Details of the Target

General Information of Target

Target ID LDTP05479
Target Name Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)
Gene Name PPP2R3A
Gene ID 5523
Synonyms
PPP2R3; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha; PP2A subunit B isoform PR72/PR130; PP2A subunit B isoform R3 isoform; PP2A subunit B isoforms B''-PR72/PR130; PP2A subunit B isoforms B72/B130; Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGIDCIVVHHSVCADLLHIPV
SQFKDADLNSMFLPHENGLSSAEGDYPQQAFTGIPRVKRGSTFQNTYNLKDIAGEAISFA
SGKIKEFSFEKLKNSNHAAYRKGRKVKSDSFNRRSVDLDLLCGHYNNDGNAPSFGLLRSS
SVEEKPLSHRNSLDTNLTSMFLQNFSEEDLVTQILEKHKIDNFSSGTDIKMCLDILLKCS
EDLKKCTDIIKQCIKKKSGSSISEGSGNDTISSSETVYMNVMTRLASYLKKLPFEFMQSG
NNEALDLTELISNMPSLQLTPFSPVFGTEQPPKYEDVVQLSASDSGRFQTIELQNDKPNS
RKMDTVQSIPNNSTNSLYNLEVNDPRTLKAVQVQSQSLTMNPLENVSSDDLMETLYIEEE
SDGKKALDKGQKTENGPSHELLKVNEHRAEFPEHATHLKKCPTPMQNEIGKIFEKSFVNL
PKEDCKSKVSKFEEGDQRDFTNSSSQEEIDKLLMDLESFSQKMETSLREPLAKGKNSNFL
NSHSQLTGQTLVDLEPKSKVSSPIEKVSPSCLTRIIETNGHKIEEEDRALLLRILESIED
FAQELVECKSSRGSLSQEKEMMQILQETLTTSSQANLSVCRSPVGDKAKDTTSAVLIQQT
PEVIKIQNKPEKKPGTPLPPPATSPSSPRPLSPVPHVNNVVNAPLSINIPRFYFPEGLPD
TCSNHEQTLSRIETAFMDIEEQKADIYEMGKIAKVCGCPLYWKAPMFRAAGGEKTGFVTA
QSFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPE
FHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHF
YVIYCKFWELDTDHDLYISQADLSRYNDQASSSRIIERIFSGAVTRGKTIQKEGRMSYAD
FVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHD
LLCQMLDLVKPAVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFAVQKDVENDG
PEPSDWDRFAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSEFGNKSNKILSASLPEK
CGKLQSVDEE
Target Bioclass
Enzyme
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Uniprot ID
Q06190
Ensemble ID
ENST00000264977.8
HGNC ID
HGNC:9307

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.E596Ter; p.T949R .
HT115 SNV: p.F477C; p.A1010V; p.F1055L .
ICC10 SNV: p.A769S .
ICC106 SNV: p.A769S .
ICC108 SNV: p.A769S .
IM95 SNV: p.R593Ter .
KMS11 SNV: p.Q104Ter; p.S632F .
L428 SNV: p.Y30D .
MELJUSO SNV: p.P674L .
MFE319 SNV: p.D85G .
NCIH146 Deletion: p.Q659RfsTer5 .
SKMEL2 SNV: p.E1101G .
TCCSUP SNV: p.N191K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K290(0.64)  LDD0277  [1]
DBIA
 Probe Info  		C571(3.30)  LDD3325  [2]
BTD
 Probe Info  		C1141(1.31)  LDD2105  [3]
AHL-Pu-1
 Probe Info  		C571(2.09)  LDD0170  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_4
 Probe Info  		C461(0.00); C485(0.00); C608(0.00); C722(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C246(1.17)  LDD2142  [3]
 LDCM0025  4SU-RNA DM93 C571(2.09)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C722(2.25)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C758(0.93); C803(0.93)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C758(0.89); C803(0.93)  LDD0813  [8]
 LDCM0226  AC11 HEK-293T C758(1.02); C803(1.07)  LDD0824  [8]
 LDCM0230  AC113 HEK-293T C758(1.03); C803(1.03)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C758(0.72); C803(0.72)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C758(0.94); C803(0.94)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C758(0.54); C803(0.54)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C758(0.75); C803(0.75)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C758(0.70); C803(0.70)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C758(0.60); C803(0.60)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C758(0.96); C803(0.93)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C758(0.90); C803(0.90)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C758(0.72); C803(0.72)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C758(0.56); C803(0.56)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C758(0.61); C803(0.61)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C758(0.64); C803(0.64)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C758(0.68); C803(0.68)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C758(1.04); C803(1.04)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C758(0.87); C803(0.87)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C758(1.20); C803(1.20)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C758(0.70); C803(0.70)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C758(0.89); C803(0.89)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C758(0.91); C803(0.91)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C758(1.15); C803(1.15)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C758(0.85); C803(0.85)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C758(0.65); C803(0.65)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C758(0.97); C803(0.97)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C758(0.89); C803(0.89)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C758(0.99); C803(0.99)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C758(1.08); C803(1.08)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C758(0.75); C803(0.75)  LDD0856  [8]
 LDCM0259  AC14 HEK-293T C758(1.09); C803(1.16)  LDD0857  [8]
 LDCM0260  AC140 HEK-293T C758(0.91); C803(0.91)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C758(0.89); C803(0.89)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C758(0.81); C803(0.81)  LDD0860  [8]
 LDCM0270  AC15 HEK-293T C758(0.95); C803(0.76)  LDD0868  [8]
 LDCM0276  AC17 HEK-293T C571(1.06); C232(0.66); C461(0.97)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C571(0.98); C232(1.09)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C232(1.43); C461(0.84); C162(0.95)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C758(0.78); C803(0.78)  LDD0877  [8]
 LDCM0280  AC20 HEK-293T C232(0.88)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C571(1.10); C232(0.93)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C571(1.07); C232(1.26); C608(1.01)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C232(1.05)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C571(0.99); C232(1.14); C608(0.82); C758(1.10)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C571(1.08); C232(0.85); C461(0.97)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C571(0.97); C232(0.99)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C232(1.44); C461(1.22); C162(0.94)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C232(0.89)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C571(1.02); C232(1.02)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C758(1.11); C803(1.11)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C571(1.02); C232(1.27); C608(0.89)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C232(0.93)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C571(0.98); C232(1.14); C608(0.98); C758(0.83)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C571(1.00); C232(0.83); C461(0.98)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C571(0.99); C232(0.75)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C232(1.16); C461(1.02); C162(0.75)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C232(0.72)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C571(0.97); C232(1.11)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C571(0.85); C232(1.04); C608(0.90)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C232(0.94)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C758(0.83); C803(0.83)  LDD0899  [8]
