Details of the Target

General Information of Target

Target ID LDTP07083
Target Name KICSTOR complex protein SZT2 (SZT2)
Gene Name SZT2
Gene ID 23334
Synonyms
C1orf84; KIAA0467; KICSTOR complex protein SZT2; Seizure threshold 2 protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASERPEPEVEEAGQVFLLMKKDYRISRNVRLAWFLSHLHQTVQATPQEMLLQSEQELEV
LSVLPPGWQPDEPVVPRPFLLVPSTRVTFLAWQYRFVIELDLSPSTGIVDDSTGEILFDE
VFHALSRCLGGLLRPFRVPGSCIDFQPEIYVTIQAYSSIIGLQSHQVLVQGCLLDPSQRE
VFLQQIYEQLCLFEDKVATMLQQQYDPQSQAEDQSPDSGDLLGRKVGVSMVTADLGLVSM
IRQGILALQLLPSNSSAGIIVITDGVTSVPDVAVCETLLNQLRSGTVACSFVQVGGVYSY
DCSFGHVPNVELMKFIAMATFGSYLSTCPEPEPGNLGLTVYHRAFLLYSFLRSGEALNPE
YYCGSQHRLFNEHLVSASSNPALALRRKKHTEKEVPADLVSTVSVRLREGYSVREVTLAK
GGSQLEVKLVLLWKHNMRIEYVAMAPWPLEPEGPRVTRVEVTMEGGYDILHDVSCALRQP
IRSLYRTHVIRRFWNTLQSINQTDQMLAHLQSFSSVPEHFTLPDSTKSGVPLFYIPPGST
TPVLSLQPSGSDSSHAQFAAYWKPVLSMDANSWQRWLHMHRLVLILEHDTPIPKHLHTPG
SNGRYSTIQCRISHSSLTSLLRDWSSFVLVEGYSYVKLLSSAPDQPPNSFYMVRIISKAP
CMVLRLGFPIGTPAPARHKIVSGLREEILRLRFPHRVQSKEPTPKVKRKGLGGAGGGSSP
SKSPPVLGPQQALSDRPCLVVLHKPLDKLLIRYEKLPLDYRAPFLLTLEPPGPLPLVSGR
SASSSLASLSRYLYHQRWLWSVPSGLAPALPLSAIAQLLSILTEVRLSEGFHFACSGEGI
INMVLELPIQNEPPGQAAAEEKHTCVVQYILFPPHSTSTKDSFSTDDDNDVEVEALEGDS
ELNLVTEVWVEPQYGRVGPGPGIWKHLQDLTYSEIPQALHPRDAACIGSMLSFEYLIQLC
QSKEWGPLPPEPRVSDGLDQGGDTCVHEIPFHFDLMGLLPQCQQLQMFFLLLAREPEGVP
FAEGSCPANDMVLCLLHSCLGQELSDREIPLTPVDQAAFLSEVLRRTCHVPGAEGPLLGV
HGIPKEQAVGSTQATGDSAFTSLSVGLPETLKPLISAQPPQWRCYARLVNPQHVFLTFLP
ATFSDVQRLAACGLEGPPQEETKPKFGDWSGAPSLKDLGGTGIKATKSHVPVLSVTLASD
NAQNQGELSPPFRRDLQAYAGRQASQTESADGPRTRCPVYIYSCSLEALREQMVGMQPPQ
APRDLIFRTQFLDHPSPSSAWMEPRYKEAANHCALLQEHAQRCYVRGLFRSLQQAQSVTS
QDLLTAVDACEELLQEIDITPFLLALCGHTWGLPHAPPSPGPLSPGPFSSSMEEGAEPRE
RAILASESSIETEDLSEPEFQSTRVPGIPDPGPEISLTDVCQLRGEAHGALHSVIQEKFL
EISRLHFRTVPSNPHYFFYCPPSSRREDEGPRDTVDRKISDLEFSEAELMGEEGDTSACC
VVTESDPELEVEYRESRESDLGPAGLDSASLSDVDTVNPDEDSFSILGGDSPTGPESFLH
DLPPLFLHLTCSVRLRGQHSSVPVCSLPTCLGQVLSSLEGPPVGGRVPLRDLSVTLDVFM
LTLPLEVELPTASDPQHHRSTSESSASFPRSPGQPSSLRSDDGLGPPLPPPEEERHPGLS
