Details of the Target

General Information of Target

Target ID LDTP06898
Target Name PDZ and LIM domain protein 3 (PDLIM3)
Gene Name PDLIM3
Gene ID 27295
Synonyms
ALP; PDZ and LIM domain protein 3; Actinin-associated LIM protein; Alpha-actinin-2-associated LIM protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESM
THADAQDRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESEPQDGNYFEHKHN
IRPKPFVIPGRSSGCSTPSGIDCGSGRSTPSSVSTVSTICPGDLKVAAKLAPNIPLEMEL
PGVKIVHAQFNTPMQLYSDDNIMETLQGQVSTALGETPLMSEPTASVPPESDVYRMLHDN
RNEPTQPRQSGSFRVLQGMVDDGSDDRPAGTRSVRAPVTKVHGGSGGAQRMPLCDKCGSG
IVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELYCETHARARTKPPEGYDTVTL
YPKA
Target Bioclass
Other
Subcellular location
Cytoplasm, myofibril, sarcomere, Z line
Function May play a role in the organization of actin filament arrays within muscle cells.
Uniprot ID
Q53GG5
Ensemble ID
ENST00000284767.12
HGNC ID
HGNC:20767

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.N240S .
BXPC3 SNV: p.R31M DBIA    Probe Info 
NCIH2172 SNV: p.N104K DBIA    Probe Info 
REH SNV: p.L237F .
SNU1 SNV: p.Q110H .
SW756 SNV: p.G162C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C297(1.70)  LDD3331  [1]
AHL-Pu-1
 Probe Info  		C77(2.57)  LDD0170  [2]
IA-alkyne
 Probe Info  		C297(0.00); C77(0.00)  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C77(2.57)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C77(2.13)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C297(0.97); C77(0.92)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C297(1.03); C77(0.89); C317(0.90)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C297(1.09); C77(0.99); C317(1.07)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C297(1.05); C77(1.14); C317(1.11)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C297(1.04); C77(1.06); C317(1.04)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C297(1.18); C77(0.96); C317(1.07)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C297(1.00); C77(0.92)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C297(1.09); C77(0.99); C317(0.83)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C297(1.04); C77(0.91); C317(1.00)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C297(1.07); C77(0.99); C317(0.96)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C297(1.04); C77(1.19); C317(1.24)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C297(0.85); C77(1.08); C317(0.90)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C297(1.05); C77(1.08); C317(0.84)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C297(1.06); C77(1.01); C317(0.98)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C297(1.07); C77(1.06); C44(0.95); C317(0.92)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C297(1.02); C77(0.93)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C297(1.01); C77(0.89); C317(0.85)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C297(1.08); C77(1.00); C317(0.94)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C297(0.99); C77(1.24); C317(0.83)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C297(1.11); C77(1.03); C317(1.18)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C297(0.99); C77(0.99); C317(0.94)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C297(0.94); C77(0.95); C317(0.94)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C297(1.05); C77(0.92); C317(1.05)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C297(1.05); C77(1.02); C44(1.12); C317(0.92)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C297(1.12); C77(1.02)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C297(1.07); C77(0.94); C317(0.97)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C77(1.06)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C77(0.96)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C77(1.24)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C77(1.00)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C77(1.02)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C297(0.98); C77(1.03); C317(0.88)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C77(1.06)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C77(1.09)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C77(1.10)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C77(1.19)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C77(1.34)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C77(1.16)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C77(1.14)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C77(1.24)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C77(1.28)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C77(1.29)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C297(0.93); C77(1.05); C317(0.97)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C77(1.30)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C77(1.50)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C77(1.44)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C77(1.20)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C77(1.32)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C77(1.23)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C77(1.14)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C77(0.99)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C77(0.96)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C77(0.83)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C297(0.98); C77(0.81); C317(0.97)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C77(1.18)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C77(0.84)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C77(1.01)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C77(0.92)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C77(0.98)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C77(1.05)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C77(0.97)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C77(0.92)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C77(1.10)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C77(1.20)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C297(1.16); C77(0.92); C317(1.03)  LDD1568  [4]
 LDCM0335  AC70 HEK-293T C77(1.19)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C77(1.12)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C77(1.23)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C77(1.22)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C77(1.10)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C77(1.17)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C77(1.19)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C77(1.16)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C77(1.22)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C77(1.00)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C297(1.01); C77(0.98); C44(1.04); C317(0.89)  LDD1569  [4]
 LDCM0346  AC80 HEK-293T C77(1.24)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C77(1.19)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C77(1.53)  LDD0946  [5]
 LDCM0248  AKOS034007472 HEK-293T C297(1.08); C77(1.03); C317(1.18)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C297(1.08); C77(0.97)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C297(1.10); C77(0.98); C44(1.02); C317(1.01)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C297(0.92); C317(0.99)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C297(0.90); C77(0.91); C317(1.14)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C297(1.00); C77(0.95); C317(1.05)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C297(1.04); C317(0.90)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C297(1.00); C77(0.90); C317(0.96)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C297(1.12); C77(1.03); C317(1.13)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C297(1.04); C77(0.90); C317(1.03)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C297(1.02); C317(1.00)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C297(1.05); C77(0.94); C317(0.95)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C297(1.06); C77(1.09); C317(1.13)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C297(1.08); C77(1.03); C317(1.09)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C297(0.95); C317(0.99)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C297(0.90); C77(0.96); C317(1.50)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C297(1.01); C77(0.94); C317(0.83)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C297(0.88); C77(0.99); C317(0.98)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C297(1.02); C77(0.88); C317(1.13)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C297(1.12); C317(1.06)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C297(1.07); C77(0.93); C317(0.90)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C297(1.00); C77(1.00); C317(1.07)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C297(1.00); C77(0.94); C317(1.23)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C77(1.22)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C77(0.98)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C77(1.19)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C297(0.93); C77(0.92); C44(1.34); C317(1.30)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C77(1.17)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C77(1.29)