Details of the Target

General Information of Target

Target ID LDTP03430
Target Name Peroxisome biogenesis factor 2 (PEX2)
Gene Name PEX2
Gene ID 5828
Synonyms
PAF1; PMP3; PMP35; PXMP3; RNF72; Peroxisome biogenesis factor 2; EC 2.3.2.27; EC 2.3.2.36; 35 kDa peroxisomal membrane protein; Peroxin-2; Peroxisomal membrane protein 3; Peroxisome assembly factor 1; PAF-1; RING finger protein 72
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRKENAKSANRVLRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACL
WVFLWRFTIYSKNATVGQSVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTIGGRWLEERC
YDLFRNHHLASFGKVKQCVNFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKP
QNICEVGFEYMNRELLWHGFAEFLIFLLPLINVQKLKAKLSSWCIPLTGAPNSDNTLATS
GKECALCGEWPTMPHTIGCEHIFCYFCAKSSFLFDVYFTCPKCGTEVHSLQPLKSGIEMS
EVNAL
Target Bioclass
Enzyme
Family
Pex2/pex10/pex12 family
Subcellular location
Peroxisome membrane
Function
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol. Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70. Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis.
Uniprot ID
P28328
Ensemble ID
ENST00000357039.9
HGNC ID
HGNC:9717

