Details of the Target

General Information of Target

Target ID LDTP04098
Target Name Neurogenic locus notch homolog protein 1 (NOTCH1)
Gene Name NOTCH1
Gene ID 4851
Synonyms
TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation; NEXT; Notch 1 intracellular domain; NICD)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDP
NPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLL
TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVT
HECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQ
LMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGA
NPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP
GYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHC
ETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKID
GYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCR
EGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRN
GGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANC
TDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQH
DVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGS
YCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLD
LPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV
GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGG
TCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTG
PECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDI
PPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYF
SDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLD
CAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYY
GREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEI
DNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPPPPAQLHFMYVA
AAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNA
SDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRMSAMAP
TPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASL
HNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQIL
IRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNN
VDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDI
AQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVRK
PSSKGLACGSKEAKDLKARRKKSQDGKGCLLDSSGMLSPVDSLESPHGYLSDVASPPLLP
SPFQQSPSVPLNHLPGMPDTHLGIGHLNVAAKPEMAALGGGGRLAFETGPPRLSHLPVAS
GTSTVLGSSSGGALNFTVGGSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQAP
SLQHGMVGPLHSSLAASALSQMMSYQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQPA
NIQQQQSLQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQE
SPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQW
SSSSPHSNVSDWSEGVSSPPTSMQSQIARIPEAFK
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
NOTCH family
Subcellular location
Nucleus; Cell membrane
Function
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
TTD ID
T07394
Uniprot ID
P46531
DrugMap ID
TTB1STW
Ensemble ID
ENST00000651671.1
HGNC ID
HGNC:7881
ChEMBL ID
CHEMBL2146346

