Details of the Target

General Information of Target

Target ID LDTP05819
Target Name Inactive tyrosine-protein kinase 7 (PTK7)
Gene Name PTK7
Gene ID 5754
Synonyms
CCK4; Inactive tyrosine-protein kinase 7; Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD
GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG
RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Family
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Subcellular location
Membrane
Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
TTD ID
T68525
Uniprot ID
Q13308
DrugMap ID
TTXH2ZN
Ensemble ID
ENST00000230418.8
HGNC ID
HGNC:9618

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G863V .
GAMG SNV: p.T635N DBIA    Probe Info 
HT SNV: p.V19A .
IGROV1 Deletion: p.P273HfsTer16 DBIA    Probe Info 
IPC298 SNV: p.A1060V DBIA    Probe Info 
J82 SNV: p.H607Q DBIA    Probe Info 
JURKAT SNV: p.Q833Ter; p.S834N .
LNCaP clone FGC SNV: p.G297E DBIA    Probe Info 
LS123 SNV: p.Q94E DBIA    Probe Info 
LS180 Insertion: p.A487SfsTer31 DBIA    Probe Info 
NB1 SNV: p.N283K DBIA    Probe Info 
NCIH1155 SNV: p.L610I DBIA    Probe Info 
RD SNV: p.D618A DBIA    Probe Info 
RKO SNV: p.A1011V DBIA    Probe Info 
RL952 SNV: p.F458L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		10.84  LDD0196  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K1035(5.24)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K518(1.76); K636(10.96)  LDD3494  [4]
DBIA
 Probe Info  		C944(1.58)  LDD3310  [5]
BTD
 Probe Info  		C1032(0.97); C936(1.23)  LDD2099  [6]
Acrolein
 Probe Info  		N.A.  LDD0223  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C391(0.00); C101(0.00); C936(0.00); C1032(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C101(0.00); C391(0.00)  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C301(0.00); C481(0.00); C391(0.00); C1032(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C911(0.00); C1032(0.00)  LDD2226  [11]
IPM
 Probe Info  		N.A.  LDD0005  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1032(1.33)  LDD2117  [6]
 LDCM0214  AC1 HEK-293T C301(1.06); C524(1.29); C1032(1.03); C101(0.91)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C301(1.08); C524(1.13); C1032(0.90); C101(0.95)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C301(0.98); C1032(0.86); C101(1.00); C1043(1.06)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C301(0.98); C524(1.09); C1032(0.94); C101(1.02)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C301(1.31); C524(0.93); C1032(0.99); C1043(1.07)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C301(1.02); C524(1.34); C1032(0.94); C101(1.07)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C301(1.06); C524(1.42); C1032(1.07); C101(0.91)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C301(0.98); C524(1.08); C1032(1.02); C101(0.87)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C301(1.42); C1032(1.04); C101(1.24); C1043(1.18)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C301(0.97); C524(1.04); C1032(0.90); C101(1.04)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C301(0.98); C524(1.03); C1032(0.88); C101(0.86)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C301(0.97); C524(1.05); C1032(1.07); C101(0.89)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C301(1.13); C524(1.02); C1032(0.91); C1043(0.99)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C301(0.99); C524(1.42); C1032(0.97); C101(0.93)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C524(0.89); C1032(1.01); C101(0.99); C1043(0.99)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C301(1.02); C524(1.38); C1032(1.10); C101(1.48)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C301(1.01); C524(1.21); C1032(0.93); C101(0.97)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C301(1.03); C1032(1.04); C101(0.95); C1043(1.02)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C301(1.05); C524(1.04); C1032(0.96); C101(0.86)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C301(0.98); C524(1.05); C1032(0.98); C101(1.06)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C301(0.99); C1032(0.82); C101(1.16); C1043(1.05)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C301(1.02); C524(0.94); C1032(0.95); C1043(1.09)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C301(1.03); C524(1.65); C1032(0.97); C101(1.01)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C524(0.96); C1032(0.95); C101(0.92); C1043(0.98)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C301(1.03); C524(1.40); C1032(1.09); C101(1.31)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C301(1.03); C524(0.98); C1032(0.92); C101(1.03)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C301(0.97); C1032(0.94); C101(0.94); C1043(1.04)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C301(1.05); C524(0.99); C1032(0.90); C101(0.93)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C301(0.88); C524(1.02); C1032(0.90); C101(1.03)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C301(1.08); C524(1.06); C1032(0.93); C1043(1.07)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C301(1.06); C524(1.67); C1032(0.91); C101(0.91)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C301(1.06); C524(1.04); C1032(0.89); C101(0.97)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C524(1.05); C1032(0.89); C101(0.80); C1043(0.97)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C301(1.07); C524(1.52); C1032(1.16); C101(1.15)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C301(1.08); C524(1.17); C1032(1.03); C101(1.30)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C301(0.96); C1032(0.94); C101(1.05); C1043(1.07)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C301(1.01); C524(1.08); C1032(0.90); C101(1.02)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C301(0.97); C524(1.01); C1032(0.97); C101(1.00)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C301(1.25); C524(1.09); C1032(0.95); C1043(1.04)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C301(1.09); C524(1.63); C1032(0.91); C101(1.17)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C524(0.99); C1032(0.91); C101(0.90); C1043(0.94)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C301(1.11); C524(1.36); C1032(0.95); C101(1.27)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C301(0.97); C524(1.02); C1032(0.96); C101(0.92)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C301(1.01); C524(1.03); C1032(0.95); C101(0.95)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C301(0.99); C1032(0.99); C101(1.00); C1043(1.06)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C301(1.03); C524(0.96); C1032(1.02); C101(0.98)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C301(0.93); C524(0.95); C1032(1.00); C101(1.00)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C301(1.28); C524(1.06); C1032(0.94); C1043(1.08)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C301(1.08); C524(1.46); C1032(0.96); C101(1.25)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C524(1.02); C1032(0.92); C101(0.85); C1043(0.98)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C301(1.05); C524(1.30); C1032(1.02); C101(1.01)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C301(0.96); C524(1.09); C1032(0.97); C101(0.91)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C301(1.04); C1032(0.98); C101(1.08); C1043(1.01)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C301(1.10); C524(0.84); C1032(0.98); C1043(1.04)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C301(1.03); C524(1.08); C1032(1.00); C101(0.82)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C301(1.02); C524(1.06); C1032(0.96); C101(0.91)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C301(1.07); C524(0.89); C1032(0.96); C1043(1.00)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C301(1.03); C524(1.70); C1032(0.97); C101(0.84)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C524(0.95); C1032(0.92); C101(0.84); C1043(0.97)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C301(0.97); C524(1.54); C1032(0.91); C101(0.66)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C524(1.13); C1032(0.95); C101(0.96); C1043(0.97)  LDD1569  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C1032(1.09)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C301(0.97); C524(0.99); C1032(0.96); C101(0.85)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C301(1.03); C524(1.38); C1032(0.98); C101(1.25)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C524(1.08); C1032(0.94); C101(0.80); C1043(0.97)  LDD1514  [16]
 LDCM0367  CL1 HEK-293T C301(0.98); C524(1.00); C1032(1.12); C101(1.04)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C301(1.71); C524(1.61); C1032(1.67); C1043(1.05)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C301(0.98); C524(0.98); C1032(0.95); C101(0.97)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C301(1.08); C524(1.16); C1032(1.05); C101(1.23)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C301(1.18); C524(0.98); C1032(1.11); C1043(1.17)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C301(1.07); C524(0.98); C1032(0.99); C101(1.26)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C301(1.07); C524(0.93); C1032(0.89); C101(0.86)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C301(1.10); C524(1.11); C1032(1.07); C101(1.00)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C301(1.09); C524(1.03); C1032(0.97); C1043(1.13)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C301(1.03); C524(0.97); C1032(1.02); C101(1.36)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C301(1.10); C524(1.00); C1032(1.03); C101(0.73)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C301(1.03); C524(1.20); C1032(1.14); C101(0.92)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C301(1.05); C524(1.86); C1032(1.05); C101(1.18)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C301(1.22); C524(1.04); C1032(1.22); C1043(1.15)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C301(1.08); C524(0.93); C1032(1.19); C101(1.15)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C301(1.08); C524(1.10); C1032(1.03); C101(1.11)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C301(0.94); C524(1.04); C1032(1.01); C101(1.04)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C301(1.30); C524(0.98); C1032(1.11); C1043(1.15)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C301(1.06); C524(0.98); C1032(1.01); C101(1.17)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C301(0.97); C524(0.93); C1032(0.93); C101(0.84)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C301(1.08); C524(1.10); C1032(0.98); C101(1.12)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C301(1.16); C524(1.04); C1032(0.97); C1043(1.12)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C301(1.03); C524(0.96); C1032(1.09); C101(1.14)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C524(1.04); C1032(0.93); C101(1.14); C1043(0.89)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C301(1.05); C524(0.93); C1032(0.92); C101(1.15)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C301(1.01); C524(1.04); C1032(1.03); C101(1.15)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C301(1.17); C524(1.03); C1032(1.00); C1043(1.11)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C301(1.13); C524(0.92); C1032(1.20); C101(1.45)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C301(1.15); C524(1.03); C1032(1.03); C101(0.84)