Details of the Target

General Information of Target

Target ID LDTP05541
Target Name 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Gene Name CYP24A1
Gene ID 1591
Synonyms
CYP24; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; EC 1.14.15.16; Cytochrome P450 24A1; Cytochrome P450-CC24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Cytochrome P450 family
Subcellular location
Mitochondrion
Function
A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) . With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product. Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin.
TTD ID
T92458
Uniprot ID
Q07973
DrugMap ID
TT82UI1
Ensemble ID
ENST00000216862.8
HGNC ID
HGNC:2602
ChEMBL ID
CHEMBL4521

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.P449S .
CAL27 SNV: p.R223I .
CCK81 SNV: p.Y293C .
HEC1 SNV: p.P133L DBIA    Probe Info 
HT SNV: p.D139G .
HUCCT1 SNV: p.Q442Ter .
MFE319 SNV: p.Q16Ter; p.Y89C .
NCIH2122 Deletion: p.L290_K292del .
NCIH2172 SNV: p.P45T .
NCIH358 SNV: p.V254F .
PATU8988T SNV: p.T265A .
SCC25 SNV: p.A401T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C512(1.38)  LDD0533  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C303(1.57)  LDD1093  [1]
 LDCM0216  AC100 HCT 116 C512(1.38)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C512(1.30)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C512(1.30)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C512(1.39)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C512(1.60)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C512(1.20)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C512(1.31)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C512(1.50)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C512(1.18)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C512(1.26)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C512(1.40)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C512(1.34)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C512(1.27)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C512(0.99)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C512(0.95)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C512(0.80)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C512(0.91)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C512(0.82)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C512(0.78)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C512(0.93)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C512(1.32)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C512(1.01)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C512(0.83)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C512(1.07)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C512(0.90)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C512(1.07)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C512(0.99)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C512(0.80)  LDD0562  [1]
 LDCM0246  AC128 PaTu 8988t C512(0.91)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C512(0.99)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C512(1.13)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C512(1.06)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C512(0.80)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C512(0.95)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C512(0.91)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C512(1.02)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C512(0.76)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C512(1.03)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C512(1.11)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C512(0.73)  LDD1137  [1]
 LDCM0260  AC140 PaTu 8988t C512(0.85)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C512(1.34)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C512(0.86)  LDD1141  [1]
 LDCM0263  AC143 HCT 116 C512(1.22)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C512(1.25)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C512(1.01)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C512(0.89)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C512(1.07)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C512(0.85)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C512(0.89)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C512(0.98)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C512(1.05)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C512(1.13)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C512(0.87)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C512(1.15)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C512(1.15)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C512(0.99)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C512(0.97)  LDD2161  [1]
 LDCM0276  AC17 PaTu 8988t C194(0.68); C512(1.22)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C194(0.65); C512(1.05)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C194(0.69); C512(1.14)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C303(1.31)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C194(0.89); C512(0.98)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C194(0.86); C512(0.84)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C194(0.83); C512(1.18)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C194(0.71); C512(0.97)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C194(0.84); C512(1.14)  LDD1163  [1]
 LDCM0285  AC25 HCT 116 C512(0.87)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C512(0.87)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C512(0.89)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C512(0.69)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C512(0.73)  LDD0606  [1]
 LDCM0290  AC3 PaTu 8988t C303(1.30)  LDD1169  [1]
 LDCM0291  AC30 HCT 116 C512(0.61)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C512(1.24)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C512(1.26)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C512(1.21)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C512(0.83)  LDD0612  [1]
 LDCM0296  AC35 PaTu 8988t C194(0.70); C303(1.04)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C194(0.56); C303(1.21)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C194(1.15); C303(1.13)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C194(1.09); C303(1.09)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C194(0.76); C303(1.30)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C303(1.17)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C194(0.85); C303(1.18)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C194(0.80); C303(1.14)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C194(0.94); C303(1.27)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C194(0.64); C303(1.17)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C194(1.02); C303(1.21)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C194(1.10); C303(1.16)  LDD1186  [1]
 LDCM0312  AC5 PaTu 8988t C303(1.44)  LDD1191  [1]
 LDCM0320  AC57 HCT 116 C512(0.78)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C512(1.18)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C512(1.41)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C512(1.54)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C512(0.77)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C512(0.99)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C512(1.19)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C512(0.81)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C512(1.29)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C512(1.24)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C512(0.83)  LDD0648  [1]
