Details of the Target

General Information of Target

Target ID LDTP05682
Target Name TP53-binding protein 1 (TP53BP1)
Gene Name TP53BP1
Gene ID 7158
Synonyms
TP53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLD
VVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSV
LGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD
VEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTA
QPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSPEPEVL
STQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSLSTNSS
DLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPVELENP
PLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGKKDGDM
HSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHRIDEDG
ENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRDDISIL
ATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHPEEGSS
GSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEAMEVET
SVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPLEGVEK
CSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSLPLVRA
DDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSFCESSS
ETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDVMSESM
VETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGERKNGST
AVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKEKLEGD
HTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTNKENPS
KALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDATVQTER
GSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYV
DGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRTSSGTS
LSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVCEEDGD
AGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKSFSRVV
PRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKWSSNGY
FYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKG
HRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAADISLD
NLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEEERSPA
KRGRKSATVKPGAVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFLLTMAT
TSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQCNTAY
QCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRIL
DWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVV
VTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR. In contrast, it is not required for classic NHEJ and V(D)J recombination. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.
TTD ID
T26983
Uniprot ID
Q12888
DrugMap ID
TTX4UE9
Ensemble ID
ENST00000263801.7
HGNC ID
HGNC:11999
ChEMBL ID
CHEMBL2424509

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K1667(1.45); K1966(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y1258(8.39); Y1259(8.21); Y1775(59.32)  LDD3495  [3]
DBIA
 Probe Info  		C1164(1.27); C1183(1.12); C324(1.22)  LDD3311  [4]
BTD
 Probe Info  		C986(0.98)  LDD2118  [5]
AHL-Pu-1
 Probe Info  		C896(4.48); C319(3.06); C1703(2.09); C1375(3.31)  LDD0168  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1159(0.00); C604(0.00); C1926(0.00); C329(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C1178(0.00); C1375(0.00)  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C1159(0.00); C986(0.00); C513(0.00); C1178(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C329(0.00); C1178(0.00); C1375(0.00); C1703(0.00)  LDD2226  [9]
TFBX
 Probe Info  		C1283(0.00); C1375(0.00); C1178(0.00); C1280(0.00)  LDD0027  [10]
WYneN
 Probe Info  		C1178(0.00); C489(0.00); C319(0.00)  LDD0021  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
Compound 10
 Probe Info  		C1159(0.00); C329(0.00); C604(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		C1159(0.00); C329(0.00); C604(0.00)  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		C319(0.00); C1178(0.00); C1038(0.00)  LDD0005  [11]
PPMS
 Probe Info  		N.A.  LDD0008  [11]
VSF
 Probe Info  		C101(0.00); C513(0.00); C1375(0.00); C604(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C1159(0.00); C1375(0.00); C1703(0.00); C896(0.00)  LDD0018  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		C1178(0.00); C1525(0.00); C319(0.00); C604(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		C1375(0.00); C772(0.00); C1178(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C1178(0.00); C513(0.00); C772(0.00); C604(0.00)  LDD0218  [15]
W1
 Probe Info  		C772(0.00); C319(0.00)  LDD0236  [16]
AOyne
 Probe Info  		10.80  LDD0443  [17]
NAIA_5
 Probe Info  		C1375(0.00); C1178(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C896(4.48); C319(3.06); C1703(2.09); C1375(3.31)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C986(2.58); C772(3.04); C489(2.13); C319(5.18)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C319(0.95); C489(1.10); C1178(0.97); C1375(1.00)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C319(0.88); C489(0.96); C1178(1.04); C1375(1.11)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C319(1.05); C489(1.05); C1178(1.00); C1375(0.94)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C319(0.97); C489(1.03); C1178(0.96); C1375(0.94)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C319(0.86); C489(1.03); C1178(1.06); C1375(1.06)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C319(1.09); C489(1.06); C1178(1.15); C1375(0.94)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C319(1.11); C489(1.15); C1178(0.89); C1375(1.04)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C319(0.95); C489(1.01); C1178(1.03); C1375(1.02)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C319(3.04); C489(1.78); C1178(2.02); C1375(0.89)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C319(0.95); C489(0.91); C1178(0.99); C1375(1.03)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