Details of the Target

General Information of Target

Target ID LDTP05237
Target Name S-adenosylmethionine synthase isoform type-1 (MAT1A)
Gene Name MAT1A
Gene ID 4143
Synonyms
AMS1; MATA1; S-adenosylmethionine synthase isoform type-1; AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVC
KTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQC
VHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDS
KTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDT
VYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVI
VRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF
Target Bioclass
Enzyme
Family
AdoMet synthase family
Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Uniprot ID
Q00266
Ensemble ID
ENST00000372213.8
HGNC ID
HGNC:6903
ChEMBL ID
CHEMBL5169142

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
IPM
 Probe Info  		C376(0.00); C34(0.00); C56(0.00); C60(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C376(1.92)  LDD3321  [3]
HHS-465
 Probe Info  		Y271(10.00)  LDD2237  [4]
Acrolein
 Probe Info  		N.A.  LDD0223  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C376(0.00); C34(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C376(0.00); C68(0.00)  LDD0037  [6]
Ox-W18
 Probe Info  		W274(0.00); W300(0.00)  LDD2175  [7]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C104(1.53); C120(1.53)  LDD1093  [8]
 LDCM0215  AC10 PaTu 8988t C104(1.37); C120(1.37)  LDD1094  [8]
 LDCM0216  AC100 PaTu 8988t C104(1.15); C120(1.15)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C104(0.95); C120(0.95)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C104(0.91); C120(0.91)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C104(1.36); C120(1.36)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C104(0.88); C120(0.88)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C104(0.84); C120(0.84)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C104(0.99); C120(0.99)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C104(0.93); C120(0.93)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C104(0.96); C120(0.96)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C104(1.24); C120(1.24)  LDD1104  [8]
 LDCM0226  AC11 PaTu 8988t C104(1.16); C120(1.16)  LDD1105  [8]
 LDCM0227  AC110 PaTu 8988t C104(1.08); C120(1.08)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C104(0.95); C120(0.95)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C104(0.78); C120(0.78)  LDD1108  [8]
 LDCM0230  AC113 PaTu 8988t C104(1.10); C120(1.10)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C104(1.24); C120(1.24)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C104(0.93); C120(0.93)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C104(1.09); C120(1.09)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C104(1.18); C120(1.18)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C104(1.20); C120(1.20)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C104(1.10); C120(1.10)  LDD1115  [8]
 LDCM0237  AC12 PaTu 8988t C104(1.23); C120(1.23)  LDD1116  [8]
 LDCM0238  AC120 PaTu 8988t C104(1.26); C120(1.26)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C104(1.14); C120(1.14)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C104(1.20); C120(1.20)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C104(1.42); C120(1.42)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C104(1.17); C120(1.17)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C104(1.36); C120(1.36)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C104(1.03); C120(1.03)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C104(1.33); C120(1.33)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C104(1.25); C120(1.25)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C104(1.32); C120(1.32)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C104(1.31); C120(1.31)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C104(1.41); C120(1.41)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C104(1.33); C120(1.33)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C104(0.99); C120(0.99)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C104(1.21); C120(1.21)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C104(1.22); C120(1.22)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C104(1.40); C120(1.40)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C104(1.13); C120(1.13)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C104(1.07); C120(1.07)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C104(1.23); C120(1.23)  LDD1137  [8]
