Details of the Target

General Information of Target

Target ID LDTP03573
Target Name Coronin-1A (CORO1A)
Gene Name CORO1A
Gene ID 11151
Synonyms
CORO1; Coronin-1A; Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFL
VLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPL
REPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIY
SVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFS
RMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSE
APFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQ
EDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRRRAAPE
ASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK
Target Bioclass
Other
Family
WD repeat coronin family
Subcellular location
Cytoplasm, cytoskeleton
Function
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Uniprot ID
P31146
Ensemble ID
ENST00000219150.10
HGNC ID
HGNC:2252
ChEMBL ID
CHEMBL5169128

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y321(20.00); Y283(14.17); Y294(11.46); Y396(10.40)  LDD0260  [1]
STPyne
 Probe Info  		K253(7.01); K439(8.18); K449(8.60); K355(14.04)  LDD2218  [2]
Probe 1
 Probe Info  		Y25(22.08)  LDD3495  [3]
DBIA
 Probe Info  		C40(1.51)  LDD3310  [4]
BTD
 Probe Info  		C332(0.46)  LDD2089  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C24(0.00); C345(0.00); C192(0.00); C195(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C24(0.00); C345(0.00); C192(0.00); C195(0.00)  LDD0036  [7]
IPIAA_H
 Probe Info  		C192(0.00); C345(0.00); C332(0.00); C40(0.00)  LDD0030  [8]
IPIAA_L
 Probe Info  		C345(0.00); C24(0.00); C40(0.00); C285(0.00)  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C24(0.00); C345(0.00); C192(0.00); C195(0.00)  LDD0037  [7]
2PCA
 Probe Info  		N.A.  LDD0034  [9]
Compound 10
 Probe Info  		C195(0.00); C24(0.00); C345(0.00); C40(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		C195(0.00); C24(0.00); C345(0.00); C40(0.00)  LDD2213  [10]
NAIA_5
 Probe Info  		C24(0.00); C345(0.00); C332(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C195(0.96)  LDD0813  [13]
 LDCM0226  AC11 HEK-293T C195(1.06)  LDD0824  [13]
 LDCM0230  AC113 HEK-293T C195(0.77)  LDD0828  [13]
 LDCM0231  AC114 HEK-293T C195(0.95)  LDD0829  [13]
 LDCM0232  AC115 HEK-293T C195(1.45)  LDD0830  [13]
 LDCM0233  AC116 HEK-293T C195(1.42)  LDD0831  [13]
 LDCM0234  AC117 HEK-293T C195(0.89)  LDD0832  [13]
 LDCM0235  AC118 HEK-293T C195(1.31)  LDD0833  [13]
 LDCM0236  AC119 HEK-293T C195(1.30)  LDD0834  [13]
 LDCM0237  AC12 HEK-293T C195(1.07)  LDD0835  [13]
 LDCM0238  AC120 HEK-293T C195(1.02)  LDD0836  [13]
 LDCM0239  AC121 HEK-293T C195(1.17)  LDD0837  [13]
 LDCM0240  AC122 HEK-293T C195(1.58)  LDD0838  [13]
 LDCM0241  AC123 HEK-293T C195(1.61)  LDD0839  [13]
 LDCM0242  AC124 HEK-293T C195(1.24)  LDD0840  [13]
 LDCM0243  AC125 HEK-293T C195(1.71)  LDD0841  [13]
 LDCM0244  AC126 HEK-293T C195(1.44)  LDD0842  [13]
 LDCM0245  AC127 HEK-293T C195(1.79)  LDD0843  [13]
 LDCM0259  AC14 HEK-293T C195(0.95)  LDD0857  [13]
 LDCM0263  AC143 HEK-293T C195(0.78)  LDD0861  [13]
