Details of the Target

General Information of Target

Target ID LDTP07043
Target Name Breast cancer metastasis-suppressor 1-like protein (BRMS1L)
Gene Name BRMS1L
Gene ID 84312
Synonyms
Breast cancer metastasis-suppressor 1-like protein; BRMS1-homolog protein p40; BRMS1-like protein p40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRME
CLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVA
GIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSE
LWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVK
TEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDKKDECPTSAVITTINHDEVWFKR
PDGSKSKLYISQLQKGKYSIKHS
Target Bioclass
Other
Family
BRMS1 family
Subcellular location
Nucleus
Function Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.
Uniprot ID
Q5PSV4
Ensemble ID
ENST00000216807.12
HGNC ID
HGNC:20512

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.M49T DBIA    Probe Info 
MCC26 SNV: p.E295K .
MFE319 SNV: p.E24Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
AHL-Pu-1
 Probe Info  		C282(2.44)  LDD0168  [2]
DBIA
 Probe Info  		C275(1.86)  LDD0080  [3]
IA-alkyne
 Probe Info  		C146(0.00); C127(0.00)  LDD0162  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
Phosphinate-6
 Probe Info  		C282(0.00); C275(0.00); C146(0.00)  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C282(2.44)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C127(3.94)  LDD0372  [2]
 LDCM0214  AC1 HEK-293T C146(1.51); C275(1.13); C127(1.01); C282(1.08)  LDD1507  [7]
 LDCM0215  AC10 PaTu 8988t C137(0.94)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C137(1.08)  LDD1105  [3]
 LDCM0237  AC12 PaTu 8988t C137(0.76)  LDD1116  [3]
 LDCM0259  AC14 PaTu 8988t C137(0.81)  LDD1138  [3]
 LDCM0270  AC15 PaTu 8988t C137(0.91)  LDD1149  [3]
 LDCM0276  AC17 PaTu 8988t C137(0.77)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C137(1.63)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C137(0.78)  LDD1157  [3]
 LDCM0279  AC2 HEK-293T C146(1.01); C137(1.02); C275(0.98); C127(0.90)  LDD1518  [7]
 LDCM0280  AC20 PaTu 8988t C137(1.02)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C137(1.09)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C137(0.69)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C137(1.37)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C137(0.90)  LDD1163  [3]
 LDCM0285  AC25 HEK-293T C146(1.22); C275(1.05); C127(1.05); C282(1.07)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C146(1.04); C137(0.99); C275(1.02); C127(0.99)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C146(1.21); C275(0.97); C127(0.93); C282(0.91)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C146(0.96); C137(0.99); C275(1.00); C127(0.98)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C146(1.22); C275(0.98); C127(0.98); C282(0.97)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C146(0.97); C275(1.02); C127(0.82); C282(1.06)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C146(1.10); C275(0.96); C127(0.97); C282(0.89)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C146(0.95); C275(1.04); C127(1.03); C282(0.94)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C275(1.04); C127(0.96); C282(1.06)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C146(1.05); C275(1.04); C127(0.99); C282(1.07)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C146(1.06); C137(1.07); C275(1.02); C127(0.90)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C146(1.00); C275(0.88); C127(0.86); C282(0.97)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C146(0.91); C137(0.89); C275(0.94); C127(0.95)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C146(1.08); C275(0.90); C127(0.90); C282(0.88)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C146(0.99); C275(1.02); C127(0.93); C282(0.85)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C146(0.78); C275(0.97); C127(0.99); C282(0.95)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C146(1.00); C137(0.92); C275(0.99); C127(1.07)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C275(0.96); C127(0.97); C282(1.00)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C146(1.00); C275(1.03); C127(1.08); C282(1.06)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C146(1.04); C137(0.96); C275(0.98); C127(0.90)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C146(1.02); C275(0.90); C127(0.94); C282(0.98)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C146(0.94); C137(0.94); C275(0.99); C127(0.96)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C146(1.01); C275(0.93); C127(0.90); C282(0.85)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C146(1.11); C275(1.00); C127(0.94); C282(0.90)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C146(1.10); C275(0.96); C127(1.01); C282(0.99)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C275(0.96); C127(0.96); C282(0.95)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C146(1.16); C275(1.03); C127(0.95); C282(1.04)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C146(1.16); C275(0.95); C127(0.93); C282(0.89)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C146(0.97); C137(1.08); C275(0.99); C127(0.93)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C146(1.11); C275(0.92); C127(0.89); C282(0.95)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C146(1.05); C137(0.95); C275(1.00); C127(0.93)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C146(1.25); C275(0.91); C127(0.86); C282(0.90)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C146(1.09); C275(0.96); C127(0.96); C282(0.99)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C146(0.97); C275(1.00); C127(0.94); C282(0.94)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C275(0.95); C127(0.93); C282(0.96)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C146(1.71); C275(1.05); C127(1.03); C282(1.10)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C146(1.06); C137(1.03); C275(0.99); C127(0.87)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C146(1.05); C275(0.91); C127(0.88); C282(0.95)  LDD1561  [7]
 LDCM0323  AC6 PaTu 8988t C137(0.78)  LDD1202  [3]
