Details of the Target

General Information of Target

Target ID LDTP06835
Target Name C2 domain-containing protein 3 (C2CD3)
Gene Name C2CD3
Gene ID 26005
Synonyms
C2 domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKQRKGQGSGGSRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPPTCVL
VRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITK
LDGLPIGRVQINGLAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLP
TTDMTENVLLSKQGFRENTEPSSTQFQVPSRPRDIHTIKIDGKELAANSSRSTTPRGKDH
VCFAENPDTIKDSSFGLQHSLNSGQSLESVTLKGRAPRKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSMLLDQVHPPINEDSLRA
STQIRAFSRNRFKDHIEDHLLPSTENTFWRHDTKADTRAIQLLLGSAELSQGNFWDGLGS
PPDSPSPGSDVYCISELNDPQYDQSLLENLFYTAPKSDTSISDFLSEEDDIVPSKKISQS
TALARSSKVLESSDHKLKKRSAGKRNRNLVEQQMLSETPEDAQTMTLSVDRLALLGRTHS
VRIIIETMGVPPDSPQMTPGKKSYAGPPPKVTTAKKRTFFVEYHFPVGFSESGLGKTALI
TEVVRLASSKITDGKVKFQQRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGS
VSLSLRAVIQSELLSFSDQLPVQQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHY
TPLCAPTSPNKALPELNQDMTCTKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPST
FVATPASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTE
EVTRSVIAWGTTQPVFNFSQVIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVK
LPLHQFYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIM
ALQRLKNEEGTLPPFSPRPAHFLDQPTAASVAMAEDRGNGLMEHCFEIHIEMVKGLAPLQ
ATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEHHHS
LLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQKVAKGTLPLSRICAMV
TTQHREDVGIQTFNLPLTPRIENRKELRNQSSGLLDVGLRYRRSPRTAEGVLAARTVSIS
VQIIRACGLQAAAKALAEREPALQFSATVGVNASVTTHLSFLPQGEQRRTHPVACSFCPE
FSHHVEFTCNLVTQHCSGEACFLAELLEFAEVIFAVYHENTKSASDIISIESCKEYLLGV
VKVPTKELLIKRSGITGWYPIILPEDGGLPHGLELMQKIVGGLELSISFTHRGDRERVLE
AAEHLGWSFENSLKDFVRMDEGEPATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYK
FYDHEAFWTPLKKPKESVNKKQIMVTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGN
DSVERPHQTDSWIGSAYVDLARLGERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSS
LSSHLEPTHELDSMDCSSHSESEQLPRRNDEVQLSPPEVISCHQKSPASTQVPCSSTTAE
VRLTQEGPADLDGTFAVSILVERAMHLSLKGSPLTERKVSIPSCCVSFATADESSPVYTQ
VVENTDSPIWNFQQQSRLSKELLLDPQQTLVFKVWHKGDEERVIGFASVDLSPLLSGFQF
VCGWYNITDFSGECQGQIKVAVSPLESLIHFKEERQARRGVETSKSLIPIYSPFSFPASD
TYAAFSSHMARQTLDQLAHASSKELDFSSPGRSDTTRSQASRHEEHVQNIRRFHESLHLQ
GEAPLPCDDKLTTSPLSSQTSILTSLRKNLSELDQIQRYFRQKLTKPFLPLSPQTQTAIS
QHQESCRDHLGPGASSLDPGSQCILEKSSNLVLQVSSLITDLQTITRDSQAALSSHRARS
RSNKATTLPDAQDTEALQERCTMPDEPLVRAPDKGTDSPSPPPLEETSNGGRMLHESLRH
AVPITRMQSSEDTEAGPAYSDEDYEEDIIEPRTLNEITTVTDKTSPWSSVISDTSEVISP
QPDEVQREGPSCPSPGPFCREELMVKSSFLSSPERAVNPHLPRQGSPSQSLVACECEASK
ARVGGESASANPQPIPCPTLSGAQQSSTFVGWSSPQTDQNKEPKSEAPAENEAATSELGD
SADSFKKLPLNLASQSRRENHKGPPIDSSDIRQRQVTTGSETSTKQSLLLPGPIVVPNFF
LPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGALSQRPCRPRPNSLPLNLPEEETLR
IARIFSSQYSQKD
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, cilium basal body
Function
Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.