 LDCM0302  AC40 HEK-293T C571(1.03); C232(1.02); C608(1.06); C758(0.99)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C571(1.10); C232(0.79); C461(1.01)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C571(0.95); C232(1.26)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C232(1.17); C461(0.99); C162(1.19)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C232(0.87)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C571(1.01); C232(0.96)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C758(0.53); C803(0.53)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C758(0.73); C803(0.73)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C758(0.75); C803(0.75)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C758(0.62); C803(0.62)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C758(0.73); C803(0.73)  LDD0910  [8]
 LDCM0313  AC50 HEK-293T C758(0.82); C803(0.82)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C758(0.66); C803(0.66)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C758(0.64); C803(0.64)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C758(0.98); C803(0.98)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C758(0.58); C803(0.58)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C758(0.59); C803(0.59)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C758(0.69); C803(0.69)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C758(1.15); C803(1.15)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C758(1.27); C803(1.27)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C758(1.13); C803(1.13)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C758(1.06); C803(0.99)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C758(1.62); C803(1.62)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C758(1.13); C803(1.13)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C758(1.21); C803(1.21)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C758(0.97); C803(0.97)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C758(1.18); C803(1.18)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C758(1.00); C803(1.00)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C758(1.33); C803(1.33)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C758(0.78); C803(0.78)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C758(0.92); C803(0.92)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C758(0.76); C803(0.76)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C758(1.08); C803(0.99)  LDD0932  [8]
 LDCM0335  AC70 HEK-293T C758(0.57); C803(0.57)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C758(0.89); C803(0.89)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C758(0.77); C803(0.77)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C758(0.88); C803(0.88)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C758(0.62); C803(0.62)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C758(0.58); C803(0.58)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C758(0.78); C803(0.78)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C758(0.73); C803(0.73)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C758(0.55); C803(0.55)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C758(0.81); C803(0.81)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C758(0.81); C803(0.55)  LDD0943  [8]
 LDCM0346  AC80 HEK-293T C758(0.54); C803(0.54)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C758(0.62); C803(0.62)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C758(0.44); C803(0.44)  LDD0946  [8]
 LDCM0248  AKOS034007472 HEK-293T C758(1.05); C803(1.08)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C758(0.80); C803(0.72)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C758(0.86); C803(0.77)  LDD0873  [8]
 LDCM0367  CL1 HEK-293T C571(1.01); C232(0.94); C461(1.10); C756(1.04)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C571(1.56); C232(1.11); C608(1.37)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C758(0.64); C803(0.64)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C758(0.80); C803(0.56)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C758(0.86); C803(0.87)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C758(0.97); C803(0.74)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C758(1.14); C803(0.73)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C571(1.13); C232(1.11); C461(0.98); C756(1.21)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C571(1.03); C232(0.81); C239(1.28); C758(1.08)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C232(0.99)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C571(1.01); C232(1.04); C461(0.95); C758(0.92)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C571(1.16); C232(0.82); C461(0.95); C756(1.53)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C232(1.01)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C571(0.96); C232(0.74); C239(1.54); C758(1.08)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C232(1.13)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C571(0.94); C232(0.76); C461(0.97); C758(0.85)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C571(1.07); C232(0.85); C461(1.00); C756(1.01)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C571(1.17); C232(0.74); C239(1.03); C758(1.43)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C232(0.99)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C571(1.08); C232(1.15); C461(1.08); C758(0.93)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C571(1.12); C232(0.85); C461(0.99); C756(1.62)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C571(1.06); C232(1.03); C239(1.21); C758(1.16)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C232(0.97)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C571(1.09); C232(0.46); C608(1.19); C758(0.91)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C571(1.04); C232(1.19); C461(1.08); C758(0.81)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C758(0.53); C803(0.53)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C758(0.65); C803(0.65)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C758(0.81); C803(0.81)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C758(0.82); C803(0.82)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C758(1.00); C803(1.00)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C758(1.01); C803(1.01)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C758(1.13); C803(1.13)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C758(1.11); C803(1.11)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C571(1.23); C232(0.86); C461(0.97); C756(0.79)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C571(0.98); C232(0.92); C239(1.23); C758(0.94)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C232(0.90)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C758(0.59); C803(0.59)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C758(0.63); C803(0.63)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C758(0.52); C803(0.52)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C758(0.69); C803(0.69)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