Details of the Target

General Information of Target

Target ID LDTP06971
Target Name N-acetyltransferase ESCO1 (ESCO1)
Gene Name ESCO1
Gene ID 114799
Synonyms
EFO1; KIAA1911; N-acetyltransferase ESCO1; EC 2.3.1.-; CTF7 homolog 1; Establishment factor-like protein 1; EFO1; EFO1p; hEFO1; Establishment of cohesion 1 homolog 1; ECO1 homolog 1; ESO1 homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQP
ELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNR
RSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVL
EVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPV
PVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKR
GSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDV
QCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRT
SFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAP
ENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKI
DTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKT
DEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILA
EYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVG
CLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRR
KKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST
Target Bioclass
Enzyme
Family
Acetyltransferase family, ECO subfamily
Subcellular location
Nucleus
Function
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
Uniprot ID
Q5FWF5
Ensemble ID
ENST00000269214.10
HGNC ID
HGNC:24645

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.M455Ter
SNV: p.N511S		 DBIA    Probe Info 
CHL1 SNV: p.R234K .
IPC298 SNV: p.I772L .
Ishikawa (Heraklio) 02 ER SNV: p.V402A DBIA    Probe Info 
MEWO SNV: p.P201S DBIA    Probe Info 
MFE319 Insertion: p.K101EfsTer10 .
P31FUJ SNV: p.S39Ter .
SKMEL2 SNV: p.Q59Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K263(5.88)  LDD0277  [1]
DBIA
 Probe Info  		C362(2.66)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		C580(0.00); C450(0.00)  LDD0147  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		C580(0.00); C450(0.00); C307(0.00)  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C362(1.16); C767(0.51)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C362(1.18)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C767(0.47)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C767(0.60)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C767(0.50)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C767(0.39)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C767(0.63)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C767(0.51)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C767(0.54)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C767(0.52)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C767(0.53)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C767(0.43)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C362(1.26)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C767(0.59)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C767(0.58)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C767(0.39)  LDD0546  [2]
 LDCM0230  AC113 PaTu 8988t C362(0.70)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C362(0.65)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C362(1.05)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C362(0.71)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C362(0.73)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C362(0.79)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C362(0.80)  LDD1115  [2]
 LDCM0237  AC12 HCT 116 C362(0.94)  LDD0554  [2]
 LDCM0238  AC120 PaTu 8988t C362(0.39)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C362(0.69)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C362(0.85)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C362(0.64)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C362(0.59)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C362(0.66)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C362(0.82)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C362(0.86)  LDD1124  [2]
 LDCM0259  AC14 HCT 116 C362(1.44)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C362(1.09)  LDD0587  [2]
 LDCM0276  AC17 HEK-293T C450(1.12); C580(1.11); C515(1.01)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C580(1.00); C362(0.94)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C580(1.41)  LDD1517  [7]
 LDCM0279  AC2 HCT 116 C767(0.56); C362(1.16)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C580(1.14); C362(1.18)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C450(1.07); C580(1.13)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C450(0.87); C580(1.05)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C450(1.05); C580(1.05)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C450(1.04); C580(1.00); C515(0.89)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C450(0.99); C580(1.03); C515(1.02)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C580(1.13); C362(0.95)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C580(1.01)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C580(1.08); C362(0.99)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C450(1.01); C580(1.00)  LDD1528  [7]
 LDCM0290  AC3 HCT 116 C767(0.75); C362(0.94)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C450(0.98); C580(1.01)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C450(1.20); C580(0.87)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C450(1.00); C580(0.97); C515(1.07)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C450(1.06); C580(1.07); C515(0.91)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C580(1.14); C362(0.98)  LDD1534  [7]
 LDCM0296  AC35 HCT 116 C362(0.72)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C362(0.73)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C362(0.60)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C362(0.77)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C362(0.88)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C767(0.64); C362(0.99)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C362(0.94)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C362(0.72)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C362(0.81)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C362(0.77)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C362(0.70)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C362(0.97)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C450(1.02); C580(1.04)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C450(1.01); C580(1.08)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C450(1.12); C580(1.09); C515(0.96)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C450(1.02); C580(1.12); C515(1.02)  LDD1550  [7]
 LDCM0312  AC5 HCT 116 C767(0.73); C362(0.80)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C580(1.11); C362(0.91)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C580(1.08)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C580(1.00); C362(1.10)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C450(1.03); C580(1.07)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C450(1.19); C580(1.15)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C450(1.14); C580(0.97)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C450(1.02); C580(0.95); C515(1.04)  LDD1558  [7]
 LDCM0320  AC57 HCT 116 C767(0.76)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C767(0.84)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C767(0.94)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C362(1.06)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C767(0.95)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C767(0.82)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C767(0.80)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C767(0.92)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C767(0.93)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C767(0.99)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C767(1.09)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C767(1.01)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C362(0.88); C767(1.10)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C362(0.99); C767(1.25)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C362(0.97)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C767(1.04); C362(1.04)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C362(0.87); C767(1.58)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C362(1.03); C767(1.69)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C362(1.41); C767(1.45)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C362(1.36); C767(2.04)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C767(1.49); C362(1.79)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C767(1.12); C362(1.22)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C362(1.08); C767(1.16)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C362(1.03); C767(1.28)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C362(0.98); C767(1.58)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C362(0.92)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C362(1.00); C767(1.40)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C362(0.82); C767(0.94)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C362(1.47); C767(1.64)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C362(2.05)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C362(1.61)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C362(1.60)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C362(1.50)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C362(1.28)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C362(1.32)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C362(1.50)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C362(1.20)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C362(2.33)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C362(2.02)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C362(1.61)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C362(1.57)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C362(1.47)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C362(1.67)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C362(1.77)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C767(0.70)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C767(0.57)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C362(1.10)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C362(1.26)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C362(0.90)  LDD0592  [2]