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C178(0.86)  LDD0532  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
AOyne
 Probe Info  		13.60  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C178(1.72); C224(1.34)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C178(0.86)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C224(1.07)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C224(1.13)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C224(1.19)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C224(1.37)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C224(2.01)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C224(0.87)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C224(0.83)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C224(0.97)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C224(0.79)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C224(1.02)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C178(0.85)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C224(1.73)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C224(1.79)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C224(2.20)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C178(1.20)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C178(1.11)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C178(1.30)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C178(1.97)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C178(1.52)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C178(1.59)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C178(1.74)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C178(1.18)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C178(1.79)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C178(1.92)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C178(2.32)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C178(2.41)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C178(1.88)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C178(2.51)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C178(3.43)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C178(3.96)  LDD0843  [1]
 LDCM0259  AC14 HCT 116 C178(0.80)  LDD0576  [1]
 LDCM0263  AC143 HEK-293T C178(0.98)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C178(1.16)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C178(1.36)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C178(1.39)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C178(1.50)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C178(1.62)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C178(0.76)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C178(1.15)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C178(1.09)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C178(1.24)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C178(1.10)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C178(0.98)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C178(0.97)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C178(1.00)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C178(1.30)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C178(1.56)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C224(0.87)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C224(1.09)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C224(1.09)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C178(1.32); C224(1.33)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C224(1.02)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C224(0.99)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C224(1.02)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C224(1.24)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C224(0.99)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C283(1.37); C178(0.83); C224(0.99); C59(0.98)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C283(1.08); C178(0.94); C224(1.06); C59(0.85)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C283(1.04); C178(0.90); C224(1.04); C59(0.82)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C283(1.02); C178(0.93); C224(1.14); C59(0.85)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C283(1.10); C178(0.89); C224(1.04); C59(0.85)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C178(1.23); C224(1.02)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C283(0.98); C178(0.89); C224(1.07); C59(0.70)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C283(1.03); C178(0.92); C224(1.16); C59(0.86)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C283(1.09); C178(0.88); C224(1.03); C59(0.99)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C283(1.16); C178(0.86); C224(0.97); C59(0.82)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C283(1.11); C178(0.96); C224(0.88); C59(1.07)  LDD1534  [6]
 LDCM0296  AC35 HCT 116 C224(0.81); C178(1.01)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C178(0.97); C224(1.10)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C224(0.69); C178(0.88)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C178(0.86); C224(1.09)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C178(0.77); C224(1.16)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C178(1.06); C224(1.18)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C178(0.77); C224(1.17)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C178(0.85); C224(1.57)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C178(0.79); C224(0.88)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C178(0.94); C224(1.38)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C178(0.82); C224(1.19)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C178(0.82); C224(0.98)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C178(1.47)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C178(2.19)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C178(2.28)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C178(1.26)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C178(1.21); C224(1.39)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C178(2.04)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C178(2.42)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C178(1.88)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C178(1.61)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C178(2.48)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C178(2.33)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C178(1.95)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C178(0.84)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C178(1.09)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C178(1.23)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C178(1.05)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C178(1.24)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C178(1.13)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C178(1.24)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C178(1.09)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C178(1.12)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C178(1.15)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C178(1.16)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C178(1.20)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C178(1.37); C224(1.33)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C178(1.40); C224(1.15)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C178(0.86)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C178(1.15); C224(1.38)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C178(1.19); C224(1.29)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C178(1.47); C224(1.39)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C178(1.45); C224(1.64)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C178(1.37); C224(1.62)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C178(1.22); C224(1.32)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C178(1.41); C224(1.22)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C178(1.18); C224(1.38)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C178(1.46); C224(1.47)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C178(1.14); C224(1.24)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C178(1.19)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C178(1.03); C224(1.75)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C178(1.58); C224(1.60)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C178(1.38); C224(1.93)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C178(1.33)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C178(1.64)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C178(1.45)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C178(1.49)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C178(1.31)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C178(1.62)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C178(2.03)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C178(1.31)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C178(1.65)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C178(1.61)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C178(1.31)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C178(1.95)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C178(1.67)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C178(1.62)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C178(3.85)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C224(0.94)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C224(1.14)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C178(0.89)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C178(1.17)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C178(0.93)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C224(0.74)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C224(0.68)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C178(1.46); C224(1.25)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C178(1.01)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C178(0.67)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C178(1.12)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C178(0.97)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C224(1.17)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C224(1.00)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C224(0.94)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C224(1.04)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C224(1.17)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C224(1.01)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C224(1.07)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C224(0.91)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C283(1.00); C178(0.94); C224(0.93); C40(1.08)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C283(0.98); C178(0.91); C224(0.98); C40(1.03)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C178(1.12); C224(1.14); C59(0.94); C40(1.11)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C283(1.05); C178(0.96); C224(0.97); C59(1.06)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C283(1.15); C178(0.94); C224(1.12); C40(1.16)  LDD1590  [6]
 LDCM0387  CL117 HCT 116 C178(0.74); C224(1.09)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C178(0.90); C224(1.51)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C178(0.94); C224(1.10)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C224(1.20)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C178(0.90); C224(1.16)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C178(1.76)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C178(1.69)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C178(2.36)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C178(1.32)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C178(0.98)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C178(0.97)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C178(1.06)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C178(1.01)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C224(0.92)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C224(0.70)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C224(0.90)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C224(1.31)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C224(1.15); C178(1.15)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C178(1.18); C224(1.45)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C178(0.88); C224(0.99)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C224(1.00)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C178(0.97); C224(1.22)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C178(1.11); C224(1.60)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C178(1.04); C224(1.66)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C178(0.83); C224(1.19)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C178(0.88); C224(1.31)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C178(0.94); C224(1.40)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C178(0.86); C224(1.35)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C178(0.81); C224(1.25)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C178(0.88); C224(1.01)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C178(0.93); C224(1.50)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C224(0.95)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C178(1.17); C224(1.07)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C178(0.92)  LDD0737  [1]
 LDCM0421  CL32 HEK-293T C178(0.98)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C178(1.83)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C178(0.95)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C178(1.06)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C178(1.19)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C178(1.24)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C178(2.00)  LDD1026  [1]
 LDCM0429  CL4 HCT 116 C224(1.01)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C178(1.36)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C178(1.95)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C178(1.91)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C178(1.85)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C178(1.40)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C178(1.62)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C178(1.07); C224(0.85)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C178(0.90); C224(1.08)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C178(1.09); C224(0.78)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C178(1.01); C224(0.88)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C224(0.82)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C178(0.96); C224(0.88)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C178(0.84); C224(0.98)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C178(1.17); C224(0.91)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C178(1.13); C224(0.79)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C178(1.00); C224(0.96)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C178(0.97); C224(0.95)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C178(1.05); C224(0.80)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C178(1.01); C224(0.79)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C178(1.02); C224(0.88)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C178(1.04); C224(1.08)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C224(0.73)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C178(0.87); C224(0.87)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C224(1.26)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C224(1.04)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C224(1.25)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C224(1.07)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C224(1.36)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C224(1.04)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C224(0.93)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C224(0.88)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C224(0.80)  LDD1059  [1]
 LDCM0462  CL7 HCT 116 C224(0.97)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C224(1.06)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C224(1.02)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C224(0.88)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C224(0.88)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C224(1.31)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C283(1.02); C178(0.96); C224(1.11); C40(1.06)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C283(1.07); C178(0.95); C224(1.00); C59(1.11)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C283(1.05); C178(0.95); C224(0.81); C59(1.25)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C283(1.21); C178(0.89); C224(0.96); C59(1.15)  LDD1675  [6]
 LDCM0473  CL8 HCT 116 C224(0.89)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C283(1.01); C178(1.00); C224(0.97); C59(1.64)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C283(1.08); C178(1.05); C224(1.06); C59(1.07)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C283(0.98); C178(1.01); C224(1.02); C59(1.59)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C283(0.92); C178(1.13); C224(1.07); C59(1.18)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C283(0.97); C178(1.09); C224(0.98); C59(1.99)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C283(0.99); C178(1.05); C224(0.98); C40(1.24)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C178(0.95); C224(1.13); C59(0.82); C40(1.05)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C283(1.08); C178(1.06); C224(0.78); C59(0.81)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C283(1.02); C178(1.03); C224(1.12); C40(1.07)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C283(1.12); C178(0.89); C224(1.04); C59(0.49)  LDD1686  [6]
 LDCM0484  CL9 HCT 116 C224(0.71)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C283(0.93); C178(1.05); C224(1.13); C59(1.16)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C178(0.76); C224(0.89)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C178(1.33); C224(1.20)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C178(1.01); C224(1.19)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C178(1.18); C224(1.51)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C178(2.34); C224(2.77)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C178(1.47); C224(1.36)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C178(1.12); C224(1.22)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C178(1.00); C224(1.28)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C178(1.16); C224(1.15)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C283(1.02); C178(0.94); C224(0.92); C59(0.77)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C224(1.42)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C178(1.07)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C178(0.95); C224(1.04); C40(0.95)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C178(0.97); C224(1.10); C40(1.02)  LDD1497  [6]
 LDCM0024  KB05 HMCB C283(1.29)  LDD3312  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840