NLATPHRLAIETTMNEIRWLLEDEMVGALRRGGIPQSPALHRAAAHIHSSPGRSTCLRQT
LPLSFVFGPERSLTQFKEEFRRLHLPGHVLLEDPDSGFFFVAAGQQPGGSHGEPSSAAWA
WHSHEDRAEGIEGETLTASPQAPGSPEDSEGVPLISLPRVPQGGSQPGPSRGLSLMSSQG
SVDSDHLGYDGGSSGSDSEGPNDTLGEKAPFTLRTPPGPAPPQPSLSGLPGPCLPDFWLI
VRVLQDRVEVYAHARSLIREDGGPGTECRHLQQLLVRRVGEICREVNQRLLLQDLHDSHV
CNSLLVAESEEDLWRSETPFHSRQRAPLPSDDYAADESCAPRGYLAATMQFVPGHFSCDV
VWGTVIRVHSRLKMGPSMGVSRAIQALRSVLNAFSVVNRKNMFVYQERATKAVYYLRLLE
TSCSDRPWKGDALPPSLALSRSQEPIYSEEASGPRSPLDMVSSRSSDAARPVGQVDRHIQ
LLVHGVGQAGPEITDELVRVLCRRLDEATLDVITVMLVRNCKLTPADVEFIQPPGSLPSE
VLHLALPTSCRPWLPALAWYLRQNLLIFLHSPKYTDSNSRNHFQHPLPPQGGLPDLDIYL
YNKPGGQGTGGKGVACITLAFVDEGGAPLSLALWPPSSPGPPDPLREEEFEQLTQVIRCP
VVVDSSSAQNGAPRLRLDVWEKGNISIVQLEEKLRGAARQALADAIIELQLLPASLCTED
TPTGSLRNGSLETKSSAGRASTFPPAPVPGEPVTPPSKAGRRSFWDMLSKTECGDLGSPK
TTDDIVLDRPEDTRGRRRHKTESVRTPGGAERAPGSDSGAQRQKRRTTQLEEGEVGTLHP
VFARVAQRWMEFMVQIGCASVSRSSAHMVSRFLLPSILSEFTALVTSMAGDTSVRIFEQH
LGSEPEIFGPCSPGQLGPSPRPAAERHLLLLGRNFLQWRRPTQQAAKAMQRFEPGGDGSS
GRNAPRQRLLLLEVVDKKLQLLTYNWAPDLGAALGRALVRLVQWQNARAHLIFCLLSQKL
GLFHHYGQLDFPVRDEKEPNPFLLPTMEVETLIRSASPPLSREQGRLSGSSRGGGPLPLD
TFPFDEALRDITAARPSSVLGPVPRPPDPVTYHGQQFLEIKMAERRELERQMKMENLFVT
WQQRSTPATMPISAGELETLKQSSRLVHYCATAMLFDPAAWLHGPPETSGPPDGQRRHRP
ESGSGSREAPTSCESLDVSPPGAREEPWLKELSLAFLQQYVQYLQSIGFVLVPLRPPSPA
RSTSRPRAMAILGTEGRGSFSCPKTKTDGSPKSTSSPVTTYHLQRALPGGIILMELAFQG
CYFCVKQFALECSRIPMGQAVNSQLSMLFTEECDKVRDLMHVHSFSYDFHLRLVHQHVLG
AHLVLRHGYHLTTFLRHFLAHHPDGPHFGRNHIYQGTLELPTPLIAAHQLYNYVADHASS
YHMKPLRMARPGGPEHNEYALVSAWHSSGSYLDSEGLRHQDDFDVSLLVCHCAAPFEEQG
EAERHVLRLQFFVVLTSQRELFPRLTADMRRFRKPPRLPPEPEAPGSSAGSPGEASGLIL
APGPAPLFPPLAAEVGMARARLAQLVRLAGGHCRRDTLWKRLFLLEPPGPDRLRLGGRLA
LAELEELLEAVHAKSIGDIDPQLDCFLSMTVSWYQSLIKVLLSRFPQSCRHFQSPDLGTQ
YLVVLNQKFTDCFVLVFLDSHLGKTSLTVVFREPFPVQPQDSESPPAQLVSTYHHLESVI
NTACFTLWTRLL
Target Bioclass
Other
Subcellular location
Lysosome membrane
Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. May play a role in the cellular response to oxidative stress.
