Details of the Target

General Information of Target

Target ID LDTP05458
Target Name Serine/arginine-rich splicing factor 11 (SRSF11)
Gene Name SRSF11
Gene ID 9295
Synonyms
SFRS11; Serine/arginine-rich splicing factor 11; Arginine-rich 54 kDa nuclear protein; p54; Splicing factor, arginine/serine-rich 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKID
ELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAK
ALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQ
SLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPD
KKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRER
GRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRS
PKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQ
VTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDM
DMSD
Target Bioclass
Other
Family
Splicing factor SR family
Subcellular location
Nucleus
Function May function in pre-mRNA splicing.
Uniprot ID
Q05519
Ensemble ID
ENST00000370949.2
HGNC ID
HGNC:10782

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S9R; p.R254C .
ETK1 SNV: p.E47Q DBIA    Probe Info 
HT115 SNV: p.R393Ter .
HUH28 SNV: p.E377K .
OVCAR4 SNV: p.E478K .
SNGM SNV: p.R372G .
SSP25 SNV: p.E47Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.70  LDD0402  [1]
C-Sul
 Probe Info  		6.54  LDD0066  [2]
STPyne
 Probe Info  		K197(1.06); K211(3.61); K459(6.67)  LDD0277  [3]
Probe 1
 Probe Info  		Y425(122.37)  LDD3495  [4]
DBIA
 Probe Info  		C455(1.25)  LDD3312  [5]
BTD
 Probe Info  		C455(0.54)  LDD2089  [6]
5E-2FA
 Probe Info  		H94(0.00); H200(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		K459(0.00); K211(0.00); K217(0.00); K453(0.00)  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
NAIA_5
 Probe Info  		N.A.  LDD2224  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		H84(0.00); H200(0.00); H94(0.00)  LDD0217  [14]
TER-AC
 Probe Info  		N.A.  LDD0426  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C455(0.73)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C455(0.89)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C455(0.95)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C455(0.97)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C455(0.73)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C455(1.07)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C455(0.83)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C455(0.73)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C455(0.71)  LDD2131  [6]
 LDCM0545  Acetamide MDA-MB-231 C455(0.42)  LDD2138  [6]
 LDCM0498  BS-3668 MDA-MB-231 C455(0.58)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa H84(0.00); H200(0.00)  LDD0222  [14]
 LDCM0625  F8 Ramos C455(1.57)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C455(0.65)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C455(1.31)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C455(0.55)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C455(0.74)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C455(0.56)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C455(0.49)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C455(0.68)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C455(0.54)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C455(0.95)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C455(0.84)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C455(1.37)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C455(0.69)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C455(0.93)  LDD2201  [16]
 LDCM0468  Fragment33 Ramos C455(1.25)  LDD2202  [16]
 LDCM0596  Fragment38 Ramos C455(0.80)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C455(0.80)  LDD2184  [16]
 LDCM0610  Fragment52 Ramos C455(1.07)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C455(1.23)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C455(0.78)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C455(0.48)  LDD2188  [16]
 LDCM0107  IAA HeLa H84(0.00); H200(0.00)  LDD0221  [14]
 LDCM0022  KB02 Ramos C455(0.92)  LDD2182  [16]
 LDCM0023  KB03 Ramos C455(0.66)  LDD2183  [16]
 LDCM0024  KB05 HMCB C455(1.25)  LDD3312  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C455(0.84)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C455(0.39)  LDD2121  [6]
 LDCM0109  NEM HeLa H84(0.00); H200(0.00); H94(0.00)  LDD0223  [14]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C455(0.54)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C455(1.02)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C455(0.66)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C455(1.30)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C455(1.23)  LDD2096  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C455(0.67)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C455(0.96)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C455(1.01)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C455(1.27)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C455(0.87)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C455(0.76)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C455(0.75)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C455(1.68)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C455(0.66)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C455(0.89)  LDD2114  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C455(1.18)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C455(1.21)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C455(2.27)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C455(1.10)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C455(1.26)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C455(0.67)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C455(1.27)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C455(0.55)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C455(1.17)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C455(0.76)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C455(0.94)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C455(0.54)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C455(0.44)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C455(0.83)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C455(0.90)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C455(0.64)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C455(0.71)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C455(1.47)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C455(3.83)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C455(3.50)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C455(0.68)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C455(6.76)  LDD2147  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C455(1.59)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C455(0.32)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C455(1.77)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C455(1.14)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC) GatC family O43716
Putative hydroxypyruvate isomerase (HYI) Hyi family Q5T013
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit delta, mitochondrial (ATP5F1D) ATPase epsilon chain family P30049
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein C-ets-1 (ETS1) ETS family P14921
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Poly(U)-binding-splicing factor PUF60 (PUF60) RRM half pint family Q9UHX1
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Splicing regulatory glutamine/lysine-rich protein 1 (SREK1) Splicing factor SR family Q8WXA9
TRAF family member-associated NF-kappa-B activator (TANK) . Q92844

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578