Uniprot ID
Q4AC94
Ensemble ID
ENST00000313663.11
HGNC ID
HGNC:24564

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1614(1.13)  LDD3323  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C76(1.05)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C76(1.14)  LDD0813  [4]
 LDCM0216  AC100 PaTu 8988t C76(0.90)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C76(0.57)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C76(0.76)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C76(0.75)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C76(0.74)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C76(0.79)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C76(0.69)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C76(1.13)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C76(0.72)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C76(0.54)  LDD1104  [4]
 LDCM0226  AC11 HEK-293T C76(1.04)  LDD0824  [4]
 LDCM0227  AC110 PaTu 8988t C76(0.61)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C76(0.80)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C76(0.45)  LDD1108  [4]
 LDCM0237  AC12 HEK-293T C76(1.18)  LDD0835  [4]
 LDCM0246  AC128 HEK-293T C76(0.72)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C76(1.08)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C76(0.87)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C76(1.14)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C76(1.80)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C76(3.38)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C76(1.31)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C76(1.51)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C76(1.95)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C76(0.41)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C76(0.99)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C76(0.54)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C76(1.25)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C76(1.65)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C76(0.56)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C76(1.90)  LDD0860  [4]
 LDCM0270  AC15 HEK-293T C76(1.27)  LDD0868  [4]
 LDCM0276  AC17 HEK-293T C76(1.48)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C76(1.25)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C76(1.28)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C76(1.17)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C76(1.55)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C76(1.40)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C76(1.41)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C76(1.39)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C76(1.36)  LDD0882  [4]
 LDCM0285  AC25 PaTu 8988t C76(1.30)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C76(1.30)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C76(1.12)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C76(1.57)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C76(1.53)  LDD1168  [4]
 LDCM0290  AC3 HEK-293T C76(0.96)  LDD0888  [4]
 LDCM0291  AC30 PaTu 8988t C76(1.29)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C76(1.51)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C76(1.85)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C76(1.37)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C76(0.95)  LDD1174  [4]
 LDCM0296  AC35 HEK-293T C76(0.83)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C76(1.03)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C76(0.99)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C76(1.04)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C76(1.03)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C76(0.93)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C76(1.04)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C76(1.03)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C76(1.26)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C76(1.17)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C76(1.12)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C76(1.00)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C1005(0.60); C2322(0.99)  LDD1547  [5]
 LDCM0310  AC48 HEK-293T C1005(1.47); C1614(1.01)  LDD1549  [5]
 LDCM0312  AC5 HEK-293T C76(1.14)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C1005(1.07); C1137(1.06); C1614(1.25)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C1005(0.95); C1137(1.05); C1614(1.24)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C1005(0.86); C2322(1.10); C1137(1.06); C1614(1.24)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C1005(1.20); C2322(0.98); C1614(1.05)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C1005(0.70); C2322(1.01)  LDD1556  [5]
 LDCM0319  AC56 HEK-293T C1005(1.14); C1614(1.06)  LDD1558  [5]
 LDCM0321  AC58 HEK-293T C1005(0.79); C1137(1.06); C1614(1.44)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C1005(1.03); C1137(1.07); C1614(0.83)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C76(1.09)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C1005(0.97); C2322(1.02); C1137(1.08); C1614(0.83)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C1005(1.01); C2322(1.01); C1614(1.01)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C1005(0.67); C2322(0.99)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C1005(1.13); C1614(1.17)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C76(1.16)  LDD0932  [4]
 LDCM0345  AC8 HEK-293T C76(1.45)  LDD0943  [4]
 LDCM0349  AC83 HEK-293T C76(0.97)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C76(1.21)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C76(1.06)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C76(1.14)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C76(1.21)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C76(1.18)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C76(1.33)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C76(1.34)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C76(1.13)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C76(1.13)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C76(1.11)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C76(1.24)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C76(1.28)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C76(1.26)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C76(2.16)  LDD0962  [4]
 LDCM0365  AC98 PaTu 8988t C76(0.52)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C76(0.63)  LDD1245  [4]
 LDCM0248  AKOS034007472 HEK-293T C76(1.14)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C76(1.42)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C76(1.30)  LDD0873  [4]
 LDCM0367  CL1 HEK-293T C1005(1.57); C2322(1.07); C1137(1.00); C304(1.18)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C1005(0.94); C2322(1.09)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C76(1.19)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C76(1.40)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C76(1.28)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C76(1.46)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C76(1.33)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C76(1.19)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C76(1.17)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C76(1.12)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C76(1.32)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C76(1.06)  LDD0976  [4]