Uniprot ID
Q5T011
Ensemble ID
ENST00000372450.8
HGNC ID
HGNC:29040

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R826Ter .
CAL51 Deletion: p.S2317PfsTer17
Insertion: p.P1944AfsTer4
SNV: p.H2158Y		 .
CHL1 Substitution: p.L822H DBIA    Probe Info 
EFO27 SNV: p.H2223P .
GAMG SNV: p.D2384E .
HCC1395 SNV: p.G1767R .
HCT116 Insertion: p.D1550RfsTer7 .
HCT15 SNV: p.S1311R; p.D1535Y; p.E2172D .
HEC1B SNV: p.R826Ter; p.Q1578Ter; p.R2106W .
HLF SNV: p.A1725T .
HT115 SNV: p.D1806G .
HUH7 Insertion: p.E2836RfsTer38 .
JHH1 SNV: p.S1651Y .
JHH7 SNV: p.P2266T .
JURKAT SNV: p.A2500G .
KPL1 SNV: p.A317G .
KYSE150 SNV: p.P2872L DBIA    Probe Info 
MCC13 Substitution: p.P673L .
MCF7 SNV: p.A317G .
MEC1 SNV: p.R604H DBIA    Probe Info 
MEWO SNV: p.R25Ter;p.S2229F
Substitution: p.P1552H		 DBIA    Probe Info 
MFE319 Deletion: p.P2425LfsTer9; p.P2901RfsTer9 .
NCIH1155 SNV: p.C738Y .
NUGC3 SNV: p.V2208M .
REH SNV: p.P1671L DBIA    Probe Info 
SKMEL3 SNV: p.R134W DBIA    Probe Info 
SW948 SNV: p.E1160Q .
TOV21G SNV: p.M506I; p.Q557K .
YSCCC SNV: p.E1504Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C3273(3.90)  LDD3310  [1]
BTD
 Probe Info  		C1963(0.85)  LDD2099  [2]
IPM
 Probe Info  		C3273(4.13); C128(1.14)  LDD1702  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
TFBX
 Probe Info  		C1152(0.00); C1963(0.00)  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1244(0.78)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C1948(1.02)  LDD0813  [5]
 LDCM0226  AC11 HEK-293T C1948(0.75)  LDD0824  [5]
 LDCM0237  AC12 HEK-293T C1948(0.81)  LDD0835  [5]
 LDCM0259  AC14 HEK-293T C1948(0.87)  LDD0857  [5]
 LDCM0263  AC143 HEK-293T C1948(1.07)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C1948(1.18)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C1948(1.38)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C1948(1.00)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C1948(1.05)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C1948(0.99)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C1948(1.39)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C1948(0.95)  LDD0868  [5]
 LDCM0271  AC150 HEK-293T C1948(0.89)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C1948(1.23)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C1948(1.12)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C1948(0.94)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C1948(1.08)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C1948(1.01)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C1948(1.19)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C1948(1.49)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C1948(2.21)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C1948(2.11)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C1948(1.68)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C1244(0.96)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C1948(2.23)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C1948(2.08)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C1948(1.68)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C1948(1.98)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C1948(1.27)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C1948(1.18)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C1948(1.49)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C1948(1.44)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C1948(2.27)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C1948(1.70)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C1244(0.94)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C1948(1.64)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C1948(1.54)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C1948(1.38)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C1948(2.00)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C1948(1.78)  LDD0893  [5]
 LDCM0296  AC35 PaTu 8988t C1948(1.28)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C1948(1.52)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C1948(1.47)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C1948(1.13)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C1948(1.39)  LDD1179  [5]
 LDCM0301  AC4 HEK-293T C1244(1.02)  LDD0899  [5]
 LDCM0302  AC40 PaTu 8988t C1948(1.19)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C1948(1.18)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C1948(1.04)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C1948(1.38)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C1948(1.66)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C1948(1.31)  LDD1186  [5]
 LDCM0308  AC46 HEK-293T C1237(1.03); C1948(0.72)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C1237(0.83); C1948(0.86)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C1237(0.84); C1948(0.83)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C1237(0.83); C1948(1.32)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C1244(0.95)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C1237(0.90); C1948(1.13)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C1237(0.81); C1948(1.09)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C1237(0.76); C1948(1.00)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C1237(0.88); C1948(1.03)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C1237(0.84); C1948(1.02)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C1237(0.90); C1948(0.86)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C1237(0.93); C1948(0.64)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C2694(0.79); C475(1.15); C1293(0.98); C3012(1.22)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C2694(0.96); C3273(1.15); C1293(0.91); C3012(1.05)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C2694(0.85); C3273(0.99); C1293(0.98); C3012(1.05)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C1948(0.80)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C2694(0.85); C475(1.12); C1913(0.82); C3012(1.05)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C2694(0.90); C3012(1.06); C738(1.02)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C2694(0.84); C3012(1.10); C1152(0.98); C1460(0.99)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C2694(0.95); C3012(1.06); C738(1.00); C610(0.93)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C2694(0.71); C475(0.83); C1293(0.88); C3012(0.96)  LDD1567  [6]