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C301(0.94); C524(1.07); C1032(1.05); C101(0.99)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C301(1.11); C524(1.01); C1032(1.07); C1043(1.00)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C301(1.05); C524(0.87); C1032(1.05); C101(1.09)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C301(0.94); C524(0.96); C1032(0.92); C101(0.90)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C301(1.03); C524(1.04); C1032(1.04); C101(1.45)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C301(1.02); C524(1.05); C1032(0.93); C1043(0.99)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C301(1.21); C524(0.95); C1032(1.32); C101(1.70)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C301(1.02); C524(0.96); C1032(0.85); C101(0.88)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C301(1.38); C524(1.36); C1032(1.37); C101(0.96)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C301(1.01); C524(1.03); C1032(0.94); C101(0.93)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C301(1.03); C1032(0.92); C101(0.96); C1043(1.12)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C301(1.03); C524(1.09); C1032(1.06); C1043(1.02)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C301(1.01); C524(1.09); C1032(0.98); C101(1.09)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C301(1.15); C524(1.00); C1032(1.61); C101(0.91)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C301(1.20); C524(1.50); C1032(1.00); C1043(1.04)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C301(1.06); C524(1.84); C1032(0.99); C101(0.77)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C524(0.96); C1032(0.90); C101(1.10); C1043(1.01)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C301(1.18); C524(1.13); C1032(1.23); C101(1.06)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C301(1.10); C524(1.00); C1032(0.95); C1043(1.05)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C301(1.03); C524(0.98); C1032(1.01); C101(1.60)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C301(1.12); C524(1.00); C1032(0.97); C101(0.84)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C301(1.12); C524(1.40); C1032(0.99); C101(0.94)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C301(1.14); C524(0.86); C1032(1.05); C101(1.23)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C301(0.99); C524(1.11); C1032(0.95); C101(0.99)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C301(1.08); C1032(1.02); C101(1.00); C1043(1.15)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C301(1.02); C524(1.08); C1032(1.00); C101(0.98)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C301(1.12); C524(1.06); C1032(1.88); C101(1.10)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C301(1.11); C524(1.36); C1032(1.14); C1043(1.07)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C301(1.08); C524(1.75); C1032(0.96); C101(1.05)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C524(1.02); C1032(0.99); C101(1.00); C1043(1.02)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C301(1.00); C524(1.10); C1032(1.02); C101(0.86)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C301(1.10); C524(1.05); C1032(1.11); C101(1.17)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C301(0.96); C524(0.92); C1032(0.98); C101(0.79)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C301(0.99); C524(0.99); C1032(0.94); C101(0.88)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C301(1.07); C524(1.36); C1032(1.09); C101(1.18)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C301(0.95); C524(1.12); C1032(0.91); C101(1.01)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C301(0.98); C1032(0.96); C101(1.21); C1043(1.11)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C301(0.96); C524(1.11); C1032(0.98); C101(0.89)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C301(1.11); C524(1.18); C1032(1.34); C101(1.23)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C301(1.30); C524(1.51); C1032(1.07); C1043(0.99)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C301(1.05); C524(1.57); C1032(1.02); C101(0.88)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C524(1.11); C1032(1.05); C101(1.13); C1043(1.07)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C301(0.90); C524(1.03); C1032(0.96); C101(0.83)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C301(0.98); C524(1.35); C1032(1.03); C101(0.99)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C301(1.25); C524(0.96); C1032(1.02); C1043(1.10)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C301(1.00); C524(0.92); C1032(0.94); C101(0.94)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C301(1.17); C524(1.26); C1032(1.32); C101(1.13)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C301(1.21); C524(0.97); C1032(1.33); C101(1.08)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C301(1.04); C1032(0.94); C101(0.93); C1043(1.07)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C301(1.04); C524(1.01); C1032(0.93); C101(1.12)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C301(1.13); C524(1.19); C1032(1.26); C101(1.30)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C301(1.36); C524(1.46); C1032(1.12); C1043(1.14)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C301(1.08); C524(1.74); C1032(0.97); C101(0.92)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C301(1.07); C524(1.02); C1032(1.17); C101(1.05)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C524(1.12); C1032(0.97); C101(0.94); C1043(0.96)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C301(0.90); C524(0.96); C1032(0.95); C101(0.98)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C301(1.03); C524(1.01); C1032(0.97); C1043(1.10)