General Information of Target

Target ID LDTP05924
Target Name Polycystin-2 (PKD2)
Gene Name PKD2
Gene ID 5311
Synonyms
TRPP2; Polycystin-2; PC2; Autosomal dominant polycystic kidney disease type II protein; Polycystic kidney disease 2 protein; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIR
QAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRP
GSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPL
EGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYG
MMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQ
TEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP
RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF
CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLE
DQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGF
AIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIY
FTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKN
TVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRD
DLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ
VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEI
HREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGG
NGSSNVHV
Target Bioclass
Transporter and channel
Family
Polycystin family
Subcellular location
Cell projection, cilium membrane
Function
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel. Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum. Together with TRPV4, forms mechano- and thermosensitive channels in cilium. PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality.
Uniprot ID
Q13563
Ensemble ID
ENST00000237596.7
HGNC ID
HGNC:9009
ChEMBL ID
CHEMBL5465

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.V2A .
KMCH1 SNV: p.F608L DBIA    Probe Info 
MEWO SNV: p.P446S DBIA    Probe Info 
NCIH1048 Insertion: p.N720KfsTer5 .
NCIH2122 SNV: p.G707D .
SKES1 SNV: p.D702E .
SNU1 SNV: p.N965D .
TFK1 SNV: p.K499Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
11.68  LDD0403  [1]
AHL-Pu-1
 Probe Info 
C164(6.59)  LDD0171  [2]
DBIA
 Probe Info 
C33(1.13); C47(1.13)  LDD0532  [3]
IPM
 Probe Info 
N.A.  LDD2156  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OEA-DA
 Probe Info 
18.90  LDD0046  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C164(6.59)  LDD0171  [2]
 LDCM0215  AC10 HCT 116 C33(1.13); C47(1.13)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C33(1.49); C47(1.49)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C33(0.88); C47(0.88)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C33(1.11); C47(1.11)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C33(1.36); C47(1.36)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C33(1.19); C47(1.19)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C33(1.21); C47(1.21)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C33(1.06); C47(1.06)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C33(1.25); C47(0.61)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C33(1.12); C47(1.93)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C33(1.20); C47(1.48)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C33(0.86); C47(0.86)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C33(1.27); C47(2.37)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C33(1.01); C47(2.61)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C33(0.95); C47(1.38)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C33(0.81); C47(0.81)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C33(0.87); C47(0.87)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C33(1.02); C47(1.02)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C33(1.05); C47(1.05)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C33(0.86); C47(0.86)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C33(1.00); C47(1.00)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C33(0.93); C47(0.93)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C33(0.90); C47(0.90)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C33(0.76); C47(0.76)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C33(0.85); C47(0.85)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C33(0.71); C47(0.71)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C33(0.83); C47(0.83)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C33(1.39); C47(1.39)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C33(1.15); C47(1.15)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C33(0.96); C47(0.96)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C33(0.86); C47(0.86)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C33(0.67); C47(0.67)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C33(0.52); C47(0.52)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C33(0.44); C47(0.44)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C33(0.45); C47(0.45)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C33(0.94); C47(0.94)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C33(0.78); C47(0.78)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C33(1.08); C47(1.08)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C33(0.71); C47(0.71)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C33(0.52); C47(0.52)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C33(0.68); C47(0.68)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C33(0.84); C47(0.84)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C33(0.66); C47(0.66)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C33(0.74); C47(0.74)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C33(0.82); C47(0.82)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C33(0.92); C47(0.92)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C33(0.62); C47(0.62)  LDD1141  [3]
 LDCM0270  AC15 HCT 116 C33(0.84); C47(0.84)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C33(1.81); C47(1.81)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C33(1.27); C47(1.27)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C33(1.83); C47(1.83)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C164(0.91)  LDD1518  [6]
 LDCM0280  AC20 HCT 116 C33(1.37); C47(1.37)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C33(1.64); C47(1.64)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C33(1.16); C47(1.16)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C33(1.71); C47(1.71)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C33(1.99); C47(1.99)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C33(0.82); C47(0.82)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C33(1.05); C47(1.05)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C33(0.78); C47(0.78)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C33(0.83); C47(0.83)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C33(0.74); C47(0.74)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C164(0.97)  LDD1529  [6]
 LDCM0291  AC30 PaTu 8988t C33(0.97); C47(0.97)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C33(0.75); C47(0.75)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C33(1.44); C47(1.44)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C33(1.18); C47(1.18)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C33(1.54); C47(1.54)  LDD1174  [3]
 LDCM0296  AC35 HEK-293T C164(1.24)  LDD1535  [6]