C571(1.02); C232(0.81); C239(1.25); C758(1.20)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C758(0.81); C803(0.81)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C758(0.89); C803(0.89)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C758(0.59); C803(0.59)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C758(1.06); C803(1.06)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C758(0.85); C803(0.85)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C758(0.57); C803(0.57)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C758(0.79); C803(0.79)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C758(0.85); C803(0.85)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C758(0.87); C803(0.87)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C758(0.84); C803(0.84)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C232(0.77)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C758(0.73); C803(0.73)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C758(0.57); C803(0.57)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C758(0.56); C803(0.56)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C758(0.31); C803(0.31)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C758(0.66); C803(0.66)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C758(0.49); C803(0.49)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C758(0.64); C803(0.64)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C758(0.63); C803(0.63)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C758(0.44); C803(0.44)  LDD1026  [8]
 LDCM0429  CL4 HEK-293T C571(1.04); C232(0.67); C461(1.27); C758(0.78)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C758(0.65); C803(0.65)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C758(0.43); C803(0.43)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C758(0.45); C803(0.45)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C758(0.51); C803(0.51)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C758(0.57); C803(0.57)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C758(0.39); C803(0.39)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C758(0.59); C803(0.59)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C758(0.83); C803(0.83)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C758(0.72); C803(0.72)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C758(0.80); C803(0.80)  LDD1037  [8]
 LDCM0440  CL5 HEK-293T C571(1.04); C232(0.75); C461(1.10)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C758(0.72); C803(0.72)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C758(0.85); C803(0.85)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C758(1.15); C803(1.15)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C758(1.24); C803(1.24)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C758(0.86); C803(0.86)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C758(0.70); C803(0.70)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C758(0.97); C803(0.97)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C758(0.92); C803(0.92)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C758(1.32); C803(1.32)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C758(0.65); C803(0.65)  LDD1048  [8]
 LDCM0451  CL6 HEK-293T C571(1.11); C232(0.91)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C758(0.65); C803(0.65)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C758(0.75); C803(0.82)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C758(0.78); C803(1.00)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C758(0.56); C803(0.75)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C758(0.76); C803(0.84)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C758(0.63); C803(0.81)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C758(0.74); C803(1.09)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C758(0.84); C803(1.03)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C758(0.80); C803(1.12)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C758(0.89); C803(1.04)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C232(1.30); C461(1.09); C162(0.66)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C758(0.94); C803(1.00)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C758(0.89); C803(0.94)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C758(0.78); C803(0.87)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C758(0.89); C803(1.01)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C758(0.57); C803(1.02)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C758(0.71); C803(0.71)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C758(0.57); C803(0.57)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C758(1.03); C803(1.03)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C758(0.79); C803(0.79)  LDD1070  [8]
 LDCM0473  CL8 HEK-293T C232(1.37)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C758(0.81); C803(0.81)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C758(0.82); C803(0.82)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C758(0.72); C803(0.72)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C758(0.49); C803(0.49)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C758(0.62); C803(0.62)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C758(0.70); C803(0.70)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C758(1.06); C803(1.06)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C758(0.50); C803(0.50)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C758(0.52); C803(0.52)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C758(0.72); C803(0.72)  LDD1081  [8]
 LDCM0484  CL9 HEK-293T C571(1.30); C232(1.17)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C758(0.44); C803(0.44)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C758(0.70); C803(0.70)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C758(0.67); C803(0.67)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C758(0.63); C803(0.63)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C758(0.41); C803(0.41)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C758(0.49); C803(0.49)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C758(0.60); C803(0.60)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C758(0.67); C803(0.67)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C758(0.74); C803(0.74)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C758(0.82); C803(0.82)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C232(1.16)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C758(0.52); C803(0.77)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C758(0.76); C803(0.76)  LDD1025  [8]
 LDCM0022  KB02 HEK-293T C232(0.98)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C232(1.05)  LDD1497  [9]
 LDCM0024  KB05 UACC257 C571(3.30)  LDD3325  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1141(1.31)  LDD2105  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1141(0.81)  LDD2120  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1141(0.70)  LDD2128  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein naked cuticle homolog 1 (NKD1) NKD family Q969G9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402