Details of the Target

General Information of Target

Target ID LDTP06061
Target Name DNA repair-scaffolding protein (SPIDR)
Gene Name SPIDR
Gene ID 23514
Synonyms
KIAA0146; DNA repair-scaffolding protein; Scaffolding protein involved in DNA repair
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRGSRARGSKRKRSWNTECPSFPGERPLQVRRAGLRTAGAAASLSEAWLRCGEGFQNTS
GNPSLTAEEKTITEKHLELCPRPKQETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQR
DELQFIDWEIDSDRAEASDCDEFEDDEGAVEISDCASCASNQSLTSDEKLSELPKPSSIE
ILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQK
PTAKFPRTPENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLT
VKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTV
RIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVI
KGLTNNSPEIQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGA
GVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKAR
QLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA
LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQL
KSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSL
FFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQ
GTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR
SRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIGL
EEIELLSAGGASAEH
Target Bioclass
Other
Subcellular location
Nucleus
Function
Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.
Uniprot ID
Q14159
Ensemble ID
ENST00000297423.9
HGNC ID
HGNC:28971

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P63S .
A673 SNV: p.S286P DBIA    Probe Info 
AN3CA SNV: p.N802S .
CAL62 SNV: p.R727C .
G415 SNV: p.G339D .
HCT15 SNV: p.V630I .
HS936T SNV: p.P365L DBIA    Probe Info 
HT SNV: p.L50R .
NCIH23 SNV: p.Q888Ter .
REC1 SNV: p.S64L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C80(20.00)  LDD2227  [1]
DBIA
 Probe Info  		C398(1.75); C402(1.75)  LDD0080  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C398(1.29); C402(1.29)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C398(1.19); C402(1.19); C817(0.61); C820(0.61)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C398(0.63); C402(0.63)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C398(0.58); C402(0.58)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C398(0.57); C402(0.57)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C398(0.89); C402(0.89)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C398(0.85); C402(0.85)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C398(0.88); C402(0.88)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C398(0.86); C402(0.86)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C398(0.89); C402(0.89)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C398(0.67); C402(0.67)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C398(0.68); C402(0.68)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C398(1.03); C402(1.03); C817(0.72); C820(0.72)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C398(0.54); C402(0.54)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C398(0.71); C402(0.71)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C398(0.55); C402(0.55)  LDD0546  [2]
 LDCM0237  AC12 HEK-293T C398(0.88); C402(0.88); C817(1.12); C820(1.12)  LDD0835  [2]
 LDCM0259  AC14 HEK-293T C398(1.14); C402(1.14); C817(0.67); C820(0.67)  LDD0857  [2]
 LDCM0263  AC143 HCT 116 C398(1.20); C402(1.20)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C398(1.07); C402(1.24)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C398(0.90); C402(1.67)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C398(0.88); C402(1.14)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C398(1.30); C402(1.37)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C398(0.78); C402(1.75)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C398(0.84); C402(1.49)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C398(0.95); C402(0.95); C817(0.88); C820(0.88)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C398(1.04); C402(1.17)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C402(1.00); C398(1.16)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C402(1.06); C398(1.06)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C398(0.83); C402(1.72)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C398(1.21); C402(1.07)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C398(0.87); C402(1.61)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C398(1.47); C402(1.26)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C398(1.06); C402(1.51)  LDD2161  [2]
 LDCM0278  AC19 HEK-293T C284(1.11); C817(1.54); C820(1.54)  LDD1517  [3]
 LDCM0279  AC2 HCT 116 C398(1.16); C402(1.16)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C817(1.04); C820(1.04)  LDD1519  [3]
 LDCM0282  AC22 HEK-293T C839(0.95)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C817(0.93); C820(0.93)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C839(1.06); C817(1.14); C820(1.14)  LDD1523  [3]
 LDCM0287  AC27 HEK-293T C284(1.01); C817(1.11); C820(1.11)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C817(0.90); C820(0.90)  LDD1527  [3]
 LDCM0290  AC3 HCT 116 C398(1.22); C402(1.22)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C839(0.99)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C817(1.15); C820(1.15)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C839(0.92); C817(1.05); C820(1.05)  LDD1532  [3]
 LDCM0296  AC35 HEK-293T C284(0.97); C817(1.03); C820(1.03)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C817(1.06); C820(1.06)  LDD1536  [3]
 LDCM0299  AC38 HEK-293T C839(1.17)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C817(1.05); C820(1.05)  LDD1539  [3]
 LDCM0301  AC4 HCT 116 C398(1.31); C402(1.31)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C839(1.08); C817(1.13); C820(1.13)  LDD1541  [3]
 LDCM0305  AC43 HEK-293T C284(1.07); C817(1.12); C820(1.12)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C817(1.13); C820(1.13)  LDD1545  [3]