 LDCM0380  CL110 HEK-293T C76(1.24)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C76(1.08)  LDD0979  [4]
 LDCM0382  CL112 PaTu 8988t C76(1.42)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C76(1.33)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C76(1.23)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C76(1.06)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C76(1.53)  LDD1265  [4]
 LDCM0387  CL117 HEK-293T C76(0.86)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C76(0.96)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C76(1.19)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C1005(1.19); C1614(1.19)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C76(1.12)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C1005(1.12); C2322(1.13); C1137(1.00); C304(1.07)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C1137(1.06); C58(1.00); C1207(1.07)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C2322(1.00); C1137(1.02)  LDD1598  [5]
 LDCM0396  CL125 HEK-293T C1005(1.07); C2322(1.08); C1137(0.96); C304(1.06)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C1137(1.16); C58(1.03); C1207(1.20)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C2322(1.02); C1137(1.07)  LDD1602  [5]
 LDCM0400  CL13 HEK-293T C1005(0.83); C2322(1.19); C1137(0.92); C304(1.02)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C1137(1.17); C58(1.09); C1207(1.23)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C2322(1.27); C1137(0.98)  LDD1606  [5]
 LDCM0405  CL18 HEK-293T C1005(0.94); C1137(0.94); C1614(1.27)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C1005(1.42); C1137(0.96); C1614(0.91)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C1137(0.90); C58(1.04); C1207(1.53)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C1005(0.93); C2322(1.25); C1137(0.78); C1614(1.02)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C1005(1.01); C2322(1.15); C1614(0.84)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C1005(0.86); C2322(1.16)  LDD1614  [5]
 LDCM0412  CL24 HEK-293T C1005(1.44); C1614(1.27)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C1005(0.99); C2322(0.98); C1137(0.86); C304(1.22)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C1137(1.00); C58(1.07); C1207(1.37)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C2322(1.11); C1137(1.03)  LDD1619  [5]
 LDCM0418  CL3 HEK-293T C2322(1.20); C1137(1.07)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C1005(1.10); C1137(0.95); C1614(1.07)  LDD1623  [5]
 LDCM0420  CL31 PaTu 8988t C76(0.96)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C76(1.03)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C76(1.00)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C76(0.83)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C76(0.98)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C76(0.87)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C76(1.19)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C76(0.84)  LDD1307  [4]
 LDCM0430  CL40 PaTu 8988t C76(1.04)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C76(0.90)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C76(1.00)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C76(1.31)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C76(1.13)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C76(0.77)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C1005(0.56); C2322(1.13)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C1005(0.94); C1614(0.84)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C1005(1.12); C2322(1.13); C1137(0.95); C304(0.86)  LDD1643  [5]
 LDCM0441  CL50 HEK-293T C1137(1.01); C58(1.08); C1207(1.30)  LDD1645  [5]
 LDCM0445  CL54 HEK-293T C1005(0.80); C1137(0.87); C1614(1.21)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C1005(1.01); C1137(0.93); C1614(0.78)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C1005(1.14); C2322(1.24); C1137(0.74); C1614(0.82)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C1005(0.91); C2322(1.17); C1614(0.96)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C1005(0.68); C2322(1.16)  LDD1652  [5]
 LDCM0451  CL6 HEK-293T C1005(0.87); C1137(1.06); C1614(1.24)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C1005(1.59); C1614(1.08)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C1005(0.94); C2322(1.11); C1137(1.03); C304(1.13)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C1137(1.04); C58(1.07); C1207(1.05)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C2322(1.10); C1137(0.96)  LDD1658  [5]
 LDCM0458  CL66 HEK-293T C1005(0.76); C1137(0.99); C1614(1.32)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C1005(1.27); C1137(0.96); C1614(0.93)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C1005(0.96); C2322(1.12); C1137(0.86); C1614(0.82)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C1005(1.06); C2322(1.15); C1614(1.05)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C1005(1.23); C1137(0.99); C1614(1.23)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C1005(0.90); C2322(1.07)  LDD1666  [5]
 LDCM0465  CL72 HEK-293T C1005(1.43); C1614(1.42)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C1005(1.67); C2322(1.03); C1137(1.04); C304(1.22)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C1137(0.97); C58(1.00); C1207(1.18)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C76(1.18)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C76(1.11)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C76(1.39)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C76(1.29)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C1005(0.84); C2322(1.04); C1137(0.87); C1614(1.24)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C76(1.25)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C76(1.24)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C76(0.99)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C76(1.08)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C76(1.23)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C76(1.27)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C76(1.45)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C76(1.25)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C76(1.31)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C76(1.27)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C1005(0.99); C2322(1.08); C1614(1.32)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C76(1.16)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C76(1.08)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C76(0.91)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C76(1.04)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C76(1.48)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C76(1.40)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C76(1.15)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C76(1.13)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C76(1.13)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C76(1.09)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C2322(1.16); C1137(1.08)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C2322(1.06); C1137(1.09)  LDD1671  [5]
 LDCM0427  Fragment51 PaTu 8988t C76(0.95)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C2322(1.01); C1614(1.11)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C2322(1.04); C1614(1.05)  LDD1497  [5]
 LDCM0024  KB05 SKMEL24 C1614(1.13)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centriole and centriolar satellite protein OFD1 (OFD1) OFD1 family O75665

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402