 LDCM0349  AC83 PaTu 8988t C303(1.04); C512(1.07)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C303(1.55); C512(1.07)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C303(1.30); C512(0.68)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C303(1.34); C512(0.83)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C303(0.92); C512(0.66)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C303(1.08); C512(1.29)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C303(0.93); C512(1.16)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C303(1.18); C512(1.28)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C303(1.17); C512(0.92)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C303(0.95); C512(1.23)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C303(1.24); C512(0.88)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C303(0.92); C512(1.70)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C303(1.18); C512(0.89)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C303(0.95); C512(1.30)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C303(1.33); C512(1.52)  LDD1243  [1]
 LDCM0365  AC98 HCT 116 C512(1.39)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C512(1.43)  LDD0683  [1]
 LDCM0367  CL1 PaTu 8988t C512(1.42)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C512(1.29)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C303(1.41)  LDD1248  [1]
 LDCM0374  CL105 PaTu 8988t C194(1.19); C512(0.80)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C194(0.83); C512(1.08)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C194(0.89); C512(1.00)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C194(0.83); C512(0.95)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C194(0.81); C512(1.05)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C512(1.20)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C194(1.02); C512(1.25)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C194(0.90); C512(1.25)  LDD1260  [1]
 LDCM0382  CL112 HCT 116 C512(0.95)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C512(1.22)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C512(1.16)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C512(0.92)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C512(1.15)  LDD0703  [1]
 LDCM0387  CL117 PaTu 8988t C194(0.99); C303(1.25)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C194(1.16); C303(1.04)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C194(0.80); C303(1.10)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C512(1.00)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C194(0.85); C303(1.13)  LDD1270  [1]
 LDCM0396  CL125 HCT 116 C512(0.83)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C512(0.92)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C512(1.32)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C512(0.80)  LDD0716  [1]
 LDCM0400  CL13 PaTu 8988t C512(0.99)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C512(1.18)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C512(1.51)  LDD1281  [1]
 LDCM0403  CL16 PaTu 8988t C194(1.25); C512(1.05)  LDD1282  [1]
 LDCM0404  CL17 HCT 116 C512(1.21)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C512(0.94)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C512(1.08)  LDD0723  [1]
 LDCM0407  CL2 PaTu 8988t C512(1.12)  LDD1286  [1]
 LDCM0408  CL20 HCT 116 C512(1.26)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C512(1.24)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C512(1.76)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C512(1.36)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C512(1.05)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C512(1.17)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C512(1.16)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C512(1.18)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C512(1.02)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C512(1.39)  LDD0734  [1]
 LDCM0418  CL3 PaTu 8988t C512(1.02)  LDD1297  [1]
 LDCM0419  CL30 HCT 116 C512(1.09)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C512(0.93)  LDD0737  [1]
 LDCM0421  CL32 PaTu 8988t C194(0.68); C512(0.75)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C194(0.84); C512(1.37)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C194(1.01); C512(0.94)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C512(0.85); C194(0.82)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C194(0.85); C512(1.11)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C194(1.23); C512(0.90)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C194(1.05); C512(0.88)  LDD1307  [1]
 LDCM0429  CL4 PaTu 8988t C512(1.42)  LDD1308  [1]
 LDCM0430  CL40 PaTu 8988t C194(0.79); C512(1.18)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C194(0.86); C512(0.88)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C194(0.83); C512(0.88)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C194(1.13); C512(1.12)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C194(0.80); C512(0.89)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C194(0.87); C512(1.54)  LDD1314  [1]
 LDCM0440  CL5 PaTu 8988t C512(1.29)  LDD1319  [1]
 LDCM0451  CL6 PaTu 8988t C512(1.30)  LDD1330  [1]
 LDCM0453  CL61 PaTu 8988t C303(0.94)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C303(1.08)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C303(0.85)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C303(1.34)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C303(0.92)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C303(1.20)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C303(1.03)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C303(1.50)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C303(1.55)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C512(1.36)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C303(1.20)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C303(1.22)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C303(1.02)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C303(1.27)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C303(1.27)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C303(1.03)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C303(1.43)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C303(1.18)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C303(1.16)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C512(1.82)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C303(1.11)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C303(1.38)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C303(1.30)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C303(1.50)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C303(1.29)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C303(1.30)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C303(1.38)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C303(1.39)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C303(1.40)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C303(1.22)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C512(1.41)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C303(1.76)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C303(1.37)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C303(2.07)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C303(1.62)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C303(1.68)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C303(3.42)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C303(1.73)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C303(1.73)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C303(1.85)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C303(1.34)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C303(1.48)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C194(1.14); C512(1.06)  LDD1306  [1]
 LDCM0022  KB02 A-549 C512(1.74); C52(2.41); C113(3.14)  LDD2260  [4]
 LDCM0023  KB03 A-549 C512(2.80); C52(4.90); C113(5.92)  LDD2677  [4]
 LDCM0024  KB05 Hs 936.T C512(1.18)  LDD3313  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Corticotropin BiotechDrug DB01285
Calcifediol Small molecular drug DB00146
Calcipotriol Small molecular drug DB02300
Calcitriol Small molecular drug DB00136
Ergocalciferol Small molecular drug DB00153
Paricalcitol Small molecular drug DB00910
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lunacalcipol Small molecular drug D00DYK
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cta018 . DB05024

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840