Details of the Target

General Information of Target

Target ID LDTP06675
Target Name LON peptidase N-terminal domain and RING finger protein 2 (LONRF2)
Gene Name LONRF2
Gene ID 164832
Synonyms
RNF192; LON peptidase N-terminal domain and RING finger protein 2; Neuroblastoma apoptosis-related protease; RING finger protein 192
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPEPVPPPPPPQCPGCDRAEPIAQRLEEGDEAFRAGDYEMAAELFRSMLAGLAQPDRGL
CLRLGDALARAGRLPEALGAFRGAARLGALRPEELEELAGGLVRAVGLRDRPLSAENPGG
EPEAPGEGGPAPEPRAPRDLLGCPRCRRLLHKPVTLPCGLTVCKRCVEPGPARPQVRRVN
VVLSGLLEKCFPAECRLRRLAGQARSLQRQQQPEAALLRCDQALELAPDDNSLLLLRAEL
YLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALSGLGRSKEVLKEFLYCLALNPECNS
VKKEAQKVMCEVLFSATANVHENLTSSIQSRLKAQGHSHMNAQALLEEGDAGSSENSSEK
SDMLGNTNSSVLYFILGLHFEEDKKALESILPTAPSAGLKRQFPDDVEDAPDLNAPGKIP
KKDLSLQRSPNSETEESQGLSLDVTDFECALCMRLLFEPVTTPCGHTFCLKCLERCLDHA
PHCPLCKDKLSELLASRNFNITVLAEELIFRYLPDELSDRKRIYDEEMSELSNLTRDVPI
FVCAMAFPTVPCPLHVFEPRYRLMIRRCMETGTKRFGMCLSAEHAGLSEYGCMLEIKDVR
TFPDGSSVVDAIGISRFRVLSHRHRDGYNTADIEYLEDEKVEGPEYEELAALHDSVHQQS
VSWFASLQDRMKEQILSHFGVMPDREPEPQSNPSGPAWSWWILAVLPLERKAQLAILGMT
SLKERLLAIRRILVIITRKMNSRQELANARERNN
Target Bioclass
Enzyme
Uniprot ID
Q1L5Z9
Ensemble ID
ENST00000393437.8
HGNC ID
HGNC:24788

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A665G .
DU4475 SNV: p.R138H .
FADU SNV: p.A20G .
HT SNV: p.R475C .
IGROV1 SNV: p.A397D .
MELJUSO SNV: p.S327F .
MEWO SNV: p.E570K .
NCIH146 SNV: p.R730L .
NCIH1975 SNV: p.G83S .
NCIH23 Substitution: p.E558L .
OSRC2 SNV: p.C220R .
PF382 SNV: p.R138H .
PFSK1 SNV: p.G572D .
SKMEL30 SNV: p.A20G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C476(3.14); C486(3.14); C483(3.14); C190(2.46)  LDD0080  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C483(0.86); C486(0.86)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C476(0.91); C483(0.98); C486(0.99)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C476(0.96); C483(0.96); C486(0.96)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C476(1.10); C483(1.10); C486(1.10)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C476(0.95); C483(0.95); C486(0.95)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C476(1.17); C483(1.17); C486(1.17)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C476(0.86); C483(0.86); C486(0.86)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C476(0.98); C483(0.98); C486(0.98)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C476(1.14); C483(1.14); C486(1.14)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C476(0.96); C483(0.96); C486(0.96)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C476(0.92); C483(0.92); C486(0.92)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C476(0.91); C483(0.91); C486(0.91)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C476(0.98); C483(1.08); C486(1.01)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C476(1.05); C483(1.05); C486(1.05)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C476(0.82); C483(0.82); C486(0.82)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C476(0.79); C483(0.79); C486(0.79)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C476(1.11); C483(1.11); C486(1.11)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C476(1.18); C483(1.18); C486(1.18)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C476(1.02); C483(1.02); C486(1.02)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C476(0.90); C483(0.90); C486(0.90)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C476(1.05); C483(1.05); C486(1.05)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C476(1.05); C483(1.05); C486(1.05)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C476(1.07); C483(1.07); C486(1.07)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C476(1.01); C483(1.12); C486(0.98)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C476(0.93); C483(0.93); C486(0.93)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C476(1.18); C483(1.18); C486(1.18)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C476(0.91); C483(0.91); C486(0.91)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C476(1.01); C483(1.01); C486(1.01)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C476(0.97); C483(0.97); C486(0.97)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C476(0.99); C483(0.99); C486(0.99)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C476(1.01); C483(1.01); C486(1.01)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C476(0.98); C483(0.98); C486(0.98)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C476(0.99); C483(0.99); C486(0.99)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C476(0.92); C483(0.92); C486(0.92)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C476(0.90); C483(0.90); C486(0.90)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C476(1.01); C483(1.01); C486(1.01)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C476(0.97); C483(0.97); C486(0.97)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C476(1.08); C483(1.08); C486(1.08)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C476(0.97); C483(0.97); C486(0.97)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C476(0.88); C483(0.88); C486(0.88)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C476(1.09); C483(1.09); C486(1.09)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C476(0.86); C483(0.86); C486(0.86)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C476(0.84); C483(0.84); C486(0.84)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C476(0.97); C483(0.97); C486(0.97)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C476(0.91); C483(0.94); C486(1.09)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C476(0.92); C483(0.92); C486(0.92)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C476(1.03); C483(1.03); C486(1.03)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C476(0.90); C483(0.90); C486(0.90)  