C319(0.98); C489(1.03); C1178(1.02); C1375(1.14)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C489(1.08); C1178(0.99); C1375(0.92); C604(0.96)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C319(1.21); C489(1.03); C1178(0.95); C1375(1.03)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C319(1.19); C489(1.03); C1178(1.07); C1375(1.03)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C319(1.12); C489(1.02); C1178(0.90); C1375(0.99)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C319(0.93); C489(1.12); C1178(1.02); C1375(0.95)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C319(0.90); C489(1.04); C1178(0.96); C1375(1.08)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C319(0.95); C489(1.02); C1178(0.98); C1375(0.91)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C319(0.97); C489(0.99); C1178(0.96); C1375(1.06)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C489(1.11); C1178(0.99); C1375(1.02); C604(1.02)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C319(0.97); C489(1.01); C1178(0.95); C1375(0.76)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C319(1.03); C489(0.99); C1178(0.99); C1375(1.06)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C319(0.98); C489(1.04); C1178(1.00); C1375(0.96)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C319(1.37); C489(1.11); C1178(0.96); C1375(0.93)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C319(1.15); C489(1.23); C1178(1.12); C1375(0.94)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C319(1.00); C489(1.03); C1178(1.00); C1375(1.00)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C319(1.10); C489(1.13); C1178(0.95); C1375(0.91)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C319(1.02); C489(1.18); C1178(0.92); C1375(1.02)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C489(0.98); C1178(0.89); C1375(1.02); C604(1.01)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C319(0.80); C489(1.01); C1178(1.04); C1375(0.99)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C319(0.92); C489(1.06); C1178(0.96); C1375(0.92)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C319(0.87); C489(0.97); C1178(0.90); C1375(1.02)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C319(1.38); C489(1.05); C1178(0.92); C1375(1.03)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C319(1.12); C489(1.07); C1178(0.93); C1375(0.95)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C319(0.97); C489(1.04); C1178(1.01); C1375(1.16)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C319(1.02); C489(1.13); C1178(1.03); C1375(0.95)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C319(0.92); C489(0.95); C1178(1.02); C1375(0.93)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C489(1.04); C1178(0.91); C1375(1.07); C604(1.04)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C319(1.14); C489(1.07); C1178(0.98); C1375(1.02)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C319(0.83); C489(1.03); C1178(1.00); C1375(0.91)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C319(1.02); C489(0.95); C1178(0.96); C1375(1.02)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C319(1.15); C489(1.11); C1178(1.06); C1375(0.89)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C489(0.98); C1178(0.94); C1375(1.06); C604(1.00)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C319(0.94); C489(1.05); C1178(0.99); C1375(1.02)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C319(1.08); C489(1.02); C1178(0.95); C1375(0.89)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C319(1.06); C489(1.33); C1178(0.99); C1375(1.09)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C489(1.02); C1178(0.96); C1375(1.05); C604(1.03)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C319(1.40); C489(1.09); C1178(1.02); C1375(1.09)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C319(1.09); C489(1.07); C1178(1.04); C1375(1.01)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C319(1.09); C489(1.00); C1178(0.95); C1375(1.02)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C319(1.08); C489(0.98); C1178(1.00); C1375(0.87)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C319(0.88); C489(0.91); C1178(1.02); C1375(1.00)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C319(1.09); C489(1.01); C1178(0.91); C1375(0.96)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C319(1.04); C489(0.99); C1178(1.09); C1375(1.02)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C319(0.94); C489(1.13); C1178(1.09); C1375(0.94)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C489(0.94); C1178(0.95); C1375(1.07); C604(1.05)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C319(1.05); C489(0.96); C1178(1.05); C1375(1.09)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C319(1.27); C489(0.96); C1178(1.06); C1375(0.93)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C319(0.93); C489(0.88); C1178(0.92); C1375(1.05)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C319(1.02); C489(0.95); C1178(1.00); C1375(0.97)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C319(0.86); C489(0.94); C1178(0.95); C1375(1.16)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C489(1.02); C1178(0.99); C1375(1.01); C604(1.02)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C319(1.02); C489(1.17); C1178(1.12); C1375(0.97)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C319(1.05); C489(1.01); C1178(0.94); C1375(1.09)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 11.94  