Details of the Target

General Information of Target

Target ID LDTP06237
Target Name Transmembrane glycoprotein NMB (GPNMB)
Gene Name GPNMB
Gene ID 10457
Synonyms
HGFIN; NMB; Transmembrane glycoprotein NMB; Hematopoietic growth factor inducible neurokinin-1 type
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE
LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG
LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
Target Type
Literature-reported
Target Bioclass
Other
Family
PMEL/NMB family
Subcellular location
Cell membrane
Function Could be a melanogenic enzyme.
TTD ID
T59856
Uniprot ID
Q14956
DrugMap ID
TT7315J
Ensemble ID
ENST00000258733.9
HGNC ID
HGNC:4462
ChEMBL ID
CHEMBL3712919

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C369(1.43)  LDD3314  [1]
HHS-482
 Probe Info  		Y220(1.00)  LDD0285  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0123  JWB131 DM93 Y220(1.00)  LDD0285  [2]
 LDCM0124  JWB142 DM93 Y220(1.50)  LDD0286  [2]
 LDCM0125  JWB146 DM93 Y220(1.12)  LDD0287  [2]
 LDCM0126  JWB150 DM93 Y220(6.05)  LDD0288  [2]
 LDCM0127  JWB152 DM93 Y220(3.37)  LDD0289  [2]
 LDCM0128  JWB198 DM93 Y220(2.33)  LDD0290  [2]
 LDCM0129  JWB202 DM93 Y220(1.07)  LDD0291  [2]
 LDCM0130  JWB211 DM93 Y220(1.36)  LDD0292  [2]
 LDCM0022  KB02 22RV1 C369(1.68)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C369(1.80)  LDD2660  [1]
 LDCM0024  KB05 IGR37 C369(1.43)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glembatumumab Vedotin . DB05996

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.