LDD0860  [1]
 LDCM0270  AC15 HEK-293T C476(1.05); C483(1.12); C486(0.98)  LDD0868  [1]
 LDCM0276  AC17 HEK-293T C476(1.62); C483(1.14); C486(0.65)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C476(1.66); C483(1.20); C486(0.74)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C476(1.07); C483(0.89); C486(0.70)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C483(1.01); C486(1.01)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C476(0.97); C483(0.94); C486(0.91)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C476(1.14); C483(0.98); C486(0.83)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C476(1.46); C483(1.18); C486(0.90)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C476(0.83); C483(0.83); C486(0.83)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C476(1.01); C483(0.97); C486(0.92)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C166(1.02); C552(1.06); C143(0.95); C464(1.30)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C166(0.97); C258(1.06); C220(1.16); C552(1.05)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C166(0.99); C220(1.02); C552(1.04); C143(1.03)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C166(1.00); C143(1.00); C476(0.94); C464(1.01)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C166(0.92); C258(1.12); C552(1.09); C143(0.98)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C483(0.69); C486(0.69)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C166(1.13); C552(0.97); C143(0.99); C476(1.02)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C166(1.04); C143(1.01); C476(1.02)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C166(0.96); C143(1.05)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C166(0.99); C552(1.08); C143(0.90); C464(1.36)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C166(0.98); C258(0.90); C220(1.07); C552(0.98)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C476(1.08); C483(1.08); C486(1.08)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C476(0.85); C483(0.85); C486(0.85)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C476(1.07); C483(1.07); C486(1.07)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C476(0.99); C483(0.99); C486(0.99)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C476(1.25); C483(1.25); C486(1.25)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C483(0.96); C486(0.96)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C476(0.98); C483(0.98); C486(0.98)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C476(1.05); C483(1.05); C486(1.05)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C476(1.01); C483(1.01); C486(1.01)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C476(0.95); C483(0.95); C486(0.95)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C476(0.97); C483(0.97); C486(0.97)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C476(0.97); C483(0.97); C486(0.97)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C476(1.08); C486(1.08)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C476(1.06); C486(1.06)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C476(1.00); C486(1.00)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C476(1.07); C486(1.07)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C483(0.82); C486(0.82)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C476(0.98); C486(0.98)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C476(1.10); C486(1.10)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C476(1.12); C486(1.12)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C476(1.08); C486(1.08)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C476(1.20); C486(1.20)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C476(1.31); C486(1.31)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C476(1.05); C486(1.05)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C476(0.97); C483(0.93); C486(0.97)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C476(1.01); C483(1.05); C486(1.01)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C476(0.92); C483(0.89); C486(0.92)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C476(0.84); C483(0.87); C486(0.98)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C476(0.72); C483(0.84); C486(0.72)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C476(0.87); C483(0.79); C486(0.87)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C476(0.91); C483(0.73); C486(0.91)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C476(0.90); C483(0.76); C486(0.90)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C476(0.98); C483(0.80); C486(0.98)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C476(0.96); C483(0.81); C486(0.96)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C476(0.95); C483(0.74); C486(0.95)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C476(0.92); C483(0.81); C486(0.92)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C476(0.93); C483(1.02); C486(0.93)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C476(0.87); C483(0.91); C486(0.87)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C476(0.83); C483(0.91); C486(0.87)  LDD0932  [1]