 LDCM0332  AC68 HEK-293T C1948(0.70)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C1948(0.90)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C1948(1.13)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C1948(0.83)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C1948(0.81)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C1948(1.00)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C1948(0.98)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C1948(1.00)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C1948(0.57)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C1948(0.67)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C1948(0.67)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C1948(0.83)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C1948(0.73)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C1948(1.13)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C1948(0.73)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C1948(0.74)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C1948(0.81)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C1237(0.88)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C1237(0.84)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C1237(0.93)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C1237(1.01)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C1237(0.85)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C1237(1.00)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C1237(0.91)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C1237(0.82)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C1237(0.88)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C1237(1.04)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C1237(0.79)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C1237(0.80)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C1237(0.97)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C1237(1.08)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C1237(1.16)  LDD0962  [5]
 LDCM0248  AKOS034007472 HEK-293T C1948(0.89)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C1948(0.76)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C1948(1.04)  LDD0873  [5]
 LDCM0367  CL1 HEK-293T C1237(1.01); C1244(1.01)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C1237(1.22); C1244(1.22)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C1244(0.96)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C1948(1.15)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C1948(1.38)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C1948(1.26)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C1948(1.35)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C1948(1.82)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C1948(1.68)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C1948(1.86)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C1948(1.99)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C1948(1.97)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C1237(1.28); C1244(1.28)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C1948(2.01)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C1948(2.80)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C1948(2.09)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C1948(1.50)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C1948(2.86)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C1948(2.14)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C1948(1.66)  LDD0984  [5]
 LDCM0387  CL117 PaTu 8988t C1948(1.08)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C1948(1.81)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C1948(1.17)  LDD1268  [5]
 LDCM0390  CL12 HEK-293T C1237(0.91); C1244(0.91)  LDD0988  [5]
 LDCM0391  CL120 PaTu 8988t C1948(1.21)  LDD1270  [5]
 LDCM0392  CL121 HEK-293T C1237(0.82); C1948(0.90)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C1237(0.83); C1948(0.89)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C1237(0.84); C1948(1.25)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C1237(0.90); C1948(0.87)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C2694(1.33); C1421(1.04); C475(1.04); C835(1.15)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C2694(0.72); C475(1.19); C2591(1.04); C1913(0.97)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C2694(0.81); C1293(0.91); C3012(1.00); C2103(1.00)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C2694(0.84); C475(0.86); C2339(1.16); C3012(1.10)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C1237(1.05); C1244(1.05)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C1237(1.00); C1244(1.00)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C1237(1.08); C1244(1.08)  LDD1000  [5]
 LDCM0403  CL16 PaTu 8988t C1948(1.30)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C1948(1.34)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C1948(1.11)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C1948(1.24)  LDD1285  [5]
 LDCM0407  CL2 HEK-293T C1237(1.05); C1244(1.05)  LDD1005  [5]
 LDCM0408  CL20 PaTu 8988t C1948(1.34)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C1948(1.84)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C1948(1.77)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C1948(1.89)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C1948(1.06)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C1948(1.23)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C1948(1.17)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C1948(1.21)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C1948(1.31)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C1948(1.89)  LDD1296  [5]
 LDCM0418  CL3 HEK-293T C1237(1.00); C1244(1.00)  LDD1016  [5]
 LDCM0419  CL30 PaTu 8988t C1948(1.01)  LDD1298  [5]