 LDCM0308  AC46 HEK-293T C817(1.19); C820(1.19)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C817(1.40); C820(1.40)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C817(1.28); C820(1.28)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C817(1.13); C820(1.13)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C398(0.98); C402(0.98)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C817(1.39); C820(1.39)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C817(1.43); C820(1.43)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C817(1.44); C820(1.44)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C817(1.82); C820(1.82)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C817(1.36); C820(1.36)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C817(1.31); C820(1.31)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C817(1.35); C820(1.35)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C398(1.38); C402(1.38)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C398(1.14); C402(1.14)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C398(1.36); C402(1.36)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C398(0.99); C402(0.99); C817(0.87); C820(0.87)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C398(1.33); C402(1.33)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C398(1.17); C402(1.17)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C398(1.35); C402(1.35)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C398(1.46); C402(1.46)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C398(1.52); C402(1.52)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C398(1.81); C402(1.81)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C398(1.77); C402(1.77)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C398(1.95); C402(1.95)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C398(1.03); C402(1.03)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C398(0.97); C402(0.97)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C398(0.83); C402(0.83); C817(0.91); C820(0.91)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C398(0.89); C402(0.89)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C398(1.09); C402(1.09)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C398(1.39); C402(1.39)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C398(1.51); C402(1.51)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C398(1.15); C402(1.15)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C398(1.56); C402(1.56)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C398(1.34); C402(1.34)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C398(1.05); C402(1.05)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C398(0.95); C402(0.95)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C398(0.89); C402(0.89)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C398(0.85); C402(0.85); C817(1.31); C820(1.31)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C398(1.13); C402(1.13)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C398(1.71); C402(1.71)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C398(1.43); C402(1.43)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C398(0.94); C402(0.94)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C398(0.60); C402(0.60)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C398(0.88); C402(0.88); C817(0.98); C820(0.98)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C398(1.06); C402(1.06); C817(0.92); C820(0.92)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C398(1.40); C402(1.40); C817(0.98); C820(0.98)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C398(1.00); C402(1.00)  LDD2171  [2]
 LDCM0632  CL-Sc Hep-G2 C80(20.00)  LDD2227  [1]
 LDCM0367  CL1 HEK-293T C817(0.98); C820(0.98)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C839(0.87)  LDD1572  [3]
 LDCM0369  CL100 HCT 116 C398(1.15); C402(1.15)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C398(0.72); C402(0.72); C817(1.22); C820(1.22)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C398(0.85); C402(0.85); C817(1.64); C820(1.64)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C398(0.74); C402(0.74); C817(1.28); C820(1.28)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C398(0.85); C402(0.85); C817(0.65); C820(0.65)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C817(0.76); C820(0.76)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C839(0.94); C817(0.92); C820(0.92)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C817(1.00); C820(1.00)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C817(0.95); C820(0.95)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C817(0.92); C820(0.92)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C817(2.01); C820(2.01)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C839(0.93); C817(1.05); C820(1.05)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C817(0.96); C820(0.96)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C817(0.93); C820(0.93)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C817(1.01); C820(1.01)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C839(1.00); C817(0.95); C820(0.95)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C817(1.02); C820(1.02)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C817(1.18); C820(1.18)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C817(0.83); C820(0.83)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C839(1.05); C817(0.87); C820(0.87)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C817(1.06); C820(1.06)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C839(1.10); C817(1.09); C820(1.09)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C817(1.08); C820(1.08)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C817(1.28); C820(1.28)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C817(1.26); C820(1.26)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C817(1.55); C820(1.55)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C817(1.10); C820(1.10)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C398(1.43); C402(1.43)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C398(1.28); C402(1.28)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C398(0.86); C402(0.86)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C398(1.38); C402(1.38)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C817(0.86); C820(0.86)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C839(0.92); C817(1.17); C820(1.17)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C817(1.01); C820(1.01)  LDD1606  [3]
 LDCM0403  CL16 HCT 116 C398(0.78); C402(0.78)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C398(0.85); C402(0.85)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C398(0.97); C402(0.97)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C398(0.83); C402(0.83)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C839(1.01); C817(0.94); C820(0.94)  LDD1611  [3]