 LDCM0298  AC37 HEK-293T C164(1.04); C82(1.13)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C82(0.95)  LDD1538  [6]
 LDCM0302  AC40 HEK-293T C164(0.97); C82(0.92)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C164(0.89)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C164(1.03)  LDD1544  [6]
 LDCM0307  AC45 HEK-293T C164(1.13); C82(0.95)  LDD1546  [6]
 LDCM0308  AC46 PaTu 8988t C33(0.74); C47(0.74)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C33(0.81); C47(0.81)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C33(0.98); C47(0.98)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C33(1.04); C47(1.04)  LDD1190  [3]
 LDCM0312  AC5 HEK-293T C164(1.04); C82(0.97)  LDD1551  [6]
 LDCM0313  AC50 PaTu 8988t C33(0.91); C47(0.91)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C33(0.86); C47(0.86)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C33(1.12); C47(1.12)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C33(1.22); C47(1.22)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C33(1.27); C47(1.27)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C33(1.00); C47(1.00)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C33(1.19); C47(1.19)  LDD1198  [3]
 LDCM0320  AC57 PaTu 8988t C33(1.05); C47(1.05)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C33(1.54); C47(1.54)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C33(1.02); C47(1.02)  LDD1201  [3]
 LDCM0323  AC6 HCT 116 C33(0.92); C47(0.92)  LDD0640  [3]
 LDCM0324  AC60 PaTu 8988t C33(1.11); C47(1.11)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C33(0.73); C47(0.73)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C33(0.87); C47(0.87)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C33(0.98); C47(0.98)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C33(0.97); C47(0.97)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C33(0.89); C47(0.89)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C33(0.92); C47(0.92)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C33(0.76); C47(0.76)  LDD1210  [3]
 LDCM0332  AC68 HCT 116 C33(0.77); C47(0.77)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C33(1.59); C47(1.59)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C33(0.94); C47(0.94)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C33(0.78); C47(0.78)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C33(0.65); C47(0.65)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C33(1.47); C47(1.47)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C33(1.58); C47(1.58)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C33(1.28); C47(1.28)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C33(1.91); C47(1.91)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C33(1.02); C47(1.02)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C33(1.02); C47(1.02)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C33(0.99); C47(0.99)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C33(0.95); C47(0.95)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C33(0.74); C47(0.74)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C33(1.23); C47(1.23)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C33(0.96); C47(0.96)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C33(0.87); C47(0.87)  LDD0665  [3]
 LDCM0349  AC83 PaTu 8988t C33(0.88); C47(0.88)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C33(0.59); C47(0.59)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C33(0.52); C47(0.52)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C33(0.58); C47(0.58)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C33(0.56); C47(0.56)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C33(0.71); C47(0.71)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C33(0.66); C47(0.66)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C33(0.74); C47(0.74)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C33(0.63); C47(0.63)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C33(0.64); C47(0.64)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C33(0.66); C47(0.66)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C33(0.63); C47(0.63)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C33(0.72); C47(0.72)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C33(0.78); C47(0.78)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C33(0.57); C47(0.57)  LDD1243  [3]
 LDCM0365  AC98 HCT 116 C33(1.53); C47(1.53)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C33(0.98); C47(0.98)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C33(0.76); C47(0.76)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C33(0.86); C47(0.86)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C33(1.44); C47(1.44)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C33(0.96); C47(0.96)  LDD2171  [3]
 LDCM0367  CL1 PaTu 8988t C33(1.07); C47(1.07)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C33(2.04); C47(2.04)  LDD1247  [3]
 LDCM0370  CL101 HCT 116 C33(0.93); C47(0.93)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C33(0.79); C47(0.79)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C33(1.06); C47(1.06)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C33(1.21); C47(1.21)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C33(1.46); C47(1.46)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C33(1.63); C47(1.63)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C33(1.13); C47(1.13)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C33(1.26); C47(1.26)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C33(1.69); C47(1.69)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C33(1.17); C47(1.17)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C33(2.20); C47(2.20)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C33(1.73); C47(1.73)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C33(1.20); C47(1.20)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C33(0.75); C47(0.75)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C33(0.84); C47(0.84)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C33(0.96); C47(0.96)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C33(0.89); C47(0.89)  LDD1265  [3]
 LDCM0388  CL118 HEK-293T C164(1.00)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C164(1.18)  LDD1593  [6]
 LDCM0390  CL12 PaTu 8988t C33(2.04); C47(2.04)  LDD1269  [3]
 LDCM0392  CL121 PaTu 8988t C33(0.85); C47(0.85)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C33(1.01); C47(1.01)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C33(1.24); C47(1.24)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C33(1.19); C47(1.19)  LDD1274  [3]
 LDCM0396  CL125 PaTu 8988t C33(1.15); C47(1.15)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C33(0.85); C47(0.85)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C33(1.12); C47(1.12)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C33(1.41); C47(1.41)  LDD1278  [3]
 LDCM0400  CL13 PaTu 8988t C33(1.59); C47(1.59)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C33(2.34); C47(2.34)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C33(1.61); C47(1.61)  LDD1281  [3]