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C1525(0.00); C513(0.00); C1178(0.00); C319(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C896(20.00); C101(20.00); C489(0.79); C604(0.72)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C319(1.02); C489(0.90); C1178(0.79); C1375(0.93)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C319(1.21); C489(1.10); C1178(0.88); C1375(0.69)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C319(0.91); C489(0.92); C1178(0.95); C1375(0.99)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C319(1.03); C489(1.05); C1178(0.91); C1375(1.14)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C319(1.11); C489(0.99); C1178(0.97); C1375(0.92)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C319(0.96); C489(1.04); C1178(0.98); C1375(1.05)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C319(0.91); C489(1.07); C1178(0.98); C1375(0.98)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C319(1.02); C489(1.13); C1178(0.94); C1375(1.01)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C319(1.12); C489(1.05); C1178(0.94); C1375(0.90)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C319(0.98); C489(0.94); C1178(1.06); C1375(1.02)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C319(0.95); C489(1.06); C1178(1.03); C1375(0.93)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C319(0.89); C489(0.96); C1178(0.88); C1375(0.81)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C319(1.18); C489(1.10); C1178(0.91); C1375(0.90)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C319(0.72); C489(1.03); C1178(1.00); C1375(0.86)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C319(1.03); C489(1.03); C1178(1.03); C1375(1.08)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C319(0.83); C489(1.05); C1178(1.04); C1375(0.99)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C319(1.13); C489(0.99); C1178(0.84); C1375(1.20)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C319(1.00); C489(1.12); C1178(0.92); C1375(0.92)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C319(0.90); C489(0.92); C1178(1.01); C1375(1.00)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C319(0.84); C489(0.98); C1178(0.99); C1375(1.04)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C319(1.26); C489(1.02); C1178(0.88); C1375(1.11)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C319(1.35); C489(1.15); C1178(1.14); C1375(1.00)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C319(0.91); C489(1.01); C1178(1.00); C1375(0.95)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C319(1.20); C489(0.92); C1178(0.92); C1375(0.92)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C319(1.03); C489(1.02); C1178(1.08); C1375(1.04)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C319(1.11); C489(0.91); C1178(0.94); C1375(1.15)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C319(0.98); C489(1.02); C1178(0.99); C1375(0.93)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C319(0.91); C489(0.84); C1178(1.01); C1375(0.88)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C319(1.01); C489(1.06); C1178(0.98); C1375(0.95)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C319(1.06); C489(0.84); C1178(0.97); C1375(0.92)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C319(0.94); C489(0.91); C1178(1.04); C1375(1.00)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C319(1.04); C489(0.74); C1178(1.03); C1375(1.01)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C319(0.78); C489(0.97); C1178(1.02); C1375(1.00)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C319(1.36); C489(1.04); C1178(1.07); C1375(1.19)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C319(0.91); C489(1.13); C1178(1.04); C1375(1.01)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C319(1.18); C489(0.98); C1178(1.09); C1375(0.92)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C319(0.86); C489(1.03); C1178(0.99); C1375(1.00)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C319(1.19); C489(1.09); C1178(0.87); C1375(0.91)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C319(0.93); C489(1.01); C1178(1.05); C1375(1.16)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C319(1.33); C489(1.06); C1178(0.97); C1375(0.93)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C319(1.04); C489(1.00); C1178(0.99); C1375(1.01)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C319(1.38); C489(1.08); C1178(0.97); C1375(0.98)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C489(1.08); C1178(1.17); C1375(1.00); C604(0.96)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C319(1.44); C489(1.05); C1178(1.17); C1375(0.66)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C319(1.66); C489(1.14); C1178(1.05); C1375(1.02)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C319(1.24); C489(0.93); C1178(1.00); C1375(0.79)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C319(1.00); C489(0.85); C1178(0.90); C1375(1.13)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C319(1.36); C489(1.07); C1178(1.00); C1375(0.96)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C319(1.05); C489(0.99); C1178(0.94); C1375(1.06)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C319(0.90); C489(1.13); C1178(0.94); C1375(0.93)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C319(1.19); C489(1.19); C1178(1.20); C1375(0.97)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C319(0.84); C489(0.82); C1178(0.96); C1375(1.01)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C319(0.92); C489(1.09); C1178(1.01); C1375(0.91)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C319(1.01); C489(1.02); C1178(1.02); C1375(0.86)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C319(1.27); C489(1.04); C1178(1.00); C1375(0.97)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C489(1.04); C1178(0.97); C1375(1.01); C604(0.84)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C319(1.35); C489(1.15); C1178(1.09); C1375(0.61)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C319(1.56); C489(1.02); C1178(1.14); C1375(0.95)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C319(1.54); C489(1.08); C1178(0.94); C1375(0.78)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C319(0.92); C489(0.86); C1178(0.99); C1375(1.10)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C319(1.12); C489(0.99); C1178(0.99); C1375(1.05)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C319(0.76); C489(0.95); C1178(0.94); C1375(0.95)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C319(1.03); C489(1.11); C1178(0.93); C1375(0.91)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C319(1.02); C489(1.05); C1178(0.95); C1375(0.99)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C319(1.01); C489(1.02); C1178(1.00); C1375(1.17)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C319(1.23); C489(1.03); C1178(0.93); C1375(0.81)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C319(1.00); C489(0.98); C1178(1.09); C1375(0.91)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C489(1.16); C1178(1.03); C1375(0.98); C604(0.99)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C319(1.15); C489(1.12); C1178(1.11); C1375(0.62)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C319(1.03); C489(1.06); C1178(1.09); C1375(0.97)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C319(1.22); C489(1.10); C1178(0.94); C1375(0.73)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C319(1.00); C489(0.93); C1178(0.80); C1375(1.05)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C319(0.86); C489(1.01); C1178(0.89); C1375(0.94)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C319(1.05); C489(1.05); C1178(0.91); C1375(0.95)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C319(1.00); C489(1.00); C1178(1.09); C1375(1.00)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C319(1.56); C489(1.02); C1178(0.92); C1375(0.90)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C319(1.02); C489(1.05); C1178(0.99); C1375(0.93)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C319(1.34); C489(1.15); C1178(0.97); C1375(0.98)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C319(1.21); C489(0.98); C1178(0.98); C1375(0.97)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C489(1.19); C1178(1.04); C1375(0.97); C604(0.97)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C319(1.37); C489(1.08); C1178(1.17); C1375(0.69)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C319(1.29); C489(1.15); C1178(1.07); C1375(0.96)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C319(0.87); C489(0.95); C1178(0.98); C1375(1.03)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C319(2.44); C489(1.01); C1178(0.90); C1375(0.87)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C319(1.11); C489(0.89); C1178(0.88); C1375(1.26)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C319(0.95); C489(1.13); C1178(0.94); C1375(1.04)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C319(0.94); C489(0.98); C1178(1.00); C1375(1.08)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C319(1.30); C489(1.01); C1178(1.00); C1375(1.04)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C319(1.12); C489(1.20); C1178(1.05); C1375(0.98)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C319(0.96); C489(1.11); C1178(0.98); C1375(0.91)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C319(1.10); C489(1.08); C1178(1.00); C1375(0.91)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C319(1.24); C489(1.10); C1178(0.82); C1375(1.01)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C489(1.08); C1178(0.95); C1375(1.08); C604(1.05)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C319(1.17); C489(1.00); C1178(0.94); C1375(0.92)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C319(1.29); C489(1.12); C1178(1.12); C1375(0.75)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C319(1.53); C489(1.12); C1178(1.07); C1375(1.01)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C319(1.77); C489(1.20); C1178(0.93); C1375(0.87)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C319(0.95); C489(0.91); C1178(0.91); C1375(1.02)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C319(0.85); C489(0.94); C1178(0.99); C1375(1.00)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C319(0.99); C489(1.05); C1178(0.91); C1375(1.06)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C319(1.33); C489(1.06); C1178(1.13); C1375(0.85)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C319(0.85); C489(0.96); C1178(1.05); C1375(0.95)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C319(1.01); C489(1.02); C1178(0.97); C1375(0.93)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C319(0.89); C489(0.76); C1178(0.88); C1375(0.76)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C319(0.99); C489(0.87); C1178(0.82); C1375(1.03)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C489(0.99); C1178(0.93); C1375(1.05); C604(1.08)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C319(1.30); C489(1.02); C1178(1.00); C1375(0.78)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C319(1.37); C489(1.02); C1178(1.17); C1375(0.97)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C319(1.21); C489(0.86); C1178(0.94); C1375(0.81)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C319(0.99); C489(0.79); C1178(0.85); C1375(1.12)