 LDCM0264  AC144 HEK-293T C195(0.73)  LDD0862  [13]
 LDCM0265  AC145 HEK-293T C195(0.88)  LDD0863  [13]
 LDCM0266  AC146 HEK-293T C195(1.28)  LDD0864  [13]
 LDCM0267  AC147 HEK-293T C195(0.79)  LDD0865  [13]
 LDCM0268  AC148 HEK-293T C195(0.99)  LDD0866  [13]
 LDCM0269  AC149 HEK-293T C195(0.69)  LDD0867  [13]
 LDCM0270  AC15 HEK-293T C195(0.98)  LDD0868  [13]
 LDCM0271  AC150 HEK-293T C195(0.75)  LDD0869  [13]
 LDCM0272  AC151 HEK-293T C195(0.90)  LDD0870  [13]
 LDCM0273  AC152 HEK-293T C195(0.82)  LDD0871  [13]
 LDCM0274  AC153 HEK-293T C195(0.89)  LDD0872  [13]
 LDCM0621  AC154 HEK-293T C195(0.90)  LDD2162  [13]
 LDCM0622  AC155 HEK-293T C195(0.91)  LDD2163  [13]
 LDCM0623  AC156 HEK-293T C195(1.11)  LDD2164  [13]
 LDCM0624  AC157 HEK-293T C195(1.38)  LDD2165  [13]
 LDCM0278  AC19 HEK-293T C24(0.80)  LDD1517  [14]
 LDCM0282  AC22 HEK-293T C285(0.71)  LDD1521  [14]
 LDCM0285  AC25 HEK-293T C195(1.51)  LDD0883  [13]
 LDCM0286  AC26 HEK-293T C195(1.49)  LDD0884  [13]
 LDCM0287  AC27 HEK-293T C195(1.43)  LDD0885  [13]
 LDCM0288  AC28 HEK-293T C195(1.30)  LDD0886  [13]
 LDCM0289  AC29 HEK-293T C195(1.48)  LDD0887  [13]
 LDCM0290  AC3 HEK-293T C24(1.14)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C195(1.52)  LDD0889  [13]
 LDCM0292  AC31 HEK-293T C195(1.65)  LDD0890  [13]
 LDCM0293  AC32 HEK-293T C195(1.32)  LDD0891  [13]
 LDCM0294  AC33 HEK-293T C195(2.03)  LDD0892  [13]
 LDCM0295  AC34 HEK-293T C195(1.82)  LDD0893  [13]
 LDCM0296  AC35 HEK-293T C24(0.85)  LDD1535  [14]
 LDCM0299  AC38 HEK-293T C285(1.12)  LDD1538  [14]
 LDCM0305  AC43 HEK-293T C24(1.10)  LDD1544  [14]
 LDCM0308  AC46 HEK-293T C195(0.88)  LDD0906  [13]
 LDCM0309  AC47 HEK-293T C195(0.92)  LDD0907  [13]
 LDCM0310  AC48 HEK-293T C195(1.19)  LDD0908  [13]
 LDCM0311  AC49 HEK-293T C195(1.31)  LDD0909  [13]
 LDCM0313  AC50 HEK-293T C195(0.90)  LDD0911  [13]
 LDCM0314  AC51 HEK-293T C195(1.15)  LDD0912  [13]
 LDCM0315  AC52 HEK-293T C195(1.24)  LDD0913  [13]
 LDCM0316  AC53 HEK-293T C195(1.21)  LDD0914  [13]
 LDCM0317  AC54 HEK-293T C195(1.29)  LDD0915  [13]
 LDCM0318  AC55 HEK-293T C195(1.00)  LDD0916  [13]
 LDCM0319  AC56 HEK-293T C195(0.96)  LDD0917  [13]
 LDCM0322  AC59 HEK-293T C24(1.05)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C195(1.05)  LDD0921  [13]
 LDCM0326  AC62 HEK-293T C285(1.48)  LDD1565  [14]
 LDCM0332  AC68 HEK-293T C195(2.31)  LDD0930  [13]
 LDCM0333  AC69 HEK-293T C195(0.89)  LDD0931  [13]
 LDCM0334  AC7 HEK-293T C195(1.13)  LDD0932  [13]
 LDCM0335  AC70 HEK-293T C195(2.05)  LDD0933  [13]
 LDCM0336  AC71 HEK-293T C195(1.08)  LDD0934  [13]
 LDCM0337  AC72 HEK-293T C195(1.08)  LDD0935  [13]
 LDCM0338  AC73 HEK-293T C195(2.18)  LDD0936  [13]
 LDCM0339  AC74 HEK-293T C195(1.64)  LDD0937  [13]
 LDCM0340  AC75 HEK-293T C195(2.62)  LDD0938  [13]
 LDCM0341  AC76 HEK-293T C195(0.94)  LDD0939  [13]
 LDCM0342  AC77 HEK-293T C195(1.26)  LDD0940  [13]
 LDCM0343  AC78 HEK-293T C195(1.91)  LDD0941  [13]
 LDCM0344  AC79 HEK-293T C195(1.21)  LDD0942  [13]
