Details of the Target

General Information of Target

Target ID LDTP03344
Target Name Integrin beta-8 (ITGB8)
Gene Name ITGB8
Gene ID 3696
Synonyms
Integrin beta-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCGSALAFFTAAFVCLQNDRRGPASFLWAAWVFSLVLGLGQGEDNRCASSNAASCARCLA
LGPECGWCVQEDFISGGSRSERCDIVSNLISKGCSVDSIEYPSVHVIIPTENEINTQVTP
GEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFF
SRDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKA
VHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIV
VPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKDLLPLLPG
TIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNITAICPDGSRKPGMEGCR
NVTSNDEVLFNVTVTMKKCDVTGGKNYAIIKPIGFNETAKIHIHRNCSCQCEDNRGPKGK
CVDETFLDSKCFQCDENKCHFDEDQFSSESCKSHKDQPVCSGRGVCVCGKCSCHKIKLGK
VYGKYCEKDDFSCPYHHGNLCAGHGECEAGRCQCFSGWEGDRCQCPSAAAQHCVNSKGQV
CSGRGTCVCGRCECTDPRSIGRFCEHCPTCYTACKENWNCMQCLHPHNLSQAILDQCKTS
CALMEQQHYVDQTSECFSSPSYLRIFFIIFIVTFLIGLLKVLIIRQVILQWNSNKIKSSS
DYRVSASKKDKLILQSVCTRAVTYRREKPEEIKMDISKLNAHETFRCNF
Target Type
Clinical trial
Target Bioclass
Other
Family
Integrin beta chain family
Subcellular location
Cell membrane
Function
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis.
TTD ID
T64597
Uniprot ID
P26012
DrugMap ID
TTIF29E
Ensemble ID
ENST00000222573.5
HGNC ID
HGNC:6163
ChEMBL ID
CHEMBL3430892