 LDCM0403  CL16 PaTu 8988t C33(2.01); C47(2.01)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C33(1.34); C47(1.34)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C33(1.18); C47(1.18)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C33(2.11); C47(2.11)  LDD1285  [3]
 LDCM0407  CL2 PaTu 8988t C33(1.27); C47(1.27)  LDD1286  [3]
 LDCM0408  CL20 PaTu 8988t C33(2.11); C47(2.11)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C33(1.97); C47(1.97)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C33(1.69); C47(1.69)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C33(1.54); C47(1.54)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C33(1.38); C47(1.38)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C33(1.44); C47(1.44)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C33(1.23); C47(1.23)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C33(1.24); C47(1.24)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C33(1.48); C47(1.48)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C33(1.57); C47(1.57)  LDD1296  [3]
 LDCM0418  CL3 PaTu 8988t C33(1.27); C47(1.27)  LDD1297  [3]
 LDCM0419  CL30 PaTu 8988t C33(1.85); C47(1.85)  LDD1298  [3]
 LDCM0420  CL31 PaTu 8988t C33(1.38); C47(1.38)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C33(1.37); C47(1.37)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C33(1.45); C47(1.45)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C33(1.41); C47(1.41)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C33(2.05); C47(2.05)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C33(1.82); C47(1.82)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C33(1.85); C47(1.85)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C33(1.32); C47(1.32)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C33(1.25); C47(1.25)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C33(1.44); C47(1.44)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C33(1.81); C47(1.81)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C33(1.83); C47(1.83)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C33(2.02); C47(2.02)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C33(1.43); C47(1.43)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C33(1.57); C47(1.57)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C33(1.26); C47(1.26)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C33(1.16); C47(1.16)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C33(1.53); C47(1.53)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C33(1.51); C47(1.51)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C33(1.73); C47(1.73)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C33(1.55); C47(1.55)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C33(1.40); C47(1.40)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C33(1.45); C47(1.45)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C33(1.77); C47(1.77)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C33(1.34); C47(1.34)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C33(1.59); C47(1.59)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C33(0.98); C47(0.98)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C33(2.08); C47(2.08)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C33(1.56); C47(1.56)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C33(2.14); C47(2.14)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C33(1.77); C47(1.77)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C33(1.70); C47(1.70)  LDD1331  [3]
 LDCM0453  CL61 HCT 116 C33(1.08); C47(1.08)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C33(0.81); C47(0.81)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C33(0.67); C47(0.67)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C33(0.92); C47(0.92)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C33(0.79); C47(0.79)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C33(1.04); C47(1.04)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C33(0.77); C47(0.77)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C33(0.66); C47(0.66)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C33(1.00); C47(1.00)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C33(2.08); C47(2.08)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C33(0.90); C47(0.90)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C33(0.86); C47(0.86)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C33(0.66); C47(0.66)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C33(0.90); C47(0.90)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C33(0.78); C47(0.78)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C33(0.96); C47(0.96)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C33(0.85); C47(0.85)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C33(0.85); C47(0.85)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C33(0.81); C47(0.81)  LDD1351  [3]
 LDCM0473  CL8 PaTu 8988t C33(1.52); C47(1.52)  LDD1352  [3]
 LDCM0474  CL80 PaTu 8988t C33(0.98); C47(0.98)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C33(0.96); C47(0.96)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C33(0.84); C47(0.84)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C33(1.22); C47(1.22)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C33(1.22); C47(1.22)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C33(0.80); C47(0.80)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C33(0.98); C47(0.98)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C33(1.15); C47(1.15)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C33(1.04); C47(1.04)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C33(1.05); C47(1.05)  LDD1362  [3]
 LDCM0484  CL9 PaTu 8988t C33(1.87); C47(1.87)  LDD1363  [3]
 LDCM0485  CL90 PaTu 8988t C33(0.96); C47(0.96)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C164(0.96)  LDD1689  [6]
 LDCM0488  CL93 HEK-293T C164(1.15); C82(1.14)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C82(1.04)  LDD1692  [6]
 LDCM0491  CL96 HEK-293T C164(1.02); C82(0.88)  LDD1694  [6]
 LDCM0493  CL98 HEK-293T C164(0.97)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C164(1.09)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C164(1.23)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C33(0.84); C47(0.84)  LDD0785  [3]
 LDCM0427  Fragment51 PaTu 8988t C33(2.20); C47(2.20)  LDD1306  [3]
 LDCM0022  KB02 HEK-293T C164(1.17); C82(1.25)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C164(1.26); C82(1.06)  LDD1497  [6]
 LDCM0024  KB05 NCI-H1299 C82(3.01)  LDD3343  [7]
 LDCM0021  THZ1 HCT 116 C33(0.96); C47(0.96)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid scramblase 1 (PLSCR1) Phospholipid scramblase family O15162
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Polycystin-1 (PKD1) Polycystin family P98161
Polycystin-2 (PKD2) Polycystin family Q13563
Short transient receptor potential channel 1 (TRPC1) Transient receptor family P48995
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Heat shock factor 2-binding protein (HSF2BP) . O75031
Melanoma-associated antigen 8 (MAGEA8) . P43361

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840