 LDCM0335  AC70 HEK-293T C476(0.83); C483(0.90); C486(0.83)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C476(0.91); C483(0.89); C486(0.91)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C476(0.84); C483(0.78); C486(0.84)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C476(0.85); C483(0.93); C486(0.85)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C476(0.75); C483(0.76); C486(0.75)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C476(0.74); C483(0.76); C486(0.74)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C476(0.82); C483(0.78); C486(0.82)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C476(0.75); C483(0.72); C486(0.75)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C476(0.80); C483(0.87); C486(0.80)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C476(0.95); C483(0.91); C486(0.95)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C476(0.96); C483(1.08); C486(0.99)  LDD0943  [1]
 LDCM0346  AC80 HEK-293T C476(0.80); C483(0.77); C486(0.80)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C476(0.98); C483(1.03); C486(0.98)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C476(0.78); C483(0.84); C486(0.78)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C476(0.67); C483(0.67); C486(0.77)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C476(0.63); C483(0.63); C486(0.72)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C476(0.66); C483(0.66); C486(0.76)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C476(0.75); C483(0.75); C486(0.90)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C476(0.90); C483(0.90); C486(0.96)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C476(0.63); C483(0.63); C486(0.75)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C476(0.66); C483(0.66); C486(0.85)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C476(0.78); C483(0.78); C486(0.94)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C476(0.81); C483(0.81); C486(1.06)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C476(0.68); C483(0.68); C486(0.81)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C476(0.84); C483(0.84); C486(0.92)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C476(0.71); C483(0.71); C486(0.89)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C476(0.69); C483(0.69); C486(0.81)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C476(0.78); C483(0.78); C486(0.81)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C476(0.69); C483(0.69); C486(0.85)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C476(1.01); C483(1.01); C486(1.01)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C476(0.92); C483(0.92); C486(0.92)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C476(1.04); C483(1.11); C486(0.93)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C476(1.03); C483(1.14); C486(1.09)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C476(0.88); C483(0.91); C486(1.06)  LDD0873  [1]
 LDCM0367  CL1 PaTu 8988t C476(0.93); C483(0.93); C486(0.93)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C476(1.20); C483(1.20); C486(1.20)  LDD1247  [1]
 LDCM0369  CL100 HEK-293T C483(0.84); C486(0.84)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C476(0.80); C483(0.83); C486(0.90)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C476(0.87); C483(0.94); C486(1.01)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C476(0.93); C483(0.95); C486(0.89)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C476(0.93); C483(0.95); C486(0.87)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C476(1.00); C483(0.95); C486(0.89)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C476(1.37); C483(1.06); C486(0.76)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C476(0.91); C483(0.91); C486(0.90)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C476(1.30); C483(0.94); C486(0.59)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C476(1.05); C483(0.92); C486(0.79)  LDD0976  [1]
 LDCM0379  CL11 PaTu 8988t C476(1.20); C483(1.20); C486(1.20)  LDD1258  [1]