 LDCM0102  BDHI 8 Jurkat C160(17.07)  LDD0204  [8]
 LDCM0367  CL1 HEK-293T C160(1.06); C450(1.02); C580(0.86); C376(1.03)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C450(0.96); C580(0.88)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C767(0.52); C362(0.88)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C362(1.03)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C362(0.92)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C362(0.91)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C362(1.01)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C160(0.98); C450(1.02); C580(1.16); C376(1.03)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C450(1.06); C580(1.03)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C160(1.42); C450(0.98); C580(0.93); C362(0.93)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C580(0.95); C376(1.23)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C160(0.96); C450(0.91); C580(1.13); C376(0.99)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C450(1.13); C580(1.12)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C450(0.97); C580(1.05)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C160(1.29); C450(1.09); C580(0.96); C362(1.10)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C580(1.13); C376(1.11)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C160(1.00); C450(0.94); C580(1.04); C376(0.97)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C450(1.21); C580(1.06)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C160(1.03); C450(1.05); C580(0.99); C362(1.03)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C580(1.08); C376(1.03)  LDD1590  [7]
 LDCM0387  CL117 HCT 116 C362(1.27)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C362(0.80)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C362(0.98)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C450(1.00); C580(0.92); C515(1.02)  LDD1594  [7]
 LDCM0391  CL120 HCT 116 C362(0.76)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C160(1.08); C450(1.05); C580(1.00); C376(0.95)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C450(0.85); C580(1.12)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C160(1.62); C450(0.94); C580(0.92); C362(0.92)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C580(0.98); C376(1.11)  LDD1599  [7]
 LDCM0396  CL125 HCT 116 C767(0.98)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C767(0.70)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C767(1.10)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C767(0.83)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C160(1.11); C450(1.06); C580(1.08); C376(0.98)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C450(0.79); C580(1.02)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C160(1.36); C450(1.07); C580(0.91); C362(0.77)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C580(1.03); C376(1.18)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C450(1.11); C580(1.07); C515(0.89)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C580(1.20); C362(1.11)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C580(1.20)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C450(1.00); C580(1.08)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C580(0.99); C362(1.06)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C450(1.34); C580(0.91)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C450(0.80); C580(1.10)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C450(1.13); C580(0.93)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C450(1.06); C580(1.04); C515(1.01)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C160(0.87); C450(0.95); C580(0.97); C376(0.93)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C450(0.87); C580(1.08)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C160(1.41); C450(1.05); C580(1.01); C362(0.77)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C580(1.00); C376(1.00)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C450(1.14); C580(1.05); C515(0.92)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C160(1.31); C450(1.01); C580(0.99); C362(0.89)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C580(1.01); C362(0.86)  LDD1623  [7]
 LDCM0420  CL31 PaTu 8988t C362(1.45)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C362(1.84)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C362(1.33)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C362(1.66)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C362(2.11)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C362(2.91)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C362(2.55)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C362(1.46)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C580(0.99); C376(1.08)  LDD1633  [7]
 LDCM0430  CL40 PaTu 8988t C362(2.25)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C362(2.21)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C362(2.55)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C362(8.10)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C362(2.16)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C362(1.57)  LDD1314  [2]
 LDCM0436  CL46 HCT 116 C362(0.96)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C362(0.86)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C362(1.09)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C362(0.85)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C450(1.02); C580(1.00); C515(0.96)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C362(0.99)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C362(0.98)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C362(1.15)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C362(1.01)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C362(1.00)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C362(0.80)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C362(0.87)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C362(0.94)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C362(0.96)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C362(0.88)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C580(0.98); C362(0.86)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C362(0.83)  LDD0769  [2]
 LDCM0453  CL61 PaTu 8988t C362(1.44)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C362(0.95)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C362(0.74)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C362(1.14)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C362(1.10)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C362(1.15)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C362(2.04)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C362(1.87)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C362(2.17)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C580(1.06)  LDD1665  [7]
 LDCM0463  CL70 PaTu 8988t C362(1.40)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C362(0.70)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C362(1.10)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C362(1.77)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C362(1.61)  LDD1346  [2]
 LDCM0469  CL76 HEK-293T C580(0.92); C376(1.10)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C450(1.05); C580(1.03); C515(0.93)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C580(1.13); C362(0.99)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C580(1.04)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C580(0.84); C362(1.11)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C580(1.05); C362(1.26)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C450(1.19); C580(1.01)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C450(0.91); C580(1.03)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C450(1.06); C580(0.91)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C450(0.99); C580(1.02); C515(1.00)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C160(0.95); C450(1.03); C580(0.92); C376(0.99)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C450(1.07); C580(0.95)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C160(1.86); C450(1.07); C580(0.95); C362(0.95)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C580(0.94); C376(1.09)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C450(1.11); C580(1.04); C515(0.89)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C450(1.44); C580(0.97)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C580(0.97); C362(0.83)  LDD1688  [7]
 LDCM0486  CL91 HCT 116 C362(0.91); C767(0.44)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C362(0.88); C767(0.60)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C362(0.81); C767(1.10)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C362(1.00); C767(0.79)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C362(0.90); C767(0.54)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C362(0.92); C767(0.66)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C362(0.86); C767(0.51)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C362(1.17); C767(0.69)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C362(1.05); C767(0.75)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C160(1.40); C450(1.15); C580(1.03); C362(1.12)  LDD1698  [7]
 LDCM0468  Fragment33 PaTu 8988t C362(1.78)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C362(2.17)  LDD1306  [2]
 LDCM0022  KB02 HCT 116 C362(2.66)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C362(2.42)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C362(3.68)  LDD0082  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.