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.C218Y .
HEC1 SNV: p.L261F DBIA    Probe Info 
HEC1B SNV: p.L261F .
HS936T SNV: p.A56V .
HT115 SNV: p.D334N; p.F686V .
Ishikawa (Heraklio) 02 ER SNV: p.V300A .
LS180 SNV: p.I685M .
MFE319 SNV: p.C593R DBIA    Probe Info 
MIAPACA2 SNV: p.I752K .
NALM6 Deletion: p.F9LfsTer81 .
SW1271 SNV: p.R604G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K176(0.43); K515(1.07)  LDD3494  [1]
DBIA
 Probe Info  		C601(1.96); C738(4.76)  LDD3332  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Acrolein
 Probe Info  		C526(0.00); C528(0.00)  LDD0217  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C607(0.99); C612(0.88)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C607(1.09)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C607(1.12)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C607(0.92)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C607(1.02)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C607(1.10)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C607(0.99)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C607(0.92)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C607(0.96)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C607(1.10)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C607(1.11)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C607(0.98)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C607(1.02)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C607(1.23)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C607(1.57)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C607(1.49)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C607(0.93); C612(1.29)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C607(1.04); C612(1.22)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C607(1.02); C612(1.46)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C607(0.96); C612(1.20)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C607(1.08); C612(1.36)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C607(1.17); C612(1.36)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C607(1.16); C612(1.57)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C607(0.91)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C607(1.08); C612(1.54)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C607(1.17); C612(1.43)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C607(1.30); C612(1.59)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C607(1.39); C612(1.73)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C607(1.18); C612(1.45)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C607(1.15); C612(1.80)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C607(1.42); C612(2.15)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C607(1.66); C612(2.48)  LDD0843  [5]
 LDCM0259  AC14 HEK-293T C607(1.07)  LDD0857  [5]
 LDCM0263  AC143 HEK-293T C607(1.02)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C607(1.34)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C607(1.42)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C607(1.24)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C607(1.49)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C607(1.32)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C607(0.97)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C607(1.14)  LDD0868  [5]
 LDCM0271  AC150 HEK-293T C607(1.15)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C607(1.27)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C607(1.17)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C607(1.35)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C607(1.08)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C607(1.12)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C607(1.44)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C607(1.65)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C607(0.97)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C607(0.93)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C607(0.90)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C607(1.05); C612(0.99)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C607(0.92)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C607(0.98)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C607(0.98)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C607(0.98)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C607(0.87)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C607(1.08)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C607(1.10)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C607(1.03)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C607(0.79)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C607(1.00)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C607(1.01); C612(0.82)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C607(1.00)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C607(0.92)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C607(0.99)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C607(1.03)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C607(0.97)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C612(1.02)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C612(1.09)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C612(1.28)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C612(1.42)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C612(1.90)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C607(1.08); C612(1.10)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C612(1.59)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C612(1.86)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C612(0.94)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C612(1.35)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C612(1.34)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C612(1.12)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C612(1.40)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C612(1.24)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C612(1.14)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C612(0.79)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C607(0.99); C612(0.89)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C612(0.80)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C612(0.94)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C612(0.82)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C612(0.73)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C612(0.71)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C612(0.93)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C612(1.24)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C607(0.98)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C607(0.94)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C607(0.97)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C607(0.97)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C607(0.99)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C607(1.01)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C607(0.97)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C607(1.11)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C607(1.00)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C607(1.05)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C607(0.97)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C607(1.05)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C607(1.10)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C607(1.10)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C607(0.94)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C607(1.17)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C607(1.19)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C607(1.19)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C607(1.18)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C607(1.10)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C607(1.15)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C607(1.16)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C607(1.21)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C607(1.25)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C607(1.19)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C607(1.03)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C607(1.17)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C607(1.12)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C607(1.35)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C607(1.06)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C607(1.07)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C607(1.13)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C607(1.03)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C607(1.13)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C607(1.12)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C607(1.09)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C607(1.05)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C607(1.18)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C607(1.11)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C607(0.94)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C607(1.16)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C607(1.17)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C607(0.98)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C607(1.52)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C607(1.01)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C607(0.91)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C607(0.90)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C607(1.19)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C607(0.97)  LDD0873  [5]
 LDCM0369  CL100 HEK-293T C607(1.07); C612(0.98)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C607(1.05)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C607(1.04)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C607(0.99)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C607(1.03)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C607(1.00)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C607(0.98)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C607(0.96)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C607(1.02)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C607(0.90)  LDD0976  [5]
 LDCM0380  CL110 HEK-293T C607(0.88)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C607(0.85)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C607(0.98)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C607(1.01)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C607(1.15)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C607(0.99)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C607(1.10)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C612(1.05)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C612(1.69)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C612(1.95)  LDD0987  [5]
 LDCM0391  CL120 HEK-293T C612(1.76)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C612(0.84)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C612(1.05)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C612(0.96)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C612(0.88)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C607(1.05)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C607(1.06)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C607(1.05)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C607(1.02)  LDD0997  [5]
 LDCM0403  CL16 HEK-293T C607(0.96)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C607(0.84)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C607(0.93)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C607(1.10)  LDD1004  [5]
 LDCM0408  CL20 HEK-293T C607(1.01)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C607(0.96)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C607(1.06)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C607(1.04)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C607(0.78)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C607(0.85)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C607(0.78)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C607(1.05)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C607(0.96)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C607(1.07)  LDD1015  [5]
 LDCM0419  CL30 HEK-293T C607(1.00)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C607(1.04)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C607(0.95)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C607(0.85)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C607(1.03)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C607(1.02)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C607(0.96)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C607(1.01)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C607(1.18)  LDD1026  [5]
 LDCM0430  CL40 HEK-293T C607(1.02)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C607(1.04)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C607(1.28)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C607(1.21)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C607(0.94)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C607(1.09)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C607(0.97)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C607(0.95)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C607(0.95)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C607(0.95)  LDD1037  [5]
 LDCM0441  CL50 HEK-293T C607(1.15)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C607(0.97)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C607(0.97)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C607(0.99)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C607(0.95)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C607(1.11)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C607(0.94)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C607(1.06)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C607(1.06)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C607(1.13)  LDD1048  [5]
 LDCM0452  CL60 HEK-293T C607(1.06)  LDD1050  [5]
 LDCM0486  CL91 HEK-293T C607(1.01); C612(0.80)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C607(1.00); C612(1.24)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C607(0.98); C612(1.28)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C607(1.18); C612(1.02)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C607(1.06); C612(0.99)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C607(1.00); C612(0.89)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C607(1.00); C612(0.90)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C607(1.05); C612(0.89)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C607(1.12); C612(0.94)  LDD1092  [5]
 LDCM0427  Fragment51 HEK-293T C607(0.89)  LDD1025  [5]
 LDCM0022  KB02 8305C C601(1.62)  LDD2248  [2]
 LDCM0023  KB03 8305C C601(2.53)  LDD2665  [2]
 LDCM0024  KB05 MKN45 C601(1.96); C738(4.76)  LDD3332  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us10035778, Example 1 Small molecular drug D0QG9P
Us10035778, Example 12 Small molecular drug D0UB5E
Us10035778, Example 16 Small molecular drug D04KXV

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.