 LDCM0380  CL110 HEK-293T C476(1.10); C483(0.94); C486(0.79)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C476(1.01); C483(0.95); C486(0.89)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C166(0.97); C258(1.05); C220(0.87); C552(1.00)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C166(1.01); C258(1.06); C464(0.90)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C166(0.84); C258(0.90); C568(0.98); C220(0.99)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C166(0.98); C258(1.08); C220(1.15); C143(1.12)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C166(1.15); C258(1.16); C220(1.01); C552(1.02)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C476(1.07); C483(1.07); C486(1.07)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C476(0.99); C483(0.99); C486(0.99)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C476(0.89); C483(0.89); C486(0.89)  LDD0987  [1]
 LDCM0390  CL12 PaTu 8988t C476(1.02); C483(1.02); C486(1.02)  LDD1269  [1]
 LDCM0391  CL120 HEK-293T C476(1.11); C483(1.11); C486(1.11)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C476(1.24); C486(1.24)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C476(1.01); C486(1.01)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C476(1.12); C486(1.12)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C476(1.08); C486(1.08)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C476(1.08); C483(1.12); C486(1.08)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C476(1.06); C483(1.08); C486(1.06)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C476(0.94); C483(0.81); C486(0.94)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C476(0.95); C483(0.88); C486(0.95)  LDD0997  [1]
 LDCM0400  CL13 PaTu 8988t C476(1.18); C483(1.18); C486(1.18)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C476(0.98); C483(0.98); C486(0.98)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C476(1.00); C483(1.00); C486(1.00)  LDD1281  [1]
 LDCM0403  CL16 HEK-293T C476(0.94); C483(0.94); C486(0.94)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C476(1.00); C483(1.00); C486(1.00)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C476(0.88); C483(0.88); C486(0.88)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C476(0.97); C483(0.97); C486(0.97)  LDD1004  [1]
 LDCM0407  CL2 PaTu 8988t C476(0.91); C483(0.91); C486(0.91)  LDD1286  [1]
 LDCM0408  CL20 HEK-293T C476(0.94); C483(0.94); C486(0.94)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C476(0.94); C483(0.94); C486(0.94)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C476(0.86); C483(0.86); C486(0.86)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C476(0.85); C483(0.85); C486(0.85)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C476(1.12); C483(1.12); C486(1.12)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C476(1.15); C483(1.15); C486(1.15)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C476(0.83); C483(0.83); C486(0.83)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C476(0.88); C483(0.88); C486(0.88)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C476(1.00); C483(1.00); C486(1.00)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C476(0.99); C483(0.99); C486(0.99)  LDD1015  [1]
 LDCM0418  CL3 PaTu 8988t C476(1.05); C483(1.05); C486(1.05)  LDD1297  [1]
 LDCM0419  CL30 HEK-293T C476(0.86); C483(0.86); C486(0.86)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C166(1.09); C220(1.16); C552(0.97); C143(1.07)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C166(0.95); C143(1.06); C476(1.01); C464(0.76)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C166(0.82); C258(0.94); C552(0.95); C143(1.06)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C166(1.01); C552(1.04); C143(1.02); C476(0.74)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C166(0.95); C143(1.14); C476(0.88)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C166(0.95); C143(1.13)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C166(1.12); C258(0.88); C464(1.14)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C166(0.87); C258(0.97); C220(1.29); C143(1.06)  LDD1632  [3]
 LDCM0429  CL4 PaTu 8988t C476(0.89); C483(0.89); C486(0.89)  LDD1308  [1]
 LDCM0430  CL40 HEK-293T C166(1.11); C258(0.99); C220(0.95); C552(1.16)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C166(0.88); C552(1.10); C143(0.92); C464(0.97)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C166(0.91); C258(1.02); C220(1.01); C552(0.88)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C166(0.95); C220(1.20); C552(1.00); C143(1.12)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C166(0.97); C143(0.97); C476(0.97); C464(0.69)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C166(0.87); C258(1.06); C552(0.77); C143(1.01)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C476(0.91); C483(0.91); C486(1.14)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C476(1.05); C483(1.05); C486(1.16)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C476(1.00); C483(1.00); C486(1.03)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C476(0.99); C483(0.99); C486(1.14)  LDD1037  [1]
 LDCM0440  CL5 PaTu 8988t C476(1.05); C483(1.05); C486(1.05)  LDD1319  [1]