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C77(1.20)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C77(1.22)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C77(1.15)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C77(1.03)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C77(1.01)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C77(0.99)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C77(0.99)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C297(0.86); C317(0.98)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C297(0.98); C77(0.98); C317(1.10)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C297(0.96); C77(0.95); C317(0.95)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C77(1.05)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C77(1.05)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C77(1.10)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C77(1.10)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C297(1.08); C77(0.94); C317(1.14)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C77(1.09)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C77(1.05)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C77(1.18)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C77(0.95)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C77(0.90)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C77(0.94)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C77(0.99)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C77(1.17)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C77(0.82)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C77(1.13)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C297(0.96); C77(1.02); C317(1.19)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C77(1.04)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C297(1.13); C77(1.02); C317(1.09)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C297(1.14); C77(1.19); C317(1.31)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C297(0.87); C77(0.91); C317(1.11)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C297(1.08); C77(1.06); C317(1.26)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C297(1.23); C77(0.97); C317(1.59)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C297(0.95); C77(0.99); C44(1.09); C317(1.24)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C297(1.00); C317(1.05)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C297(1.05); C77(0.94); C317(0.99)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C297(0.91); C77(0.86); C317(1.08)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C297(1.15); C77(1.00); C317(1.18)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C297(1.03); C77(0.98)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C297(1.19); C77(0.94); C317(0.89)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C297(1.12); C77(1.10); C317(1.29)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C297(1.13); C77(0.98); C317(1.32)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C297(0.89); C77(0.90); C317(1.34)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C297(1.11); C77(1.00); C317(1.22)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C297(1.06); C77(0.94); C317(1.46)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C297(0.90); C77(0.98); C44(1.06); C317(1.28)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C297(1.13); C317(1.03)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C297(1.05); C77(0.93)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C297(1.08); C77(1.07); C317(0.96)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C297(1.15); C77(0.96); C317(1.07)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C297(1.02); C77(0.89)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C297(1.13); C77(0.82); C317(0.99)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C297(1.05); C77(1.06); C317(1.44)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C297(1.07); C77(1.07); C317(1.40)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C297(0.89); C77(0.86); C317(1.28)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C297(1.30); C77(0.93); C317(1.34)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C297(1.20); C77(0.91); C317(1.45)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C297(0.97); C77(0.84); C317(1.09)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C297(1.05); C77(0.95); C44(1.25); C317(1.45)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C77(1.00)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C77(1.07)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C77(1.36)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C77(1.05)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C77(1.14)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C77(1.07)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C77(1.16)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C77(1.08)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C77(0.86)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C297(0.96); C77(1.11); C317(1.26)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C77(0.99)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C77(1.17)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C77(0.86)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C77(1.15)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C77(1.48)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C297(1.03); C77(0.95); C317(1.21)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C297(0.89); C77(0.85)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C297(1.15); C77(0.95); C317(0.98)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C297(1.06); C77(1.08); C317(1.10)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C297(0.76); C77(0.73); C317(0.84)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C297(1.06); C77(1.57); C317(1.11)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C297(1.27); C77(1.07); C317(1.05)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C297(1.10); C77(1.08); C317(1.24)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C297(1.07); C77(0.87); C317(1.28)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C297(0.98); C77(0.96); C44(1.31); C317(1.30)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C297(1.07); C317(1.28)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C297(1.02); C77(1.03); C317(1.00)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C297(1.03); C77(0.98); C317(1.06)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C297(1.04); C77(0.95); C317(0.98)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C297(1.12); C77(0.96)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C297(0.83); C77(0.95); C317(1.40)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C297(0.98); C77(0.73); C317(0.95)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C297(1.10); C77(1.07); C317(0.98)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C297(1.10); C77(1.35); C317(0.99)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C297(1.07); C77(0.92); C317(1.08)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C297(1.21); C77(0.89); C317(1.32)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C297(0.95); C77(0.83); C317(1.10)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C297(0.93); C77(0.88); C44(1.27); C317(1.00)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C297(0.93); C317(0.90)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C297(1.09); C77(0.97); C317(0.98)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C297(0.87); C77(1.06); C317(1.06)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C297(0.95); C77(1.01); C317(1.12)  LDD1698  [4]
 LDCM0625  F8 Ramos C77(1.08)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C77(0.94)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C77(4.05)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C77(1.07)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C77(1.31)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C77(0.89)  LDD2193  [6]
 LDCM0579  Fragment20 Ramos C77(0.73)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C77(1.01)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C77(1.37)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C77(1.04)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C77(0.61)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C77(1.32)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C77(1.27)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C77(1.18)  LDD2201  [6]
 LDCM0468  Fragment33 HEK-293T C77(1.52)  LDD1066  [5]
 LDCM0596  Fragment38 Ramos C77(0.87)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C77(0.77)  LDD2184  [6]
 LDCM0427  Fragment51 HEK-293T C297(1.13); C77(1.03); C317(1.09)  LDD1631  [4]
 LDCM0610  Fragment52 Ramos C77(2.04)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C77(1.68)  LDD2205  [6]
 LDCM0569  Fragment7 Ramos C77(0.60)  LDD2186  [6]
 LDCM0571  Fragment9 Ramos C77(0.79)  LDD2188  [6]
 LDCM0022  KB02 HEK-293T C77(0.94); C297(1.20)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C77(1.13); C297(1.08)  LDD1497  [4]
 LDCM0024  KB05 MKN-1 C297(1.70)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 SUMO-protein ligase RanBP2 (RANBP2) RanBP2 E3 ligase family P49792
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578