.98)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C1164(0.88); C395(1.02); C262(0.95); C719(1.04)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C1164(0.97); C395(1.05); C262(0.71); C719(1.02)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C1164(1.17); C395(1.10); C719(1.04); C1020(1.08)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C947(0.77); C1164(0.87); C395(0.84); C262(1.09)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C1164(0.94); C262(1.07); C719(0.95); C848(0.73)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C262(1.15); C719(0.97); C1020(1.18); C1386(1.05)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C1164(1.34); C395(0.94); C262(1.00); C848(1.13)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C1164(0.80); C262(0.99); C848(0.95); C1020(0.86)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C1164(0.99); C262(0.90); C719(0.90); C272(1.00)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C1164(1.35); C262(0.97); C848(1.11); C1020(1.05)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C947(0.69); C1164(0.88); C395(0.87); C262(1.24)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C1164(0.97); C395(0.96); C719(1.04); C1020(1.11)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C1164(0.84); C262(1.03); C1020(1.04); C1379(1.06)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C1164(0.73); C395(1.05); C262(1.03); C719(1.18)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C1164(0.86); C395(1.09); C719(1.08); C1020(1.34)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C947(0.77); C1164(0.96); C395(0.79); C262(1.13)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C1164(1.07); C262(1.12); C719(1.06); C848(0.81)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C262(1.22); C719(1.03); C1020(1.03); C1386(1.23)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C1164(1.29); C395(1.04); C262(1.22); C848(1.67)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C1164(0.83); C262(0.99); C848(0.93); C1020(0.95)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C1164(1.13); C262(1.03); C719(1.07); C272(1.09)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C947(0.75); C1164(0.98); C395(0.96); C262(1.29)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C1164(1.07); C262(1.04); C848(0.95); C1020(1.03)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C947(0.80); C1164(0.82); C395(1.10); C262(1.34)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C1164(0.88); C262(1.36); C1020(1.06); C1379(1.04)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C1164(1.09); C395(1.15); C262(1.10); C719(1.13)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C1164(0.89); C395(1.07); C262(1.59); C719(1.07)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C1164(0.85); C395(0.91); C719(1.02); C1020(0.99)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C947(1.35); C1164(1.11); C395(0.86); C262(1.24)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C1164(0.99); C262(0.94); C719(0.98); C848(0.82)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C262(1.14); C719(1.04); C1020(1.01); C1386(0.97)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C1164(1.03); C395(1.77); C262(1.07); C848(0.76)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C1164(0.95); C262(0.85); C719(0.97); C848(1.20)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C1164(0.93); C262(1.07); C848(0.97); C1020(1.03)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C1164(1.19); C262(0.94); C719(0.97); C272(1.06)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C1164(1.22); C262(0.95); C848(1.02); C1020(0.89)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C947(0.65); C1164(0.81); C395(1.01); C262(1.26)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C1164(1.04); C262(0.99); C1020(1.09); C1379(0.91)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C1164(1.02); C395(1.03); C262(0.74); C719(1.13)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C1164(1.00); C395(0.88); C719(1.06); C1020(1.03)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C947(0.95); C1164(0.98); C395(0.85); C262(1.21)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C1164(1.01); C262(0.91); C719(0.98); C848(0.76)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C262(1.27); C719(0.93); C1020(0.81); C1386(1.19)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C262(0.90); C719(1.00); C1020(1.04); C1386(1.01)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C1164(1.07); C395(1.07); C262(1.03); C848(0.85)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C1164(0.81); C262(1.02); C848(1.04); C1020(1.02)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C1164(0.83); C262(1.12); C719(1.01); C272(1.03)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C1164(0.97); C262(1.01); C848(0.90); C1020(0.82)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C947(0.80); C1164(0.94); C395(0.79); C262(1.17)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C1164(1.20); C262(1.04); C1020(1.04); C1379(0.90)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C1164(0.90); C395(1.14); C262(1.06); C719(1.01)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C1164(0.63); C395(1.12); C262(1.66); C719(1.21)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C1164(0.90); C395(1.02); C719(1.06); C1020(1.14)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C1164(1.07); C395(0.98); C262(1.08); C848(1.04)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C947(0.76); C1164(0.94); C395(0.89); C262(0.94)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C1164(0.90); C262(1.13); C719(0.97); C848(0.92)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C262(1.18); C719(1.05); C1020(1.04); C1386(1.12)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C1164(0.93); C395(0.94); C262(1.10); C848(1.89)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C1164(1.06); C262(1.22); C848(0.96); C1020(1.04)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C1164(1.22); C262(0.82); C719(1.01); C272(0.90)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C1164(1.56); C262(0.94); C848(1.03); C1020(1.01)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C947(0.86); C1164(0.91); C395(0.96); C262(1.11)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C1164(1.11); C262(0.89); C1020(1.11); C1379(0.69)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C1164(1.17); C395(1.09); C262(1.00); C719(1.07)  LDD1697  [13]
 LDCM0634  CY-0357 Hep-G2 C848(0.56)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C1164(1.35); C395(0.91); C262(1.16); C719(1.03)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C92(4.11); C719(1.46)  LDD1702  [14]
 LDCM0580  Fragment21 Ramos C1164(2.17)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C1164(1.68)  LDD2196  [15]
 LDCM0586  Fragment28 Ramos C1164(1.12)  LDD2198  [15]
 LDCM0589  Fragment31 Ramos C1164(1.27)  LDD2200  [15]
 LDCM0468  Fragment33 HEK-293T C1164(0.98); C395(0.93); C262(0.96); C719(1.10)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C1164(1.48)  LDD2203  [15]
 LDCM0427  Fragment51 HEK-293T C1164(1.28); C262(1.11); C1020(1.00); C1379(1.08)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C947(1.07); C1507(0.94); C272(1.02); C262(1.34)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C1164(6.70)  LDD0209  [4]
 LDCM0024  KB05 IGR37 C886(1.46)  LDD3314  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840