 LDCM0324  AC60 HEK-293T C146(1.02); C137(0.93); C275(0.96); C127(0.99)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C146(1.28); C275(0.95); C127(0.89); C282(0.99)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C146(1.06); C275(0.97); C127(0.92); C282(1.04)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C146(0.68); C275(0.94); C127(0.99); C282(0.97)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C275(0.93); C127(0.95); C282(1.11)  LDD1567  [7]
 LDCM0334  AC7 PaTu 8988t C137(0.61)  LDD1213  [3]
 LDCM0345  AC8 PaTu 8988t C137(0.73)  LDD1224  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C137(0.76)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C137(1.02)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C137(1.13)  LDD1154  [3]
 LDCM0632  CL-Sc Hep-G2 C275(1.30)  LDD2227  [5]
 LDCM0367  CL1 PaTu 8988t C137(1.03)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C137(0.86)  LDD1247  [3]
 LDCM0369  CL100 HEK-293T C146(1.10); C275(0.85); C127(0.90); C282(1.11)  LDD1573  [7]
 LDCM0370  CL101 PaTu 8988t C137(1.23)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C137(0.95)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C137(0.73)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C137(0.91)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C137(0.86)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C137(0.75)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C137(0.71)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C137(0.96)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C137(1.08)  LDD1257  [3]
 LDCM0379  CL11 PaTu 8988t C137(0.83)  LDD1258  [3]
 LDCM0380  CL110 PaTu 8988t C137(1.31)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C137(1.29)  LDD1260  [3]
 LDCM0382  CL112 HEK-293T C146(1.00); C275(0.95); C127(0.91); C282(0.90)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C146(0.94); C137(0.84); C275(0.91); C127(0.96)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C146(1.15); C137(0.88); C275(0.88); C127(0.90)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C146(0.90); C275(0.95); C127(0.96); C282(1.05)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C146(1.05); C275(0.86); C127(0.88); C282(0.96)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C146(1.08); C137(0.99); C275(0.88); C127(0.94)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C146(1.06); C137(0.93); C275(1.04); C127(1.01)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C146(1.15); C275(0.95); C127(0.99); C282(0.91)  LDD1593  [7]
 LDCM0390  CL12 PaTu 8988t C137(1.03)  LDD1269  [3]
 LDCM0391  CL120 HEK-293T C146(1.04); C275(0.86); C127(0.89); C282(0.99)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C146(1.23); C137(0.99); C275(0.88); C127(0.87)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C146(1.08); C137(0.86); C275(0.97); C127(0.97)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C146(0.98); C275(0.88); C127(0.90); C282(0.85)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C146(1.03); C275(0.86); C127(0.85); C282(0.97)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C146(1.20); C137(0.95); C275(0.83); C127(0.95)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C146(0.98); C137(0.84); C275(0.93); C127(0.88)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C146(0.98); C275(0.92); C127(0.91); C282(0.99)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C146(0.98); C275(0.86); C127(0.86); C282(0.99)  LDD1603  [7]
 LDCM0400  CL13 PaTu 8988t C137(1.14)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C137(1.00)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C137(0.97)  LDD1281  [3]
 LDCM0403  CL16 HEK-293T C146(1.04); C275(0.96); C127(0.95); C282(0.88)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C146(1.10); C275(1.01); C127(0.91); C282(0.97)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C146(1.03); C137(1.07); C275(1.06); C127(0.90)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C146(1.54); C275(1.00); C127(0.95); C282(0.94)  LDD1610  [7]
 LDCM0407  CL2 PaTu 8988t C137(0.86)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C146(1.00); C137(0.89); C275(1.11); C127(1.08)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C146(1.11); C275(0.96); C127(0.88); C282(0.89)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C146(1.00); C275(1.00); C127(1.03); C282(1.21)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C146(0.85); C275(1.10); C127(1.07); C282(0.98)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C275(1.08); C127(1.05); C282(1.12)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C146(1.11); C137(0.78); C275(0.86); C127(0.93)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C146(0.96); C137(1.01); C275(1.01); C127(0.98)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C146(0.93); C275(0.98); C127(1.00); C282(0.98)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C146(0.96); C275(0.89); C127(0.93); C282(0.94)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C146(1.28); C275(1.04); C127(1.08); C282(1.02)  LDD1621  [7]
 LDCM0418  CL3 PaTu 8988t C137(1.03)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C146(1.02); C137(1.04); C275(1.04); C127(1.01)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C146(1.16); C275(1.08); C127(1.01); C282(1.01)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C146(0.97); C137(1.05); C275(1.12); C127(1.03)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C146(1.34); C275(1.01); C127(0.98); C282(0.89)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C146(1.06); C275(0.94); C127(0.99); C282(1.01)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C146(0.78); C275(1.21); C127(1.17); C282(1.03)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C275(1.29); C127(1.05); C282(0.93)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C146(1.00); C137(0.88); C275(0.85); C127(0.96)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C146(0.89); C275(0.92); C127(0.96); C282(1.00)  LDD1632  [7]
 LDCM0429  CL4 PaTu 8988t C137(0.91)  LDD1308  [3]
