Details of the Target

General Information of Target

Target ID LDTP02113
Target Name DNA-directed RNA polymerase III subunit RPC4 (POLR3D)
Gene Name POLR3D
Gene ID 661
Synonyms
BN51; BN51T; DNA-directed RNA polymerase III subunit RPC4; RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RPC53 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEGNAAGEPSTPGGPRPLLTGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTP
NIISRKIKEEPKEEVTVKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKKK
GNWDKTVDVSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFLDDPGLRNDTRNMPVQL
PLAHSGWLFKEENDEPDVKPWLAGPKEEDMEVDIPAVKVKEEPRDEEEEAKMKAPPKAAR
KTPGLPKDVSVAELLRELSLTKEEELLFLQLPDTLPGQPPTQDIKPIKTEVQGEDGQVVL
IKQEKDREAKLAENACTLADLTEGQVGKLLIRKSGRVQLLLGKVTLDVTMGTACSFLQEL
VSVGLGDSRTGEMTVLGHVKHKLVCSPDFESLLDHKHR
Target Bioclass
Enzyme
Family
Eukaryotic RPC4/POLR3D RNA polymerase subunit family
Subcellular location
Nucleus
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.
Uniprot ID
P05423
Ensemble ID
ENST00000306433.9
HGNC ID
HGNC:1080

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C316(1.11)  LDD0532  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C316(2.46)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C316(1.11)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C316(1.01)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C316(1.11)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C316(0.93)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C316(0.94)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C316(1.02)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C316(1.01)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C316(1.11)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C316(1.19)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C316(1.01)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C316(1.10)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C316(1.07)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C316(1.07)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C316(1.39)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C316(0.98)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C316(1.30)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C316(1.02)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C316(1.06)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C316(1.16)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C316(1.05)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C316(0.89)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C316(1.04)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C316(0.93)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C316(1.03)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C316(1.03)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C316(0.96)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C316(1.15)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C316(0.94)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C316(0.84)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C316(0.84)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C316(0.81)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C316(0.83)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C316(0.99)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C316(0.89)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C316(0.95)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C316(1.28)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C316(1.23)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C316(1.29)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C316(1.01)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C316(1.19)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C316(1.35)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C316(1.04)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C316(1.22)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C316(1.00)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C316(1.00)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C316(0.99)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C316(0.93)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C316(1.06)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C316(1.04)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C316(0.97)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C316(0.99)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C316(1.01)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C316(1.01)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C316(1.08)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C316(1.04)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C316(0.98)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C316(1.03)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C316(1.05)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C316(0.91)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C316(1.07)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C316(1.15)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C316(0.89)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C316(1.09)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C316(1.10)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C316(0.99)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C316(1.08)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C316(1.10)  LDD1546  [10]
 LDCM0308  AC46 HCT 116 C316(1.20)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C316(0.90)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C316(1.19)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C316(1.06)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C316(1.27)  LDD0910  [1]
 LDCM0313  AC50 HCT 116 C316(1.04)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C316(1.21)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C316(1.04)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C316(1.08)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C316(0.98)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C316(1.14)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C316(1.28)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C316(1.02)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C316(1.17)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C316(0.99)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C316(0.96)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C316(1.04)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C316(1.10)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C316(0.96)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C316(0.99)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C316(1.06)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C316(1.05)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C316(1.04)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C316(0.90)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C316(1.01)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C316(0.98)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C316(0.89)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C316(0.89)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C316(0.83)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C316(0.80)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C316(0.94)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C316(0.74)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C316(0.70)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C316(0.85)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C316(0.84)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C316(0.73)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C316(0.70)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C316(0.75)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C316(0.90)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C316(0.75)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C316(0.80)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C316(0.92)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C316(0.92)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C316(1.17)  LDD0592  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C316(1.05)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C316(1.05)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C316(1.06)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C316(1.08)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C316(0.96)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C316(1.04)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C316(0.98)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C316(1.10)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C316(1.02)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C316(1.24)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C316(1.10)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C316(1.17)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C316(1.11)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C316(1.14)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C316(1.06)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C316(0.94)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C316(1.07)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C316(0.85)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C316(0.97)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C316(0.93)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C316(1.01)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C316(0.86)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C316(0.98)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C316(1.02)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C316(1.03)  LDD1595  [10]
 LDCM0392  CL121 HCT 116 C316(0.88)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C316(1.19)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C316(1.07)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C316(1.23)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C316(0.85)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C316(0.76)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C316(0.93)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C316(0.79)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C316(1.05)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C316(0.82)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C316(1.13)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C316(0.97)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C316(1.14)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C316(0.98)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C316(1.15)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C316(0.92)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C316(1.21)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C316(1.19)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C316(1.05)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C316(1.22)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C316(1.03)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C316(0.97)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C316(0.85)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C316(0.95)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C316(0.89)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C316(0.97)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C316(1.15)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C316(1.05)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C316(1.13)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C316(1.17)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C316(1.15)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C316(0.98)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C316(1.09)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C316(0.96)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C316(1.07)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C316(1.06)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C316(1.02)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C316(1.16)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C316(1.08)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C316(1.04)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C316(0.97)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C316(0.95)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C316(0.95)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C316(1.12)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C316(1.03)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C316(1.27)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C316(1.07)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C316(1.05)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C316(1.24)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C316(1.12)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C316(0.95)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C316(1.00)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C316(0.95)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C316(1.07)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C316(0.93)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C316(1.02)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C316(0.99)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C316(1.27)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C316(1.01)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C316(1.20)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C316(1.09)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C316(1.06)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C316(1.10)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C316(1.03)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C316(1.02)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C316(0.86)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C316(0.87)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C316(0.79)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C316(0.90)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C316(1.07)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C316(0.95)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C316(0.92)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C316(1.00)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C316(0.86)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C316(1.05)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C316(1.00)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C316(1.04)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C316(0.98)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C316(1.04)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C316(1.16)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C316(1.03)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C316(1.04)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C316(1.00)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C316(1.19)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C316(1.04)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C316(1.12)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C316(0.86)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C316(1.02)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C316(1.06)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C316(1.08)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C316(1.09)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C316(1.15)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C316(1.02)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C316(0.94)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C316(0.93)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C316(1.44)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C316(1.33)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C316(1.14)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C316(1.13)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C316(1.07)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C316(1.06)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C316(1.00)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C316(0.80)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C316(0.82)  LDD1025  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C316(0.98)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C316(0.99)  LDD1497  [10]
 LDCM0024  KB05 MV4-11 C316(2.40)  LDD3338  [11]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840