Details of the Target

General Information of Target

Target ID LDTP04022
Target Name Carnitine O-acetyltransferase (CRAT)
Gene Name CRAT
Gene ID 1384
Synonyms
CAT1; Carnitine O-acetyltransferase; Carnitine acetylase; EC 2.3.1.137; EC 2.3.1.7; Carnitine acetyltransferase; CAT; CrAT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLAFAARTVVKPLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSE
EEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSP
GVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSC
RVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSS
LQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVY
RSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPPIVTLLDYVIE
YTKKPELVRSPLVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKD
FPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVK
AMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMD
TSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNA
ARLAHYLEKALLDMRALLQSHPRAKL
Target Type
Discontinued
Target Bioclass
Enzyme
Family
Carnitine/choline acetyltransferase family
Subcellular location
Endoplasmic reticulum; Mitochondrion; Peroxisome
Function
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates.
TTD ID
T45074
Uniprot ID
P43155
DrugMap ID
TTC8M31
Ensemble ID
ENST00000318080.7
HGNC ID
HGNC:2342
ChEMBL ID
CHEMBL3184

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.E394K DBIA    Probe Info 
HCC1395 SNV: p.Y209C .
HCT116 Deletion: p.M581WfsTer89 DBIA    Probe Info 
JURKAT Deletion: p.R623GfsTer47
SNV: p.M614I		 .
LNCaP clone FGC SNV: p.P376L; p.K559N DBIA    Probe Info 
PF382 SNV: p.T326A .
RKO SNV: p.A600V .
TOV21G SNV: p.G319C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y606(20.00)  LDD0260  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
HHS-475
 Probe Info  		Y606(0.52)  LDD0264  [3]
DBIA
 Probe Info  		C169(1.85); C180(1.85)  LDD0533  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [7]
SF
 Probe Info  		N.A.  LDD0028  [8]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Crotonaldehyde
 Probe Info  		C449(0.00); H31(0.00)  LDD0219  [10]
HHS-465
 Probe Info  		N.A.  LDD2240  [11]
HHS-482
 Probe Info  		Y606(0.20)  LDD2239  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C287(1.32)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C449(1.21); C169(0.97)  LDD1508  [13]
 LDCM0216  AC100 HCT 116 C169(1.85); C180(1.85)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C169(1.87); C180(1.87)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C169(1.38); C180(1.38)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C169(1.84); C180(1.84)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C169(1.71); C180(1.71)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C169(1.96); C180(1.96)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C169(2.16); C180(2.16)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C169(2.32); C180(2.32)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C169(1.60); C180(1.60)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C169(1.42); C180(1.42)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C449(0.90); C169(1.11)  LDD1509  [13]
 LDCM0227  AC110 HCT 116 C169(1.55); C180(1.55)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C169(2.12); C180(2.12)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C169(1.60); C180(1.60)  LDD0546  [4]
 LDCM0237  AC12 HEK-293T C449(0.96)  LDD1510  [13]
 LDCM0246  AC128 HCT 116 C169(1.09); C180(1.09)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C169(1.46); C180(1.46)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C169(1.59); C180(1.59)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C169(1.27); C180(1.27)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C169(2.01); C180(2.01)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C169(1.48); C180(1.48)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C169(1.33); C180(1.33)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C169(1.66); C180(1.66)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C169(1.41); C180(1.41)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C169(1.65); C180(1.65)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C169(1.48); C180(1.48)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C169(2.03); C180(2.03)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C287(1.17); C169(1.00)  LDD1512  [13]
 LDCM0260  AC140 HCT 116 C169(1.78); C180(1.78)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C169(1.79); C180(1.79)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C169(1.51); C180(1.51)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C169(1.02); C180(1.02)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C169(1.10); C180(1.10)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C169(0.93); C180(0.93)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C169(1.00); C180(1.00)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C169(0.97); C180(0.97)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C169(0.89); C180(0.89)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C169(1.03); C180(1.03)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C287(0.94); C449(1.06); C169(1.10)  LDD1513  [13]
 LDCM0271  AC150 HCT 116 C169(0.98); C180(0.98)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C169(1.00); C180(1.00)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C169(1.12); C180(1.12)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C169(0.86); C180(0.86)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C169(0.99); C180(0.99)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C169(0.88); C180(0.88)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C169(1.04); C180(1.04)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C169(0.85); C180(0.85)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C169(0.95); C180(0.95)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C169(1.17); C180(1.17)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C169(0.97); C180(0.97)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C449(0.96); C169(1.06)  LDD1518  [13]