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C319(0.80); C489(0.76); C1178(0.91); C1375(1.00)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C319(0.99); C489(0.81); C1178(0.94); C1375(0.99)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C319(0.97); C489(0.85); C1178(1.01); C1375(0.99)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C319(1.11); C489(0.95); C1178(0.94); C1375(0.90)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C489(0.96); C1178(1.02); C1375(1.08); C604(1.00)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C319(0.93); C489(0.88); C1178(0.84); C1375(0.77)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C319(1.08); C489(0.91); C1178(0.88); C1375(0.86)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C319(1.01); C489(0.92); C1178(0.87); C1375(0.93)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C489(0.94); C1178(0.88); C1375(0.98); C604(0.97)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C319(1.23); C489(0.97); C1178(1.00); C1375(0.81)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C319(1.08); C489(1.13); C1178(1.04); C1375(0.94)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C319(1.13); C489(0.69); C1178(0.92); C1375(0.88)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C319(1.08); C489(0.92); C1178(0.88); C1375(1.23)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C319(0.91); C489(1.02); C1178(0.92); C1375(0.94)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C319(0.93); C489(1.01); C1178(0.97); C1375(1.07)  LDD1697  [18]
 LDCM0634  CY-0357 Hep-G2 C1178(1.01); C772(0.64); C1375(0.53); C1159(0.33)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C319(1.11); C489(0.97); C1178(0.98); C1375(1.00)  LDD1698  [18]
 LDCM0625  F8 Ramos C1178(1.78); C513(0.11); C1375(1.45); C1703(2.27)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C1178(1.71); C513(1.12); C1375(0.95)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C1178(0.41); C513(2.00); C1375(1.71); C1159(20.00)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C1178(1.51); C513(2.76); C1375(0.65); C1703(1.04)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C1178(1.12); C513(0.93); C1375(0.83)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C1178(0.99); C513(1.27); C1375(1.04); C1159(0.47)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C1178(1.20); C513(0.85); C1375(0.67); C1703(0.54)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C1178(1.43); C513(1.15); C1375(1.01)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C1178(2.11); C513(1.31); C1375(1.00)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C1178(1.41); C1375(1.04)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C1178(0.41); C1375(0.67); C1159(0.81)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C1178(1.62); C1375(1.22); C1703(0.92)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C1178(1.81); C1375(1.02)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C1178(1.97); C513(2.70); C1375(1.16); C1703(1.23)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C319(0.87); C489(0.80); C1178(0.98); C1375(1.03)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C1178(0.97); C513(0.90); C1375(0.82)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C1178(0.91); C513(0.13); C1375(0.90); C1159(5.06)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C319(1.16); C489(1.12); C1178(0.98); C1375(0.93)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C1178(1.27); C1375(1.62)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C1178(1.92); C513(2.07); C1375(0.99)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C1178(1.05); C513(0.12); C1375(0.88); C1159(1.63)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C1178(1.36); C513(1.33); C1375(0.79)  LDD2188  [19]
 LDCM0107  IAA HeLa H1967(0.00); C1525(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C319(1.00); C489(1.05); C1178(0.92); C1375(0.85)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C319(1.15); C489(0.99); C1178(1.12); C1375(1.01)  LDD1497  [18]
 LDCM0024  KB05 G361 C1164(1.27); C1183(1.12); C324(1.22)  LDD3311  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C986(0.98)  LDD2118  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C986(1.02)  LDD2122  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C986(0.96)  LDD2126  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C986(0.93)  LDD2149  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) Cation transport ATPase (P-type) (TC 3.A.3) family P13637
60 kDa heat shock protein, mitochondrial (HSPD1) Chaperonin (HSP60) family P10809
Caspase-6 (CASP6) Peptidase C14A family P55212
Phospholipase D1 (PLD1) Phospholipase D family Q13393
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
Serine/threonine-protein kinase VRK1 (VRK1) CK1 Ser/Thr protein kinase family Q99986
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
B-cell lymphoma 6 protein (BCL6) . P41182
Homeobox protein MOX-2 (MEOX2) . P50222
T-cell leukemia homeobox protein 3 (TLX3) . O43711
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2AX (H2AX) Histone H2A family P16104
Histone H2B type 1-C/E/F/G/I (H2BC4; H2BC6; H2BC7; H2BC8; H2BC10) Histone H2B family P62807
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Vimentin (VIM) Intermediate filament family P08670
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Zinc finger HIT domain-containing protein 1 (ZNHIT1) ZNHIT1 family O43257
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
Nuclear receptor coactivator 6 (NCOA6) . Q14686
PAX-interacting protein 1 (PAXIP1) . Q6ZW49
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578