 LDCM0259  AC14 PaTu 8988t C104(0.97); C120(0.97)  LDD1138  [8]
 LDCM0260  AC140 PaTu 8988t C104(1.49); C120(1.49)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C104(1.05); C120(1.05)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C104(1.28); C120(1.28)  LDD1141  [8]
 LDCM0263  AC143 PaTu 8988t C104(1.19); C120(1.19)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C104(1.28); C120(1.28)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C104(1.28); C120(1.28)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C104(0.95); C120(0.95)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C104(0.89); C120(0.89)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C104(1.23); C120(1.23)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C104(1.15); C120(1.15)  LDD1148  [8]
 LDCM0270  AC15 PaTu 8988t C104(1.08); C120(1.08)  LDD1149  [8]
 LDCM0271  AC150 PaTu 8988t C104(1.36); C120(1.36)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C104(1.24); C120(1.24)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C104(1.26); C120(1.26)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C104(1.11); C120(1.11)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C104(1.03); C120(1.03)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C104(1.09); C120(1.09)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C104(1.15); C120(1.15)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C104(1.00); C120(1.00)  LDD2169  [8]
 LDCM0276  AC17 PaTu 8988t C104(1.10); C120(1.10)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C104(1.32); C120(1.32)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C104(1.07); C120(1.07)  LDD1157  [8]
 LDCM0279  AC2 PaTu 8988t C104(1.89); C120(1.89)  LDD1158  [8]
 LDCM0280  AC20 PaTu 8988t C104(1.35); C120(1.35)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C104(1.16); C120(1.16)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C104(1.45); C120(1.45)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C104(1.25); C120(1.25)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C104(1.29); C120(1.29)  LDD1163  [8]
 LDCM0285  AC25 PaTu 8988t C104(1.05); C120(1.05)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C104(1.00); C120(1.00)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C104(1.29); C120(1.29)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C104(1.20); C120(1.20)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C104(1.09); C120(1.09)  LDD1168  [8]
 LDCM0290  AC3 PaTu 8988t C104(1.59); C120(1.59)  LDD1169  [8]
 LDCM0291  AC30 PaTu 8988t C104(1.17); C120(1.17)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C104(1.06); C120(1.06)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C104(1.27); C120(1.27)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C104(1.12); C120(1.12)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C104(1.12); C120(1.12)  LDD1174  [8]
 LDCM0296  AC35 PaTu 8988t C104(1.06); C120(1.06)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C104(1.38); C120(1.38)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C104(1.69); C120(1.69)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C104(1.48); C120(1.48)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C104(1.35); C120(1.35)  LDD1179  [8]
 LDCM0301  AC4 PaTu 8988t C104(1.17); C120(1.17)  LDD1180  [8]
 LDCM0302  AC40 PaTu 8988t C104(1.30); C120(1.30)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C104(0.93); C120(0.93)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C104(1.10); C120(1.10)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C104(1.24); C120(1.24)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C104(1.60); C120(1.60)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C104(1.30); C120(1.30)  LDD1186  [8]
 LDCM0312  AC5 PaTu 8988t C104(1.55); C120(1.55)  LDD1191  [8]
 LDCM0323  AC6 PaTu 8988t C104(1.28); C120(1.28)  LDD1202  [8]
 LDCM0334  AC7 PaTu 8988t C104(1.01); C120(1.01)  LDD1213  [8]
 LDCM0345  AC8 PaTu 8988t C104(0.99); C120(0.99)  LDD1224  [8]
 LDCM0365  AC98 PaTu 8988t C104(1.29); C120(1.29)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C104(1.19); C120(1.19)  LDD1245  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C104(1.14); C120(1.14)  LDD1127  [8]
 LDCM0356  AKOS034007680 PaTu 8988t C104(1.14); C120(1.14)  LDD1235  [8]
 LDCM0275  AKOS034007705 PaTu 8988t C104(1.08); C120(1.08)  LDD1154  [8]
