Details of the Target

General Information of Target

Target ID LDTP07052
Target Name Protein phosphatase 1 regulatory subunit 29 (ELFN2)
Gene Name ELFN2
Gene ID 114794
Synonyms
KIAA1904; LRRC62; PPP1R29; Protein phosphatase 1 regulatory subunit 29; Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2; Leucine-rich repeat and fibronectin type-III domain-containing protein 6; Leucine-rich repeat-containing protein 62
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRLGLCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDL
RLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTE
GMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVC
ELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSLNAITV
LQAKCRNGSLPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIK
LHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSDVMTLKNKKEIVTLDKLRAHTEYTFC
VTSLRNSRRFNHTCLTFTTRDPVPGDLAPSTSTTTHYIMTILGCLFGMVIVLGAVYYCLR
KRRMQEEKQKSVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVSRMASIPSMIGEK
LPTAKGLEAGLDTPKVATKGNYIEVRTGAGGDGLARPEDDLPDLENGQGSAAEISTIAKE
VDKVNQIINNCIDALKLDSASFLGGGSSSGDPELAFECQSLPAAAAASSATGPGALERPS
FLSPPYKESSHHPLQRQLSADAAVTRKTCSVSSSGSIKSAKVFSLDVPDHPAATGLAKGD
SKYIEKGSPLNSPLDRLPLVPAGSGGGSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEG
ADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGYSSSPEYSSESTHKIWERFRPYKKHH
REEVYMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQQKL
Target Bioclass
Other
Subcellular location
Membrane
Function Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
Uniprot ID
Q5R3F8
Ensemble ID
ENST00000402918.7
HGNC ID
HGNC:29396

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C551(0.94)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C551(0.94)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C551(1.30)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C551(1.33)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C551(0.84)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C551(1.02)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C551(1.15)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C551(1.15)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C551(1.43)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C551(1.12)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C551(1.15)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C551(1.00)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C551(0.95)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C551(1.33)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C551(1.41)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C551(1.37)  LDD0546  [1]
 LDCM0237  AC12 HCT 116 C551(0.83)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C551(0.99)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C551(0.91)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C551(1.06)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C551(1.02)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C551(0.99)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C551(1.16)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C551(1.05)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C551(1.00)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C551(0.96)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C551(1.07)  LDD0601  [1]
 LDCM0323  AC6 HCT 116 C551(0.98)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C551(0.92)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C551(1.01)  LDD0662  [1]
 LDCM0365  AC98 HCT 116 C551(1.32)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C551(1.27)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C551(0.88)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C551(1.00)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C551(1.20)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C551(1.02)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C551(0.81)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C551(0.83)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C551(1.11)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C551(1.02)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C551(1.07)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C551(0.90)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C551(1.03)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C551(0.98)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C551(0.99)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C551(1.14)  LDD0698  [1]
 LDCM0420  CL31 HCT 116 C551(0.93)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C551(0.91)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C551(0.93)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C551(1.12)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C551(1.00)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C551(0.94)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C551(1.02)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C551(1.14)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C551(0.97)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C551(1.10)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C551(1.09)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C551(0.96)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C551(1.02)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C551(1.02)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C551(1.11)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C551(1.02)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C551(1.07)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C551(1.11)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C551(1.23)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C551(1.20)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C551(1.14)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C551(1.11)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C551(1.18)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C551(0.99)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C551(1.25)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C551(1.31)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C551(1.16)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C551(1.08)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C551(1.09)  LDD0769  [1]
 LDCM0427  Fragment51 HCT 116 C551(1.29)  LDD0744  [1]
 LDCM0022  KB02 786-O C629(1.98)  LDD2247  [2]
 LDCM0023  KB03 786-O C629(2.28)  LDD2664  [2]
 LDCM0024  KB05 OVCAR-3 C572(1.52)  LDD3365  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840