Details of the Target

General Information of Target

Target ID LDTP06544
Target Name snRNA-activating protein complex subunit 1 (SNAPC1)
Gene Name SNAPC1
Gene ID 6617
Synonyms
SNAP43; snRNA-activating protein complex subunit 1; SNAPc subunit 1; Proximal sequence element-binding transcription factor subunit gamma; PSE-binding factor subunit gamma; PTF subunit gamma; Small nuclear RNA-activating complex polypeptide 1; snRNA-activating protein complex 43 kDa subunit; SNAPc 43 kDa subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTPPGLQTDCEALLSRFQETDSVRFEDFTELWRNMKFGTIFCGRMRNLEKNMFTKEALA
LAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVLKFQQDLVNAQHF
DAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEEFKDPSDRVMKLITSDVLEEM
LNVHDHYQNMKHVISVDKSKPDKALSLIKDDFFDNIKNIVLEHQQWHKDRKNPSLKSKTN
DGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQASKSRRHRQVKLDSSDSDSASGQGQ
VKATRKKEKKERLKPAGRKMSLRNKGNVQNIHKEDKPLSLSMPVITEEEENESLSGTEFT
ASKKRRKH
Target Bioclass
Other
Subcellular location
Nucleus
Function
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Uniprot ID
Q16533
Ensemble ID
ENST00000216294.5
HGNC ID
HGNC:11134

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C43(1.58)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C43(0.84)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C43(1.25)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C43(1.06)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C43(1.03)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C43(1.11)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C43(1.29)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C43(1.16)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C43(1.37)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C43(0.94)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C43(1.04)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C43(1.47)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C43(0.84)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C43(1.27)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C43(1.06)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C43(1.30)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C43(1.25)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C43(0.88)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C43(1.19)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C43(0.99)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C43(0.90)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C43(1.28)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C43(1.04)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C43(0.70)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C43(0.89)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C43(0.99)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C43(0.90)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C43(0.99)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C43(0.84)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C43(1.27)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C43(1.02)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C43(0.94)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C43(1.45)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C43(1.35)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C43(1.54)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C43(1.16)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C43(1.56)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C43(1.24)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C43(1.32)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C43(1.22)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C43(1.15)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C43(1.07)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C43(1.12)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C43(1.03)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C43(0.92)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C43(0.92)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C43(0.97)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C43(1.15)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C43(0.77)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C43(0.74)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C43(0.82)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C43(0.82)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C43(0.77)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C43(0.78)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C43(0.68)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C43(0.86)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C43(0.75)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C43(0.83)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C43(0.72)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C43(0.76)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C43(0.93)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C43(0.77)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C43(0.84)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C43(0.78)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C43(0.62)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C43(0.61)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C43(0.68)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C43(0.89)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C43(0.71)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C43(2.46)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C43(0.72)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C43(0.62)  LDD0601  [2]
 LDCM0288  AC28 HEK-293T C91(1.06)  LDD1527  [5]
 LDCM0296  AC35 HCT 116 C43(0.74)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C43(0.97)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C43(0.82)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C43(1.27)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C43(0.81)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C91(1.10)  LDD1540  [5]
 LDCM0302  AC40 HCT 116 C43(0.97)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C43(1.03)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C43(1.01)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C43(1.00)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C43(1.03)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C43(1.07)  LDD0624  [2]
 LDCM0315  AC52 HEK-293T C91(0.94)  LDD1554  [5]
 LDCM0320  AC57 HCT 116 C43(0.77)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C43(0.83)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C43(0.70)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C43(0.74)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C43(0.89)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C43(0.76)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C43(0.72)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C43(0.83)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C43(0.95)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C43(0.71)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C43(0.81)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C43(0.65)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C43(0.95)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C43(1.08)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C43(0.84)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C43(0.75)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C43(1.26)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C43(1.15)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C43(1.00)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C43(1.11)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C43(1.08)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C43(0.91)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C43(0.97)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C43(1.06)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C43(1.17)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C43(0.68)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C43(0.92)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C43(1.04)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C43(0.99)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C43(1.10)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C43(1.02)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C43(1.02)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C43(1.05)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C43(1.05)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C43(1.08)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C43(1.06)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C43(1.21)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C43(1.07)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C43(1.24)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C43(1.06)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C43(1.05)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C43(1.07)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C43(1.03)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C43(1.04)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C43(1.36)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C43(1.15)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C43(0.95)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C43(0.88)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C43(0.81)  LDD0592  [2]
 LDCM0370  CL101 HCT 116 C43(0.90)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C43(1.16)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C43(0.68)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C43(1.07)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C43(0.75)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C43(0.59)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C43(1.06)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C43(0.84)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C43(0.62)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C43(0.65)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C43(0.47)  LDD0698  [2]
 LDCM0385  CL115 HEK-293T C43(0.94)  LDD1589  [5]
 LDCM0387  CL117 HCT 116 C43(1.02)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C43(1.02)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C43(0.93)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C43(1.01)  LDD0708  [2]
 LDCM0394  CL123 HEK-293T C43(1.13)  LDD1598  [5]
 LDCM0396  CL125 HCT 116 C43(0.67)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C43(0.55)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C43(0.60)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C43(0.68)  LDD0716  [2]
 LDCM0402  CL15 HEK-293T C43(1.07)  LDD1606  [5]
 LDCM0403  CL16 HCT 116 C43(0.89)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C43(0.90)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C43(1.25)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C43(0.84)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C43(0.87)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C43(1.01)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C43(1.08)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C43(1.13)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C43(0.87)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C43(0.89)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C43(0.87)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C43(0.89)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C43(0.86)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C43(0.98)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C43(1.15)  LDD1622  [5]
 LDCM0419  CL30 HCT 116 C43(1.22)  LDD0736  [2]
 LDCM0421  CL32 HEK-293T C91(1.02)  LDD1625  [5]
 LDCM0428  CL39 HEK-293T C43(1.20)  LDD1632  [5]
 LDCM0434  CL44 HEK-293T C91(0.93)  LDD1638  [5]
 LDCM0447  CL56 HEK-293T C91(1.22)  LDD1650  [5]
 LDCM0453  CL61 HCT 116 C43(0.93)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C43(0.81)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C43(0.92)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C43(0.91)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C43(0.93)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C43(0.82)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C43(1.01)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C43(0.92)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C43(0.86)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C43(0.95)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C43(0.87)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C43(1.02)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C43(0.98)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C43(0.93)  LDD0784  [2]
 LDCM0473  CL8 HEK-293T C91(0.94)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C91(0.88)  LDD1677  [5]
 LDCM0481  CL87 HEK-293T C43(1.02)  LDD1684  [5]
 LDCM0487  CL92 HEK-293T C91(1.08)  LDD1690  [5]
 LDCM0494  CL99 HEK-293T C43(1.10)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C43(1.07)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C43(0.88)  LDD0785  [2]
 LDCM0022  KB02 HCT 116 C43(1.58)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C43(2.46)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C43(1.42)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase type B catalytic subunit (HAT1) HAT1 family O14929
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
snRNA-activating protein complex subunit 3 (SNAPC3) SNAPC3/SRD2 family Q92966
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402