 LDCM0367  CL1 PaTu 8988t C104(1.18); C120(1.18)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C104(1.22); C120(1.22)  LDD1247  [8]
 LDCM0369  CL100 PaTu 8988t C104(1.12); C120(1.12)  LDD1248  [8]
 LDCM0370  CL101 PaTu 8988t C104(1.09); C120(1.09)  LDD1249  [8]
 LDCM0371  CL102 PaTu 8988t C104(1.07); C120(1.07)  LDD1250  [8]
 LDCM0372  CL103 PaTu 8988t C104(1.23); C120(1.23)  LDD1251  [8]
 LDCM0373  CL104 PaTu 8988t C104(1.14); C120(1.14)  LDD1252  [8]
 LDCM0374  CL105 PaTu 8988t C104(1.18); C120(1.18)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C104(1.05); C120(1.05)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C104(1.08); C120(1.08)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C104(1.13); C120(1.13)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C104(1.16); C120(1.16)  LDD1257  [8]
 LDCM0379  CL11 PaTu 8988t C104(1.13); C120(1.13)  LDD1258  [8]
 LDCM0380  CL110 PaTu 8988t C104(1.16); C120(1.16)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C104(1.26); C120(1.26)  LDD1260  [8]
 LDCM0382  CL112 PaTu 8988t C104(0.90); C120(0.90)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C104(1.09); C120(1.09)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C104(0.98); C120(0.98)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C104(1.05); C120(1.05)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C104(0.96); C120(0.96)  LDD1265  [8]
 LDCM0387  CL117 PaTu 8988t C104(1.27); C120(1.27)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C104(1.28); C120(1.28)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C104(1.04); C120(1.04)  LDD1268  [8]
 LDCM0390  CL12 PaTu 8988t C104(0.96); C120(0.96)  LDD1269  [8]
 LDCM0391  CL120 PaTu 8988t C104(1.20); C120(1.20)  LDD1270  [8]
 LDCM0400  CL13 PaTu 8988t C104(0.97); C120(0.97)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C104(1.09); C120(1.09)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C104(1.13); C120(1.13)  LDD1281  [8]
 LDCM0403  CL16 PaTu 8988t C104(1.02); C120(1.02)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C104(0.93); C120(0.93)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C104(0.93); C120(0.93)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C104(0.97); C120(0.97)  LDD1285  [8]
 LDCM0407  CL2 PaTu 8988t C104(1.15); C120(1.15)  LDD1286  [8]
 LDCM0408  CL20 PaTu 8988t C104(0.82); C120(0.82)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C104(0.82); C120(0.82)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C104(0.91); C120(0.91)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C104(1.21); C120(1.21)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C104(1.08); C120(1.08)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C104(1.02); C120(1.02)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C104(0.93); C120(0.93)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C104(1.10); C120(1.10)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C104(0.90); C120(0.90)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C104(0.87); C120(0.87)  LDD1296  [8]
 LDCM0418  CL3 PaTu 8988t C104(1.44); C120(1.44)  LDD1297  [8]
 LDCM0419  CL30 PaTu 8988t C104(0.95); C120(0.95)  LDD1298  [8]
 LDCM0420  CL31 PaTu 8988t C104(1.07); C120(1.07)  LDD1299  [8]
 LDCM0421  CL32 PaTu 8988t C104(1.35); C120(1.35)  LDD1300  [8]
 LDCM0422  CL33 PaTu 8988t C104(1.02); C120(1.02)  LDD1301  [8]
 LDCM0423  CL34 PaTu 8988t C104(1.24); C120(1.24)  LDD1302  [8]
 LDCM0424  CL35 PaTu 8988t C104(1.20); C120(1.20)  LDD1303  [8]
 LDCM0425  CL36 PaTu 8988t C104(1.15); C120(1.15)  LDD1304  [8]
 LDCM0426  CL37 PaTu 8988t C104(1.18); C120(1.18)  LDD1305  [8]
 LDCM0428  CL39 PaTu 8988t C104(1.23); C120(1.23)  LDD1307  [8]
 LDCM0429  CL4 PaTu 8988t C104(1.36); C120(1.36)  LDD1308  [8]
 LDCM0430  CL40 PaTu 8988t C104(1.10); C120(1.10)  LDD1309  [8]
 LDCM0431  CL41 PaTu 8988t C104(1.13); C120(1.13)  LDD1310  [8]
 LDCM0432  CL42 PaTu 8988t C104(1.05); C120(1.05)  LDD1311  [8]
 LDCM0433  CL43 PaTu 8988t C104(0.94); C120(0.94)  LDD1312  [8]
 LDCM0434  CL44 PaTu 8988t C104(1.30); C120(1.30)  LDD1313  [8]
 LDCM0435  CL45 PaTu 8988t C104(1.19); C120(1.19)  LDD1314  [8]
 LDCM0436  CL46 PaTu 8988t C104(1.04); C120(1.04)  LDD1315  [8]
 LDCM0437  CL47 PaTu 8988t C104(0.95); C120(0.95)  LDD1316  [8]
 LDCM0438  CL48 PaTu 8988t C104(0.96); C120(0.96)  LDD1317  [8]
 LDCM0439  CL49 PaTu 8988t C104(0.98); C120(0.98)  LDD1318  [8]
 LDCM0440  CL5 PaTu 8988t C104(1.22); C120(1.22)  LDD1319  [8]
 LDCM0441  CL50 PaTu 8988t C104(1.12); C120(1.12)  LDD1320  [8]