 LDCM0280  AC20 HCT 116 C169(0.87); C180(0.87)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C169(0.91); C180(0.91)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C169(0.88); C180(0.88)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C169(0.77); C180(0.77)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C169(1.05); C180(1.05)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C287(0.97)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C449(1.02); C169(0.83)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C449(1.03); C169(0.88)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C449(0.93)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C449(1.35); C169(0.97)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C449(1.10); C169(0.96)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C287(1.11); C169(0.95)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C287(1.01); C449(0.99); C169(1.12)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C449(1.03); C169(1.03)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C287(1.08)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C449(1.10); C169(0.94)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C449(0.93); C169(1.14)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C449(1.10)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C449(1.13); C169(1.05)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C287(1.29); C169(1.15)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C287(1.07); C449(1.01); C169(1.08)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C449(0.83)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C449(1.23); C169(1.02)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C287(1.13)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C449(0.87); C169(1.02)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C449(0.87); C169(1.00)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C449(0.89)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C449(1.08); C169(0.98)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C287(1.07); C169(1.08)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C287(0.88); C449(0.97); C169(0.92)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C449(0.99); C169(1.08)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C287(1.04)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C449(1.25); C169(0.92)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C449(1.08); C169(1.11)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C449(0.79); C169(0.92)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C449(1.07)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C449(1.05); C169(0.99)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C287(1.12); C169(1.15)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C287(1.13); C449(1.07); C169(0.96)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C449(1.11); C169(0.96)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C287(0.97)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C449(1.10); C169(0.99)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C449(0.98); C169(1.08)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C287(0.80); C169(1.07)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C449(0.88)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C449(1.04); C169(0.94)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C287(0.81); C169(1.12)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C287(0.99); C449(0.98); C169(0.93)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C449(0.93); C169(1.10)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C287(0.88); C449(0.97); C169(1.09)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C449(1.02); C169(1.01)  LDD1569  [13]
 LDCM0349  AC83 HCT 116 C169(0.98); C180(0.98)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C169(1.12); C180(1.12)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C169(0.88); C180(0.88)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C169(1.03); C180(1.03)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C169(0.85); C180(0.85)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C169(0.91); C180(0.91)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C169(0.86); C180(0.86)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C169(0.88); C180(0.88)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C169(0.86); C180(0.86)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C169(0.96); C180(0.96)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C169(0.86); C180(0.86)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C169(0.95); C180(0.95)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C169(0.95); C180(0.95)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C169(1.04); C180(1.04)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C169(0.98); C180(0.98)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C169(1.55); C180(1.55)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C169(2.01); C180(2.01)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C449(1.03); C169(1.13)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C287(1.06)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C449(0.96); C169(1.03)  LDD1514  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C287(0.89); C169(1.00)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C287(1.38); C169(0.66)  LDD1572  [13]
 LDCM0370  CL101 HEK-293T C287(0.90); C169(1.14)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C287(1.18); C449(0.76); C169(0.94)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C287(0.95)  LDD1576  [13]
 LDCM0374  CL105 HCT 116 C169(0.84); C180(0.84)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C169(0.82); C180(0.82)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C169(0.82); C180(0.82)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C169(0.82); C180(0.82)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C169(1.13); C180(1.13)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C287(1.23); C449(1.21); C169(1.11)  LDD1583  [13]
 LDCM0380  CL110 HCT 116 C169(0.96); C180(0.96)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C169(1.00); C180(1.00)  LDD0698  [4]
 LDCM0383  CL113 HEK-293T C287(1.02); C169(0.97)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C287(1.18); C449(0.85); C169(0.80)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C287(0.94)  LDD1589  [13]
 LDCM0387  CL117 HEK-293T C287(1.28); C169(1.16)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C287(1.46); C449(0.77); C169(0.81)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C287(1.08)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C449(1.35); C169(0.83)  LDD1594  [13]
 LDCM0392  CL121 HEK-293T C287(1.01); C169(1.16)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C287(0.96); C449(0.68); C169(0.80)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C287(1.25)  LDD1598  [13]
 LDCM0396  CL125 HEK-293T C287(1.13); C169(1.10)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C287(1.03); C449(0.64); C169(0.73)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C287(0.94)  LDD1602  [13]
 LDCM0400  CL13 HEK-293T C287(0.95); C169(1.19)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C287(1.09); C449(0.71); C169(0.82)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C287(0.79)  LDD1606  [13]
 LDCM0404  CL17 HCT 116 C169(1.30); C180(1.30)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C169(0.88); C180(0.88)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C169(1.10); C180(1.10)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C287(0.98); C449(1.28); C169(0.59)  LDD1611  [13]