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K185(1.80); K1607(6.40)  LDD3494  [1]
IPM
 Probe Info  		C2168(2.34)  LDD1702  [2]
DBIA
 Probe Info  		C1293(1.14); C1295(1.14)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C1536(0.98)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C1536(1.13)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C1536(1.45)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C1536(1.15)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C1536(1.20)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C1528(0.70); C1536(0.86)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1528(0.68); C1536(0.91)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1528(0.84); C1536(0.91)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C1295(1.08)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C1528(0.46); C1536(0.81)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1528(0.73); C1536(0.86)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1528(0.80); C1536(0.88)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1528(0.99); C1536(1.05)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1528(0.80); C1536(0.92)  LDD0601  [3]
 LDCM0286  AC26 HEK-293T C1295(1.07)  LDD1525  [7]
 LDCM0288  AC28 HEK-293T C2168(0.98)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C1304(0.98)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C2168(0.92)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C2168(1.01); C1304(0.92)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C2168(0.96)  LDD1532  [7]
 LDCM0295  AC34 HEK-293T C1295(1.12)  LDD1534  [7]
 LDCM0297  AC36 HEK-293T C2168(0.95)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C1304(0.89)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C2168(0.95)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C2168(0.91); C1304(0.86)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C2168(1.02)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C2168(0.96)  LDD1541  [7]
 LDCM0304  AC42 HEK-293T C1295(1.06)  LDD1543  [7]
 LDCM0306  AC44 HEK-293T C2168(1.02)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C1304(0.91)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C2168(0.97)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C2168(1.01); C1304(0.86)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C2168(1.00)  LDD1549  [7]
 LDCM0312  AC5 HEK-293T C1304(0.88)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C1295(1.05)  LDD1552  [7]
 LDCM0315  AC52 HEK-293T C2168(1.04)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C1304(0.97)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C2168(0.93)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C2168(0.97); C1304(0.85)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C2168(0.96)  LDD1558  [7]
 LDCM0320  AC57 HCT 116 C1528(0.78); C1536(0.78)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1528(0.72); C1536(0.72)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1528(1.07); C1536(1.07)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C1536(1.13)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C1528(0.87); C1536(0.87)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1528(0.69); C1536(0.69)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1528(0.96); C1536(0.96)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1528(0.76); C1536(0.76)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1528(0.87); C1536(0.87)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1528(0.80); C1536(0.80)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1528(0.81); C1536(0.81)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1528(0.77); C1536(0.77)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1528(0.93); C1536(0.93)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1528(0.84); C1536(0.84)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1536(1.08)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C1528(0.90); C1536(0.90)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1528(0.81); C1536(0.81)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1528(0.79); C1536(0.79)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1528(0.90); C1536(0.90)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1528(0.95); C1536(0.95)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1528(1.04); C1536(1.04)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1528(1.05); C1536(1.05)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1528(0.90); C1536(0.90)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1528(0.80); C1536(0.80)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1528(0.78); C1536(0.78)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C1536(1.19)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C1528(0.86); C1536(0.86)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1528(1.05); C1536(1.05)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1528(1.16); C1536(1.16)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1528(1.45); C1536(1.45)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1528(1.45); C1536(1.45)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1528(1.11); C1536(1.11)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1528(1.12); C1536(1.12)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1528(0.94); C1536(0.94)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1528(1.31); C1536(1.31)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1528(1.24); C1536(1.24)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1528(1.15); C1536(1.15)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1528(1.47); C1536(1.47)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1528(1.50); C1536(1.50)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1528(1.28); C1536(1.28)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1528(1.27); C1536(1.27)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1528(0.84); C1536(0.84)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1528(1.41); C1536(1.41)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1528(1.52); C1536(1.52)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C1536(1.15)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1536(1.17)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1536(1.04)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C1293(1.14); C1295(1.14)  LDD0078  [3]
 LDCM0368  CL10 HEK-293T C2168(0.93)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C1284(0.82)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C1536(1.19)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1536(1.13)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1536(1.17)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1536(1.00)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1536(0.96); C1528(0.99)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1536(0.91); C1528(1.01)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1528(0.94); C1536(0.98)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1528(1.08); C1536(1.10)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1528(0.90); C1536(1.03)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C2168(0.94); C1304(1.18)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C1536(1.24); C1528(1.30)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1536(1.21); C1528(1.28)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C1284(0.94)  LDD1586  [7]
 LDCM0386  CL116 HEK-293T C1284(0.97)  LDD1590  [7]
 LDCM0390  CL12 HEK-293T C2168(0.95)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C1284(0.93)  LDD1595  [7]
 LDCM0395  CL124 HEK-293T C1284(0.87)  LDD1599  [7]
 LDCM0396  CL125 HCT 116 C1528(0.90); C1536(0.90)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C1528(1.00); C1536(1.00)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1528(0.97); C1536(0.97)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1528(0.94); C1536(0.94)  LDD0716  [3]
 LDCM0403  CL16 HEK-293T C1284(0.96)  LDD1607  [7]
 LDCM0405  CL18 HEK-293T C1295(1.18)  LDD1609  [7]
 LDCM0408  CL20 HEK-293T C2168(0.98)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C1304(1.10)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C2168(1.00)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C2168(0.98); C1304(1.32)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C2168(0.98)  LDD1616  [7]
 LDCM0416  CL28 HEK-293T C1284(0.98)  LDD1620  [7]
 LDCM0419  CL30 HEK-293T C1295(0.89)  LDD1623  [7]
 LDCM0421  CL32 HEK-293T C2168(1.00)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C1304(1.17)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C2168(1.01)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C2168(1.10); C1304(1.70)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C2168(0.98)  LDD1629  [7]
 LDCM0429  CL4 HEK-293T C1284(0.90)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C1284(0.87)  LDD1634  [7]
 LDCM0432  CL42 HEK-293T C1295(1.06)  LDD1636  [7]
 LDCM0434  CL44 HEK-293T C2168(1.10)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C1304(0.53)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C2168(1.05)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C2168(1.01); C1304(1.64)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C2168(0.99)  LDD1642  [7]
 LDCM0443  CL52 HEK-293T C1284(0.85)  LDD1646  [7]
 LDCM0445  CL54 HEK-293T C1295(0.97)  LDD1648  [7]
 LDCM0447  CL56 HEK-293T C2168(1.09)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C1304(1.08)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C2168(1.00)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C2168(1.09); C1304(1.30)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C1295(1.07)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C2168(0.97)  LDD1655  [7]
 LDCM0456  CL64 HEK-293T C1284(0.88)  LDD1659  [7]
 LDCM0458  CL66 HEK-293T C1295(1.10)  LDD1661  [7]
 LDCM0460  CL68 HEK-293T C2168(0.99)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C1304(1.18)  LDD1664  [7]
 LDCM0463  CL70 HEK-293T C2168(1.09)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C2168(1.05); C1304(1.36)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C2168(0.99)  LDD1668  [7]
 LDCM0469  CL76 HCT 116 C1528(0.58); C1536(0.58)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1528(0.96); C1536(0.96)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1528(0.84); C1536(0.84)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1528(0.96); C1536(0.96)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C2168(0.98)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C1528(0.72); C1536(0.72)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1528(0.86); C1536(0.86)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1528(0.78); C1536(0.78)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1528(0.96); C1536(0.96)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1528(1.13); C1536(1.13)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1528(1.03); C1536(1.03)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1528(0.92); C1536(0.92)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1528(0.67); C1536(0.67)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1528(0.87); C1536(0.87)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1528(1.12); C1536(1.12)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C1304(1.12)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C1528(1.53); C1536(1.53)  LDD0802  [3]
 LDCM0487  CL92 HEK-293T C2168(1.01)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C1304(0.98)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C2168(1.02)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C2168(1.08); C1304(0.97)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C2168(1.01)  LDD1694  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C2168(2.34)  LDD1702  [2]
 LDCM0022  KB02 HCT 116 C2168(2.06)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C2168(1.31)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C2168(1.87)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C1357(1.15); C1363(1.15); C2168(1.00); C1293(1.06)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
F-box/WD repeat-containing protein 7 (FBXW7) . Q969H0
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neurogenic locus notch homolog protein 1 (NOTCH1) NOTCH family P46531
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Recombining binding protein suppressor of hairless (RBPJ) Su(H) family Q06330
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Nuclear factor NF-kappa-B p105 subunit (NFKB1) . P19838
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) . Q8N423
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mastermind-like protein 1 (MAML1) Mastermind family Q92585
Mastermind-like protein 2 (MAML2) Mastermind family Q8IZL2
Mastermind-like protein 3 (MAML3) Mastermind family Q96JK9
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Protein jagged-1 (JAG1) . P78504

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ly3039478 Small molecular drug D08WOW
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Omp-52m51 Antibody D0X3YY

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402