 LDCM0430  CL40 HEK-293T C146(1.03); C275(0.91); C127(0.98); C282(1.06)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C146(1.12); C275(1.04); C127(1.04); C282(0.88)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C146(1.00); C137(1.18); C275(0.99); C127(1.02)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C146(0.92); C275(0.98); C127(1.08); C282(1.00)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C146(1.02); C137(0.97); C275(1.06); C127(0.97)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C146(1.13); C275(1.06); C127(1.02); C282(0.93)  LDD1639  [7]
 LDCM0436  CL46 PaTu 8988t C137(0.90)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C137(0.67)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C137(1.13)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C137(0.94)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C137(1.25)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C137(1.25)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C137(2.00)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C137(1.42)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C137(1.72)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C137(2.28)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C137(1.69)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C137(0.21)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C137(1.67)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C137(1.60)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C137(1.73)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C137(1.64)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C137(1.92)  LDD1331  [3]
 LDCM0453  CL61 HEK-293T C146(1.19); C137(0.94); C275(0.87); C127(0.97)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C146(0.89); C137(0.92); C275(0.95); C127(0.94)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C146(1.03); C275(0.97); C127(0.94); C282(0.93)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C146(1.13); C275(0.80); C127(0.91); C282(0.90)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C146(1.11); C275(1.11); C127(1.03); C282(1.12)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C146(1.01); C137(1.06); C275(1.04); C127(0.89)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C146(1.20); C275(1.03); C127(0.92); C282(0.98)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C146(0.99); C137(1.00); C275(1.05); C127(0.94)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C146(1.09); C275(1.05); C127(0.92); C282(0.88)  LDD1664  [7]
 LDCM0462  CL7 PaTu 8988t C137(1.25)  LDD1341  [3]
 LDCM0463  CL70 HEK-293T C146(1.01); C275(1.02); C127(1.01); C282(1.09)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C146(0.74); C275(1.08); C127(1.03); C282(1.07)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C275(1.08); C127(1.02); C282(0.99)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C146(1.44); C137(0.88); C275(0.86); C127(0.88)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C146(1.06); C137(0.90); C275(0.96); C127(0.93)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C146(1.14); C275(0.85); C127(0.92); C282(0.89)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C146(0.97); C275(0.99); C127(0.88); C282(0.95)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C146(1.00); C137(1.05); C275(1.07); C127(0.99)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C146(1.32); C275(0.95); C127(0.90); C282(0.93)  LDD1675  [7]
 LDCM0473  CL8 PaTu 8988t C137(0.91)  LDD1352  [3]
 LDCM0474  CL80 HEK-293T C146(0.96); C137(1.00); C275(1.12); C127(1.02)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C146(1.31); C275(1.04); C127(0.96); C282(0.88)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C146(1.06); C275(0.98); C127(0.98); C282(1.10)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C146(0.76); C275(1.04); C127(1.03); C282(0.99)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C275(1.07); C127(0.97); C282(1.01)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C146(1.01); C137(0.82); C275(0.91); C127(1.02)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C146(1.12); C137(0.87); C275(1.02); C127(0.99)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C146(1.07); C275(0.90); C127(1.01); C282(0.94)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C146(1.10); C275(0.84); C127(0.86); C282(0.92)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C146(1.16); C275(1.10); C127(0.97); C282(1.00)  LDD1686  [7]
 LDCM0484  CL9 PaTu 8988t C137(1.08)  LDD1363  [3]
 LDCM0485  CL90 HEK-293T C146(1.23); C137(1.13); C275(0.84); C127(0.86)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C146(1.00); C275(0.95); C127(0.99); C282(1.00)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C146(1.07); C137(0.91); C275(1.00); C127(0.96)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C146(1.51); C275(0.97); C127(0.92); C282(0.91)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C146(1.06); C275(0.93); C127(0.98); C282(1.08)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C146(1.04); C275(1.06); C127(0.97); C282(0.94)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C275(0.99); C127(0.99); C282(1.01)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C146(1.05); C137(0.87); C275(0.86); C127(0.93)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C146(1.00); C137(0.97); C275(1.02); C127(0.89)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C146(1.02); C275(0.98); C127(0.97); C282(1.04)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C146(1.10); C275(0.89); C127(0.91); C282(0.91)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C146(0.92); C275(0.89); C127(1.01); C282(0.99)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C146(0.99); C137(0.93); C275(1.02); C127(0.98)  LDD1631  [7]
 LDCM0022  KB02 HCT 116 C275(1.86)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C275(1.27)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C275(1.89)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-B-cell leukemia transcription factor 1 (PBX1) TALE/PBX homeobox family P40424
Pre-B-cell leukemia transcription factor 2 (PBX2) TALE/PBX homeobox family P40425
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Alpha-taxilin (TXLNA) Taxilin family P40222
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402