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C301(1.04); C524(0.94); C1032(1.06); C101(1.35)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C301(1.14); C524(0.95); C1032(1.25); C101(1.03)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C301(1.07); C524(1.41); C1032(0.95); C101(0.75)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C301(1.06); C524(1.12); C1032(0.92); C101(0.98)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C301(1.02); C1032(0.85); C101(0.98); C1043(1.05)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C301(1.02); C524(1.11); C1032(1.00); C101(0.87)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C301(1.11); C524(1.14); C1032(1.02); C101(1.23)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C301(0.96); C1032(0.96); C101(1.05); C1043(1.02)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C301(1.26); C524(1.63); C1032(0.99); C1043(1.04)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C301(1.11); C524(1.77); C1032(0.96); C101(0.84)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C524(0.95); C1032(0.92); C101(1.07); C1043(1.01)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C301(1.02); C524(0.99); C1032(1.14); C101(0.85)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C301(1.02); C524(0.95); C1032(0.92); C1043(1.05)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C301(0.98); C524(0.98); C1032(0.95); C101(0.94)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C301(1.26); C524(1.37); C1032(1.17); C101(1.04)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C301(1.00); C524(1.10); C1032(0.89); C101(0.84)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C301(1.00); C1032(0.95); C101(0.82); C1043(1.08)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C301(1.31); C524(1.04); C1032(1.80); C101(0.96)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C301(0.97); C524(1.03); C1032(0.93); C101(0.75)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C301(1.00); C524(1.10); C1032(0.98); C101(0.85)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C301(1.17); C524(1.48); C1032(0.96); C1043(1.07)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C301(1.06); C524(1.87); C1032(1.10); C101(0.83)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C524(1.04); C1032(1.00); C101(1.01); C1043(1.14)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C301(0.90); C524(1.04); C1032(0.94); C101(0.98)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C301(0.99); C524(0.94); C1032(0.92); C1043(0.99)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C301(1.04); C524(0.88); C1032(1.01); C101(1.25)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C301(0.98); C524(0.88); C1032(0.84); C101(0.97)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C301(1.06); C524(1.49); C1032(0.97); C101(0.95)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C301(1.12); C524(1.07); C1032(1.07); C101(0.98)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C301(1.64); C524(1.00); C1032(1.67); C101(1.13)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C301(0.99); C1032(0.96); C101(0.92); C1043(1.13)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C301(1.10); C524(1.00); C1032(1.09); C101(0.86)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C301(0.97); C524(1.05); C1032(1.21); C101(0.99)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C301(1.11); C524(1.50); C1032(0.96); C1043(1.08)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C301(1.47); C524(1.72); C1032(1.64); C101(1.02)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C524(0.93); C1032(1.05); C101(0.92); C1043(1.04)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C301(1.06); C524(0.98); C1032(1.09); C101(1.09)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C301(1.08); C524(0.98); C1032(0.94); C1043(1.07)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C301(1.08); C524(0.94); C1032(1.17); C101(1.02)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C301(1.18); C524(1.01); C1032(1.11); C101(1.00)  LDD1698  [16]
 LDCM0468  Fragment33 HEK-293T C301(1.10); C524(0.88); C1032(1.14); C101(1.24)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C301(1.07); C524(1.02); C1032(1.06); C1043(1.10)  LDD1631  [16]
 LDCM0022  KB02 HEK-293T C301(0.84); C524(0.80); C1032(0.91); C101(0.84)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C301(1.02); C524(0.97); C1032(1.02); C101(1.11)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C944(1.58)  LDD3310  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1032(0.97); C936(1.23)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1032(1.04)  LDD2101  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1032(0.96); C936(0.96)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1032(0.97); C936(0.67)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1032(0.93)  LDD2111  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1032(1.10)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1032(0.90); C936(0.99)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1032(1.08); C936(0.98)  LDD2127  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1032(0.82)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1032(1.05)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1032(0.72)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1032(1.01); C936(1.29)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1032(1.40)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1032(0.86)  LDD2140  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C936(1.24)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C936(0.74)  LDD2146  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pf-06647020 . D0AD3V

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402