 LDCM0441  CL50 HEK-293T C476(0.91); C483(0.91); C486(1.01)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C476(1.08); C483(1.08); C486(1.18)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C476(1.13); C483(1.13); C486(1.35)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C476(1.06); C483(1.06); C486(1.26)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C476(1.47); C483(1.47); C486(1.81)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C476(1.20); C483(1.20); C486(1.27)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C476(1.31); C483(1.31); C486(1.53)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C476(1.31); C483(1.31); C486(1.43)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C476(1.46); C483(1.46); C486(1.39)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C476(1.21); C483(1.21); C486(1.43)  LDD1048  [1]
 LDCM0451  CL6 PaTu 8988t C476(0.96); C483(0.96); C486(0.96)  LDD1330  [1]
 LDCM0452  CL60 HEK-293T C476(1.15); C483(1.15); C486(1.36)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C476(1.01); C483(1.17); C486(1.33)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C476(0.92); C483(1.13); C486(1.34)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C476(0.94); C483(0.98); C486(1.03)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C476(1.65); C483(1.32); C486(0.98)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C476(1.22); C483(1.35); C486(1.47)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C476(1.16); C483(1.30); C486(1.45)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C476(1.27); C483(1.30); C486(1.33)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C476(0.88); C483(1.41); C486(1.94)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C476(1.21); C483(1.47); C486(1.72)  LDD1059  [1]
 LDCM0462  CL7 PaTu 8988t C476(0.98); C483(0.98); C486(0.98)  LDD1341  [1]
 LDCM0463  CL70 HEK-293T C476(1.19); C483(1.37); C486(1.55)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C476(1.75); C483(1.69); C486(1.63)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C476(1.64); C483(1.42); C486(1.20)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C476(1.06); C483(1.26); C486(1.45)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C476(1.01); C483(1.18); C486(1.35)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C166(1.09); C258(1.06); C220(0.99); C552(1.14)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C166(0.91); C552(0.96); C143(0.92); C464(1.31)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C166(0.98); C258(0.77); C220(1.09); C552(0.92)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C166(1.05); C220(1.44); C552(1.01); C143(1.08)  LDD1675  [3]
 LDCM0473  CL8 PaTu 8988t C476(0.97); C483(0.97); C486(0.97)  LDD1352  [1]
 LDCM0474  CL80 HEK-293T C166(0.93); C143(1.15); C476(1.04); C464(1.11)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C166(0.98); C258(1.00); C552(0.94); C143(1.11)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C166(0.97); C552(0.94); C143(1.01); C476(0.89)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C166(0.95); C143(1.13); C476(0.94)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C166(0.94); C143(0.98)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C166(1.22); C258(1.14); C464(1.19)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C166(0.97); C258(0.90); C568(1.00); C220(1.05)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C166(1.09); C258(1.01); C220(0.89); C143(1.09)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C166(1.02); C258(1.15); C220(1.21); C552(1.07)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C166(1.12); C552(1.19); C143(0.90); C464(1.28)  LDD1686  [3]
 LDCM0484  CL9 PaTu 8988t C476(0.94); C483(0.94); C486(0.94)  LDD1363  [1]
 LDCM0485  CL90 HEK-293T C166(0.89); C258(1.12); C220(0.91); C552(0.92)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C483(1.01); C486(1.01)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C483(1.01); C486(1.01)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C483(0.84); C486(0.84)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C483(1.11); C486(1.11)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C483(0.95); C486(0.95)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C483(0.73); C486(0.73)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C483(0.88); C486(0.88)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C483(0.91); C486(0.91)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C483(1.11); C486(1.11)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C166(1.06); C258(0.94); C220(1.18); C143(1.01)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C476(1.39); C483(1.39); C486(1.40)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C166(0.95); C258(0.94); C568(1.04); C220(1.57)  LDD1631  [3]
 LDCM0022  KB02 HCT 116 C476(3.14); C486(3.14); C483(3.14); C190(2.46)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C476(14.69); C486(14.69); C483(14.69); C190(4.16)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C476(3.63); C486(3.63); C483(3.63); C190(2.29)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c (CYCS) Cytochrome c family P99999
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
T-complex protein 1 subunit epsilon (CCT5) TCP-1 chaperonin family P48643
Gelsolin (GSN) Villin/gelsolin family P06396
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402