 LDCM0408  CL20 HCT 116 C398(1.28); C402(1.28)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C398(1.19); C402(1.19)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C398(1.49); C402(1.49)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C398(0.69); C402(0.69)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C398(0.88); C402(0.88)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C398(0.79); C402(0.79)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C398(0.89); C402(0.89)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C398(1.06); C402(1.06)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C398(0.89); C402(0.89)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C398(1.41); C402(1.41)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C817(0.99); C820(0.99)  LDD1622  [3]
 LDCM0419  CL30 HCT 116 C398(0.89); C402(0.89)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C398(0.82); C402(0.82)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C398(0.84); C402(0.84)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C398(1.35); C402(1.35)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C398(1.02); C402(1.02)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C398(0.89); C402(0.89)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C398(0.91); C402(0.91)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C398(1.08); C402(1.08)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C398(1.00); C402(1.00)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C817(1.07); C820(1.07)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C398(1.06); C402(1.06)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C398(1.13); C402(1.13)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C398(1.10); C402(1.10)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C398(1.33); C402(1.33)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C398(0.89); C402(0.89)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C398(1.17); C402(1.17)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C398(0.99); C402(0.99)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C398(0.73); C402(0.73)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C398(0.97); C402(0.97)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C398(0.97); C402(0.97)  LDD1037  [2]
 LDCM0441  CL50 HEK-293T C398(1.12); C402(1.12)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C398(1.55); C402(1.55)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C398(0.86); C402(0.86)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C398(0.96); C402(0.96)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C398(0.85); C402(0.85)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C398(0.82); C402(0.82)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C398(0.87); C402(0.87)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C398(1.67); C402(1.67)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C398(1.02); C402(1.02)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C398(1.04); C402(1.04)  LDD1048  [2]
 LDCM0452  CL60 HEK-293T C398(1.17); C402(1.17)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C398(1.33); C402(1.33)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C398(1.09); C402(1.09)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C398(0.82); C402(0.82)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C398(1.35); C402(1.35)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C398(0.92); C402(0.92)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C398(1.27); C402(1.27)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C398(1.08); C402(1.08)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C398(1.07); C402(1.07)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C398(1.31); C402(1.31)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C284(1.08); C817(1.17); C820(1.17)  LDD1665  [3]
 LDCM0463  CL70 HCT 116 C398(1.08); C402(1.08)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C398(1.03); C402(1.03)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C398(0.87); C402(0.87)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C398(1.09); C402(1.09)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C398(1.04); C402(1.04)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C817(1.10); C820(1.10)  LDD1672  [3]
 LDCM0472  CL79 HEK-293T C284(1.00); C817(1.06); C820(1.06)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C817(0.98); C820(0.98)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C817(1.24); C820(1.24)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C839(0.92)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C817(1.48); C820(1.48)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C839(1.05); C817(1.43); C820(1.43)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C817(0.92); C820(0.92)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C839(0.86); C817(0.77); C820(0.77)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C817(0.96); C820(0.96)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C817(1.15); C820(1.15)  LDD1685  [3]
 LDCM0486  CL91 HCT 116 C398(1.00); C402(1.00)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C398(0.94); C402(0.94)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C398(0.88); C402(0.88)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C398(1.18); C402(1.18)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C398(1.38); C402(1.38)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C398(1.14); C402(1.14)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C398(1.31); C402(1.31)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C398(1.34); C402(1.34)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C398(0.91); C402(0.91)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C817(1.11); C820(1.11)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C398(1.01); C402(1.01)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C398(0.85); C402(0.85)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C398(1.75); C402(1.75)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C398(3.96); C402(3.96)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C398(2.20); C402(2.20)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C398(1.00); C402(1.00)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RecQ-like DNA helicase BLM (BLM) Helicase family P54132
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA repair protein RAD51 homolog 1 (RAD51) RecA family Q06609

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402