 LDCM0345  AC8 HEK-293T C195(1.74)  LDD0943  [13]
 LDCM0346  AC80 HEK-293T C195(1.81)  LDD0944  [13]
 LDCM0347  AC81 HEK-293T C195(1.59)  LDD0945  [13]
 LDCM0348  AC82 HEK-293T C195(1.85)  LDD0946  [13]
 LDCM0349  AC83 HEK-293T C24(0.85)  LDD0947  [13]
 LDCM0350  AC84 HEK-293T C24(0.49)  LDD0948  [13]
 LDCM0351  AC85 HEK-293T C24(0.85)  LDD0949  [13]
 LDCM0352  AC86 HEK-293T C24(0.67)  LDD0950  [13]
 LDCM0353  AC87 HEK-293T C24(0.73)  LDD0951  [13]
 LDCM0354  AC88 HEK-293T C24(0.63)  LDD0952  [13]
 LDCM0355  AC89 HEK-293T C24(0.37)  LDD0953  [13]
 LDCM0357  AC90 HEK-293T C24(0.46)  LDD0955  [13]
 LDCM0358  AC91 HEK-293T C24(0.49)  LDD0956  [13]
 LDCM0359  AC92 HEK-293T C24(0.66)  LDD0957  [13]
 LDCM0360  AC93 HEK-293T C24(0.86)  LDD0958  [13]
 LDCM0361  AC94 HEK-293T C24(0.37)  LDD0959  [13]
 LDCM0362  AC95 HEK-293T C24(0.47)  LDD0960  [13]
 LDCM0363  AC96 HEK-293T C24(5.00)  LDD0961  [13]
 LDCM0364  AC97 HEK-293T C24(0.09)  LDD0962  [13]
 LDCM0248  AKOS034007472 HEK-293T C195(1.07)  LDD0846  [13]
 LDCM0356  AKOS034007680 HEK-293T C195(1.11)  LDD0954  [13]
 LDCM0275  AKOS034007705 HEK-293T C195(1.36)  LDD0873  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C195(0.83); C24(1.50)  LDD0965  [13]
 LDCM0368  CL10 HEK-293T C195(1.91); C24(0.20)  LDD0966  [13]
 LDCM0370  CL101 HEK-293T C195(1.26)  LDD0968  [13]
 LDCM0371  CL102 HEK-293T C195(1.27)  LDD0969  [13]
 LDCM0372  CL103 HEK-293T C195(1.39)  LDD0970  [13]
 LDCM0373  CL104 HEK-293T C195(1.24)  LDD0971  [13]
 LDCM0374  CL105 HEK-293T C24(0.90)  LDD1578  [14]
 LDCM0378  CL109 HEK-293T C24(1.15)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C195(1.53); C24(0.22)  LDD0977  [13]
 LDCM0382  CL112 HEK-293T C195(1.87)  LDD0980  [13]
 LDCM0383  CL113 HEK-293T C195(1.53)  LDD0981  [13]
 LDCM0384  CL114 HEK-293T C195(1.94)  LDD0982  [13]
 LDCM0385  CL115 HEK-293T C195(1.86)  LDD0983  [13]
 LDCM0386  CL116 HEK-293T C195(1.79)  LDD0984  [13]
 LDCM0387  CL117 HEK-293T C24(0.78)  LDD1591  [14]
 LDCM0390  CL12 HEK-293T C195(1.10); C24(1.83)  LDD0988  [13]
 LDCM0392  CL121 HEK-293T C195(1.21)  LDD0990  [13]
 LDCM0393  CL122 HEK-293T C195(1.08)  LDD0991  [13]
 LDCM0394  CL123 HEK-293T C195(0.87)  LDD0992  [13]
 LDCM0395  CL124 HEK-293T C195(1.05)  LDD0993  [13]
 LDCM0396  CL125 HEK-293T C24(1.08)  LDD1600  [14]
 LDCM0400  CL13 HEK-293T C195(1.12); C24(1.28)  LDD0998  [13]
 LDCM0401  CL14 HEK-293T C195(1.16); C24(1.31)  LDD0999  [13]
 LDCM0402  CL15 HEK-293T C195(1.24); C24(0.65)  LDD1000  [13]
 LDCM0403  CL16 HEK-293T C24(0.71)  LDD1001  [13]
 LDCM0404  CL17 HEK-293T C24(0.59)  LDD1002  [13]
 LDCM0405  CL18 HEK-293T C24(0.40)  LDD1003  [13]
 LDCM0406  CL19 HEK-293T C24(0.71)  LDD1004  [13]
 LDCM0407  CL2 HEK-293T C195(1.16); C24(1.23)  LDD1005  [13]
 LDCM0408  CL20 HEK-293T C24(0.57)  LDD1006  [13]
 LDCM0409  CL21 HEK-293T C24(0.38)  LDD1007  [13]
 LDCM0410  CL22 HEK-293T C24(0.39)  LDD1008  [13]
 LDCM0411  CL23 HEK-293T C24(0.51)  LDD1009  [13]
 LDCM0412  CL24 HEK-293T C24(0.80)  LDD1010  [13]
 LDCM0413  CL25 HEK-293T C24(0.45)  LDD1011  [13]