 LDCM0420  CL31 HEK-293T C1244(1.23)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C1244(1.06)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C1244(1.04)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C1244(1.16)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C1244(0.98)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C1244(0.98)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C1244(1.03)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C1244(1.27)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C1237(0.90); C1244(0.90)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C1244(1.10)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C1244(1.19)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C1244(1.30)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C1244(1.28)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C1244(1.03)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C1244(1.27)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C1237(1.75); C1244(1.43)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C1237(1.02); C1244(0.99)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C1237(2.02); C1244(1.47)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C1237(1.67); C1244(1.46)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C1237(0.97); C1244(0.97)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C1237(1.12); C1244(1.18)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C1237(0.97); C1244(1.11)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C1237(1.05); C1244(1.10)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C1237(0.87); C1244(1.01)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C1237(1.08); C1244(1.06)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C1237(1.06); C1244(1.03)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C1237(1.11); C1244(0.96)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C1237(1.03); C1244(1.22)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C1237(1.28); C1244(1.16)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C1237(1.37); C1244(1.22)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C1237(0.88); C1244(0.88)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C1237(1.20); C1244(1.23)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C1244(0.79); C1948(1.54)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C1244(1.13); C1948(1.86)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C1244(0.89); C1948(1.04)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C1244(1.28); C1948(1.57)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C1244(1.14); C1948(1.15)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C1244(1.25); C1948(1.18)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C1244(1.17); C1948(1.06)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C1244(1.09); C1948(1.05)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C1244(1.02); C1948(1.62)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C1237(1.07); C1244(1.07)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C1244(1.05); C1948(1.02)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C1244(0.94); C1948(1.02)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C1244(1.16); C1948(1.68)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C1244(1.01); C1948(1.34)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C1244(1.35); C1948(1.27)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C1948(0.71)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C1948(1.26)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C1948(0.71)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C1948(0.81)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C1237(1.22); C1244(0.37)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C1948(0.63)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C1948(0.83)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C1948(1.55)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C1948(0.91)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C1948(0.80)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C1948(0.69)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C1948(0.57)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C1948(1.12)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C1948(1.23)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C1948(0.99)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C1237(1.17); C1244(0.55)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C1948(1.22)  LDD1083  [5]
 LDCM0486  CL91 HEK-293T C1244(0.92)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C1244(0.96)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C1244(0.88)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C1244(1.09)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C1244(1.15)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C1244(1.10)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C1244(1.07)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C1244(1.11)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C1244(1.09)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C2694(0.76); C1293(0.96); C3012(1.00); C2103(0.92)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C3273(4.13); C128(1.14)  LDD1702  [2]
 LDCM0625  F8 Ramos C128(0.65)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C128(0.82)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C128(0.37)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C128(0.72)  LDD2191  [7]
 LDCM0575  Fragment13 Ramos C128(0.99)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C128(0.76)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C128(0.69)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C128(1.19)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C128(0.50)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C128(0.93)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C128(0.68)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C128(0.85)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C128(0.94)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C128(0.64)  LDD2201  [7]
 LDCM0468  Fragment33 HEK-293T C1244(1.22); C1948(1.40)  LDD1066  [5]
 LDCM0596  Fragment38 Ramos C128(0.88)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C128(0.51)  LDD2184  [7]
 LDCM0427  Fragment51 HEK-293T C1244(1.13)  LDD1025  [5]
 LDCM0610  Fragment52 Ramos C128(1.18)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C128(1.00)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C128(0.55)  LDD2186  [7]
 LDCM0571  Fragment9 Ramos C128(0.79)  LDD2188  [7]
 LDCM0022  KB02 HEK-293T C2019(0.95); C1152(0.96); C2893(1.22)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C2019(0.95); C1152(0.96); C2893(1.26)  LDD1497  [6]
 LDCM0024  KB05 COLO792 C3273(3.90)  LDD3310  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1963(0.85)  LDD2099  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GATOR2 complex protein WDR24 (WDR24) WD repeat WDR24 family Q96S15
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GATOR1 complex protein NPRL3 (NPRL3) NPR3 family Q12980

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578