 LDCM0442  CL51 PaTu 8988t C104(1.07); C120(1.07)  LDD1321  [8]
 LDCM0443  CL52 PaTu 8988t C104(1.10); C120(1.10)  LDD1322  [8]
 LDCM0444  CL53 PaTu 8988t C104(0.99); C120(0.99)  LDD1323  [8]
 LDCM0445  CL54 PaTu 8988t C104(0.94); C120(0.94)  LDD1324  [8]
 LDCM0446  CL55 PaTu 8988t C104(1.15); C120(1.15)  LDD1325  [8]
 LDCM0447  CL56 PaTu 8988t C104(1.14); C120(1.14)  LDD1326  [8]
 LDCM0448  CL57 PaTu 8988t C104(1.17); C120(1.17)  LDD1327  [8]
 LDCM0449  CL58 PaTu 8988t C104(1.11); C120(1.11)  LDD1328  [8]
 LDCM0450  CL59 PaTu 8988t C104(1.15); C120(1.15)  LDD1329  [8]
 LDCM0451  CL6 PaTu 8988t C104(1.25); C120(1.25)  LDD1330  [8]
 LDCM0452  CL60 PaTu 8988t C104(1.08); C120(1.08)  LDD1331  [8]
 LDCM0453  CL61 PaTu 8988t C104(0.99); C120(0.99)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C104(0.69); C120(0.69)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C104(0.85); C120(0.85)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C104(0.95); C120(0.95)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C104(0.90); C120(0.90)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C104(0.89); C120(0.89)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C104(0.89); C120(0.89)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C104(0.85); C120(0.85)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C104(0.95); C120(0.95)  LDD1340  [8]
 LDCM0462  CL7 PaTu 8988t C104(1.09); C120(1.09)  LDD1341  [8]
 LDCM0463  CL70 PaTu 8988t C104(0.95); C120(0.95)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C104(0.73); C120(0.73)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C104(0.62); C120(0.62)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C104(1.01); C120(1.01)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C104(0.90); C120(0.90)  LDD1346  [8]
 LDCM0469  CL76 PaTu 8988t C104(1.25); C120(1.25)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C104(1.17); C120(1.17)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C104(1.40); C120(1.40)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C104(1.53); C120(1.53)  LDD1351  [8]
 LDCM0473  CL8 PaTu 8988t C104(1.38); C120(1.38)  LDD1352  [8]
 LDCM0474  CL80 PaTu 8988t C104(1.36); C120(1.36)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C104(1.48); C120(1.48)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C104(1.50); C120(1.50)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C104(1.73); C120(1.73)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C104(1.36); C120(1.36)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C104(1.24); C120(1.24)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C104(1.37); C120(1.37)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C104(1.46); C120(1.46)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C104(1.41); C120(1.41)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C104(1.44); C120(1.44)  LDD1362  [8]
 LDCM0484  CL9 PaTu 8988t C104(1.16); C120(1.16)  LDD1363  [8]
 LDCM0485  CL90 PaTu 8988t C104(1.40); C120(1.40)  LDD1364  [8]
 LDCM0486  CL91 PaTu 8988t C104(2.47); C120(2.47)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C104(1.95); C120(1.95)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C104(1.68); C120(1.68)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C104(1.97); C120(1.97)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C104(1.33); C120(1.33)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C104(1.00); C120(1.00)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C104(1.35); C120(1.35)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C104(2.53); C120(2.53)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C104(1.88); C120(1.88)  LDD1373  [8]
 LDCM0468  Fragment33 PaTu 8988t C104(0.98); C120(0.98)  LDD1347  [8]
 LDCM0427  Fragment51 PaTu 8988t C104(1.44); C120(1.44)  LDD1306  [8]
 LDCM0022  KB02 A101D C376(1.18)  LDD2250  [3]
 LDCM0023  KB03 A101D C376(1.52)  LDD2667  [3]
 LDCM0024  KB05 SH4 C376(1.92)  LDD3321  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylmethionine synthase isoform type-1 (MAT1A) AdoMet synthase family Q00266
S-adenosylmethionine synthase isoform type-2 (MAT2A) AdoMet synthase family P31153
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ademetionine Small molecular drug DB00118
Methionine Small molecular drug DB00134
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-oxiran-2ylalanine . DB03191
L-2-amino-4-methoxy-cis-but-3-enoic Acid . DB03611

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.