 LDCM0408  CL20 HCT 116 C169(0.95); C180(0.95)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C169(1.52); C180(1.52)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C169(1.16); C180(1.16)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C169(0.78); C180(0.78)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C169(0.98); C180(0.98)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C169(1.14); C180(1.14)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C169(0.85); C180(0.85)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C169(1.07); C180(1.07)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C169(1.07); C180(1.07)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C169(1.19); C180(1.19)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C287(0.81)  LDD1622  [13]
 LDCM0419  CL30 HCT 116 C169(1.13); C180(1.13)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C169(0.91); C180(0.91)  LDD0737  [4]
 LDCM0421  CL32 HEK-293T C449(1.19)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C449(1.08); C169(0.71)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C287(1.03); C169(0.68)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C287(0.97); C449(1.21); C169(0.90)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C449(0.89); C169(0.68)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C287(1.05); C169(1.04)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C287(1.03)  LDD1632  [13]
 LDCM0431  CL41 HEK-293T C287(1.01)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C449(0.89); C169(1.15)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C449(1.04); C169(1.06)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C449(0.97)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C449(1.05); C169(0.82)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C180(1.16)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C180(1.21)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C180(0.80)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C180(1.53)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C287(1.14)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C180(3.38)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C180(1.33)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C180(0.93)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C180(1.08)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C180(1.18)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C180(1.36)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C180(0.94)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C180(1.10)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C180(0.96)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C180(1.43)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C449(1.14); C169(0.94)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C180(1.85)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C287(1.25); C169(1.10)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C287(1.14); C449(1.11); C169(0.91)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C287(0.90)  LDD1658  [13]
 LDCM0457  CL65 HEK-293T C287(1.11)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C449(0.94); C169(1.04)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C449(0.98); C169(1.02)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C449(0.93)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C449(1.17); C169(0.82)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C449(1.01); C169(0.98)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C287(1.17); C169(0.77)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C287(1.06); C449(0.95); C169(1.04)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C449(1.16); C169(0.81)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C287(0.87); C169(1.02)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C287(1.17); C449(0.75); C169(1.01)  LDD1670  [13]
 LDCM0470  CL77 HEK-293T C287(1.10)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C449(0.89); C169(1.04)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C449(1.26); C169(1.00)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C449(0.62)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C449(1.04)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C449(1.15); C169(0.83)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C287(1.25); C169(0.82)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C287(1.29); C449(1.02); C169(1.30)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C449(0.78); C169(0.90)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C287(1.26); C169(1.20)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C287(1.11); C449(0.95); C169(0.72)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C287(0.98)  LDD1684  [13]
 LDCM0483  CL89 HEK-293T C287(1.32)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C449(1.23); C169(0.78)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C449(0.79); C169(1.05)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C449(1.28); C169(0.96)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C449(0.83)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C449(1.03); C169(0.80)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C287(1.32); C169(0.92)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C287(0.94); C449(0.89); C169(0.84)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C449(1.34); C169(1.06)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C287(0.97); C169(1.02)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C287(0.89); C449(0.82); C169(0.83)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C287(0.88)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C287(1.15)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C287(1.15)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C287(0.99); C449(0.93); C169(0.75)  LDD1631  [13]
 LDCM0116  HHS-0101 DM93 Y606(0.52)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y606(0.64)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y606(0.61)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y606(0.70)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y606(0.45)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C287(0.84); C449(1.09)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C287(0.96); C449(1.04)  LDD1497  [13]
 LDCM0024  KB05 HMCB C287(1.56)  LDD3312  [14]
 LDCM0109  NEM HeLa H65(0.00); H31(0.00)  LDD0223  [10]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Levocarnitine Small molecular drug DB00583
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coenzyme A Small molecular drug D0W3NA
(3-carboxy-2-(R)-hydroxy-propyl)-trimethyl-ammonium . DB02648
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Teglicar Small molecular drug D01FCK
Lxr-015-2 . D0LR2Q

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840