 LDCM0414  CL26 HEK-293T C24(0.78)  LDD1012  [13]
 LDCM0415  CL27 HEK-293T C24(0.65)  LDD1013  [13]
 LDCM0416  CL28 HEK-293T C24(0.48)  LDD1014  [13]
 LDCM0417  CL29 HEK-293T C24(0.66)  LDD1015  [13]
 LDCM0418  CL3 HEK-293T C195(1.61); C24(1.44)  LDD1016  [13]
 LDCM0419  CL30 HEK-293T C24(0.19)  LDD1017  [13]
 LDCM0420  CL31 HEK-293T C195(1.19); C24(1.92)  LDD1018  [13]
 LDCM0421  CL32 HEK-293T C195(1.21); C24(1.02)  LDD1019  [13]
 LDCM0422  CL33 HEK-293T C195(1.00); C24(1.32)  LDD1020  [13]
 LDCM0423  CL34 HEK-293T C195(0.92); C24(0.65)  LDD1021  [13]
 LDCM0424  CL35 HEK-293T C195(1.25); C24(1.11)  LDD1022  [13]
 LDCM0425  CL36 HEK-293T C195(1.13); C24(0.90)  LDD1023  [13]
 LDCM0426  CL37 HEK-293T C195(1.09); C24(1.14)  LDD1024  [13]
 LDCM0428  CL39 HEK-293T C195(1.36); C24(0.26)  LDD1026  [13]
 LDCM0429  CL4 HEK-293T C195(1.00); C24(0.83)  LDD1027  [13]
 LDCM0430  CL40 HEK-293T C195(1.18); C24(0.77)  LDD1028  [13]
 LDCM0431  CL41 HEK-293T C195(1.33); C24(0.48)  LDD1029  [13]
 LDCM0432  CL42 HEK-293T C195(1.29); C24(0.31)  LDD1030  [13]
 LDCM0433  CL43 HEK-293T C195(1.23); C24(0.38)  LDD1031  [13]
 LDCM0434  CL44 HEK-293T C195(1.30); C24(0.88)  LDD1032  [13]
 LDCM0435  CL45 HEK-293T C195(1.20); C24(0.90)  LDD1033  [13]
 LDCM0436  CL46 HEK-293T C24(0.66)  LDD1034  [13]
 LDCM0437  CL47 HEK-293T C24(0.86)  LDD1035  [13]
 LDCM0438  CL48 HEK-293T C24(1.13)  LDD1036  [13]
 LDCM0439  CL49 HEK-293T C24(0.77)  LDD1037  [13]
 LDCM0440  CL5 HEK-293T C195(1.43); C24(1.17)  LDD1038  [13]
 LDCM0441  CL50 HEK-293T C24(0.27)  LDD1039  [13]
 LDCM0442  CL51 HEK-293T C24(0.83)  LDD1040  [13]
 LDCM0443  CL52 HEK-293T C24(0.86)  LDD1041  [13]
 LDCM0444  CL53 HEK-293T C24(0.93)  LDD1042  [13]
 LDCM0445  CL54 HEK-293T C24(0.79)  LDD1043  [13]
 LDCM0446  CL55 HEK-293T C24(0.75)  LDD1044  [13]
 LDCM0447  CL56 HEK-293T C24(0.88)  LDD1045  [13]
 LDCM0448  CL57 HEK-293T C24(1.08)  LDD1046  [13]
 LDCM0449  CL58 HEK-293T C24(1.21)  LDD1047  [13]
 LDCM0450  CL59 HEK-293T C24(0.51)  LDD1048  [13]
 LDCM0451  CL6 HEK-293T C195(0.96); C24(1.07)  LDD1049  [13]
 LDCM0452  CL60 HEK-293T C24(0.29)  LDD1050  [13]
 LDCM0453  CL61 HEK-293T C195(2.02); C24(0.85)  LDD1051  [13]
 LDCM0454  CL62 HEK-293T C195(0.82); C24(0.62)  LDD1052  [13]
 LDCM0455  CL63 HEK-293T C195(1.26); C24(0.62)  LDD1053  [13]
 LDCM0456  CL64 HEK-293T C195(1.13); C24(1.36)  LDD1054  [13]
 LDCM0457  CL65 HEK-293T C195(1.21); C24(0.73)  LDD1055  [13]
 LDCM0458  CL66 HEK-293T C195(0.88); C24(0.69)  LDD1056  [13]
 LDCM0459  CL67 HEK-293T C195(0.87); C24(1.25)  LDD1057  [13]
 LDCM0460  CL68 HEK-293T C195(1.14); C24(1.02)  LDD1058  [13]
 LDCM0461  CL69 HEK-293T C195(1.08); C24(0.63)  LDD1059  [13]
 LDCM0462  CL7 HEK-293T C195(1.76); C24(0.70)  LDD1060  [13]
 LDCM0463  CL70 HEK-293T C195(0.94); C24(0.68)  LDD1061  [13]
 LDCM0464  CL71 HEK-293T C195(1.51); C24(0.75)  LDD1062  [13]
 LDCM0465  CL72 HEK-293T C195(1.49); C24(0.67)  LDD1063  [13]
 LDCM0466  CL73 HEK-293T C195(0.92); C24(0.51)  LDD1064  [13]
 LDCM0467  CL74 HEK-293T C195(1.35); C24(0.18)  LDD1065  [13]
 LDCM0472  CL79 HEK-293T C24(0.86)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C195(0.77); C24(0.21)  LDD1071  [13]
 LDCM0476  CL82 HEK-293T C285(1.51)  LDD1679  [14]
 LDCM0479  CL85 HEK-293T C24(0.82)  LDD1682  [14]
 LDCM0484  CL9 HEK-293T C195(1.02); C24(0.88)  LDD1082  [13]
 LDCM0486  CL91 HEK-293T C24(1.18)  LDD1689  [14]
 LDCM0489  CL94 HEK-293T C285(1.14)  LDD1692  [14]
 LDCM0492  CL97 HEK-293T C24(0.93)  LDD1695  [14]
 LDCM0625  F8 Ramos C24(0.75); C345(0.82); C40(0.65); C332(1.25)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C24(0.66); C345(0.56); C40(0.65); C332(0.41)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C24(0.54); C345(0.05); C40(0.31)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C24(0.71); C345(0.74); C40(0.68); C332(0.62)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C24(1.04); C345(1.15); C40(1.05); C332(0.83)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C24(0.89); C345(0.94); C40(0.84); C332(0.44)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C24(0.59); C345(0.83); C40(0.60); C332(0.46)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C24(1.01); C345(1.05); C40(0.99); C332(0.90)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C24(1.04); C345(2.56); C40(1.17); C332(0.91)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C24(1.08); C345(1.05); C40(1.07); C332(1.07)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C24(0.73); C345(0.69); C40(0.85); C332(0.50)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C24(1.28); C345(1.35); C40(1.08); C332(1.03)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C24(1.07); C345(1.34); C40(1.33); C332(1.04)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C24(0.65); C345(0.85); C40(0.67); C332(0.64)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C195(1.94); C24(1.03)  LDD1066  [13]
 LDCM0596  Fragment38 Ramos C24(1.11); C345(1.05); C40(0.95); C332(0.68)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C24(0.74); C345(0.97); C40(0.73); C332(0.79)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C195(1.10); C24(1.16)  LDD1025  [13]
 LDCM0610  Fragment52 Ramos C24(1.47); C345(1.33); C40(1.06); C332(1.74)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C24(1.36); C345(1.20); C40(1.13); C332(1.04)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C24(0.74); C345(0.55); C40(0.54); C332(0.66)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C24(0.62); C345(0.49); C40(0.65); C332(0.40)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C24(0.67)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C24(0.88)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C40(1.51)  LDD3310  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C332(0.46)  LDD2089  [5]
 LDCM0131  RA190 MM1.R C24(1.37); C192(1.20); C195(1.20); C40(1.11)  LDD0304  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Melanoma-associated antigen 11 (MAGEA11) . P43364

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.